Formulation design and development to produce orodispersible tablets by direct compression

2007 ◽  
Vol 17 (3) ◽  
pp. 199-203 ◽  
Author(s):  
L. Segale ◽  
L. Maggi ◽  
E. Ochoa Machiste ◽  
S. Conti ◽  
U. Conte ◽  
...  
Keyword(s):  
Direct Compression ◽  
Design And Development ◽  
Formulation Design ◽  
Orodispersible Tablets

scholarly journals Paediatric Formulation: Design and Development

2020 ◽  
Vol 21 (19) ◽  
pp. 7118
Author(s):  
Antonio Lopalco ◽  
Nunzio Denora
Keyword(s):  
Drug Delivery ◽  
Patient Population ◽  
State Of The Art ◽  
Original Research ◽  
Special Issue ◽  
Formulation Development ◽  
Design And Development ◽  
Formulation Design ◽  
Age Appropriate ◽  
Paediatric Formulation

The development of medicines designed for children can be challenging since this distinct patient population requires specific needs. A formulation designed for paediatric patients must consider the following aspects: patient population variability; dose flexibility; route of administration; patient compliance; drug and excipient tolerability. The purpose of this Special Issue entitled “Paediatric Formulation: Design and Development” is to provide an update on both state-of-the-art methodology and operational challenges in the design and development of paediatric formulations. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients. This editorial, briefly, summarizes the objects of nine original research and review papers published in this Special Issue.

scholarly journals Preparation and evaluation of diclofenac sodium orally disintegrating tablets

2016 ◽  
Vol 27 (1) ◽  
pp. 58-61
Author(s):  
Valeriu Iancu ◽  
Florentina Roncea ◽  
Radu George Cazacincu ◽  
Dumitru Lupuleasa
Keyword(s):  
Diclofenac Sodium ◽  
Magnesium Stearate ◽  
Dosage Forms ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Orodispersible Tablets ◽  
Orally Disintegrating Tablets ◽  
Wetting Time ◽  
Preparation And Evaluation

Abstract Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can be attained by addition of different varieties of excipients. Pharmaburst™ 500 is a co-processed excipient system which allows rapid disintegration and low adhesion to punches. The aim of the present study was to develop and evaluate 25 mg diclofenac sodium ODTs (orodispersible tablets) batches by direct compression method at different compression forces 10 kN (F1) and 20 kN (F2) and directly compressible excipients used in different ratio (Avicel PH 102, magnesium stearate and coprocessed excipient Pharmaburst™ 500, 70% and 80% w/w). The obtained batches were analyzed for appearance, tablet thickness, uniformity of weight, hardness, friability, disintegration time, and non-compendial methods (wetting time). Co-processed Pharmaburst™ 500 excipient 70% used for sodium diclofenac ODT obtaining determined good results for quality control tests evaluation.

scholarly journals Formulation and in vitro evaluation of orodispersible tablets of fexofenadine hydrochloride

2020 ◽  
Vol 19 (5) ◽  
pp. 919-925
Author(s):  
Durgaramani Sivadasan ◽  
Muhammad Hadi Sultan ◽  
Osama Madkhali ◽  
Shamama Javed ◽  
Aamena Jabeen
Keyword(s):  
Guar Gum ◽  
Polymer Concentration ◽  
In Vitro Release ◽  
Direct Compression ◽  
Compression Technique ◽  
Disintegration Time ◽  
Weight Fluctuation ◽  
Orodispersible Tablets ◽  
Croscarmellose Sodium

Purpose: To develop orodispersible tablets (ODTs) of fexofenadine hydrochloride using three different superdisintegrants in various ratios and to compare their disintegration properties.Methods: Direct compression technique was used for the preparation of ODTs. Mannitol and Avicel CE-15 (microcrystalline cellulose and guar gum) were used as direct compression diluents. The disintegration time of tablets using each polymer (superdisintegrant) was evaluated as well as othertablet properties including weight fluctuation, hardness, friability, wetting time and water absorption ratio.Results: Satisfactory values were obtained for all the evaluated parameters. As the polymer concentration increased, there was a decrease in disintegration time. A comparison of the three different polymers used revealed that CCM3 formulated with 12 % croscarmellose sodium and 14.66 % lactose had the least disintegration time of 32.33 ± 3.23 s. In vitro release studies showed that the maximum drug release of 94.38 ± 0.12 % in 25 min was obtained for ODT tablets containing croscarmellose sodium (CCM3).Conclusion: The orodispersible tablets had quick disintegrating property which was achieved using superdisintegrants. Thus, superdisintegrants improve the disintegration efficiency of orodispersible fexofenadine tablets at low concentrations, when compared to traditional disintegrants. Keywords: Croscarmellose sodium, Direct compression, Fexofenadine, Orodispersible tablets

scholarly journals FORMULATION AND EVALUATION OF TASTE MASKED ORODISPERSIBLE TABLETS OF AMLODIPINE BESYLATE BY DIRECT COMPRESSION

2013 ◽  
Vol 4 (7) ◽  
pp. 123-130 ◽  
Author(s):  
B Sree Giri Prasad ◽  
V R M Gupta ◽  
N Devanna ◽  
N Siva Subramanian ◽  
CH Naveen Kumar ◽  
...  
Keyword(s):  
Direct Compression ◽  
Amlodipine Besylate ◽  
Orodispersible Tablets

New SeDeM-ODT expert system: an expert system for formulation of orodispersible tablets obtained by direct compression

2013 ◽  
pp. 137-154 ◽  
Author(s):  
Johnny Edward Aguilar ◽  
Encarna García Montoya ◽  
Pilar Pérez Lozano ◽  
Josep M. Suñe Negre ◽  
Montserrat Miñarro Carmona ◽  
...  
Keyword(s):  
Expert System ◽  
Direct Compression ◽  
Orodispersible Tablets

SeDeM Expert System, An Innovative Tool for Developing Directly Compressible Tablets: A Review

2020 ◽  
Vol 12 ◽  
Author(s):  
Inderbir Singh ◽  
Ajay Kumar Thakur ◽  
Rajni Bala ◽  
Reecha Madan
Keyword(s):  
Expert System ◽  
Sustained Release ◽  
Active Ingredient ◽  
Development Time ◽  
Review Paper ◽  
Direct Compression ◽  
Sediment Delivery ◽  
Delivery Model ◽  
Orodispersible Tablets ◽  
Innovative Tool

Background: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameter and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameter derived diagram that can be used as a research tool for reducing the product development time. Best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability. Objective: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained release formulations and development of tablets of taste masked drugs. Conclusion: In the present review paper development and applications of SeDeM and SeDeM-ODT systems have been discussed in detail.

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