β-CAROTENE NORMALIZES OXIDATIVE DAMAGE IN CAROTENOID-DEPLETED WOMEN

1999 ◽  
pp. 231-233 ◽  
Author(s):  
Betty Jane Burri ◽  
Andrew Clifford ◽  
Zisca Dixon
Keyword(s):  
Oxidative Damage ◽  
Β Carotene

Potent protective effect of apricot and β-carotene on methotrexate-induced intestinal oxidative damage in rats

2008 ◽  
Vol 46 (9) ◽  
pp. 3015-3022 ◽  
Author(s):  
Nigar Vardi ◽  
Hakan Parlakpinar ◽  
Feral Ozturk ◽  
Burhan Ates ◽  
Mehmet Gul ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Protective Effect ◽  
Β Carotene

DNA damage and susceptibility to oxidative damage in lymphocytes: effects of carotenoidsin vitroandin vivo

2004 ◽  
Vol 91 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Siân B. Astley ◽  
David A. Hughes ◽  
Anthony J. A. Wright ◽  
Ruan M. Elliott ◽  
Susan Southon
Keyword(s):  
Oxidative Damage ◽  
Ex Vivo ◽  
Human Peripheral Blood ◽  
Plasma Concentrations ◽  
Peripheral Blood Lymphocytes ◽  
Repair Mechanisms ◽  
Oxidative Challenge ◽  
Β Carotene

Reports on the effects of carotenoids are conflicting. The present paper examines similarities and differences from contiguous studiesin vitroandin vivo. Single-cell gel electrophoresis was used to measure the frequency of single-strand breaks (SSB) in the cell line MOLT-17 (as a model system) and human peripheral blood lymphocytes (PBL). MOLT-17 cells were supplemented with β-carotene, lutein or lycopene at a range of concentrations (0·00–8·00 μmol/l) using a liposome delivery method. Uptake was dose-dependent. β-Carotene concentration in the media had no effect on SSB in control cells, but incubation with lycopene or lutein (>2·00 μmol/l) increased the numbers of SSB in control cells. MOLT-17 DNA was less susceptible to oxidative damage (100 μmol H2O2/l, 5 min, 4 °C) following incubation with carotenoids between 0·50 and 1·00 μmol/l; at >1·00 μmol/l the effects were ambiguous. Apparently healthy male volunteers supplemented their habitual diets with lutein, β-carotene or lycopene (natural isolate capsules, 15 mg/d, 4 weeks) in three independent studies, raising plasma concentrations to different extents. Lycopene and lutein had no effect on SSB in control PBL or following oxidative challenge. However, increased plasma β-carotene was associated with more SSB in control cells whilst PBL DNA resistance to oxidative damageex vivowas unaffected. These results suggest that the carotenoids are capable of exerting two overlapping but distinct effects: antioxidant protection by scavenging DNA-damaging free radicals and modulation of DNA repair mechanisms.

Antioxidant Activity of 2-Bromo-3-hydroxy-2-nitroproylcinnamte against Alcohol Induced Oxidative Damage

2020 ◽  
Vol 5 (2) ◽  
pp. 156-160
Author(s):  
Rajesh Kumar Malik ◽  
Dharmendra Kumar Singh ◽  
Anuradha ◽  
Surendra Kumar
Keyword(s):  
Antioxidant Activity ◽  
Oxidative Damage ◽  
Reduced Glutathione ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Thiobarbituric Acid ◽  
Alcohol Concentration ◽  
Enzymatic Antioxidants ◽  
Glutathione S Transferase ◽  
Β Carotene

The present study demonstrated the antioxidant activity of 2-bromo-3-hydroxy-2-nitroproylcinnamte versus alcohol induced oxidative damage in albino wistar rats. In this study, 30 % alcohol exposed rats were found to be more prone to peroxidative risk as they are calculated by species of thiobarbituric acid. It was observed that after the rats induction with 30% alcohol, concentration of lipid peroxidation has been obtained expressively (p ≤ 0.001) high in a liver and serum, beside with concomitant substantial (p ≤ 0.001) reduced in enzymatic and non-enzymatic antioxidants levels like catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), vitamin E (tocopherol), reduced glutathione (GSH), glutathione-s-transferase (GST), vitamin C (ascorbic acid), β-carotene as well as ceruloplasmin in serum along with liver, only 30% alcohol was treated. If rats obtained 2- bromo-3-hydroxy-2-nitroproylcinnamte at the dose level of 20 mg/kg bw/day, PO, for 30 days, the peroxidative damage has been marginal in serum along with liver, alongside efficiently encouraging the potential of antioxidant in the rats treated by alcohol. This study revealed that in liver the raised peroxidative risk is probably allied with alcohol induction pathology that can be decreased by increasing the antioxidant potential by free radical scavenging activity, therefore promising as artificial antioxidants for 2-bromo-3-hydroxy-2-nitroproylcinnamte.

Protection by vitamin E, selinium, and β-carotene against oxidative damage in rat liver slices and homogenate

1993 ◽  
Vol 14 (5) ◽  
pp. 473-482 ◽  
Author(s):  
Hao Chen ◽  
Lori J. Pellett ◽  
Henrik J. Andersen ◽  
A.L. Tappel
Keyword(s):  
Vitamin E ◽  
Oxidative Damage ◽  
Rat Liver ◽  
Liver Slices ◽  
Β Carotene

Astaxanthin, canthaxanthin and β-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes

2009 ◽  
Vol 18 (3) ◽  
pp. 222-231 ◽  
Author(s):  
Emanuela Camera ◽  
Arianna Mastrofrancesco ◽  
Claudia Fabbri ◽  
Felicitas Daubrawa ◽  
Mauro Picardo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Β Carotene
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