Nutritional Status, Muscle Strength and Functional Capacity in Children and Adolescents with Cystic Fibrosis

ABSTRACT Objective: To verify the association between quality of life, functional capacity and clinical and nutritional status in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study, including patients from eight to 18 years old with CF. Quality of life, functional capacity, nutritional status and clinical status were evaluated with the Cystic Fibrosis Questionnaire; the 6-minute walk test (6MWT) and manual gripping force (MGF); the height percentiles for age and body mass index for age and respiratory function test, respectively. Pearson and Spearman correlation tests and logistic regression were used to analyze the data. Results: A total of 45 patients, 13.4±0.5 years old, 60% female, 60% colonized by Pseudomonas aeruginosa and 57.8% with at least one F508del mutation participated in the study. When assessing the perception of quality of life, the weight domain reached the lowest values, and the digestive domain, the highest. In the pulmonary function test, the forced expiratory volume of the first second was 77.3±3.3% and the 6MWT and MGF presented values within the normal range. There was an association between quality of life and functional capacity, nutritional status and clinical status of CF patients. Conclusions: The study participants had good clinical conditions and satisfactory values of functional capacity and quality of life. The findings reinforce that the assessment of quality of life may be important for clinical practice in the management of treatment.

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ASSOCIATIONS OF PERIPHERAL MUSCLE STRENGTH, PULMONARY FUNCTION AND FUNCTIONAL CAPACITY IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS

Respirology ◽

10.1111/resp.13700_432 ◽

2019 ◽

Vol 24 (S2) ◽

pp. 233-233

Keyword(s):

Cystic Fibrosis ◽

Muscle Strength ◽

Pulmonary Function ◽

Children And Adolescents ◽

Functional Capacity ◽

Peripheral Muscle

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Peripheral muscle strength is associated with lung function and functional capacity in patients with cystic fibrosis

Physiotherapy Research International ◽

10.1002/pri.1771 ◽

2019 ◽

Vol 24 (3) ◽

Cited By ~ 2

Author(s):

Paula Maria Eidt Rovedder ◽

Gabrielle Costa Borba ◽

Mariluce Anderle ◽

Josani Flores ◽

Bruna Ziegler ◽

...

Keyword(s):

Cystic Fibrosis ◽

Muscle Strength ◽

Lung Function ◽

Functional Capacity ◽

Peripheral Muscle

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Relationship between peripheral muscle strength, exercise capacity and body composition in children and adolescents with cystic fibrosis

Physiotherapy Theory and Practice ◽

10.1080/09593985.2021.1973165 ◽

2021 ◽

pp. 1-8

Author(s):

Juliana Cardoso ◽

Janaina Scalco ◽

Francieli Mucha ◽

Fabrizio Caputo ◽

CamilaIsabel Santos Schivinski

Keyword(s):

Cystic Fibrosis ◽

Body Composition ◽

Muscle Strength ◽

Children And Adolescents ◽

Exercise Capacity ◽

Strength Exercise ◽

Peripheral Muscle

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Six-minute walk test as a determinant of the functional capacity of children and adolescents with cystic fibrosis: A systematic review

Respiratory Medicine ◽

10.1016/j.rmed.2018.02.016 ◽

2018 ◽

Vol 137 ◽

pp. 83-88 ◽

Cited By ~ 6

Author(s):

Cibelle Andrade Lima ◽

Armèle Dornelas de Andrade ◽

Shirley Lima Campos ◽

Daniella Cunha Brandão ◽

Ianny Pereira Mourato ◽

...

Keyword(s):

Systematic Review ◽

Cystic Fibrosis ◽

Children And Adolescents ◽

Functional Capacity ◽

Walk Test ◽

Six Minute Walk Test ◽

Minute Walk

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310 Respiratory muscle strength and nutritional status in Cystic Fibrosis patients

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(06)80281-x ◽

2006 ◽

Vol 5 ◽

pp. S72

Author(s):

T. Moudiou ◽

A. Galli-Tsinopoulou ◽

M. Eboriadou ◽

S. Nousia-Arvanitakis

Keyword(s):

Cystic Fibrosis ◽

Muscle Strength ◽

Nutritional Status ◽

Respiratory Muscle ◽

Respiratory Muscle Strength

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PREVALENCE OF HEPATIC STEATOSIS AMONG CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS AND ITS ASSOCIATION WITH NUTRITIONAL STATUS

Revista Paulista de Pediatria ◽

10.1590/1984-0462/;2019;37;4;00007 ◽

2019 ◽

Vol 37 (4) ◽

pp. 435-441

Author(s):

Amanda Oliva Gobato ◽

Ana Carolina Junqueira Vasques ◽

Antonio Fernando Ribeiro ◽

Roberto Massao Yamada ◽

Gabriel Hessel

Keyword(s):

Cystic Fibrosis ◽

Nutritional Status ◽

Children And Adolescents ◽

Hepatic Steatosis ◽

Statistical Tests ◽

The Body ◽

Significant Difference ◽

Group A ◽

The Mean ◽

Group B

ABSTRACT Objective: To determine the prevalence of hepatic steatosis (HS) in children and adolescents with cystic fibrosis (CF) and associate it with nutritional status. Methods: Cross-sectional study with children and adolescents with CF diagnosis. Weight and height were used to calculate the body mass index (BMI) and subsequent classification of the nutritional status. The midarm circumference (MAC), triceps skinfold thickness (TSF) and midarm muscle circumference (MAMC) were used to evaluate body composition. Abdominal ultrasonography was performed for diagnosis of HS. The statistical tests used were Student’s t test, Mann-Whitney test and chi-square test with significance level of 5%. Results: 50 patients with CF were evaluated, 18 (36%) were diagnosed with HS (Group A) and 32 (64%) without HS (Group B). The mean age of Group A was 13,2±4,9 years old and Group B 11,7±4,9; for BMI, the value for Group A was 18,0±4,1 and Group B was 15,7±3,8; the TSF of Group A was 8,4±3,5 mm and Group B was 7,0±2,5 mm. For these variables, there was no significant difference between the groups. The mean of MAC and MAMC differed significantly between the groups, being higher in the HS group, with p values of 0,047 and 0,043. Conclusions: The frequency of HS in patients with CF is high and it is not related to malnutrition, according to the parameters of BMI, TSF and MAMC. The values of MAC and MAMC indicated a greater reserve of muscle mass in patients with HS.

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