Australia Antigen and Neonatal Hepatitis Syndrome

PEDIATRICS ◽  
1974 ◽  
Vol 54 (2) ◽  
pp. 157-164
Author(s):  
Christos A. Kattamis ◽  
Demetrios Demetrios ◽  
Nicholas S. Matsaniotis
Keyword(s):  
Hepatitis Virus ◽  
Newborn Infants ◽  
Neonatal Hepatitis ◽  
Cmv Infection ◽  
Australia Antigen ◽  
High Prevalence ◽  
The Status ◽  
Antigen Antibody ◽  
Hepatitis Type B ◽  
Hepatitis Virus B

The status of Australia antigen (Au-Ag) and Australia antigen antibody (Au-Ab) was investigated in 27 infants less than 4 months of age with direct reacting hyperbilirubinemia, and in their parents. A diagnosis of viral hepatitis could be excluded in eight infants; of the remaining 19, ten were positive for Au-Ag and another three had suggestive evidence of hepatitis virus B (HBV) infection. The high proportion of infants with neonatal hepatitis associated with Au-Ag in this series is attributed to the high prevalence of Au-Ag carriers in Greece as well as to the high frequency of exchange transfusions in newborn infants. The other 14 cases of direct-reacting hyperbilirubinemia, none of which showed Au-Ag or evidence of HBV, were due to congenital malformation of the biliary tract (four cases), septicemia (three cases), cytomegalovirus (CMV) infection (one case), and fructosemia (one case). The remaining five patients, all of whom recovered, are believed to have hepatitis virus A infection. The detection of Au-Ag in prolonged neonatal jaundice with direct bilirubinemia favors a diagnosis of hepatitis type B, which in our experience carries a graver prognosis reflected in deaths and cirrhosis when compared to neonatal hepatitis not associated with Au-Ag. In our patients, it is inferred that transmission of Au-Ag to the infants occurred at or after birth, rather than during intrauterine life.

scholarly journals High Prevalence of Three Potyviruses Infecting Cucurbits in Oklahoma and Phylogenetic Analysis of Cucurbit Aphid-Borne Yellows Virus Isolated from Pumpkins

Pathogens ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 53
Author(s):  
Vivek Khanal ◽  
Harrington Wells ◽  
Akhtar Ali
Keyword(s):  
Phylogenetic Analysis ◽  
Mosaic Virus ◽  
Zucchini Yellow Mosaic Virus ◽  
Yellow Mosaic Virus ◽  
Watermelon Mosaic Virus ◽  
High Prevalence ◽  
The Us ◽  
Close Relationship ◽  
The Status ◽  
Low Incidence

Field information about viruses infecting crops is fundamental for understanding the severity of the effects they cause in plants. To determine the status of cucurbit viruses, surveys were conducted for three consecutive years (2016–2018) in different agricultural districts of Oklahoma. A total of 1331 leaf samples from >90 fields were randomly collected from both symptomatic and asymptomatic cucurbit plants across 11 counties. All samples were tested with the dot-immunobinding assay (DIBA) against the antisera of 10 known viruses. Samples infected with papaya ringspot virus (PRSV-W), watermelon mosaic virus (WMV), zucchini yellow mosaic virus (ZYMV), and cucurbit aphid-borne-yellows virus (CABYV) were also tested by RT-PCR. Of the 10 viruses, PRSV-W was the most widespread, with an overall prevalence of 59.1%, present in all 11 counties, followed by ZYMV (27.6%), in 10 counties, and WMV (20.7%), in seven counties, while the remaining viruses were present sporadically with low incidence. Approximately 42% of the infected samples were positive, with more than one virus indicating a high proportion of mixed infections. CABYV was detected for the first time in Oklahoma, and the phylogenetic analysis of the first complete genome sequence of a CABYV isolate (BL-4) from the US showed a close relationship with Asian isolates.

scholarly journals Does the Presence of Hepatitis Virus B & C Influence the Evolution of Diffuse Large B-Cell Lymphomas?

2014 ◽  
Vol 25 ◽  
pp. iv331
Author(s):  
J. Rubio-Martínez ◽  
F. Franco ◽  
E. Almagro-Casado ◽  
D. Pérez-Callejo ◽  
M. Palka ◽  
...  
Keyword(s):  
B Cell ◽  
Hepatitis Virus ◽  
B Cell Lymphomas ◽  
Hepatitis Virus B ◽  
Large B Cell

scholarly journals Food allergy in infants assessed in two German birth cohorts 10 years after the EuroPrevall Study

2021 ◽  
Author(s):  
Daniela Roehrl ◽  
Susanne Brandstetter ◽  
Linda Siziba ◽  
Dietrich Rothenbacher ◽  
Vincent Gaertner ◽  
...  
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Turn Of The Century ◽  
Food Allergies ◽  
Birth Cohorts ◽  
High Prevalence ◽  
The Status ◽  
Health Studies ◽  
Exposure During Pregnancy ◽  
Personalized Health

Background: The prevalence of food allergies (FA) in children increased rapidly at the turn of the century. The EuroPrevall study identified Germany as a country with very high prevalence of FA at that time. Using two large German birth cohorts we provide an update of the status quo ten years later. Methods: KUNO Kids and Ulm SPATZ Health studies are two ongoing prospective birth cohorts. Information on FA was obtained by questionnaires at birth and after 6, 12 and 24 months. Univariate logistic regression analyses were performed to investigate risk factors during pregnancy, birth and early childhood. Results: In 1139 and 1006 children from KUNO Kids and SPATZ the point prevalence of parent-reported FA symptoms at the ages of 1 and 2 years was 13.2% and 13.9 % in KUNO Kids. Doctor’s diagnosed FA at 1 and 2 years was 2.4% and 2.7% in KUNO Kids and 2.3% and 3% in SPATZ. Cow’s milk and citrus fruits were most frequently suspected by parents to cause FA symptoms. Atopy in the child was associated with a higher frequency of FA at any time, whereas atopy in first degree relatives was only associated with FA at year 1. Smoke exposure during pregnancy was a risk for FA at age 2. Conclusion: The prevalence of food allergy seems to have plateaued in the last 10 years in Germany. FA is often suspected by parents but only rarely diagnosed by oral food challenge. Risk factor analysis may help to establish personalized health approaches.

Radioimmunoprecipitation Assay for Australia Antigen, Antibody, and Antigen-Antibody Complexes

1971 ◽  
Vol 138 (1) ◽  
pp. 249-257 ◽  
Author(s):  
J. A. Coller ◽  
I. Millman ◽  
T. C. Halbherr ◽  
B. S. Blumberg
Keyword(s):  
Australia Antigen ◽  
Radioimmunoprecipitation Assay ◽  
Antigen Antibody

scholarly journals The Status of Vaccine Development Against the Human Cytomegalovirus

2020 ◽  
Vol 221 (Supplement_1) ◽  
pp. S113-S122 ◽  
Author(s):  
Stanley A Plotkin ◽  
Dai Wang ◽  
Abdel Oualim ◽  
Don J Diamond ◽  
Camille N Kotton ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Vaccine Development ◽  
National Institutes Of Health ◽  
Cmv Infection ◽  
Hematopoietic Stem ◽  
Stage Of Development ◽  
The Status ◽  
Cmv Disease ◽  
Transplanted Organs ◽  
Congenital Cmv

Abstract Numerous candidate vaccines against cytomegalovirus (CMV) infection and disease are in development. Whereas the previous article [1] provides background and opinions about the issues relating to vaccination, this article provides specifics about the vaccines in active development, as reported at a National Institutes of Health-sponsored meeting in Bethesda on September 4–6, 2018. Here, vaccine developers provide synopses of their candidate vaccines to immunize women to protect against congenital CMV disease and to prevent the consequences of CMV disease in recipients of transplanted organs or hematopoietic stem calls. The projects are presented here roughly in the descending order of their stage of development in the opinion of the first author.

Reactivation of Hepatitis Virus B Infection in a Patient With Rheumatoid Arthritis After Treatment With Rituximab

2014 ◽  
Vol 10 (3) ◽  
pp. 196-197
Author(s):  
Tarek Carlos Salman-Monte ◽  
María Pilar Lisbona ◽  
Montserrat García-Retortillo ◽  
Joan Maymó
Keyword(s):  
Rheumatoid Arthritis ◽  
Hepatitis Virus ◽  
Hepatitis Virus B

Potential role of cytomegalovirus in risk factor of breast cancer/strong

2020 ◽  
Vol 8 (1) ◽  
pp. 34-40
Author(s):  
Maitham Yousif
Keyword(s):  
Breast Cancer ◽  
Potential Role ◽  
Histopathological Examination ◽  
Breast Mass ◽  
Cmv Infection ◽  
Breast Examination ◽  
High Prevalence ◽  
Malignant Breast ◽  
Cancer Clinic

It has been hypothesized that human cytomegalovirus (CMV) may be associated with many cancers in human. However, the role of CMV infection in breast cancer remains unclear. We aimed to assess whether CMV infection have a role in development of breast cancer. A 120 women presented to breast cancer clinic with breast mass. Full history from each woman was taken, full examination including breast examination and lymph-node. Blood was aspirated from each woman for detection of CMV IgG, IgM, tp53 and CA15-3 by ELISA. A 50 patients were documented to have breast cancer by histopathological examination. The study reveal that was heights level of CMV IgG and IgM among patients with malignant breast mass (12/50) and (8/50) respectively in other side the lowest level in benign tumor (6/50) and (2/50) respectively and high prevalence of CMV in breast cancer. In conclusion There is strong evidence suggest that CMV has an important role in the development of breast cancer.

Sign in / Sign up

Export Citation Format

Share Document