A Ten-Year Assessment of Methicillin-Associated Side Effects

PEDIATRICS ◽  
1976 ◽  
Vol 58 (3) ◽  
pp. 329-334
Author(s):  
Martha D. Yow ◽  
Larry H. Taber ◽  
Fred F. Barrett ◽  
A. Aaron Mintz ◽  
G. Richard Blankinship ◽  
...  
Keyword(s):  
Side Effects ◽  
Great Majority ◽  
Incidence Rates ◽  
Term Therapy ◽  
Average Dose ◽  
True Incidence ◽  
Number Of Patients ◽  
Chemical Irritation ◽  
Long Term Therapy

The exact incidence and importance of side effects associated with methicillin therapy in children is unknown. During the ten-year period from 1964 to 1974 approximately 3,000 Houston children who received methicillin were observed for side effects. The great majority of these patients received the drug for less than ten days; however, side effects were more common in patients receiving long-term therapy. In order to assess these side effects, experiences with 124 children who received methicillin for ten days or longer were reviewed in depth. The average dose of methicillin was 200 mg/kg/day and the average duration was 22 days. In this highly selected group there were no adverse side effects in 54.8% and only eosinophilia in an additional 13%. Leukopenia occurred in 16%, microscopic hematuria in 8%, gross hematuria in 4%, skin rash in 6%, and "drug fever" in 6%. In many instances several of these side effects occurred within a single patient so that the total number of patients with definite side effects was 39 of 124 (31.5%). The true incidence figure of overall side effects is much lower than 31.5%. Corrected incidence rates based on a conservative figure of 3,000 methicillin-treated children are less than 1.5% for all side effects. In some patients the mechanism producing the adverse reactions seemed to be chemical irritation or toxicity and in others hypersensitivity. In nine of the 39 patients follow-up studies were not optimal. In the other 30 patients all side effects were reversible.

New opioid side effects and implications for long-term therapy

2011 ◽  
Vol 1 (1) ◽  
pp. 18-21 ◽  
Author(s):  
S. Raghavan ◽  
A.D. Harvey ◽  
S.R. Humble
Keyword(s):  
Side Effects ◽  
Term Therapy ◽  
Long Term Therapy

Aspects of Long-Term Treatment with Neuroleptics Historical and Literature Review—Personal Experience with Fluspirilene and Penfluridol

1975 ◽  
Vol 3 (2) ◽  
pp. 114-124 ◽  
Author(s):  
Lucian Floru
Keyword(s):  
Side Effects ◽  
Literature Review ◽  
Personal Experience ◽  
Term Treatment ◽  
Term Therapy ◽  
Tabular Form ◽  
Long Term Effects ◽  
Long Term Treatment ◽  
Long Term Therapy

The literature on neuroleptics with substance-specific long-term effects (fluspirilene, penfluridol) is reviewed in tabular form. This is followed by a report of personal investigations on 76 schizophrenics who were treated with fluspirilene initially within the hospital and later on an out-patient basis, on 86 patients who were treated with it exclusively at the out-patients' department, as well as on 123 schizophrenic psychoses treated with penfluridol in the out-patients' department. The side-effects caused by the two substances are compared. Pre-requisites for effective long-term therapy with a few complications are discussed.

scholarly journals Imaging in phenytoin induced neurotoxicity: a case series

2017 ◽  
Vol 6 (1) ◽  
pp. 355
Author(s):  
Manali Arora ◽  
Deb Kumar Boruah ◽  
Vishal Thakker ◽  
Sangeeta Bhanwra
Keyword(s):  
Side Effects ◽  
Megaloblastic Anemia ◽  
Cerebellar Atrophy ◽  
Case Series ◽  
Cerebral Atrophy ◽  
Term Therapy ◽  
Seizure Disorders ◽  
Anti Epileptic Drug ◽  
Long Term Therapy

Phenytoin is a commonly used anti-epileptic drug for various types of seizure disorders except for absent seizures. Long term dose dependant neurological side effects of phenytoin therapy include cerebellar atrophy, cerebral atrophy and brain stem atrophy. Skull hyperostosis, gum hypertrophy and megaloblastic anemia are other known effects of Long term therapy. We present four cases depicting clinical and neuroimaging findings of Phenytoin induced Toxicity.

scholarly journals Study of the Side effects profile of different antihypertensive drugs among the Hypertensive patient

2013 ◽  
Vol 9 (1) ◽  
pp. 25-29 ◽  
Author(s):  
RK Shrestha ◽  
GM Khan ◽  
P Thapa ◽  
R Koju
Keyword(s):  
Side Effects ◽  
Hypertensive Patient ◽  
Antihypertensive Drugs ◽  
Cross Sectional Study ◽  
Term Therapy ◽  
Cross Sectional ◽  
Precise Understanding ◽  
Number Of Patients ◽  
Significant Difference ◽  
Long Term Therapy

Background Hypertension is the leading cause of morbidity and mortality worldwide. Because hypertension is usually asymptomatic yet requires long term therapy, consideration of potential of undesirable effects of drugs used for its treatment is important for making the appropriate choice. In this context, a precise understanding typical adverse reaction profile of the different drugs is essential. Objective This study was done to assess the side effects profile of different antihypertensive drugs (calcium channel blocker, beta blocker, ACE inhibitor) among the hypertensive patient. Methods A mixed retrospective & prospective cross sectional study of 61 patients was done at Medical Out Patient Department of Dhulikhel Hospital KUTH were included in the study. Result Dry cough was experienced by most of the patients (66.7%) and both dry cough and dizziness was reported by only one patient (6.7%) taking enalapril. In case of atenolol, bradycardia, dizziness and insomnia were experienced by same number of patients (14.3%) separately. Among amlodipine users, side effects experienced were peripheral edema (23%), flushing (2.6%), dyspnoea (2.6%), headache (5.1%), dizziness (2.6%), palpitation (2.6%) and insomnia (2.6%).Patients on enalapril had significantly more complaints regarding side effects (73.3%) compared to those taking amlodipine (41%) (OR=4, p=0.033) and atenolol (42.9%).There was no significant difference in the occurrence of side effects between enalapril- atenolol (p >0.05) and amlodipine- atenolol (p >0.05). Conclusion Although all three drugs were well tolerated, more side effects were seen in case of enalapril. Enalapril has 4 times higher rate of side effects than amlodipine. DOI: http://dx.doi.org/10.3126/njh.v9i1.8344 Nepalese Heart Journal Vol.9(1) 2012 pp.25-29

scholarly journals Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Domenico Albano ◽  
Massimo Benenati ◽  
Antonio Bruno ◽  
Federico Bruno ◽  
Marco Calandri ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Side Effects ◽  
Term Therapy ◽  
Biologic Drugs ◽  
Normal Tissues ◽  
Oncology Research ◽  
Pictorial Review ◽  
Long Term Therapy ◽  
Effective Radiation

AbstractNewer biologic drugs and immunomodulatory agents, as well as more tolerated and effective radiation therapy schemes, have reduced treatment toxicity in oncology patients. However, although imaging assessment of tumor response is adapting to atypical responses like tumor flare, expected changes and complications of chemo/radiotherapy are still routinely encountered in post-treatment imaging examinations. Radiologists must be aware of old and newer therapeutic options and related side effects or complications to avoid a misinterpretation of imaging findings. Further, advancements in oncology research have increased life expectancy of patients as well as the frequency of long-term therapy-related side effects that once could not be observed. This pictorial will help radiologists tasked to detect therapy-related complications and to differentiate expected changes of normal tissues from tumor relapse.

Long-term side effects of high-risk neuroblastoma survivors in a referral center in central Illinois.

2017 ◽  
Vol 35 (5_suppl) ◽  
pp. 129-129
Author(s):  
Beth Speckhart ◽  
Reuben Antony ◽  
Karen S. Fernandez
Keyword(s):  
Side Effects ◽  
High Risk ◽  
Term Therapy ◽  
Solid Organ ◽  
Long Term Effects ◽  
Improved Outcomes ◽  
Risk Patients ◽  
Central Illinois ◽  
Long Term Therapy

129 Background: Neuroblastoma (NBL) is the most common extra-cranial solid organ malignancy in children. Although low and intermediate-risk patients have a survival of close to 90%, the same cannot be said for patients with high risk (HR) disease. In the last decade multi-modality treatment of HR NBL patients has been intensified to include chemotherapy, surgery, radiation, bone marrow transplantation and immunotherapy and has resulted in improved survival (Yu, 2009). Data regarding the medium to long-term side effects of this intensive multi-modality therapy is now being collected as the population of HR neuroblastoma survivors continues to grow. Methods: We retrospectively reviewed the clinical data of survivors of HR NBL treated at the Children’s Hospital of Illinois diagnosed since 2009 and evaluated the long-term side effects of survivors through 2015. Results: We found 14 NBL patients of whom 10 had HR disease. Four patients died of progressive disease. Therapy-related, long-term side effects occurred in 6 patients: hearing loss (n = 6), adrenal insufficiency (n = 2), focal nodular hyperplasia of the liver (n = 2), linear growth retardation (n = 1). No patient in our cohort developed thyroid or cardiac problems and no patient was diagnosed with a second malignancy in the 5 years of observation. Conclusions: While the improved outcomes seen in HR NBL patients is encouraging, we found in our small cohort hat survivors of multimodality therapy for high-risk neuroblastoma experience significant long-term effects of treatment which impact their quality of life as well as growth and development. As the number of NBL survivors increases our understanding of the long-term therapy related side effects will continue to improve. Larger longitudinal studies are needed to monitor for other possible side effects that may manifest overtime such as cardiomyopathy, disturbances in sexual development, fertility, intellectual function, learning problems and therapy related second malignancies later in life.

Long-term therapy with disopyramide phosphate: Side effects and effectiveness

1986 ◽  
Vol 111 (4) ◽  
pp. 654-660 ◽  
Author(s):  
Jerry L. Bauman ◽  
Jose Gallastegui ◽  
Boris Strasberg ◽  
Steven Swiryn ◽  
Julie Hoff ◽  
...  
Keyword(s):  
Side Effects ◽  
Term Therapy ◽  
Long Term Therapy
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