Suppression of Exercise-induced Asthma by Salbutamol, Theophylline, Atropine, Cromolyn, and Placebo in a Group of Asthmatic Children

PEDIATRICS ◽  
1975 ◽  
Vol 56 (5s) ◽  
pp. 930-934
Author(s):  
Simon Godfrey ◽  
Peter König
Keyword(s):  
Comparative Study ◽  
Exercise Test ◽  
Significant Degree ◽  
Cromolyn Sodium ◽  
The Other ◽  
Treadmill Running ◽  
Duration Of Action ◽  
Asthmatic Children ◽  
Site Of Action ◽  
Exercise Induced

A number of drugs are known to it exercise-induced asthma (EIA), but the results in some cases have been difficult to interpret due to the techniques employed. A comparative study was carried out in a group of children to investigate the effects of salbutamol, choline theophyllinate, cromolyn sodium, atropine, and placebo. The exercise test took the form of six minutes of standardized treadmill running. All the drugs, but not the placebo, were able to inhibit EIA to a significant degree, the effect being most marked with salbutamol. Cromolyn sodium caused no bronchodilatation at rest, while all the other drugs were bronchodilators, the effect being most marked with the aerosol atropine during exercise. It was impossible to distinguish the type of drug used for inhibition of EIA if it caused bronchodilatation at rest. The manner in which an exercise test can be used to investigate the duration of action or site of action of drugs is noted.

Albuterol Protects Against Exercise-Induced Asthma Longer Than Metaproterenol Sulfate

PEDIATRICS ◽  
1986 ◽  
Vol 77 (2) ◽  
pp. 173-178
Author(s):  
Robert Berkowitz ◽  
Eugene Schwartz ◽  
Don Bukstein ◽  
Michael Grunstein ◽  
Hyman Chai
Keyword(s):  
Duration Of Action ◽  
Asthmatic Children ◽  
Serial Testing ◽  
Exercise Challenge ◽  
Exercise Induced ◽  
Age Range ◽  
Single Blind ◽  
Randomized Crossover Study ◽  
Equal Efficacy ◽  
Better Than

Both metaproterenol sulfate and albuterol are inhaled medications commonly used to prevent exercise-induced bronchospasm. Their efficacy and duration of action in controlling exercise-induced bronchospasm were compared with placebo in 18 asthmatic children (age range: 12 to 17 years) in a single-blind randomized crossover study. Standardized treadmill exercise challenges were repeated every two hours for up to six hours following the initial exercise test. With the initial exercise challenge, both active medications blocked exercise-induced bronchospasm with equal efficacy. On the other hand, when the duration of action of the medications was compared: (1) albuterol blocked exercise-induced bronchospasm longer than metaproterenol sulfate in eight subjects, (2) the reverse was true in only one patient, and (3) the medications blocked for equal duration in nine subjects. Thus, although both active agents were equally efficacious in blocking exercise-induced bronchospasm initially, the duration of action of albuterol was significantly (P < .05) longer on serial testing than that of metaproterenol sulfate. Both medications were significantly better than placebo in efficacy and duration of action.

scholarly journals The Effect of Cromolyn Sodium and Nedocromil Sodium Administered by A pressurized Aerosol with A spacer Device on Exercise-Induced Asthma in Children

1994 ◽  
Vol 3 (7) ◽  
pp. S35-S37 ◽  
Author(s):  
F. M. de Benedictis ◽  
G. Tuteri ◽  
A. Niccoli ◽  
D. Mezzetti ◽  
L. Rossi ◽  
...  
Keyword(s):  
Cromolyn Sodium ◽  
Nedocromil Sodium ◽  
Controlled Study ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Double Blind ◽  
Asthmatic Children ◽  
Metered Dose ◽  
Exercise Induced ◽  
Better Than

To compare the effectiveness of cromolyn sodium (CS) (10 mg) and nedocromil sodium (NS) (4 mg) administered by a metered dose inhaler (MDI) with a spacer device in preventing exercise-induced asthma (EIA), eight asthmatic children with EIA were studied in a randomized double-blind, cross-over, placebo-controlled study, CS and NS provided significant, comparable protection from EIA and both were better than placebo. We conclude that CS and NS administered by a pressurized aerosol with a spacer device provide equal protection against EIA in children.

Exercise-Induced Asthma in Children: a Comparative Study of Free and Treadmill Running

1998 ◽  
Vol 80 (3) ◽  
pp. 232-236 ◽  
Author(s):  
Servando Garcia de la Rubia ◽  
Manuel J Pajaron-Fernandez ◽  
Manuel Sanchez-Solis ◽  
Ignacio Martinez-Gonzalez Moro ◽  
Domingo Perez-Flores ◽  
...  
Keyword(s):  
Comparative Study ◽  
Treadmill Running ◽  
Asthma In Children ◽  
Exercise Induced

Exercise-induced bronchoconstriction diagnosis in asthmatic children: comparison of treadmill running and eucapnic voluntary hyperventilation challenges

2015 ◽  
Vol 115 (4) ◽  
pp. 277-281 ◽  
Author(s):  
Marcelo José Chateaubriand do Nascimento Silva Filho ◽  
Adriana Velozo Gonçalves ◽  
Marcelo Tavares Viana ◽  
Décio Medeiros Peixoto ◽  
Emanuel Sávio Cavalcanti Sarinho ◽  
...  
Keyword(s):  
Treadmill Running ◽  
Voluntary Hyperventilation ◽  
Asthmatic Children ◽  
Eucapnic Voluntary Hyperventilation ◽  
Exercise Induced

Comparative Study of Proactivators of the Fibrinolysin System in Three Mammalian Species

1969 ◽  
Vol 21 (03) ◽  
pp. 594-603 ◽  
Author(s):  
Y Takada ◽  
A Takada ◽  
J. L Ambrus
Keyword(s):  
Guinea Pig ◽  
Comparative Study ◽  
Human Plasma ◽  
Mammalian Species ◽  
Gel Filtration ◽  
Plasminogen Activators ◽  
The Other ◽  
Rabbit Plasma ◽  
Plate Test ◽  
Fibrin Plate

SummarySephadex gel filtration of human plasma gave results suggesting the presence of two proactivators of plasminogen, termed proactivators A and B.Activity resembling that of proactivator A was found in rabbit plasma, but not in guinea pig plasma.Plasminogen activators produced by the interaction of proactivator A of human plasma with streptokinase had no caseinolytic or TAMe esterolytic effect.Proactivator A can be separated in a form apparently free from plasminogen, as shown by the heated fibrin plate test and by immunological analysis. On the other hand, proactivator B concentrates prepared so far are contamined with plasminogen.Human proactivators appear to be far more susceptible to streptokinase than are rabbit proactivators.Inhibitors of the fibrinolysin system were observed in the plasmas of all 3 species. These inhibitors are not present in the euglobulin fraction of plasma. Sephadex fractionation of euglobulin fractions results in proactivator preparations that do not contain inhibitors.

Empire Loyalism and Nationalism in Ukraine and Ireland

2020 ◽  
Vol 53 (3) ◽  
pp. 88-106
Author(s):  
Taras Kuzio
Keyword(s):  
Soviet Union ◽  
Northern Ireland ◽  
Comparative Study ◽  
The Other ◽  
History And Memory ◽  
Memory Politics ◽  
Irish History ◽  
British Rule ◽  
Five Factors ◽  
Post Colonialism

This is the first comparative article to investigate commonalities in Ukrainian and Irish history, identity, and politics. The article analyzes the broader Ukrainian and Irish experience with Russia/Soviet Union in the first and Britain in the second instance, as well as the regional similarities in conflicts in the Donbas region of Eastern Ukraine and the six of the nine counties of Ulster that are Northern Ireland. The similarity in the Ukrainian and Irish experiences of treatment under Russian/Soviet and British rule is starker when we take into account the large differences in the sizes of their territories, populations, and economies. The five factors that are used for this comparative study include post-colonialism and the “Other,” religion, history and memory politics, language and identities, and attitudes toward Europe.

Liturgical Poetry in the Late Antique Near East

2010 ◽  
Vol 1 (3) ◽  
pp. 336-361 ◽  
Author(s):  
Ophir Münz-Manor
Keyword(s):  
Comparative Study ◽  
Late Antiquity ◽  
Near East ◽  
The Other ◽  
Late Antique ◽  
Biblical Poetry ◽  
Contemporary View ◽  
Cultural Dialogue ◽  
The One

The article presents a contemporary view of the study of piyyut, demonstrating that Jewish poetry of late antiquity (in Hebrew and Aramaic) was closely related to Christian liturgical poetry (both Syriac and Greek) and Samaritan liturgy. These relations were expressed primarily by common poetic and prosodic characteristics, derived on the one hand from ancient Semitic poetry (mainly biblical poetry), and on the other from innovations of the period. The significant connections of content between the different genres of poetry reveal the importance of comparative study. Thus the poetry composed in late antiquity provides additional evidence for the lively cultural dialogue that took place at that time.

Formation of contracts for the international sale of goods under Korean law and the CISG

2017 ◽  
Vol 21 (3) ◽  
pp. 208-223
Author(s):  
Byung Mun Lee
Keyword(s):  
Comparative Study ◽  
Design Methodology ◽  
Case Law ◽  
The Other ◽  
Basic Question ◽  
Content Type ◽  
International Sale Of Goods ◽  
The Comparative Study ◽  
International Sales ◽  
Insight Into

Purpose The purpose of this paper is to describe and analyze the rules on the formation of contracts under Korean law and the Contracts for the International Sale of Goods (CISG) in a comparative way and introduce the relevant proposed rules under the Amendment Draft of the Korean Civil Code (KCC). In addition, it attempts to compare and evaluate them in light of the discipline of comparative law. Design/methodology/approach In order to achieve the purposes of the study, it executes a comparative study of the rules as to the formation of contracts of the CISG, Korean law and the Amendment Draft of the KCC. The basic question for this comparative study is placed on whether a solution from one jurisdiction is more logical than the others and to what extent each jurisdiction has responded to protect the reasonable expectations of the parties in the rules as to the formation of contracts. Findings The comparative study finds that most of the rules under the CISG are quite plausible and logical and they are more or less well reflected in the proposals advanced by the KCC amendment committee. On the other hand, the other rules under the CISG which have brought criticisms in terms of their complexity and inconsistent case law invite us their revision or consistent interpretation. The drawbacks of the CISG have also been well responded in the Amendment Draft of the KCC. Nevertheless, it is quite unfortunate that the Amendment Draft of the KCC still has a rule that regards any purported performance with non-material alteration of the terms of an offer as an acceptance. Originality/value This study may provide legal and practical advice to both the seller and the buyer when they enter into a contract for international sales of goods. In addition, it may render us an insight into newly developed or developing rules in this area and show us how they interact with each other. Furthermore, it may be particularly useful in Korea where there is an ongoing discussion for revision of the KCC.

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