Trypanocidal function of Terminalia catappa leaf extract in Albino rat

The synthesis of eco-friendly nanoparticles is evergreen branch of nanoscience for biomedical application. Low cost of synthesis and non toxicity are main features make it more attractive potential option for biomedical field and elsewhere. Here, we report the synthesis of gold nanoparticles in aqueous medium usingTerminalia catappa(Almond) leaf extract as the reducing and stabilizing agent. On treating chloroauric acid solutions withTerminalia catappa(TC) leaf extract rapid reduction of chloroaurate ions is observed leading to the formation of highly stable gold nanoparticles in solution. TEM analysis of the gold nanoparticles indicated that they ranged in size from 10 to 35 nm with average size of 21.9 nm.

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Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats

Asian Journal of Research in Biochemistry ◽

10.9734/ajrb/2019/v4i130058 ◽

2019 ◽

pp. 1-10

Author(s):

Ezekiel E. Ben ◽

Asuquo E. Asuquo ◽

Daniel U. Owu

Keyword(s):

Body Weight ◽

Interleukin 6 ◽

Leaf Extract ◽

Serum Levels ◽

Diabetic Rats ◽

C Reactive Protein ◽

Reactive Protein ◽

Terminalia Catappa ◽

Aqueous Leaf Extract ◽

Anti Inflammatory

Background: The association between diabetes mellitus and inflammation is established but the use of non-steroidal anti-inflammatory drugs is not without some health risk. Aim: The study was aimed at comparing the levels of some inflammatory biomarkers in diabetic rats treated with aqueous leaf extract of Terminalia catappa, non steroidal anti-inflammatory drugs (NSAIDs) and exogenous insulin. Materials and Methods: Thirty six (36) Wistar rats were assigned to 6 groups of 6 animals each. Group 1 and 2 served as normal and diabetic controls and received orally 5ml/kg body weight of distilled water. Group 3 was diabetic treated orally with 130mg/kg body weight of aqueous leaf extract of Terminalia catappa. And groups 4, 5 and 6 were administered orally with aspirin (30mg/kg), meloxicam (2mg/kg) and 0.75U/kg body weight of insulin subcutaneously. Diabetes was induced with intraperitoneal injection of 150mg/kg body weight of alloxan solution and diabetes confirmed after 72 hours with blood glucose levels ≥200mg/dl. The experiment lasted for 14 days and blood was collected by cardiac puncture for serum analysis of C-reactive protein, Interleukin-6 and Fibrinogen by ELISA method. Results: The results showed significant (P<0.05) increase in serum levels of C-reactive protein, Interleukin-6 and blood fibrinogen in diabetic group compared to control. These inflammatory biomarker were significantly (P<0.05) reduced by the extract, aspirin, meloxicam and insulin. Conclusion: The reduced levels of C-reactive protein, Interleukin-6 and fibrinogen by aqueous leaf extract of Terminalia catappa was significant compared to aspirin and meloxicam. This may present the extract as a potent anti-inflammatory agent and could complement the function of insulin in diabetes treatment.

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The Role of Serum Alpha-Amylase and Glycogen Synthase in the Anti-Diabetic Potential of Terminalia catappa Aqueous Leaf Extract in Diabetic Wistar Rats

Asian Journal of Research in Medical and Pharmaceutical Sciences ◽

10.9734/ajrimps/2019/v6i230096 ◽

2019 ◽

pp. 1-11

Author(s):

Ezekiel E. Ben ◽

Asuquo E. Asuquo ◽

D. U. Owu

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Wistar Rats ◽

Leaf Extract ◽

Glycogen Synthase ◽

Alpha Amylase ◽

Distilled Water ◽

Terminalia Catappa ◽

Aqueous Leaf Extract

Background: The endocrinal abnormalities in diabetes mellitus as one of the numerous metabolic disorders is associated with derangement in exocrine functions of the pancreas and ultimately influences blood glucose regulation. Aim: The study was aimed at assessing the role of alpha-amylase and glycogen synthase in anti-diabetic potential of Terminalia catappa in diabetic rats. Materials and Methods: Thirty five (35) Wistar rats were assigned to 5 groups of 7 animals each. Group 1 served as the control administered distilled water at 5ml/kg bodyweight and group 2 was a non diabetic group given orally, 130/kg body weight of aqueous leaf extract of Terminalia catappa. Groups 3, 4 and 5 received a single dose of 150mg/kg body weight of alloxan solution intraperitoneally to induce diabetes and rats with blood glucose levels ≥200mg/dl after 72 hours were considered diabetic. This was followed by oral administration of 5ml/kg bodyweight of distilled water, 130mg/kg body weight of Terminalia catappa leaf extract orally and subcutaneous administration of insulin, 0.75U/kg body weight to groups 3 (diabetic), 4(diabetic + extract) and 5 (diabetic + insulin) respectively. Results: The results showed significant (P<.05) increase in serum level of alpha-amylase and glycogen synthase in both non-diabetic extract treated and diabetic groups when compared to control. But these enzymes significantly (P<.05) reduced in diabetic extract and insulin treated groups when compared to the diabetic group. Conclusion: Therefore the hypoglycaemic potential of Terminalia catappa leaf extract could be attributed to its ability to reduce alpha-amylase level while lowered glycogen synthase might be secondary to reduction in blood glucose.

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Antidepressant like effects of hydrolysable tannins of Terminalia catappa leaf extract via modulation of hippocampal plasticity and regulation of monoamine neurotransmitters subjected to chronic mild stress (CMS)

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2016.12.031 ◽

2017 ◽

Vol 86 ◽

pp. 414-425 ◽

Cited By ~ 21

Author(s):

Y. Chandrasekhar ◽

E.M. Ramya ◽

K. Navya ◽

G. Phani Kumar ◽

K.R. Anilakumar

Keyword(s):

Leaf Extract ◽

Chronic Mild Stress ◽

Mild Stress ◽

Monoamine Neurotransmitters ◽

Hippocampal Plasticity ◽

Terminalia Catappa ◽

Hydrolysable Tannins

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Antioxidant and Antibacterial Activities of Biosynthesized Silver Nanoparticles using Aqueous Terminalia catappa Leaf Extracts as Novel Reducing Agent

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22749 ◽

2020 ◽

Vol 32 (8) ◽

pp. 2079-2083

Author(s):

Paweena Porrawatkul ◽

Rungnapa Pimsen ◽

Saksit Chanthai ◽

Prawit Nuengmatcha

Keyword(s):

Particle Size ◽

Silver Nanoparticles ◽

Leaf Extract ◽

Particle Size Analysis ◽

Reducing Agent ◽

Size Analysis ◽

Main Peak ◽

Leaf Extracts ◽

Characteristic Functional ◽

Terminalia Catappa

In this study, silver nanoparticles (AgNPs) were successfully synthesized from aqueous Terminalia catappa leaf extract that acts as a novel reducing agent. Various parameters, including pH, temperature and reaction time, were determined. The UV-visible spectra showed the main peak at 416 nm, which was the characteristic surface plasmon resonance of AgNPs. The spherical shape and particle size of 49 ± 0.01 nm were observed from SEM, TEM and laser particle size analysis (LPSA). FTIR spectra of the leaf extract exhibited the characteristic functional groups that should be responsible for Ag+ ion reduction. The EDX spectrum proved that the obtained sample is silver. The antioxidant activity of AgNPs treated with the leaf extract as determined by the DPPH assay was higher compared to that of Terminalia catappa leaf extract, and the treated AgNP sample exhibited high antibacterial potential against both Gram-positive and Gram-negative bacteria.

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Hemogram and iron indices in renal anemia and the amelioration with Carica papaya leaf extract applied on albino rat model

Bioscience Reports ◽

10.1042/bsr20181699 ◽

2019 ◽

Vol 39 (4) ◽

Author(s):

Ibtsam Gheith ◽

Abubakr El-Mahmoudy

Keyword(s):

Leaf Extract ◽

Carica Papaya ◽

Binding Capacity ◽

Transferrin Saturation ◽

Albino Rats ◽

Dependent Manner ◽

Iron Binding ◽

Albino Rat ◽

Blood Profile ◽

Iron Binding Capacity

AbstractThe present study was designed to look at the hematological disorders in gentamicin nephrotoxicity model, as kidney is considered as one of the hemopoietic organs. In a previous study, novel and classical kidney injury biomarkers were utilized to evaluate the nephroprotective potential of Carica papaya leaf extract (CPLE) in the same model in albino rats. Gentamicin (100 mg/kg, subcutaneously, for 21 consecutive days) resulted in significant decreases in red blood cell (RBC) count, hemoglobin concentration (HGB), and packed cell volume (PCV) value, with minimal alterations in erythrocytic indices. Leucogram showed leukocytosis, granulocytosis, and thrombocytopenia. Erythropoietin (EPO) levels were also drastically decreased by the end of the experimental course. Serum iron, unsaturated iron-binding capacity (UIBC), total iron binding capacity (TIBC), transferrin saturation %, and serum transferrin concentration values were significantly decreased in contrast to ferritin, which was increased. When concurrently administered with gentamicin, CPLE (150 and 300 mg/kg, orally via gastric tube, for 21 days) significantly protected against the drastic effects of the former on the blood profile with improving potentials on erythrogram, leukogram, thrombocytes, EPO, iron and its indices, in a dose-dependent manner. These data may suggest CPLE as an appreciated blood homeostatic and nephroprotective agent from a natural source that could be a good remedy in conditions associated with blood disorders.

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Effectiveness of Aqueous Leaf Extract of Peperomia pellucida and Terminalia catappa in the Management of Cyst Nematode (Heterodera sacchari) on Selected Rice Varieties

Cercetari Agronomice in Moldova ◽

10.1515/cerce-2017-0025 ◽

2017 ◽

Vol 50 (3) ◽

pp. 47-60

Author(s):

N.B. Izuogu ◽

A.R. Saliu ◽

H.S. Baba ◽

C.M. Olajide

Keyword(s):

Leaf Extract ◽

Soil Analysis ◽

Cyst Nematode ◽

Nematode Population ◽

Growth And Yield ◽

Soil Nematode ◽

Rice Varieties ◽

Terminalia Catappa ◽

Significant Difference ◽

Aqueous Leaf Extract

Abstract Experiments were conducted at the teaching and research farm of Faculty of Agriculture, University of Ilorin, Nigeria to determine the effect of aqueous extract of Peperomia pelliucida and Terminalia catappa on the management of cyst nematode, Heterodera sacchari on some selected rice varieties. A screenhouse preliminary study was first carried out in December, 2014 to assess the pathogenicity of H. sacchari on ten varieties of rice from which five varieties were selected for field trials. The five selected rice varieties were grown on soil inoculated with cysts of H. sacchari. The field experiment was a 5×3 factorial type fitted into a randomized complete block design (RCBD). Soil nematode population, physiochemical soil analysis and phytochemical screening of the tests plants were carried out. Treatment application of aqueous leaf extract were conducted at the 2nd and 7th weeks after transplanting. Data were collected on the plant height, shoot, root weights, yield and soil nematode population. All numerical data were subjected to analysis of variance (Anova) using GENSTAT statistical package 12th edition and where significant differences were observed, means were separated using fisher’s protected LSD. Results from the study revealed that treatment combination of P. pellucida and T. catappa singly with FARO 60, FARO 61, and NERICA 8 performed significantly higher (p>0.05) than the other rice varieties for most of the growth and yield parameter measured. Significant differences occurred between shoot, root, and yield weight of treated plants and their control counterparts. There was no significant difference between the two plant extracts used with respect to parameters measured. Treated plants performed significantly higher than the control. Based on the results of the study, paddy farmers experiencing H. sacchari infestation are encouraged to treat the field with P. pellucida and or T. catappa, especially when planting FARO 60, FARO 61, and NERICA 8 as these combinations promise to give higher yield.

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