Is GH a cancer growth factor?

2017 ◽  
Author(s):  
Shlomo Melmed
Keyword(s):  
Growth Factor ◽  
Cancer Growth

Glipizide Combined with ANP Suppresses Breast Cancer Growth and Metastasis by Inhibiting Angiogenesis through VEGF/VEGFR2 Signaling

2021 ◽  
Vol 21 ◽  
Author(s):  
Guanquan Mao ◽  
Shuting Zheng ◽  
Jinlian Li ◽  
Xiaohua Liu ◽  
Qin Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Natriuretic Peptide ◽  
Umbilical Vein ◽  
Tube Formation ◽  
Cancer Growth ◽  
Vascular Endothelial ◽  
Breast Cancer Growth ◽  
Endothelial Growth Factor

Background: Breast cancer is one of the most common cancers worldwide among women, and angiogenesis has an important effect on its growth and metastasis. Glipizide, which is a widely used drug for type 2 diabetes mellitus, has been reported to inhibit tumor growth and metastasis by upregulating the expression of natriuretic peptide receptor A (NPRA). Atrial natriuretic peptide (ANP), the receptor of NPRA, plays an important role in angiogenesis. The purpose of this study was to explore the effect of glipizide combined with ANP on breast cancer growth and metastasis. Methods: To investigate the effect of glipizide combined with ANP on breast cancer, glipizide, ANP or glipizide combined with ANP was intraperitoneally injected into MMTV-PyMT mice. To explore whether the anticancer efficacy of glipizide combined with ANP was correlated with angiogenesis, a tube formation assay was performed. Results: Glipizide combined with ANP was found to inhibit breast cancer growth and metastasis in MMTV-PyMT mice, which spontaneously develop breast cancer. Furthermore, the inhibitory effect of ANP combined with glipizide was better than that of glipizide alone. ANP combined with glipizide significantly inhibited tube formation of human umbilical vein endothelial cells (HUVECs) by suppressing vascular endothelial growth factor (VEGF)/VEGFR2 (vascular endothelial growth factor receptor 2) signaling. Conclusions: These results demonstrate that glipizide combined with ANP has a greater potential than glipizide alone to be repurposed as effective agents for the treatment of breast cancer by targeting tumor-induced angiogenesis.

scholarly journals Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone

2017 ◽  
Vol 34 (3-4) ◽  
pp. 261-271 ◽  
Author(s):  
Annika Nordstrand ◽  
Sofia Halin Bergström ◽  
Elin Thysell ◽  
Erik Bovinder-Ylitalo ◽  
Ulf H. Lerner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Rat Model ◽  
Cancer Growth ◽  
Insulin Like Growth Factor ◽  
Acute Effects

scholarly journals Downregulation of CD9 promotes pancreatic cancer growth and metastasis through upregulation of epidermal growth factor on the cell surface

2015 ◽  
Vol 34 (1) ◽  
pp. 350-358 ◽  
Author(s):  
MAOCHUN TANG ◽  
GUOJIAN YIN ◽  
FENG WANG ◽  
HUA LIU ◽  
SHU ZHOU ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Surface ◽  
Cancer Growth ◽  
Epidermal Growth
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