Postoperative Cardiac Troponin I (cTnI) Level and Its Prognostic Value for Patients Undergoing Mitral Valve Surgery

Introduction: Corona Virus Disease (COVID -19) patients present mainly with respiratory manifestations and viral pneumonia. The cardiovascular system presentation includes early signs of acute myocardial injury. Cardiac troponin I (cTnI) is a gold-standard biomarker for necrosis and myocardial risk assessment. Aim of the work: This study aimed to assess the prognostic value of cTnI in COVID-19 patients. Methodology: We report a prospective study that included 92 COVID-19 patients admitted to the El Helal Hospital, Sohag, Egypt. Upon admission, routine investigations including cTnI, chest Computed Tomography (CT), and Electrocardiogram (ECG) were carried out. The patients admitted to the intensive care unit (ICU) also had echocardiography. Results: More than half of the patients (55.4%) were admitted to ICU; cTnI level was elevated in 30 patients (58.8%), of whom 17 died (56.7%). There were statistically significant differences regarding the relation between cTnI level, D-dimer and the need for ICU admission and death (p=0.001). Conclusion: We conclude that cardiac troponin I levels are a prognostic factor for ICU admission and mortality in COVID-19 patients.

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Prognostic Value of Cardiac Troponin I In Infective Endocarditis

European Heart Journal Supplements ◽

10.1093/eurheartj/suab069.011 ◽

2021 ◽

Vol 23 (Supplement_D) ◽

Author(s):

Salma M Thabet ◽

Marwa Meshaal ◽

Yasser Yazied ◽

Yasser Sharaf

Keyword(s):

Heart Failure ◽

Infective Endocarditis ◽

Cardiac Troponin ◽

Prognostic Value ◽

Troponin I ◽

Cardiac Troponin I ◽

P Value ◽

Significant Relation ◽

P Values ◽

Septic Pulmonary Embolism

Abstract Aim The aim of this study is to assess the prognostic value of cardiac troponin I as a predictor of in-hospital morbidity and mortality in patients with infective endocarditis. Methods This study included 48 patients with definite and possible IE according to modified Duke’s criteria for diagnosis of IE. This prospective longitudinal study was conducted on patients admitted to the cardiovascular department of Cairo University hospitals. All patients were subjected to full history taking and clinical examination, all laboratory and radiological investigations which included chest radiography, echocardiogram and other diagnostic procedures as needed for diagnosis and follow-up of IE were done with emphasis on cardiac troponin I level on admission. Results Troponin I was found to be statistically significant predictor for heart failure (NYHA III/IV), septic pulmonary embolism and in-hospital mortality in infective endocarditis patients by univariate and multivariate regression analysis with P values 0.023, 0.037and 0.002 respectively. Tricuspid valve vegetations had showed significant relation to troponin I levels with p value 0.033. Also it was found that SOFA score on first day of admission showed significant relation to troponin I level with P value 0.045 and 0.004 for prediction of hospital stay duration. Shock and intracranial hemorrhage showed borderline significance with P values 0.097, 0.069. On other hand, troponin I as predictor of pulmonary edema, mechanical complications, systemic embolization, acute kidney injury and presence of aortic root abscess had no statistical significance in our studied patients. Conclusions This study showed that there is as significant predictive value of elevated cardiac troponin I with heart failure, septic pulmonary embolism and all cause in-hospital mortality. In addition, it was significant predictor of the length of hospital stay, lymphocytosis and SOFA score. These results are emphasizing that cTn I level may predict higher risk patients who would need early and aggressive control of infection medically alone or combined with surgery in IE patients.

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Prognostic Value of Troponin I with Echocardiography Assessment in Septic Patients

QJM ◽

10.1093/qjmed/hcab086.001 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Sherif Farouk Ibrahim ◽

Ashraf Elsayed Elagmy ◽

Abdelrhman Gamal Abdelsabour

Keyword(s):

Septic Shock ◽

Acute Coronary Syndrome ◽

Intensive Care ◽

Cardiac Troponin ◽

Prognostic Value ◽

Troponin I ◽

Cardiac Troponin I ◽

Coronary Syndrome ◽

Sepsis And Septic Shock

Abstract Background Sepsis is heterogenous with regard to factors such as causal microorganism, patient predisposition, co-morbidity and response to therapy, a key element and unifying feature is the manifestation of cardiovascular dysfunction. Elevated concentrations of cardiac troponin I (cTnI) are frequently observed in patients with severe sepsis and septic shock even in the absence of an acute coronary syndrome (ACS). Objective To evaluate the prognostic value of (cTnI) with echocardiography assessment in septic patients. Patients and Methods This study was conducted at the intensive care units of Ain Shams university hospitals. 20 patients of both sexes with age ranging from 18 to 70 years diagnosed with sepsis admitted to Intensive care unit were included in prospective observational study. Results Baseline cTnI had a significant positive correlation with follow up troponine (p = 0.0016). Baseline EF had a significant negative correlation with follow up troponine (p = 0.036). Using ROC-curve analysis, troponin level at a cutoff point (>1.9) predicted patients with mortality, with good (87%) accuracy, sensitivity= 90% and specificity= 90% (p < 0.01). Conclusion Elevated concentrations of cardiac troponin I (cTnI) are frequently observed in patients with sepsis and septic shock even in the absence of an acute coronary syndrome.

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Short-term prognostic value of serum cardiac troponin I levels in neonates with perinatal asphyxia

Alexandria Journal of Pediatrics ◽

10.4103/ajop.ajop_3_18 ◽

2017 ◽

Vol 30 (3) ◽

pp. 108

Author(s):

BahaaS Hammad ◽

MohamedH Gouda ◽

MohamedA Amen

Keyword(s):

Cardiac Troponin ◽

Prognostic Value ◽

Troponin I ◽

Perinatal Asphyxia ◽

Cardiac Troponin I ◽

Short Term ◽

Serum Cardiac Troponin

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Prognostic value of high-sensitive cardiac troponin I in asymptomatic chronic hemodialysis patients

Journal of Nephrology ◽

10.1007/s40620-019-00610-5 ◽

2019 ◽

Vol 33 (1) ◽

pp. 129-136

Author(s):

Barbara Maresca ◽

Andrea Manzione ◽

Alessandra Moioli ◽

Gerardo Salerno ◽

Patrizia Cardelli ◽

...

Keyword(s):

Cardiac Troponin ◽

Prognostic Value ◽

Troponin I ◽

Hemodialysis Patients ◽

Chronic Hemodialysis ◽

Cardiac Troponin I

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Evaluation of atrial natriuretic peptide and cardiac troponin I concentrations for assessment of disease severity in dogs with naturally occurring mitral valve disease

Journal of the American Veterinary Medical Association ◽

10.2460/javma.256.3.340 ◽

2020 ◽

Vol 256 (3) ◽

pp. 340-348

Author(s):

Yasutomo Hori ◽

Masayuki Iguchi ◽

Atsushi Hirakawa ◽

Zenta Kamiya ◽

Shigeki Yamano ◽

...

Keyword(s):

Mitral Valve ◽

Atrial Natriuretic Peptide ◽

Disease Severity ◽

Natriuretic Peptide ◽

Mitral Valve Disease ◽

Cardiac Troponin ◽

Troponin I ◽

Cardiac Troponin I ◽

Valve Disease ◽

Naturally Occurring

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Prognostic value of elevated cardiac troponin I in patients with intracerebral hemorrhage

Clinical Cardiology ◽

10.1002/clc.23320 ◽

2019 ◽

Vol 43 (4) ◽

pp. 338-345

Author(s):

Yangchun He ◽

Qigong Liu ◽

Jing Wang ◽

Dao Wen Wang ◽

Hu Ding ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

Cardiac Troponin ◽

Prognostic Value ◽

Troponin I ◽

Cardiac Troponin I

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Pre-cardiopulmonary bypass administration of dexmedetomidine decreases cardiac troponin I level following cardiac surgery with sevoflurane postconditioning

Journal of International Medical Research ◽

10.1177/0300060519856750 ◽

2019 ◽

Vol 47 (8) ◽

pp. 3623-3635

Author(s):

Hong-mei Zhou ◽

Xiao-yan Ling ◽

Yun-jian Ni ◽

Cheng Wu ◽

Zhi-peng Zhu

Keyword(s):

New York ◽

Cardiac Surgery ◽

Cardiopulmonary Bypass ◽

Cardiac Troponin ◽

Troponin I ◽

Myocardial Damage ◽

Heart Association ◽

Cardiac Troponin I ◽

Sevoflurane Postconditioning ◽

Ctni Level

Objective This study was performed to determine the effect of dexmedetomidine (DEX) administration on myocardial damage in cardiac surgery with sevoflurane postconditioning. Methods We retrospectively examined all cardiac valve replacement surgeries from 1 April 2016 to 30 April 2017. Eligible patients were divided into two groups based on whether DEX was infused. DEX infusion was permitted only between intubation and the beginning of cardiopulmonary bypass (CPB). Sevoflurane was inhaled via the standard postconditioning procedure starting at aortic declamping. The cardiac troponin I (cTnI) level was measured at different time points. The postoperative outcomes and complications were also analyzed. Results One hundred patients were included in the study (DEX group, n = 53; non-DEX group, n = 47). Increased cTnI levels were significantly correlated with the New York Heart Association classification, CPB time, and DEX use. DEX use and the CPB time were potential independent factors contributing to changes in the cTnI level. The cTnI level at 6, 12, and 24 hours postoperatively was remarkably lower in the DEX than non-DEX group by 1.14, 7.83, and 5.86 ng/mL, respectively. Conclusions DEX decreased the cTnI level after CPB when sevoflurane postconditioning was used, especially at 6, 12, and 24 hours postoperatively.

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