Efficiency of Minimized Circuits of a Heart Roller Pump on Systemic Inflammatory Response Syndrome and Multiorgan Effects in a Rat Model

Background: The aim of this study is to compare the effects of tubing length on systemic inflammatory response syndrome and myocardial protection in a rat model of cardiopulmonary bypass (CPB) from a histological standpoint. Methods: Twelve adult male Wistar Albino rats weighing >180 g were randomly selected and divided into 2 groups. In 1 group, the pump lines were kept 1 m shorter than standard. The right jugular vein and tail artery were cannulated using a 16-gauge catheter. Animals received 500 IU/kg intravenous heparin. Cardiac index and rectal temperature were set at 2.4 mL and 36°C, respectively. Total line volume was maintained at 8 mL. A roller pump was adjusted to supply a blood flow of 6 to 28 mL/min (mean 10 mL/min), similar to the typical cardiac output of rats. CPB duration was 15 minutes throughout the experiment. After sacrifice, tissue samples were collected from heart, liver, and kidney for histomorphologic examination. Results: All histochemical and histomorphologic analyses, performed by 2 blinded researchers, revealed band loss in cardiomyocytes, mononuclear (MNL) cell infiltration, and impaired fibrillar organization in the standard-line group. Additionally in that group, sinusoidal dilatation in the liver, low-level congestion, focal necrosis, and periportal MNL infiltration were noted. In the shorter-line group, on the other hand, MNL cell infiltration, band loss in myofibrils, and cardiomyocyte degeneration were rarely observed. Higher liver congestion and lower MNL cell infiltration were observed in the shorter-line group. No significant differences were found in kidney samples. Conclusion: In a shorter-line roller pump test model, less multiorgan damage and fewer systemic inflammatory responses were observed. It may be applicable to keep CPB lines as close to the table as possible, especially in pediatric cardiac surgery cases.

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Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study

Scientific Reports ◽

10.1038/s41598-021-94224-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Ismael Luna-Reyes ◽

Eréndira G. Pérez-Hernández ◽

Blanca Delgado-Coello ◽

Miguel Ángel Ávila-Rodríguez ◽

Jaime Mas-Oliva

Keyword(s):

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Glucose Uptake ◽

Inflammatory Responses ◽

Serum Levels ◽

Systemic Inflammatory Response ◽

Positron Emission ◽

Inflammatory Molecules ◽

Circulating Levels ◽

Lps Treatment

AbstractThe present investigation using Positron Emission Tomography shows how peptide VSAK can reduce the detrimental effects produced by lipopolysaccharides in Dutch dwarf rabbits, used to develop the Systemic Inflammatory Response Syndrome (SIRS). Animals concomitantly treated with lipopolysaccharides (LPS) and peptide VSAK show important protection in the loss of radiolabeled-glucose uptake observed in diverse organs when animals are exclusively treated with LPS. Treatment with peptide VSAK prevented the onset of changes in serum levels of glucose and insulin associated with the establishment of SIRS and the insulin resistance-like syndrome. Treatment with peptide VSAK also allowed an important attenuation in the circulating levels of pro-inflammatory molecules in LPS-treated animals. As a whole, our data suggest that peptide VSAK might be considered as a candidate in the development of new therapeutic possibilities focused on mitigating the harmful effects produced by lipopolysaccharides during the course of SIRS.

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Glycyrrhizin inhibits the manifestations of anti-inflammatory responses that appear in association with systemic inflammatory response syndrome (SIRS)-like reactions

Cytokine ◽

10.1016/j.cyto.2006.10.002 ◽

2006 ◽

Vol 35 (5-6) ◽

pp. 295-301 ◽

Cited By ~ 18

Author(s):

Miwa Takei ◽

Makiko Kobayashi ◽

David N. Herndon ◽

Richard B. Pollard ◽

Fujio Suzuki

Keyword(s):

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Inflammatory Responses ◽

Systemic Inflammatory Response ◽

Anti Inflammatory

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In vitro effects of emodin on peritoneal macrophages that express membrane-bound CD14 protein in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome

Molecular Medicine Reports ◽

10.3892/mmr.2013.1771 ◽

2013 ◽

Vol 9 (1) ◽

pp. 355-359 ◽

Cited By ~ 6

Author(s):

QINGQIANG NI ◽

KANG SUN ◽

GUOYUE CHEN ◽

DONG SHANG

Keyword(s):

Acute Pancreatitis ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Severe Acute Pancreatitis ◽

Rat Model ◽

Peritoneal Macrophages ◽

Systemic Inflammatory Response ◽

Membrane Bound ◽

In Vitro Effects

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Longitudinal Profiles of Metabolism and Bioenergetics Associated with Innate Immune Hormonal Inflammatory Responses and Amino-Acid Kinetics in Severe Sepsis and Systemic Inflammatory Response Syndrome in Children

Journal of Parenteral and Enteral Nutrition ◽

10.1002/jpen.1050 ◽

2018 ◽

Vol 42 (6) ◽

pp. 1061-1074 ◽

Cited By ~ 13

Author(s):

Anna Maria Spanaki ◽

Theonymfi Tavladaki ◽

Helen Dimitriou ◽

Andrey V. Kozlov ◽

J. Catharina Duvigneau ◽

...

Keyword(s):

Severe Sepsis ◽

Amino Acid ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Inflammatory Responses ◽

Systemic Inflammatory Response ◽

Innate Immune ◽

Longitudinal Profiles

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Perioperative application of dexmedetomidine for postoperative systemic inflammatory response syndrome in patients undergoing percutaneous nephrolithotomy lithotripsy: results of a randomised controlled trial

BMJ Open ◽

10.1136/bmjopen-2017-019008 ◽

2018 ◽

Vol 8 (11) ◽

pp. e019008

Author(s):

Yingqing Deng ◽

Fang Tan ◽

Xiaoliang Gan ◽

Xiaoyun Li ◽

Mian Ge ◽

...

Keyword(s):

Randomised Controlled Trial ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Inflammatory Responses ◽

Controlled Trial ◽

Incidence Rates ◽

Systemic Inflammatory Response ◽

Saline Control ◽

Tnf Α ◽

Randomised Controlled

ObjectiveOur previous retrospective study demonstrated that perioperative dexmedetomidine (Dex) administration was associated with low systemic inflammatory response syndrome (SIRS) incidence. The present study was designed to investigate whether perioperative administration of Dex decreases the incidence of postpercutaneous nephrolithotomy lithotripsy (PCNL) SIRS in patients who undergo PCNL.DesignA randomised controlled trial was designed.ParticipantsA total of 190 patients were randomly assigned to receive Dex (DEX group, n=95) or saline control (CON group, n=95) and completed the study. In the DEX group, Dex was loaded (1 µg/kg) before anaesthesia induction and was infused (0.5 µg/kg/h) during surgery.OutcomesThe incidences of postoperative SIRS were recorded. Serum interleukin-6 (IL-6) and tumour necrosis factor α(TNF-α) were measured.ResultsThe incidence rates of SIRS were significantly lower in the DEX group than in the CON group (35.8% vs 50.5%, p=0.04). No patients developed sepsis in either group. These results might be attributed to inhibition of inflammatory responses and the resulting lower serum levels of IL-6 and TNF-α, caused by Dex administration. However, compared with the CON group, the lower incidence rate of SIRS in the DEX group did not result in better outcomes, such as shorter postoperative hospitalisation stays and lower costs.ConclusionThe present study showed that Dex administration during PCNL might be beneficial for decreasing the incidence of SIRS through inhibiting the release of inflammatory mediators, but not clinical consequences such as postoperative hospitalisation duration and costs. Further effects of Dex administration on SIRS in patients who are scheduled for PCNL should be explored in future studies.Trial registration numberChiCTR-ICR-15006167.

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