From dwarves to giants: South American’s contribution to the history of growth hormone and related disorders

Author(s):  
Boguszewski CL ◽  
MC da Silva Boguszewski ◽  
de Herder WW
2020 ◽  
Vol 10 (2) ◽  
pp. 48-65
Author(s):  
Alan G. Hartman

Abstract Colombia is a South American nation that has captured the imagination of the world. It is a land of beautiful colonial cities and towns, famous for coffee production, rich emerald mines, and the literature of José Asunción Silva and Gabriel García Márquez. Colombia’s beauty and rich literary history, however, are often overshadowed by the memory of Pablo Escobar, a notorious drug lord, and numerous deadly guerilla groups. Their roles in the international drug trade made Colombia the top producer and exporter of cocaine, which resulted in terrorism and violence that left the country one of the world’s most dangerous.1 In this article, I will explore how violence in Colombia has perpetuated the theme of hopelessness in the nation’s literature beginning in the mid-twentieth century. I will show this in three parts. Firstly, I will trace the history of violence in Colombia through the nineteenth and twentieth centuries and show that a literary genre of violence was absent in the nation until 1946, when the period known as “la Violencia” commenced. Secondly, I will explore how hopelessness resulted from violence in Colombia beginning in the period of “la Violencia.” Thirdly, I will show how violence is depicted as an evil that traps the protagonists of the contemporary Colombian novels La Virgen de Los Sicarios and Satanás in a state of hopelessness due to their powerlessness to truly change themselves because of the frustrated society in which they live.


2018 ◽  
Vol 91 (2) ◽  
pp. 881-891 ◽  
Author(s):  
J. Andrew Nunnery ◽  
Sherilyn C. Fritz ◽  
Paul A. Baker ◽  
Wout Salenbien

AbstractVarious paleoclimatic records have been used to reconstruct the hydrologic history of the Altiplano, relating this history to past variability of the South American summer monsoon. Prior studies of the southern Altiplano, the location of the world’s largest salt flat, the Salar de Uyuni, and its neighbor, the Salar de Coipasa, generally agree in their reconstructions of the climate history of the past ∼24 ka. Some studies, however, have highly divergent climatic records and interpretations of earlier periods. In this study, lake-level variation was reconstructed from a ∼14-m-long sediment core from the Salar de Coipasa. These sediments span the last ∼40 ka. Lacustrine sediment accumulation was apparently continuous in the basin from ∼40 to 6 ka, with dry or very shallow conditions afterward. The fossil diatom stratigraphy and geochemical data (δ13C, δ15N, %Ca, C/N) indicate fluctuations in lake level from shallow to moderately deep, with the deepest conditions correlative with the Heinrich-1 and Younger Dryas events. The stratigraphy shows a continuous lake of variable depth and salinity during the last glacial maximum and latter stages of Marine Oxygen Isotope Stage 3 and is consistent with environmental inferences and the original chronology of a drill core from Salar de Uyuni.


1999 ◽  
Vol 26 (3) ◽  
pp. 355-382
Author(s):  
Cristina Altman

Summary When mention is made of Brazil in connection with American linguistics, it usually amounts to a reference to the Linguistic Circle of New York, where Roman Jakobson (1896–1982) and Claude Lévi-Strauss (b.1908), who had come from Brazil where he had done ethnological work, met and exchanged ideas. This singular event has cast a shadow on other contacts between Brazil and American linguistics, of which, the one between Jakobson and the Brazilian linguist Joaquim Mattoso Câmara (1904–1970) was much more consequential, at least as far as the implementation of structural linguistics in Brazil and in South America generally during the 1950s and the 1960s is concerned. Mattoso Câmara came to the United States and spent most of his time in New York City (September 1943 till April 1944), where he got exposure to Praguean type structuralism, notably through Jakobson’s lectures he attended at Columbia University and at the École Libre of New York, which had been established by European refugees at the time. He also participated in the first meetings of the Linguistic Circle of New York in 1943 as one of its co-founders. Following his return to Rio de Janeiro, Mattoso Câmara proposed, in 1949, as his doctoral thesis a phonemic description of Brazilian Portuguese. The work was published a few years later, in 1953. His most influential work, Princípios de Lingüística Gerai, first published in 1954, had two more revised and updated editions (1958, 1967) and served to introduce several generations of Brazilian as well as other South American students to structural linguistics during the 1950s and 1960s.


mBio ◽  
2013 ◽  
Vol 4 (2) ◽  
Author(s):  
Timothy D. Read ◽  
Sandeep J. Joseph ◽  
Xavier Didelot ◽  
Brooke Liang ◽  
Lisa Patel ◽  
...  

ABSTRACT Chlamydia psittaci is an obligate intracellular bacterium. Interest in Chlamydia stems from its high degree of virulence as an intestinal and pulmonary pathogen across a broad range of animals, including humans. C. psittaci human pulmonary infections, referred to as psittacosis, can be life-threatening, which is why the organism was developed as a bioweapon in the 20th century and is listed as a CDC biothreat agent. One remarkable recent result from comparative genomics is the finding of frequent homologous recombination across the genome of the sexually transmitted and trachoma pathogen Chlamydia trachomatis. We sought to determine if similar evolutionary dynamics occurred in C. psittaci. We analyzed 20 C. psittaci genomes from diverse strains representing the nine known serotypes of the organism as well as infections in a range of birds and mammals, including humans. Genome annotation revealed a core genome in all strains of 911 genes. Our analyses showed that C. psittaci has a history of frequently switching hosts and undergoing recombination more often than C. trachomatis. Evolutionary history reconstructions showed genome-wide homologous recombination and evidence of whole-plasmid exchange. Tracking the origins of recombinant segments revealed that some strains have imported DNA from as-yet-unsampled or -unsequenced C. psittaci lineages or other Chlamydiaceae species. Three ancestral populations of C. psittaci were predicted, explaining the current population structure. Molecular clock analysis found that certain strains are part of a clonal epidemic expansion likely introduced into North America by South American bird traders, suggesting that psittacosis is a recently emerged disease originating in New World parrots. IMPORTANCE Chlamydia psittaci is classified as a CDC biothreat agent based on its association with life-threatening lung disease, termed psittacosis, in humans. Because of the recent remarkable findings of frequent recombination across the genome of the human sexually transmitted and ocular trachoma pathogen Chlamydia trachomatis, we sought to determine if similar evolutionary dynamics occur in C. psittaci. Twenty C. psittaci genomes were analyzed from diverse strains that may play a pathogenic role in human disease. Evolution of the strains revealed genome-wide recombination occurring at a higher rate than for C. trachomatis. Certain strains were discovered to be part of a recent epidemic clonal expansion originating in South America. These strains may have been introduced into the United States from South American bird traders, suggesting that psittacosis is a recently emerged disease originating in New World parrots. Our analyses indicate that C. psittaci strains have a history of frequently switching hosts and undergoing recombination.


Viruses ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 258 ◽  
Author(s):  
Dominique L. Chaput ◽  
David Bass ◽  
Md. Mehedi Alam ◽  
Neaz Al Hasan ◽  
Grant D. Stentiford ◽  
...  

Tilapia lake virus (TiLV), a negative sense RNA virus with a 10 segment genome, is an emerging threat to tilapia aquaculture worldwide, with outbreaks causing over 90% mortality reported on several continents since 2014. Following a severe tilapia mortality event in July 2017, we confirmed the presence of TiLV in Bangladesh and obtained the near-complete genome of this isolate, BD-2017. Phylogenetic analysis of the concatenated 10 segment coding regions placed BD-2017 in a clade with the two isolates from Thailand, separate from the Israeli and South American isolates. However, phylogenetic analysis of individual segments gave conflicting results, sometimes clustering BD-2017 with one of the Israeli isolates, and splitting pairs of isolates from the same region. By comparing patterns of topological difference among segments of quartets of isolates, we showed that TiLV likely has a history of reassortment. Segments 5 and 6, in particular, appear to have undergone a relatively recent reassortment event involving Ecuador isolate EC-2012 and Israel isolate Til-4-2011. The phylogeny of TiLV isolates therefore depends on the segment sequenced. Our findings illustrate the need to exercise caution when using phylogenetic analysis to infer geographic origin and track the movement of TiLV, and we recommend using whole genomes wherever possible.


1995 ◽  
Vol 167 (4) ◽  
pp. 522-526 ◽  
Author(s):  
John D. C. Mellers ◽  
Niall P. Quinn ◽  
Maria A. Ron

BackgroundThe growth hormone (GH) response to apomorphine, thought to reflect central dopaminergic receptor sensitivity, has been reported as enhanced in acute schizophrenia. We investigated this response in relation to the psychotic episodes associated with Parkinson's disease (PD).MethodThe GH response to apomorphine was measured in three groups of patients with Parkinson's disease: those currently psychotic (n = 9), those with a past history of psychosis (n = 7) and those who had never been psychotic (n = 8).ResultsApomorphine-induced GH response was not related to psychosis but was unexpectedly associated with measures of depression.ConclusionsVisual hallucinations were a prominent feature in the psychotic patients and the atypical nature of these psychoses might explain why we found no evidence of dopaminergic sensitivity. Serotonergic dysfunction would be in keeping with this. Dopaminergic mechanisms may contribute to the minor depressive symptomatology seen in PD.


2020 ◽  
Vol 79 (4) ◽  
pp. 865-889
Author(s):  
Brian Lander ◽  
Mindi Schneider ◽  
Katherine Brunson

Pigs have played a central role in the subsistence and culture of China for millennia. The close relationship between pigs and people began when humans gradually domesticated wild pigs over 8,000 years ago. While pigs initially foraged around settlements, population growth led people to pen their pigs, which made them household trash processors and fertilizer producers. Household pigs were in daily contact with people, who bred them to fatten quickly and produce larger litters. Early modern Europeans found Chinese pigs far superior to their own and bred the two to create the breeds now employed in industrial pork production around the world, including China. In recent decades, industrial farms that scientifically control every aspect of pigs’ lives have spread rapidly. Until recently, most Chinese people ate pork only on special occasions; their ability in recent decades to eat it regularly exemplifies China's increasing prosperity. Meanwhile, vast areas of North and South American farmland are now devoted to growing soybeans to feed hundreds of millions of pigs in China, and the methane, manure, and antibiotic resistance they produce creates environmental and health problems on a global scale.


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