NEONATAL AND MATERNAL THROMBOCYTOPENIC PURPURA DUE TO QUININE
Keyword(s):
A case of quinine induced thrombocytopenic purpura in a mother and her newborn born infant is presented. In-vitro confirmation of the presence of quinine-platelet "antibodies" in the plasma of both mother and infant was obtained just after delivery. Five months later the "antibody" was still demonstrable in the mother, though backing in the infant. It is suggested that the neonatal thrombocytopenic purpura in this infant resulted from transplacental passage of antibody and quinine from the mother. A careful search for possible drug sensitization seems warranted in other cases of neonatal thrombocytopenia not explained by other means.
2005 ◽
Vol 75A
(3)
◽
pp. 648-655
Keyword(s):