scholarly journals Study of the Side effects profile of different antihypertensive drugs among the Hypertensive patient

2013 ◽  
Vol 9 (1) ◽  
pp. 25-29 ◽  
Author(s):  
RK Shrestha ◽  
GM Khan ◽  
P Thapa ◽  
R Koju
Keyword(s):  
Side Effects ◽  
Hypertensive Patient ◽  
Antihypertensive Drugs ◽  
Cross Sectional Study ◽  
Term Therapy ◽  
Cross Sectional ◽  
Precise Understanding ◽  
Number Of Patients ◽  
Significant Difference ◽  
Long Term Therapy

Background Hypertension is the leading cause of morbidity and mortality worldwide. Because hypertension is usually asymptomatic yet requires long term therapy, consideration of potential of undesirable effects of drugs used for its treatment is important for making the appropriate choice. In this context, a precise understanding typical adverse reaction profile of the different drugs is essential. Objective This study was done to assess the side effects profile of different antihypertensive drugs (calcium channel blocker, beta blocker, ACE inhibitor) among the hypertensive patient. Methods A mixed retrospective & prospective cross sectional study of 61 patients was done at Medical Out Patient Department of Dhulikhel Hospital KUTH were included in the study. Result Dry cough was experienced by most of the patients (66.7%) and both dry cough and dizziness was reported by only one patient (6.7%) taking enalapril. In case of atenolol, bradycardia, dizziness and insomnia were experienced by same number of patients (14.3%) separately. Among amlodipine users, side effects experienced were peripheral edema (23%), flushing (2.6%), dyspnoea (2.6%), headache (5.1%), dizziness (2.6%), palpitation (2.6%) and insomnia (2.6%).Patients on enalapril had significantly more complaints regarding side effects (73.3%) compared to those taking amlodipine (41%) (OR=4, p=0.033) and atenolol (42.9%).There was no significant difference in the occurrence of side effects between enalapril- atenolol (p >0.05) and amlodipine- atenolol (p >0.05). Conclusion Although all three drugs were well tolerated, more side effects were seen in case of enalapril. Enalapril has 4 times higher rate of side effects than amlodipine. DOI: http://dx.doi.org/10.3126/njh.v9i1.8344 Nepalese Heart Journal Vol.9(1) 2012 pp.25-29

scholarly journals Treatment outcomes and influencing factors on patients with Pulmonary Tuberculosis: a retrospective study

2021 ◽  
Vol 3 (2) ◽  
pp. 105-108
Author(s):  
Jamshid Ayatollahi ◽  
◽  
Abolhasan Halvani ◽  
Mohammadhesam Gharaei Khezri ◽  
Hossein Shahcheraghi ◽  
...  
Keyword(s):  
Side Effects ◽  
Frequency Distribution ◽  
Cross Sectional Study ◽  
The Body ◽  
Sputum Culture ◽  
Response To Treatment ◽  
Sputum Smear ◽  
Drug Side Effects ◽  
Cross Sectional ◽  
Significant Difference

Introduction: Tuberculosis infection caused by Mycobacterium tuberculosis is one of the most common infectious diseases, especially in countries such as Iran. The course of treatment and the number of drugs used vary depending on the severity of the disease and the parts of the body involved. The resistant tuberculosis to treatment has increased in recent years. Thus, this study was conducted to investigate the frequency distribution of response to treatment of patients with tuberculosis in Sirjan, Iran. Methods: This descriptive cross-sectional study investigated all patients with tuberculosis in Sirjan city who had referred to health centers during the years 2011-2019. The data collection tool was a pre-prepared checklist that included information on age, sex, sputum smear results, sputum culture results, diabetes, patients' nationality, drug side effects, and response to treatment. Finally, data was entered into SPSS version 22, and analyzed. Results: In this study, the overall response rate was 83% and the mortality rate was 10%. Between the frequency distribution of response to treatment in terms of gender, age, sputum smear results, sputum culture results, patients' nationality and diabetes was not statistically significant difference. Also, no statistically significant difference was found between the frequency distribution of pulmonary TB treatment response in terms of drug allergy, drug hepatitis and other drug side effects. Conclusion: According to results, can be concluded that none of the variables: age, sex, smear and culture result, and history of diabetes have no an effect on response to treatment and mortality of tuberculosis.

scholarly journals A Cross-Sectional Study of Antibiotic Self-Medication

Thrita ◽  
2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Fatemeh Mousavi ◽  
Parisa Shojaei ◽  
Azadeh Nazemi ◽  
Atefe Dadashi
Keyword(s):  
Logistic Regression ◽  
Side Effects ◽  
Cross Sectional Study ◽  
Study Data ◽  
P Value ◽  
Sectional Study ◽  
Self Medication ◽  
Chi Square ◽  
Cross Sectional ◽  
Significant Difference

Objectives: This research has been conducted to study antibiotic self-medication, prevalence, and reasons. Methods: A questionnaire containing 30 comprehensive questions in terms of the experience of antibiotic self-medication was prepared. In this cross-sectional study, data were analyzed using analytical statistics bases on chi-square and logistic regression. Results: The results showed that 61.3% of the participants were self-antibiotic users. There was a significant difference only between gender and self-medication such that self-medication in males was more than females (P value = 0.027). Conclusions: Self-medication of antibiotics is almost high and requires more information about the side effects of these drugs in order to promote rational and physically prescribed use.

scholarly journals What Do Our Nurses Know about Managing Patient with Permanent Pacemakers?

Jurnal NERS ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. 157
Author(s):  
Muhamad Al Muizz Ismail ◽  
Nor Marini Ibrahim ◽  
Muhammad Kamil Che Hasan
Keyword(s):  
Clinical Laboratory ◽  
Pearson Correlation ◽  
Demographic Data ◽  
Descriptive Analysis ◽  
Pacemaker Implantation ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Significant Difference ◽  
Level Of Knowledge

Introduction: The number of patients with pacemaker implant is increasing in the health services sector in Malaysia, which requires nurses to have expertise in patient care with pacemaker implantation. Therefore, this study was conducted to analyse the level of knowledge among nurses regarding the management of patients with pacemaker implantation.Methods: A cross-sectional study was conducted through purposive sampling among all nurses working at the critical care unit, intensive care unit, cardiac rehabilitation ward, investigation clinical laboratory, and non-invasive clinical laboratory in a public hospital in Kelantan. A questionnaire consisted of demographic data and nurses’ knowledge was distributed. Data were analysed for descriptive analysis and using Pearson correlation test.Results: Results from all respondents (n=70), show  48.6 % of the respondents had moderate knowledge about patient management with pacemaker implantation, 32.9 % had a low level of knowledge and only 13.6% had high knowledge regarding management of patient with pacemaker implantation. There is a significant difference between the level of knowledge and demographic data, that is between the level of education (p=0.027), age (p=0.011) and length of service (p=0.015). There is no significant relationship between knowledge and demographic data, such as gender (p=0.481), marital status (p=0.315), and post-basic (p=0.067).Conclusion: Level of knowledge among nurses about the management of patient with pacemaker implantation is low to moderate. Additional education and exposure among nurses are needed to enhance the knowledge of nurses and improve the quality of care among patients with pacemaker implant.

scholarly journals Assessment of Antibiotic Knowledge Among Final Year Pharmacy Students at Baghdad University

2019 ◽  
Vol 12 (1) ◽  
pp. 379-383
Author(s):  
Ehab Mudher Mikhael ◽  
Mohammed Khudhair Hasan ◽  
Sama Zaid Abdulridha
Keyword(s):  
Antibiotic Resistance ◽  
Side Effects ◽  
Cross Sectional Study ◽  
Legal Issues ◽  
Pharmacy Students ◽  
Public Health Issue ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
Life Saving ◽  
Significant Difference

Background: Antibiotics are life-saving drugs that if misused lead to antibiotic resistance and consequently to a substantial public health issue. Pharmacists have a major role in ensuring the rational use of antibiotics to prevent antibiotic resistance. This study aimed to assess antibiotic knowledge among final year pharmacy students at Baghdad University. Methods: A cross sectional study using a newly developed and validated questionnaire was given for 148 final year (5th stage) students at Baghdad University – College of Pharmacy during November 2016. Only 140 students (response rate 93%) completed the questionnaire. The 10 items-questionnaire consisted of 5 major domains: Antibiotic effectiveness, side effects, resistance, use in specific cases (e.g., during pregnancy and septicemia), and the legal issues of antibiotic dispensing. Results: Only 20% of students have good overall antibiotic knowledge. The least knowledge for pharmacy student was in regard to antibiotic side effects and antibiotic resistance at which only 22% and 19% of pharmacists possessed good antibiotic knowledge respectively. Knowledge of student was the best in legal issues of antibiotic dispensing. There was a non-significant difference in antibiotic knowledge between male and female pharmacy students. Conclusion: Antibiotic knowledge among pharmacy students at Baghdad University was very poor and less than expected.

scholarly journals Perception of Side Effects of Chemotherapy among Cancer Patients in B.P. Koirala Memorial Cancer Hospital Bharatpur, Nepal

2016 ◽  
Vol 11 (4) ◽  
pp. 14-19 ◽  
Author(s):  
Sharmila Gurung ◽  
Radha Acharya Pandey
Keyword(s):  
Side Effects ◽  
Cancer Patients ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
Demand Information ◽  
And Gender ◽  
Loss Of Appetite ◽  
Patient’S Perception

jdjBackground & Objectives: These side effects of chemotherapy affect the patients’ daily life and quality of life adversely. It affects the different body system resulting in physical and non physical (psychosocial) side effects. Cancer patients demand information to understand chemotherapy-related adverse effects and actions to be taken. The aim of the study is to find out the perception of side effects of chemotherapy among cancer patients.Materials and methods: A descriptive cross-sectional study was conducted among 200 cancer patients, using purposive sampling technique and data was collected via face to face interview. Descriptive as well as inferential statistics (T-test) was used to see the significant difference between dependent and independent variables.Results: The overall perceived side effects of chemotherapy include: affects work and home duties (non physical side effect), followed by anxiety, loss of appetite, affects family, affect partner, feel constantly tired (fatigue), affects social activities, feel irritable, nausea and constipation respectively. There is significant difference between perception of side effects of chemotherapy and gender of respondents.Conclusion: The perceptions of side effects of chemotherapy are different from individual to individual. Patient’s perception of side effects of chemotherapy is concerned with non physical side effects rather than physical side effects.Journal of College of Medical Sciences-Nepal, Vol.11(4) 2015: 14-19

Frequency and Causes of Consuming Sports Supplements and Understanding their Side Effects Among Bodybuilders in Fitness Gyms of Kermanshah City

2019 ◽  
Vol 15 (7) ◽  
pp. 735-744
Author(s):  
Nadya Baharirad ◽  
Saeid Komasi ◽  
Alireza Khatooni ◽  
Farideh Moradi ◽  
Ali Soroush
Keyword(s):  
Side Effects ◽  
Female Athletes ◽  
Correlation Coefficients ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Sufficient Information ◽  
Chi Square ◽  
Cross Sectional ◽  
Sports Supplements ◽  
Significant Difference

Background: Nowadays, paying attention to sports nutrition, particularly focus on using supplements among athletes is increasing rapidly. Objective: This study has been carried out in order to investigate the frequency and causes of consuming supplements and understanding the side effects related to their consumption among bodybuilders in Kermanshah City. Methods: The samples of this cross-sectional study include teenagers and young adults who are the members of fitness gyms around Kermanshah City. 244 individuals were selected as samples using simple random sampling. In order to gather the required data, a four-sectioned questionnaire designed by the research team was used. The data analysis was done using chi-square, independent ttest, and Pearson's and Spearman's correlation coefficients by SPSS-20. Results: The majority of bodybuilders participating in the study (95.3%) have used supplements. The sources suggesting the consumption of supplements included other athletes, the coach, the media, nutrition specialists, and medical doctors, respectively. Generally, 37 types of sports supplements are used by the bodybuilders. Based on their rank, the supplements include vitamin C, Creatine, vitamin E, multivitamin, and iron. The most frequent reasons for consuming sports supplements included muscle building, increasing energy, and improving athletic performance. There is a significant difference between male and female athletes with regards to knowing the psychological and sexual side effects of consuming sports supplements (P<0.05). In general, the level of understanding and knowing the side effects of consuming sports supplements among athletes is not desirable. Conclusion: Since a significant percentage of athletes, particularly male athletes, have a history of consuming sports supplements, it is necessary that the people related to this issue including athletes, coaches, doctors, and nutrition specialists, get sufficient information about the ingredients, side effects, benefits, and applications of various nutritional supplements. Dysfunctional beliefs about the supplements consumption or non-consumption should be discussed.

A Ten-Year Assessment of Methicillin-Associated Side Effects

PEDIATRICS ◽  
1976 ◽  
Vol 58 (3) ◽  
pp. 329-334
Author(s):  
Martha D. Yow ◽  
Larry H. Taber ◽  
Fred F. Barrett ◽  
A. Aaron Mintz ◽  
G. Richard Blankinship ◽  
...  
Keyword(s):  
Side Effects ◽  
Great Majority ◽  
Incidence Rates ◽  
Term Therapy ◽  
Average Dose ◽  
True Incidence ◽  
Number Of Patients ◽  
Chemical Irritation ◽  
Long Term Therapy

The exact incidence and importance of side effects associated with methicillin therapy in children is unknown. During the ten-year period from 1964 to 1974 approximately 3,000 Houston children who received methicillin were observed for side effects. The great majority of these patients received the drug for less than ten days; however, side effects were more common in patients receiving long-term therapy. In order to assess these side effects, experiences with 124 children who received methicillin for ten days or longer were reviewed in depth. The average dose of methicillin was 200 mg/kg/day and the average duration was 22 days. In this highly selected group there were no adverse side effects in 54.8% and only eosinophilia in an additional 13%. Leukopenia occurred in 16%, microscopic hematuria in 8%, gross hematuria in 4%, skin rash in 6%, and "drug fever" in 6%. In many instances several of these side effects occurred within a single patient so that the total number of patients with definite side effects was 39 of 124 (31.5%). The true incidence figure of overall side effects is much lower than 31.5%. Corrected incidence rates based on a conservative figure of 3,000 methicillin-treated children are less than 1.5% for all side effects. In some patients the mechanism producing the adverse reactions seemed to be chemical irritation or toxicity and in others hypersensitivity. In nine of the 39 patients follow-up studies were not optimal. In the other 30 patients all side effects were reversible.

Changes in eyelid position after glaucoma filtering surgery

2021 ◽  
pp. 112067212110637
Author(s):  
Teresa Salvá-Palomeque ◽  
Pablo Muñoz-Ramón ◽  
Gema Rebolleda ◽  
Victor Aguado-Casanova ◽  
Cristina Ye-Zhu ◽  
...  
Keyword(s):  
Case Reports ◽  
Glaucoma Surgery ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Palpebral Fissure ◽  
Eyelid Retraction ◽  
Upper Eyelid ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Significant Difference

Background While ptosis is a well-known consequence of glaucoma surgery, some isolated case reports point to the possibility of upper eyelid retraction occurring after glaucoma surgery. This study aims to analyze the occurrence of ptosis and eyelid retraction after glaucoma surgery and to evaluate factors contributing to these palpebral fissure changes. Methods Cross-sectional study including 100 eyes of 100 patients that had undergone unilateral glaucoma surgery. Upper eyelid height in the operated eye was measured by digital photography and compared with the fellow, non-operated eye. The main outcome was to determine if ptosis or retraction occurred in the operated eye in comparison with the fellow eye. The secondary outcome was to determine if any variable was associated with ptosis or retraction. A clinically significant difference (either toward ptosis or retraction) was defined as a difference ≥1 mm between both eyes. Results Of 100 eyes included 81 (81%) showed no change in eyelid height (−0.133 mm ± 0.496), 11 (11%) showed ptosis (−1.348 mm ± 0.387) and 8 eyes (8%) showed retraction (1.705 ± 0.634). A statistically significant relation was found between ptosis and pseudoexfoliation glaucoma (p = 0.003). A trend toward lower postoperative IOP and higher conjunctival blebs was found in eyes with postoperative eyelid retraction. Conclusions Eyelid retraction was present in 8% of patients and ptosis in 11%. Patients with eyelid retraction showed around a 3 mmHg lower postoperative IOP than eyes without retraction. The presence of pseudoexfoliation may be a risk factor for this complication. A prospective study with a large number of patients would be required to confirm these results.

scholarly journals Adverse drug reaction monitoring in patients of hypertension at a tertiary care hospital, Aurangabad, Maharashtra, India

2021 ◽  
Vol 10 (6) ◽  
pp. 720
Author(s):  
Shruti Chandra ◽  
Sukhmeen Kaur ◽  
Deepali Jayabhaye ◽  
Amol Ubale
Keyword(s):  
Antihypertensive Drugs ◽  
Patient Adherence ◽  
Tertiary Care ◽  
Term Therapy ◽  
Care Hospital ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Long Term Therapy

Background: Hypertension is one of the highest prevailing diseases worldwide. Due to long term therapy antihypertensive drugs are commonly associated with adverse drug reactions (ADRs). Therefore, the study was conducted with the objective to examine the incidence of different types of ADRs in drug treated hypertensive patients.Methods: Present study was a prospective cross sectional observational study carried out in the outpatient of department of medicine of MGM hospital, a tertiary care teaching hospital, in Aurangabad. 320 diagnosed hypertensive patients were studied. Questionnaire was asked and their prescription were analysed and follow up was done.Results: Among 320 patient’s 75 patients were reported ADR. Males accounted for higher percent of ADRs 46 (61%) than females 29 (38.6%). Most of the patients 147 (55.9%) were on mono therapy. Calcium channel blocker was the frequently used class of drug, showed maximum number of ADR (30.6%) followed by ACE inhibitor (28%) and ARB (21.3%). As per WHO-UMC scale, type of reactions and their percentage were as certain (9.3%), Probable/ Likely (64%), possible (22.6%), and unlikely (4%). According to Naranjo scale most of the reactions were possible (64%). severity assessment is done by Hartwig and Siegel scale. No lethal ADR were reported. 4% reactions were severe, 32% were of moderate category and 64% were mild reactions.Conclusions: Such type of studies are helpful in selection of appropriate medicines for hypertensive patients, enhancing patient adherence with the therapy by selecting medicines of lesser ADR profile, reducing unnecessary economic burden to the patients due to unwanted effects of the therapy.

scholarly journals Practices, Attitude & Perceived Barriers of Dental Students in Substance Use Screening & Interventions in Dental Practice: A Cross-Sectional Study

2020 ◽  
pp. 124-131
Author(s):  
Shree Goyal ◽  
Ritu Gupta ◽  
Ipseeta Menon ◽  
Dipshikha Das ◽  
Lavanya Rohatgi
Keyword(s):  
Substance Abuse ◽  
Illicit Drugs ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Dental Students ◽  
North India ◽  
Chi Square ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Significant Difference

Context: Tobacco, the leading preventable cause of death including alcohol and illicit drug abuse, cause morbidity and mortality. Dentists deal with such patients & can/ should intervene, preventing any deleterious habits with apt knowledge and training. Aims: The study assesses the knowledge, attitude and practices amongst dental students to manage patients with tobacco, alcohol and substance abuse in a clinical set up. Methodology: A cross-sectional questionnaire (self-administered 22 items) survey was conducted among 300 dental students (Undergraduates, Interns, Postgraduates) in a dental college, North India to assess their knowledge, attitude and practices regarding substance abuse- tobacco, alcohol and other illicit drugs. Data were analyzed using SPSS version 16.0 and subjected to Chi-square test to determine the significant difference between the dental study groups (p≤ 0.05) Results: There were 37.1% males and 62.9% of females. Final years (33.8%), interns (29.8%) and Post graduates (36.5%) completed the questionnaire. 85.5% Postgraduates, 74.3% final years and 71.9% interns knew where to refer the patients of substance abuse which was statistically significant (p≤ 0.05).A majority (91.1%) of interns prescribe or provide tobacco cessation, followed by 87.1% final years and 78.2% post graduates that were significant values. Conclusions: Although there’s huge awareness on the management of patients with substance abuse habits, only a few practice it on patients correctly. Lack of training and its application due to many barriers have been discussed in detail pointing out the disparity in the number of patients with habit history being screened and to those being managed.

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