scholarly journals Molybdenum oxide based sensors

2021 ◽  
pp. 28-41
Author(s):  
Nazerke Zhumasheva ◽  
Leyla Kudreeva ◽  
Diana Kosybayeva
Keyword(s):  
Molybdenum Oxide ◽  
Electrochemical Sensors ◽  
Review Article ◽  
Sodium Potassium ◽  
Laser Method ◽  
Time Sensitivity ◽  
Epidermal Growth ◽  
Comparison Table ◽  
Electro Catalytic Activity ◽  
Precipitation Pulse

In this review article were considered the works of electrochemical sensors modified with molybdenum oxide. The work of sensors based on molybdenum oxide was systematized, a comparison table was developed, the sensors were classified according to the purpose of use. Methods of molybdenum oxide synthesis used to modify the working electrode in electrochemical sensors were considered. The various methods have been used to synthesize molybdenum oxide, such as a thermal, hydrothermal, electrochemical, electric spark, pulsed laser method, acid condensation, electrophoretic precipitation, pulse potential precipitation. The main parameters of the molybdenum oxide modified sensors, such as the detection limit, linear range, response time, sensitivity, and other parameters were compared. As a result of studies, it was found that molybdenum oxide is selected as a modifying material in electrochemical sensors due to the unique physicochemical properties of molybdenum oxide, in particular because of mechanical strength, electrical conductivity, electro catalytic activity, crystallinity. The features of electrochemical biosensors coated with molybdenum oxide were described for the detection of important compounds in specific samples. Sensors based on molybdenum oxide have been used for detection of glucose, dopamine, ethanol, ascorbic acid, troponin-1, norepinephrine, procalcitonin, L-lactate, bromate, chlorate, E110, tartrazine, hydrochlorothiazide, human epidermal growth factor-2, lithium,sodium,potassium. This paper provides general summarized information about current aspects of research works related to electrochemical sensors based on molybdenum oxide.

scholarly journals The Sodium/Proton Exchanger NHE8 Regulates Late Endosomal Morphology and Function

2010 ◽  
Vol 21 (20) ◽  
pp. 3540-3551 ◽  
Author(s):  
Scott P. Lawrence ◽  
Nicholas A. Bright ◽  
J. Paul Luzio ◽  
Katherine Bowers
Keyword(s):  
Protein Trafficking ◽  
Protein Sorting ◽  
M Cells ◽  
Sodium Potassium ◽  
Cellular Volume ◽  
Data Points ◽  
Intracellular Organelles ◽  
Epidermal Growth ◽  
And Function ◽  
Golgi Network

The pH and lumenal environment of intracellular organelles is considered essential for protein sorting and trafficking through the cell. We provide the first evidence that a mammalian NHE sodium (potassium)/proton exchanger, NHE8, plays a key role in the control of protein trafficking and endosome morphology. At steady state, the majority of epitope-tagged NHE8 was found in the trans-Golgi network of HeLa M-cells, but a proportion was also localized to multivesicular bodies (MVBs). Depletion of NHE8 in HeLa M-cells with siRNA resulted in the perturbation of MVB protein sorting, as shown by an increase in epidermal growth factor degradation. Additionally, NHE8-depleted cells displayed striking perinuclear clustering of endosomes and lysosomes, and there was a ninefold increase in the cellular volume taken up by LAMP1/LBPA-positive, dense MVBs. Our data points to a role for the ion exchange activity of NHE8 being required to maintain endosome morphology, as overexpression of a nonfunctional point mutant protein (NHE8 E225Q) resulted in phenotypes similar to those seen after siRNA depletion of endogenous NHE8. Interestingly, we found that depletion of NHE8, despite its function as a sodium (potassium)/proton antiporter, did not affect the overall pH inside dense MVBs.

A review of the advanced developments of electrochemical sensors for the detection of toxic and bioactive molecules

2019 ◽  
Vol 6 (12) ◽  
pp. 3418-3439 ◽  
Author(s):  
Rasu Ramachandran ◽  
Tse-Wei Chen ◽  
Shen-Ming Chen ◽  
Thangaraj Baskar ◽  
Ramanjam Kannan ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Heavy Metal Ions ◽  
Electrochemical Sensors ◽  
Cost Effective ◽  
Nitro Compounds ◽  
Review Article ◽  
Electrochemical Sensing ◽  
Bioactive Molecules ◽  
The Novel ◽  
Recent Developments

The recent developments made regarding the novel, cost-effective, and environmentally friendly nanocatalysts for the electrochemical sensing of biomolecules, pesticides, nitro compounds and heavy metal ions are discussed in this review article.

scholarly journals Investigation on the Printed CNT-Film-Based Electrochemical Sensor for Detection of Liquid Chemicals

Sensors ◽  
2021 ◽  
Vol 21 (15) ◽  
pp. 5179
Author(s):  
Jaeha Noh ◽  
Sangsu An ◽  
Changhan Lee ◽  
Jiho Chang ◽  
Snagtae Lee ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Electrochemical Sensors ◽  
Mechanical Stability ◽  
Limit Of Detection ◽  
Superior Performance ◽  
Detection Mechanism ◽  
Time Sensitivity ◽  
Sensor Structure ◽  
Optimum Sensor ◽  
Pet Substrate

We studied electrochemical sensors using printed carbon nanotubes (CNT) film on a polyethylene telephtalate (PET) substrate. The mechanical stability of the printed CNT film (PCF) was confirmed by using bending and Scotch tape tests. In order to determine the optimum sensor structure, a resistance-type PCF sensor (R-type PCF sensor) and a comb-type PCF sensor (C-type PCF sensor) were fabricated and compared using a diluted NH3 droplet with various concentrations. The magnitude of response, response time, sensitivity, linearity, and limit of detection (LOD) were compared, and it was concluded that C-type PCF sensor has superior performance. In addition, the feasibility of PCF electrochemical sensor was investigated using 12 kinds of hazardous and noxious substances (HNS). The detection mechanism and selectivity of the PCF sensor are discussed.

scholarly journals ELTD1—An Emerging Silent Actor in Cancer Drama Play

2021 ◽  
Vol 22 (10) ◽  
pp. 5151
Author(s):  
Ani-Simona Sevastre ◽  
Iuliana M. Buzatu ◽  
Carina Baloi ◽  
Alexandru Oprita ◽  
Alexandra Dragoi ◽  
...  
Keyword(s):  
Transmembrane Domain ◽  
Current Knowledge ◽  
Review Article ◽  
G Protein Coupled Receptors ◽  
Cancer Prognosis ◽  
Research Groups ◽  
Important Data ◽  
Pathological Angiogenesis ◽  
Epidermal Growth ◽  
G Protein Coupled

The epidermal growth factor, latrophilin, and seven transmembrane domain–containing protein 1 (ELTD1), is a member of the G–protein coupled receptors (GPCRs) superfamily. Although discovered in 2001, ELTD1 has been investigated only by a few research groups, and important data about its role in normal and tumor cells is still missing. Even though its functions and structure are not yet fully understood, recent studies show that ELTD1 has a role in both physiological and pathological angiogenesis, and it appears to be a very important biomarker and a molecular target in cancer diseases. Upregulation of ELTD1 in malignant cells has been reported, and correlated with poor cancer prognosis. This review article aims to compile the existing data and to discuss the current knowledge on ELTD1 structure and signaling, and its role in physiological and neoplastic conditions.

scholarly journals Metal and Metal Oxide Based Advanced Ceramics for Electrochemical Biosensors-A Short Review

2021 ◽  
Vol 8 ◽  
Author(s):  
G. Bala Subbaiah ◽  
K. Venkata Ratnam ◽  
S. Janardhan ◽  
K. Shiprath ◽  
H. Manjunatha ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Medical Diagnosis ◽  
Electrochemical Sensors ◽  
Short Review ◽  
Review Article ◽  
Electrochemical Biosensors ◽  
Advanced Ceramics ◽  
The Past ◽  
Recent Developments ◽  
Particulate Reinforced

Identifying and quantifying the biological concentrations of certain biomolecules such as dopamine, glucose, tyrosine, and cholesterol, etc. has become the basis for medical diagnosis in the treatment of a number of related diseases. In most cases, the concentrations of these biomolecules in biofluids like blood acts as a biomarker and becomes crucial in the treatment of diseases. On the other hand, advanced ceramics refers to oxides (alumina, zirconia), non-oxides: (carbides, borides, nitrides, silicides), Composites (particulate reinforced combinations of oxides and non-oxides), etc. This review article discusses recent developments in the field of electrochemical sensors developed using metal and metal oxide based advanced ceramics with an emphasis on developments in the field over the past five years. The article presents the key results, important findings, and interesting chemistry of biosensing advanced ceramic based electrochemical biosensors for some important biomolecules such as acetaminophen, glucose, and dopamine, etc.

scholarly journals Introduction of HER-2 and a Short Review on Its Role in Prognosis and Treatment of Breast Cancer

2014 ◽  
Vol 3 (3) ◽  
pp. 132-44
Author(s):  
Seyed Abbas Mirmalek ◽  
Fatemeh Elhamkani ◽  
Seyed Alireza Salimi Tabatabaee ◽  
Hossein Mahmoodzadeh ◽  
Yekta Parsa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Predictive Factor ◽  
Growth Factor Receptor ◽  
Short Review ◽  
Review Article ◽  
Her 2 ◽  
Epidermal Growth

Human Epidermal growth factor Receptor-2 (HER-2) as a new prognostic and predictive factor has been believed as an essential measurement in breast carcinoma. About 280 articles were reviewed and 115 were referred in this review article on HER-2. HER-2 is an oncoprotein epidermal growth factor receptor produced by a so-called cell surface oncogene. Overexpression results in aggressive behavior, early metastasis to lymph nodes and distant areas, and poor prognosis in breast cancer. HER-2 seems to be a prognostic and predictive factor and must be considered in all breast cancer cases.

Performance of Gem Premier blood gas/electrolyte analyzer evaluated

1993 ◽  
Vol 39 (9) ◽  
pp. 1890-1893 ◽  
Author(s):  
E Jacobs ◽  
M Nowakowski ◽  
N Colman
Keyword(s):  
Electrochemical Sensors ◽  
Point Of Care ◽  
Blood Gases ◽  
Ionized Calcium ◽  
Blood Gas ◽  
Point Of Care Testing ◽  
Sodium Potassium ◽  
Plasma Electrolyte ◽  
Waste Container ◽  
Blood Gas Analyzer

Abstract We evaluated a new analyzer designed for point-of-care testing of blood gases, sodium, potassium, ionized calcium, and hematocrit. The Gem Premier (Mallinckrodt) system has two components: the analyzer and a disposable cartridge. Analysis takes place in the cartridge, which contains the electrochemical sensors, the calibrants, the reagents, the sampling stylus, and the waste container. The system was evaluated for imprecision and accuracy. With aqueous control materials, total imprecision (CV) was: pH, 0.10-0.18%; PCO2, 3.16-5.78%; PO2, 2.92-4.85%; sodium, 0.82-1.44%; potassium, 1.35-1.48%; ionized calcium, 0.75-1.45%; and hematocrit, 1.13-1.83%. Accuracy of the system was assessed by split-sample comparison with the Radiometer ABL 330 blood gas analyzer for pH and blood gases, the Nova Stat Profile 5 for whole-blood electrolyte and hematocrit analysis, and the IL Phoenix for plasma electrolyte analysis. After outlier correction, regression statistics were excellent for all analytes except sodium, which demonstrated Sy[x values between 1.80 and 2.30 mmol/L and 0.85 < or = r < 0.90.

Therapeutic Strategies to Improve the Efficacy of Oxaliplatin in Gastrointestinal Tumors

2004 ◽  
Vol 19 (3) ◽  
pp. 183-189 ◽  
Author(s):  
R. Sarmiento ◽  
A. Saponiero ◽  
G. Gasparini
Keyword(s):  
Pancreatic Cancer ◽  
Quality Control ◽  
Combined Therapy ◽  
Growth Factor Receptor ◽  
Therapeutic Strategies ◽  
Review Article ◽  
Gastrointestinal Tumors ◽  
Epidermal Growth ◽  
Single Tumor

The pharmacological characteristics of oxaliplatin make it one of the better chemotherapeutics to be combined with novel molecular-targeted anticancer treatments for the therapy of gastrointestinal tumors. The purposes of this review article are to report the preliminary data of combined therapy of oxaliplatin with inhibitors of angiogenesis or epidermal growth factor receptor and to suggest novel oxaliplatin-based therapeutic strategies. It is hypothesized that well designed, personalized, molecular-based treatments may improve the efficacy of oxaliplatin for the treatment of colorectal, gastric and pancreatic cancer. It is mandatory to rationalize such an approach by adequate determination of predictive surrogate biomarkers of response related to the targets in each single tumor against which therapy is aimed, using standardized assays and quality control.

Desiderata in connection by the calibration of the MK-system

1966 ◽  
Vol 24 ◽  
pp. 348-349
Author(s):  
Th. Schmidt-Kaler
Keyword(s):  
Absolute Magnitude ◽  
Review Article ◽  
Stellar Systems ◽  
Astronomical Data ◽  
Intrinsic Colour

This is only an informal remark about some difficulties I am worrying about.I have tried to recalibrate the MK system in terms of intrinsic colour (B–V)0and absolute magnitudeMv. The procedures used have been described in a review article by Voigt (Mitt. Astr. Ges.1963, p. 25–35), and the results for stars of the luminosity classes Ia-O,I and II have been given also in Blaauw's article on the calibration of luminosity criteria in vol. III (Basic Astronomical Data, p. 401) ofStars and Stellar Systems.

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