scholarly journals Association of proinsulin and hepatic steatosis in a random, population-based sample

2013 ◽  
Vol 168 (2) ◽  
pp. 195-202 ◽  
Author(s):  
Sonja Wengert ◽  
Suemeyra Oeztuerk ◽  
Mark Martin Haenle ◽  
Wolfgang Koenig ◽  
Armin Imhof ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Cell Function ◽  
Predictive Marker ◽  
Abdominal Ultrasound ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Β Cell Function ◽  
Western Germany ◽  
Upper Abdominal

ObjectiveProinsulin may represent a predictive marker for assessing insulin resistance and reduced β-cell function. The objective of this study was to investigate the association between hepatic steatosis, proinsulin and other parameters in a random, population-based sample.DesignCross-sectional study, conducted in south-western Germany.MethodsUpper abdominal ultrasound examinations were performed in 343 subjects (147 females, 196 males; average age 40.0±11.5 years). Proinsulin, the proinsulin-to-insulin ratio and other laboratory parameters were determined, and the BMI, waist-to-hip ratio (WHR) and other anthropometric data were documented.ResultsHepatic steatosis was observed in 80 subjects (23.3%: 29.6%, males; 15.0%, females). Multivariate analysis showed an association with hepatic steatosis for male gender (P=0.0212), advancing age (P=0.0241), elevated BMI (P<0.0001), elevated WHR (P=0.0024), alanine aminotransferase (P=0.0046), proinsulin (P=0.0403) and proinsulin-to-insulin ratio (P=0.0116).ConclusionsThere is an association between elevated proinsulin concentrations and hepatic steatosis.

scholarly journals Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or β-Cell Function in Chinese Obese Children

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Fengyun Wang ◽  
Ting Chen ◽  
Ling Sun ◽  
Haitao Lv ◽  
Xuan Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Energy Homeostasis ◽  
Cell Function ◽  
Cross Sectional Study ◽  
Obese Children ◽  
Cross Sectional ◽  
Pathological Mechanism ◽  
Adult Humans ◽  
Β Cell Function

Progranulin (PGRN), a novel peptide that has recently emerged as an important regulatory adipokine, is relevant to energy homeostasis and obesity in animals and adult humans. Little is known about its roles in children. The aim of the current study was to determine the potential role of PGRN and explore its relationship to various obesity-related markers in obese children. This was a cross-sectional study composed of 77 children (43 obese and 34 healthy, age 8.68 ± 0.28 and 8.46 ± 0.45 years, resp.). The PGRN levels were significantly higher in obese children (102.44 ± 4.18 ng/mL) comparing to controls (69.32 ± 5.49 ng/mL) (P<0.05). Moreover, the PGRN levels were positively correlated with triglyceride (TG), total cholesterol (TC), IL-6, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in obese children after adjusted for BMI and age. However, there was no correlation of serum PGRN levels with OGTT-derived dynamic parameters, HOMA-IR, or HOMA-β in obese children. The results suggest that serum PGRN levels are significantly higher in obese children in China and correlate significantly with obesity-related markers. Increased PGRN levels may be involved in the pathological mechanism of childhood obesity.

scholarly journals Association of Insulin Resistance and β-cell Function With Bone Turnover Biomarkers in Dysglycemia Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Hui Guo ◽  
Chiyu Wang ◽  
Boren Jiang ◽  
Shaohong Ge ◽  
Jian Cai ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Bone Turnover ◽  
Type I Collagen ◽  
Cell Function ◽  
Cross Sectional Study ◽  
Type I ◽  
Model Assessment ◽  
Β Cell ◽  
Cross Sectional ◽  
Β Cell Function

BackgroundThe interrelation between glucose and bone metabolism is complex and has not been fully revealed. This study aimed to investigate the association between insulin resistance, β-cell function and bone turnover biomarker levels among participants with abnormal glycometabolism.MethodsA total of 5277 subjects were involved through a cross-sectional study (METAL study, http://www.chictr.org.cn, ChiCTR1800017573) in Shanghai, China. Homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell dysfunction (HOMA-%β) were applied to elucidate the nexus between β-C-terminal telopeptide (β-CTX), intact N-terminal propeptide of type I collagen (P1NP) and osteocalcin (OC). β-CTX, OC and P1NP were detected by chemiluminescence.ResultsHOMA-IR was negatively associated with β-CTX, P1NP and OC (regression coefficient (β) -0.044 (-0.053, -0.035), Q4vsQ1; β -7.340 (-9.130, -5.550), Q4vsQ1 and β -2.885 (-3.357, -2.412), Q4vsQ1, respectively, all P for trend &lt;0.001). HOMA-%β was positively associated with β-CTX, P1NP and OC (β 0.022 (0.014, 0.031), Q4vsQ1; β 6.951 (5.300, 8.602), Q4vsQ1 and β 1.361 (0.921, 1.800), Q4vsQ1, respectively, all P for trend &lt;0.001).ConclusionsOur results support that lower bone turnover biomarker (β-CTX, P1NP and OC) levels were associated with a combination of higher prevalence of insulin resistance and worse β-cell function among dysglycemia patients. It is feasible to detect bone turnover in diabetes or hyperglycemia patients to predict the risk of osteoporosis and fracture, relieve patients’ pain and reduce the expenses of long-term cure.

scholarly journals Impact of Endoscopic Ultrasound in Evaluation of Upper Abdominal Pain

2021 ◽  
Vol 33 (1) ◽  
pp. 1-6
Author(s):  
Bimal Chandra Shil ◽  
Madhusudan Saha ◽  
Md Royes Uddin ◽  
ANM Saifullah ◽  
Md Rehan Habib ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Endoscopic Ultrasound ◽  
Epigastric Pain ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Abdominal Ultrasound ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Presenting Symptoms ◽  
Medicine Today ◽  
Upper Abdominal

Introduction: Upper abdominal pain is found to be one of the most common presenting symptoms. Endoscopic ultrasound may be a useful tool to yield a specific diagnosis. Aim of our study was to find the etiology of upper abdominal pain with normal endoscopic findings and compare the findings of endoscopic ultrasound with those of trans-abdominal ultrasound. Materials and Methods: This was a cross sectional study conducted in the department of gastroenterology, Sir Salimullah Medical College from January 2015 to December 2019. Total 238 patients suffering from upper abdominal pain who previously underwent endoscopy with normal results and trans abdominal ultrasound with doubtful findings were enrolled in this study. All patients were evaluated properly with history, clinical examination and relevant blood investigations. Then the patients underwent endoscopic ultrasound with conscious sedation. Computed tomorgraphy, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography were done in cases where needed and correlated with endoscopic ultrasound results. Results: Among the total 238 patients, 137 were male and 101 were female. Most predominant age range was 31-40 years. Pain was moderate in severity in 43.27%, epigastric pain was in 59.66% and pain referred to back was in 37.39% patients. Comparison with trans abdominal ultrasound regarding etiologies of upper abdominal pain was statistically significant (P=0.000). Comparative analysis between the two modalities regarding gall bladder, common bile duct, pancreas were also found significant with P values of 0.040, 0.005, 0.000 respectively. Forty two patients were diagnosed as chronic pancreatitis based on Rosemont criteria by endoscopic ultrasound. Conclusion: Endoscopic ultrasound is a modern diagnostic tool which can detect hepato-pancreato-biliary pathologies and also mucosal irregularities of stomach and esophagus. So, it can be considered as a first line investigation to diagnose the underlying etiology of upper abdominal pain. Medicine Today 2021 Vol.33(1): 1-6

scholarly journals Significantly decreased islet β cell function and increased fasting plasma glucose in patients with chronic hepatitis B: a cross-sectional study

2021 ◽  
Author(s):  
Dafeng Liu ◽  
Lingyun Zhou ◽  
Xinyi Zhag ◽  
Yilan Zeng ◽  
Lang Bai ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Hepatitis B ◽  
Cell Function ◽  
Cross Sectional Study ◽  
Contributing Factors ◽  
Β Cell ◽  
Cross Sectional ◽  
Abnormal Glucose Metabolism ◽  
Β Cell Function ◽  
Hbeag Status

Abstract Background: The contributing factors of abnormal glucose metabolism and the characteristics of the homeostasis model assessment of β cell function (HOMA-β) value in chronic hepatitis B (CHB) patients are unclear and worth studying.Method: This cross-sectional study recruited 110 CHB patients (CHB group) and 110 patients without hepatitis B virus (non-HBV group); the groups were matched according to sex, age, and body mass index. The contributing factors of abnormal glucose metabolism and the characteristics and differences in glucose metabolism parameters between the two groups were analyzed. Results: The abnormal glucose metabolism rate was higher in CHB patients with liver cirrhosis (LC) and patients with hepatitis B envelope antigen (HBeAg) (-) status. In addition, under the same glucose metabolism conditions, the fasting plasma glucose (FPG) levels of the CHB group was higher than that of the non-HBV group, especially in those with LC that had higher FPG levels (all p=0.000), while the HOMA-β values was significantly lower in the CHB group than in the non-HBV group, especially under normal glucose tolerance conditions (all p=0.000). Further analyses revealed that the main contributing factors of abnormal glucose metabolism were HBeAg (-) status and hepatitis B envelope antibody levels, but HBV serological and virological indicators had no direct effect on the HOMA-β value.Conclusion: These findings provide a reference that will allow clinicians to monitor abnormal glucose metabolism in CHB patients, especially those with LC or HBeAg (-) status, focus on the protection of islet β-cell function, and avoid the application of insulin secretagogues in CHB patients with abnormal glucose metabolism.

Overweight, obesity, and their associations with insulin resistance and β-cell function among Chinese: a cross-sectional study in China

Metabolism ◽  
2010 ◽  
Vol 59 (12) ◽  
pp. 1823-1832 ◽  
Author(s):  
Gang Chen ◽  
Chune Liu ◽  
Jin Yao ◽  
Qiqin Jiang ◽  
Nianhui Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Function ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Β Cell ◽  
Cross Sectional ◽  
Β Cell Function
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