Core muscles trainig for muscle strength improvement in patients with osteoporotic compression vertebral fractures

Background:Due to the demand for special rehabilitation programs for patients with osteoporotic vertebral fractures (VFs), it is of interest to study the functional abilities of those patients. The scientific hypothesis suggests that osteoporotic VFs would cause muscle weakness, muscle dysfunction and conditional disturbances.Objectives:to estimate muscle strength, motor function and coordination disorders in patients with VFs in the setting of systemic osteoporosis as a basis for rehabilitation programs developing.Methods:120 patients aged 43−80 with primary osteoporosis were enrolled. Study group comprised of 60 subjects (56 women, 4 men) with at least 1 VF confirmed by X-rays. Control group included 60 subjects (56 women, 4 men) with osteoporosis but without any osteoporotic fracture. The examination program included back muscles tenzodynamometry, balance tests and stabilometry.Results:Muscle strength deficiency was estimated in study group in trunk flexors (TF) — 40.9% and in trunk extensors (TE) — 18.1% with an adequate function of the left lateral flexors (LLF) and in right lateral flexors (RLF). Patients with VFs had the lower muscle strength vs controls of TE (15.64±9.8 vs 27.73±9.9 kg, p=0.00002), TF (14.61±8.98 vs 21.28±8.38 kg, p=0.0006), LLF (13.10±7.2 vs 24.06±8.9 kg, p=0.005) and RLF 13.44±7.43 vs 24.26±7.65 kg, p=0.0003). Patients with VFs lose their balance faster during one-leg-standing test with open eyes (5.0 [1.0; 10.0] vs 7.5 [5.0; 10.5] sec in control group, p=0.03) and with closed eyes (2.0 [0; 3.0] vs 3.5 [3.0; 5.0] sec, p=0.04). Fukuda-Unterberger test showed greater side dislocation in study group — 40° [25; 45] vs controls 30° [10; 45], (p=0.02). According to stabilometry study group was characterized vs control group by lower balance coefficient with open eyes (77.2±7.6 vs 85.7±9.4%, p=0.002) and with closed eyes (67.1±9.8 vs 73.4±9.9%, p=0.03), greater sagittal displacement (6.8 [2.1; 37.7] vs 4.8 [1.8; 10.7] mm, p=0.025) and deviation in the saggital plane (1.2 [-1.07; 1.5] vs -1.2 [-1.5; 1.2] mm, p=0.01), and also less pressure center velocity (9.51±4.4 vs 7.1±2.7 mm/sec, р=0.009).Conclusion:Osteoporotic VFs are associated with reduction of trunk muscles strength and negatively affect static and dynamic balance function that should be taken into account when developing rehabilitation programs for these patients.Disclosure of Interests:None declared.

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Effect of muscle strength and endurance development on blood flow

Journal of Applied Physiology ◽

10.1152/jappl.1961.16.5.873 ◽

1961 ◽

Vol 16 (5) ◽

pp. 873-877 ◽

Cited By ~ 12

Author(s):

Ellen R. Vanderhoof ◽

Charles J. Imig ◽

H. M. Hines

Keyword(s):

Blood Flow ◽

Muscle Strength ◽

Training Program ◽

Strength Development ◽

Flow Response ◽

Hand Grip ◽

Vascular Bed ◽

Flow Through ◽

Test Exercise ◽

Strength Improvement

Studies were carried out to investigate the effect of hand grip strength and/or endurance improvement on blood flow through the muscles involved. One group of subjects trained for strength development and another for endurance development throughout a 29-week period. At regular intervals blood flow was measured under resting conditions and also following three different test exercise stresses designed to test the functional capacity of the vascular bed. Subjects who participated in the strength training program made significant gains in strength but not in endurance, while those subjects who trained for endurance improved in both strength and endurance. Resting blood flow was not changed significantly as a result of either training program. Significant changes in the blood flow response to the test exercise stresses were noted; these changes were associated with endurance rather than strength improvement. Submitted on April 3, 1961

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Kinesio Taping Relieves Pain and Improves Isokinetic Not Isometric Muscle Strength in Patients with Knee Osteoarthritis—A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph181910440 ◽

2021 ◽

Vol 18 (19) ◽

pp. 10440

Author(s):

Hsin-Yu Mao ◽

Meng-Tzu Hu ◽

Yea-Yin Yen ◽

Shou-Jen Lan ◽

Shin-Da Lee

Keyword(s):

Muscle Strength ◽

Knee Osteoarthritis ◽

Conventional Therapy ◽

Meta Analysis ◽

Total Effect ◽

Jadad Score ◽

Knee Oa ◽

Isokinetic Muscle Strength ◽

Strength Improvement ◽

Isometric Muscle

This study investigated the effects of kinesio taping (KT) or KT plus conventional therapy on pain, muscle strength, funrefction, and range of motion in patients with knee osteoarthritis (OA). Data sources: Databases included PubMed, Ovid Medline, CINAHL, Airiti Library, EMBASE, and WOS search engines. Search terms related to KT and knee OA were combined and searched. Articles that met the inclusion criteria and were graded with a Jadad score ≥3 were included in a meta-analysis to calculate the total effect. The exclusion criteria were non-English-language articles, non-original articles, non-full-text articles, no description of the intervention, or articles with a Jadad score ≤2. Eleven articles were included in the meta-analysis. KT treatment had a significant small total effect on pain reduction (p < 0.001; n = 1509; standardized mean difference (SMD) = −0.42; 95% CI = −0.65 to −0.18) and a significant moderate total effect on isokinetic muscle strength improvement (p = 0.001; n = 447; SMD = 0.72; 95% CI = 0.28 to 1.16). No significant total effects of KT on isometric muscle strength, time to complete functional tasks, or ROM improvement were found. KT or KT plus conventional therapy has a significant effect on pain relief and isokinetic but not isometric muscle strength improvement in patients with knee OA. KT can be an effective tool for treating knee OA pain and is especially valuable for aiding in isokinetic muscle strength. (PROSPERO register ID: CRD42021252313)

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The effectiveness of mechanotherapeutic methods for spine deep stabilization system training in patients with osteoporotic vertebral fractures

Journal of restorative medicine and rehabilitation ◽

10.38025/2078-1962-2020-96-2-33-40 ◽

2020 ◽

Vol 96 (2) ◽

pp. 33-40 ◽

Cited By ~ 1

Author(s):

E.V. Makarova ◽

L.A. Marchenkova ◽

M.A. Eremushkin ◽

E.M. Styazkina ◽

E.I. Chesnikova ◽

...

Keyword(s):

Muscle Strength ◽

Vertebral Fractures ◽

Physical Rehabilitation ◽

Control Group ◽

Physical Exercises ◽

Osteoporotic Vertebral Fractures ◽

Unstable Platform ◽

Group 2 ◽

Group 1

The aim of the study was to estimate the effect of new physical rehabilitation complex using of mechanotherapeutic methods on spine muscle strength in patients with osteoporosis (OP) and vertebral fractures (VF). Material and methods: Study comprised of 90 osteoporotic patients aged 50-80 years old (65.4±9.1 years) with OP VFs who were randomized as 2:1 into intervention group (group1, n=60) and control group (group2, n=30). Patients in group 1 received an intensive rehabilitation course including back muscle training with mechanical loads #10; sensorimotor training on double unstable platform #10; kinesohydrotherapy in a pool #15; physical exercises in a gym #10. Group 2 was prescribed only physical exercises in a gym #15. All patients undergo tenzodynamometry on BackCheck diagnostic unit (Dr. Wolff, Germany) at baseline, in 3 weeks at the end of rehabilitation course and in a month of follow-up. Results: In group 1 after the rehabilitation course muscle strength improved in trunk extensors (TE) from 15.8±10.1 to 21.7±13.1 kg (p<0.001), trunk flexors (TF) from 14.5±9.1 to 18.9±10.2 kg (p<0.001), left lateral flexors (LLF) from 12.8±7.2 to 17.5±9.6kg (p<0.001) and right lateral flexors (RLF) from 13.2 ± 7.1 to 17.8 ± 9.2 kg (p<0.01). Strength deficiency significantly decreased in all muscles (p<0.001 for TE and TF, p<0.05 for LLF, p<0.01 for RLF). The achieved effect lasted for a month of follow-up. In group 2 positive dynamics of strength was observed after 3 weeks only in TE and TF (p<0.05), however, after a month of observation, the strength of all the studied muscles did not differ from the baseline (p>0.05). Conclusion: The new 3-week complex of physical rehabilitation using of mechanotherapeutic methods lead to increase of spine muscle strength and improvement of muscle strength deficiency in patients with osteoporotic VFs. Rehabilitation effect lasts for at least a month after the treatment completion.

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Novel Myostatin-Specific Antibody Enhances Muscle Strength in Muscle Disease Models

10.21203/rs.3.rs-116413/v1 ◽

2020 ◽

Author(s):

Hiroyasu Muramatsu ◽

Taichi Kuramochi ◽

Hitoshi Katada ◽

Atsunori Ueyama ◽

Yoshinao Ruike ◽

...

Keyword(s):

Muscle Strength ◽

Transforming Growth Factor ◽

Muscle Growth ◽

Muscle Disease ◽

Negative Regulator ◽

Disease Models ◽

Muscular Disorders ◽

Disease Therapy ◽

Improve Muscle Strength ◽

Strength Improvement

Abstract Myostatin, a member of the transforming growth factor-b superfamily, is an attractive target for muscle disease therapy because of its role as a negative regulator of muscle growth and strength. Here, we describe a novel antibody therapeutic approach that maximizes the potential of myostatin-targeted therapy. We generated an antibody, GYM329, that specifically binds the latent form of myostatin and inhibits its activation. Additionally, via “sweeping antibody technology”, GYM329 reduces or “sweeps” myostatin in the muscle and plasma. Compared with conventional anti-myostatin agents, GYM329 and its surrogate antibody exhibit superior muscle strength-improvement effects in three different mouse disease models. We also demonstrate that the superior efficacy of GYM329 is due to its myostatin specificity and sweeping capability. Furthermore, we show that a GYM329 surrogate increases muscle mass in normal cynomolgus monkeys without any obvious toxicity. Our findings indicate the potential of GYM329 to improve muscle strength in patients with muscular disorders.

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Back extensor training increases muscle strength in postmenopausal women with osteoporosis, kyphosis and vertebral fractures

Advances in Physiotherapy ◽

10.3109/14038196.2011.581696 ◽

2011 ◽

Vol 13 (3) ◽

pp. 110-117 ◽

Cited By ~ 15

Author(s):

Ingrid Bergström ◽

Karin Bergström ◽

Ann-Charlotte Grahn Kronhed ◽

Susanne Karlsson ◽

Jonas Brinck

Keyword(s):

Muscle Strength ◽

Postmenopausal Women ◽

Vertebral Fractures ◽

Back Extensor

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The evaluation of functional abilities of patients with osteoporotic vertebral fractures as a basis for rehabilitation programs developing

Russian Journal of Physiotherapy Balneology and Rehabilitation ◽

10.17816/1681-3456-2020-19-3-3 ◽

2021 ◽

Vol 19 (3) ◽

pp. 152-159

Author(s):

L. A. Marchenkova ◽

E. V. Makarova ◽

M. A. Eryomushkin ◽

M. Yu. Герасименко ◽

E. M. Styazkina ◽

...

Keyword(s):

Muscle Strength ◽

Vertebral Fractures ◽

Dynamic Balance ◽

Trunk Muscles ◽

Control Group ◽

Study Group ◽

Primary Osteoporosis ◽

Functional Abilities ◽

Rehabilitation Programs ◽

Osteoporotic Vertebral Fractures

Background.Due to the demand for special rehabilitation programs for patients with osteoporotic vertebral fractures (VFs), it is of interest to study the functional abilities of those patients. The scientific hypothesis suggests that osteoporotic VFs would cause muscle weakness, muscle dysfunction and conditional (basic motor) disturbances. Objective:to estimate muscle strength, motor function and coordination disorders in patients with VFs in the setting of systemic osteoporosis as a basis for rehabilitation programs developing. Methods. 120 patients aged 4380 with primary osteoporosis were enrolled. Study group comprised of 60 subjects (56 women, 4 men) with at least 1 VF confirmed by X-ray. Control group included 60 subjects (56 women, 4 men) with osteoporosis but without any osteoporotic fracture. The examination program consist of back muscles tenzodynamometry, balance tests and stabilometry. Results. Muscle strength deficiency was estimated in study group in trunk flexors (TF) 40.9% and in trunk extensors (TE) 18.1% with an adequate function of the left lateral flexors (LLF) and in right lateral flexors (RLF). Patients with VFs had the lower muscle strength vs controls of TE (15.64 9.8 vs 27.73 9.9 kg, p = 0.00002), TF (14.61 8.98 vs 21.28 8.38 kg, p = 0.0006), LLF (13.10 7.2 vs 24.06 8.9 kg, p = 0.005) and RLF 13.44 7.43 vs 24.26 7.65 kg, p = 0.0003). Patients with VFs lose their balance faster during one-leg-standing test with open eyes (5.0 [1.0;10.0]vs 7.5 [5.0;10.5]sec in control group, p=0.03) and with closed eyes (2.0[0;3.0] vs 3.5[3.0;5.0]sec, p = 0.04). Fukuda-Unterberger test showed greater side dislocation in study group 40 [25;45]vs controls 30 [10; 45], (p=0.02). According to stabilometry study group was characterized vs control group by lower balance coefficient with open eyes (77.27.6 vs 85.79.4%, p=0.002) and with closed eyes (67.19.8 vs 73.49.9%, p=0.03), greater sagittal displacement(6.8 [2.1;37.7]vs4.8 [1.8;10.7]mm, p=0.025) and deviation in the saggital plane(1.2 [-1.07;1.5]vs-1.2 [-1.5;1.2]mm, p = 0.01), and also less pressure center velocity (9.51 4.4 vs 7.1 2.7 mm/sec, р=0.009). Conclusions.VFs in osteoporotic patients are associated with reduction of trunk muscles strength and negatively affect static and dynamic balance function. The obtained data should be taken into account when developing rehabilitation programs for patients with osteoporosis who have suffered compression VFs.

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