scholarly journals Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour

Reproduction ◽  
2017 ◽  
Vol 154 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Anders Hay-Schmidt ◽  
Olivia T Ejlstrup Finkielman ◽  
Benjamin A H Jensen ◽  
Christine F Høgsbro ◽  
Jacob Bak Holm ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Sexual Behaviour ◽  
Reproductive Tract ◽  
Reproductive Behaviour ◽  
Postnatal Life ◽  
Similar Reduction ◽  
Foetal Development ◽  
Male Adult ◽  
Male Sexual Behaviour ◽  
Neuronal Number

Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinised during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood. Both androgens and prostaglandins are known to be inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we found that exposure to APAP decreased neuronal number in the sexually dimorphic nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male adult offspring. Likewise, exposure to the environmental pollutant and precursor of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in the SDN-POA is associated with reductions in male sexual behaviour. Consistent with the changes, male mice exposed in uteri to APAP exhibited changes in urinary marking behaviour as adults and had a less aggressive territorial display towards intruders of the same gender. Additionally, exposed males had reduced intromissions and ejaculations during mating with females in oestrus. Together, these data suggest that prenatal exposure to APAP may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming. These findings add to the growing body of evidence suggesting the need to limit the widespread exposure and use of APAP by pregnant women.

THE COMPARATIVE ACTIONS OF TESTOSTERONE PROPIONATE AND 5α-ANDROSTAN17β-OL-3-ONE PROPIONATE ON THE REPRODUCTIVE BEHAVIOUR, PHYSIOLOGY AND MORPHOLOGY OF MALE RATS

1971 ◽  
Vol 51 (2) ◽  
pp. 241-NP ◽  
Author(s):  
H. H. FEDER
Keyword(s):  
Body Weight ◽  
Seminal Vesicle ◽  
Sexual Behaviour ◽  
Testosterone Propionate ◽  
Reproductive Behaviour ◽  
Male Rats ◽  
Male Sexual Behaviour ◽  
Testicular Weight ◽  
Seminal Vesicle Weight ◽  
Experienced Adult

SUMMARY 5α-Androstan-17β-ol-3-one in its free or in its propionate form was injected systemically (125 μg/day/rat) into sexually experienced, adult, castrated, male rats. These compounds were ineffective in activating masculine behaviour patterns, despite having measurable effects on body weight, seminal vesicle weight and penile morphology. The propionate form also had strong anti-gonadotrophic properties, since when it was injected for 6 days into intact, immature, male rats it significantly reduced testicular weight. In contrast, testosterone propionate (125 μg/day/rat) restored male sexual behaviour to the levels found before castration when injected systemically. Testosterone propionate also affected body weight, seminal vesicle weight, penile morphology and the testicular weight of immature males. These effects may have been due in part to conversion of testosterone to 5α-androstan-17β-ol-3-one, but this metabolic step does not seem to be obligatory for activation of male sexual behaviour in rats.

scholarly journals Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats

2021 ◽  
Vol 219 ◽  
pp. 112323
Author(s):  
Xiang Zhou ◽  
Tongtong Zhang ◽  
Lebin Song ◽  
Yichun Wang ◽  
Qijie Zhang ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Prenatal Exposure ◽  
Adult Rats ◽  
Male Adult ◽  
Butyl Phthalate

Abstract 996: Growth Differentiation Factor-5 (GDF-5) Dictates Cardiac Remodelling in a Mouse Model of Myocardial Infarction

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Syed Zaidi ◽  
Ali M Riazi ◽  
Qingling Huang ◽  
Md A Momen ◽  
Mansoor Husain
Keyword(s):  
Myocardial Infarction ◽  
Systolic Pressure ◽  
Left Ventricular ◽  
Cardiac Remodelling ◽  
Postnatal Life ◽  
Mrna Levels ◽  
Vegf Mrna ◽  
Foetal Development ◽  
Differentiation Factor ◽  
Growth Differentiation Factor 5

Background: Bone Morphogenetic Proteins (BMPs) regulate diverse cellular functions during foetal development and postnatal life. Growth Differentiation Factor 5 (GDF5 a.k.a. BMP-14) is a BMP, which is expressed in a variety of tissues including heart. We previously showed that cardiac GDF5 mRNA levels are elevated after experimental myocardial infarction (MI) caused by permanent left anterior descending coronary artery (LAD) ligation. However, the significance of this finding was not known. Methods & Results: GDF5 knock-out (KO; n = 18 for MI) and wild-type (WT; n = 18 for MI) littermate controls were subjected to chronic LAD ligation in order to investigate the consequences resulting from the loss of GDF5 signalling following MI. At 28 days post-LAD ligation or sham (n = 12 for KO; n = 10 for WT), invasive hemodynamic parameters of cardiac function were examined just prior to sacrifice. Histopathology was assessed by morphometric analyses of perfusion fixed hearts and subsequent immunostaining. At 28 days post-MI, GDF5-KO mice exhibited decreased left ventricular systolic pressure and peak positive- and negative- dP/dt , and increased heart rate as compared to WT littermates ( P < 0.005 for each parameters). GDF5-KO mice also exhibited a significant increase in the area, length and transmural expansion of the infarct, scar thinning and cardiac dilatation ( P < 0.05 for each parameter). In addition, GDF5-KO mice displayed significantly fewer myocardial vessels in the infarct and peri-infarct regions as compared to WT littermates ( P < 0.05) . To explore mechanisms underlying this phenotype, we assessed gene expression levels of relevant potential downstream targets of GDF5. At 7d post-MI, quantitative RT-PCR revealed a significant reduction (35%) in VEGF mRNA levels in hearts of KO (n = 6) as compared to WT mice (n = 5, P = 0.033). Summary & Conclusion: These data suggest that increased GDF5 expression observed in hearts after MI plays an important role in cardiac remodelling. Absence of GDF5 expression in KO mice confers detrimental effects on healing and repair of myocardial and vascular tissues after MI. Regulated levels of GDF5, a BMP family member, play an important role in the repair process following cardiac injury.

Male sexual behaviour not abolished after medial preoptic lesion in adult rats

Neuroreport ◽  
1996 ◽  
Vol 7 (9) ◽  
pp. 1481-1484 ◽  
Author(s):  
Velayudhan Mohan Kumar ◽  
Naseem Ahmad Khan ◽  
Joshi John
Keyword(s):  
Sexual Behaviour ◽  
Adult Rats ◽  
Male Sexual Behaviour

scholarly journals Oestrogen's masculine side: mediation of mating in male mice

Reproduction ◽  
2002 ◽  
pp. 331-338 ◽  
Author(s):  
EM Scordalakes ◽  
DB Imwalle ◽  
EF Rissman
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Dopamine Agonist ◽  
Sexual Behaviour ◽  
Oestrogen Receptor ◽  
Neuronal Nitric Oxide Synthase ◽  
Receptor Alpha ◽  
Male Sexual Behaviour ◽  
Oestrogen Receptor Alpha ◽  
Oxide Synthase

This review focuses on the role of oestrogen in male sexual behaviour using oestrogen receptor alpha and beta knockout (ERalphaKO and ERbetaKO) mouse models. ERbetaKO mice are capable of mating and producing offspring, whereas ERalphaKO mice are unable to do either. When ERalphaKO males are treated with testosterone or dihydrotestosterone (DHT), < 50% display mounting behaviour, few intromit and none ejaculate. However, concurrent treatment with testosterone and a dopamine agonist instates masculine sexual behaviour in both male and female ERalphaKO mice. Dopamine content in the preoptic area and associated regions is not affected by oestrogen receptor alpha gene disruption. However, expression of neuronal nitric oxide synthase immunoreactivity is severely reduced in ERalphaKO males compared with wild-type males. These findings, together with studies conducted in aromatase knockout mice, are at odds with the dogma that oestrogen is required during development for expression of male sexual behaviour in adults. However, they do support a role for oestrogens, mediated by oestrogen receptor alpha, in regulation and production of neuronal nitric oxide synthase, which in turn may control dopamine agonist release. As has been shown in male rats, in mice dopamine agonist release is likely to be an essential component of the neural pathway that mediates male sexual behaviour.

POSSIBLE INVOLVEMENT OF CYCLIC AMP IN REGULATION OF MASCULINE SEXUAL BEHAVIOUR BY TESTOSTERONE

1974 ◽  
Vol 61 (1) ◽  
pp. 153-161 ◽  
Author(s):  
L. W. CHRISTENSEN ◽  
L. G. CLEMENS
Keyword(s):  
Cyclic Amp ◽  
Sexual Behaviour ◽  
Adrenal Glands ◽  
Testosterone Propionate ◽  
Major Effect ◽  
Concurrent Administration ◽  
Adrenal Androgen ◽  
Mediating Role ◽  
Male Sexual Behaviour ◽  
Masculine Sexual Behaviour

SUMMARY Experiments were carried out to assess the possible involvement of cyclic AMP in the regulation of masculine sexual behaviour by testosterone in the laboratory rat. Doses of testosterone propionate which were ineffective in maintaining or inducing male sexual behaviour were potentiated by concurrent administration of theophylline. Since removal of the adrenal glands had no effect on this potentiation, the possibility that theophylline increased adrenal androgen secretion and thereby influenced sexual behaviour, can be ruled out. A major effect of theophylline is to increase levels of cyclic AMP by inhibiting the enzyme which inactivates this nucleotide. These results suggest that cyclic AMP may play a mediating role in the regulation of masculine sexual behaviour by testosterone.

scholarly journals Sexual dysfunction in old age

2000 ◽  
Vol 6 (4) ◽  
pp. 270-277 ◽  
Author(s):  
André Ludovic Phanjoo
Keyword(s):  
Sexual Dysfunction ◽  
Older People ◽  
Old Age ◽  
Sexual Behaviour ◽  
Scientific Research ◽  
Psychological Effects ◽  
Institutional Setting ◽  
Male Sexual Behaviour ◽  
Physical Problems ◽  
The Subject

The sexual behaviour of older people is more often the target of jocularity or ridicule than the subject of serious scientific research. As a consequence, relatively little is known about the sexual behaviour of the over-65s and such information as is available shows a polarisation according to gender, male sexual behaviour and dysfunction being viewed very much in the light of physical problems, whereas women's sexual behaviour revolves around attitudes towards sexuality and the psychological effects of ageing. This review will address the biological changes associated with ageing, the psychological and social concomitants, the prevalence of sexual dysfunction, its aetiological factors, and the management of common sexual problems including those found in an institutional setting.

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