Aflatoxin B1: Its Role in the Etiology of Reye's Syndrome

PEDIATRICS ◽  
1979 ◽  
Vol 64 (1) ◽  
pp. 71-75 ◽  
Author(s):  
Nell J. Ryan ◽  
Gwendolyn R. Hogan ◽  
A. Wallace Hayes ◽  
Peter D. Unger ◽  
Mohamed V. Siraj
Keyword(s):  
United States ◽  
Acute Phase ◽  
Aflatoxin B1 ◽  
Case Reports ◽  
The United States ◽  
Reye's Syndrome ◽  
Autopsy Specimens

Seven cases of Reye's syndrome in which aflatoxin B1 was isolated from the blood or liver or both are presented. In two cases aflatoxin B1 was found in the blood during the acute phase of the disease; a finding not previously reported. In six cases aflatoxin B1 was recovered from autopsy specimens of liver. A number of case reports linking aflatoxin B1 to Reye's syndrome have appeared in the literature but until now only one case has been reported from the United States. Aflatoxin B1 and its possible role in the etiology of Reye's syndrome is discussed. It is concluded that Reye's syndrome is the result of multiple interrelated factors.

scholarly journals 354. The Epidemiology and Clinical Features of Acanthamoeba Disease in the United States, 1956–2018

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S246-S246
Author(s):  
Kevin O’Laughlin ◽  
Jennifer R Cope ◽  
Zachary A Marsh
Keyword(s):  
United States ◽  
Case Reports ◽  
The United States ◽  
Severe Illness ◽  
People Living With Hiv ◽  
Cutaneous Lesions ◽  
Free Living ◽  
Organ Systems ◽  
Free Living Ameba ◽  
Soil And Water

Abstract Background Acanthamoeba is a free-living ameba found worldwide in soil and water that can cause severe illness. Transmission is thought to be through the skin, eyes, or lungs; Acanthamoeba can cause disseminated infection (Acanthamoeba disease) in addition to the more widely recognized Acanthamoeba keratitis. Infections however are rare, and only case reports or small case series have been published. We review Acanthamoeba disease cases from the Centers for Disease Control and Prevention (CDC) free-living ameba registry to characterize the disease in the United States. Methods CDC maintains a free-living ameba (FLA) registry of laboratory-confirmed Acanthamoeba cases (excluding keratitis) sourced from published case reports, CDC case report forms, and CDC laboratory results. SAS© version 9.4 software was used to calculate descriptive statistics and frequencies. Results We identified 163 cases of Acanthamoeba disease between 1956 and 2018. Of cases with documented outcome, 85% were fatal (105/124). Most (88%) cases were in patients who were immunocompromised (136/155): 66 people living with HIV (of whom 49 were classified as having AIDS); 33 recipients of organ transplantation; 30 people diagnosed with malignancy. The most common manifestation of disease was encephalitis (49%). Other clinical presentations included cutaneous lesions (20%) and rhinosinusitis (6%); 40 cases involved multiple organ systems. Median patient age was 42 years (range 0–83 years). Males accounted for 71% (114/160) of cases. California (29) and Texas (14) had the most case reports; 30 other states reported cases. The source of exposure was unknown in most cases (75%); soil and water were documented in 14 and 17 cases, respectively. Conclusion Acanthamoeba disease in the United States is primarily characterized by encephalitis and cutaneous lesions that affect predominately immunocompromised individuals. Acanthamoeba as a cause of encephalitis in immunocompromised patients should be considered by clinicians, which may lead to earlier diagnosis and treatment. Disclosures All Authors: No reported disclosures

Sexually acquired HIV infections in the United States due to acute-phase HIV transmission: an update

AIDS ◽  
2009 ◽  
Vol 23 (13) ◽  
pp. 1792-1794 ◽  
Author(s):  
Vimalanand S Prabhu ◽  
Angela B Hutchinson ◽  
Paul G Farnham ◽  
Stephanie L Sansom
Keyword(s):  
United States ◽  
Acute Phase ◽  
Hiv Transmission ◽  
Hiv Infections ◽  
The United States

scholarly journals Case Reports of Fatalities Involving Tianeptine in the United States

2018 ◽  
Vol 42 (7) ◽  
pp. 503-509 ◽  
Author(s):  
Erica L Bakota ◽  
Warren C Samms ◽  
Teresa R Gray ◽  
Deanna A Oleske ◽  
Merrill O Hines
Keyword(s):  
United States ◽  
Case Reports ◽  
The United States

scholarly journals A Patient Presenting with Cardiac Tamponade and the Challenges of Finding Its Cause: A Cardiac Angiosarcoma

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Roshanak Habibi ◽  
Negar Faramarzi ◽  
Alvaro J. Altamirano ◽  
Shahriar Dadkhah
Keyword(s):  
United States ◽  
Case Report ◽  
Pericardial Effusion ◽  
Rare Case ◽  
Case Reports ◽  
The United States ◽  
Disease Entity ◽  
Single Center ◽  
Cardiac Angiosarcoma ◽  
Multimodality Approach

Primary malignancies of the heart are so rare that most of the available data come from case reports or large single-center-based studies, with the overall incidence of 0.02% in the United States. Diagnosis in case of an isolated pericardial effusion as presentation is challenging, and determining that an angiosarcoma is even more challenging. Here, we presented a rare case of pericardial angiosarcoma which presented to us with tamponade. The patient eventually was diagnosed through pericardiectomy. A multimodality approach was attempted to treat the cancer. The clinical details of such a unique disease entity inspired us to present it as a case report.

Early Case Reports of Dyslexia in the United States and Europe

2001 ◽  
Vol 34 (1) ◽  
pp. 9-21 ◽  
Author(s):  
Peggy L. Anderson ◽  
Regine Meier-Hedde
Keyword(s):  
United States ◽  
Case Reports ◽  
The United States ◽  
Early Case

Kikuchi–Fujimoto's Disease in a Pediatric Patient with Mycobacterium tuberculosis Infection

2017 ◽  
Vol 14 (05) ◽  
pp. 260-263 ◽  
Author(s):  
Muayad Alali ◽  
Jefree J. Schulte ◽  
Barbara A. Hendrickson
Keyword(s):  
United States ◽  
Mycobacterium Tuberculosis ◽  
Lupus Erythematosus ◽  
Clinical Symptoms ◽  
Case Reports ◽  
Young Male ◽  
The United States ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Laboratory Findings

AbstractKikuchi–Fujimoto's disease (KFD), alternatively termed histiocytic necrotizing lymphadenitis, was first described in 1972. KFD is rare in children, with most of the cases occurring between the ages of 20 and 30 years with a female-to-male ratio of 4:1. The etiology is unknown, although infectious and autoimmune mechanisms have been proposed. KFD manifests with a spectrum of nonspecific clinical symptoms and laboratory findings. KFD is without a definitive diagnostic test and is a diagnosis of exclusion, which must be differentiated from other disease processes with associated lymphadenopathy. Significant overlap in both clinical presentation and histological features with other diseases, such as non-Hodgkin lymphoma, systemic lupus erythematosus, and active tuberculosis (TB), presents challenges in diagnosis. A small number of case reports have been published describing the coexistence of KFD and active TB. Most reported cases occur in TB endemic areas. In the largest analysis of KFD, TB infection was concurrent in 2% of cases. Most of the cases occurred in adult patients. To our knowledge, there have been no pediatric cases of KFD with concurrent TB infection reported in the United States. This study describes a case of KFD with concurrent Mycobacterium tuberculosis infection in a young male from the United States.

scholarly journals Bayesian Inference of State-Level COVID-19 Basic Reproduction Numbers across the United States

2021 ◽  
Author(s):  
Abhishek Mallela ◽  
Jacob Neumann ◽  
Ely F Miller ◽  
Ye Chen ◽  
Richard G Posner ◽  
...  
Keyword(s):  
United States ◽  
Bayesian Inference ◽  
Disease Transmission ◽  
Case Reports ◽  
Herd Immunity ◽  
State Level ◽  
The United States ◽  
Expected Number ◽  
Reproduction Numbers ◽  
A Posteriori Estimates

Although many persons in the United States have acquired immunity to COVID-19, either through vaccination or infection with SARS-CoV-2, COVID-19 will pose an ongoing threat to non-immune persons so long as disease transmission continues. We can estimate when sustained disease transmission will end in a population by calculating the population-specific basic reproduction number R_0, the expected number of secondary cases generated by an infected person in the absence of any interventions. The value of R_0 relates to a herd immunity threshold (HIT), which is given by 1-1/R_0. When the immune fraction of a population exceeds this threshold, sustained disease transmission becomes exponentially unlikely (barring mutations allowing SARS-CoV-2 to escape immunity). Here, we report state-level R_0 estimates obtained using Bayesian inference. Maximum a posteriori estimates range from 7.1 for New Jersey to 2.3 for Wyoming, indicating that disease transmission varies considerably across states and that reaching herd immunity will be more difficult in some states than others. R_0 estimates were obtained from compartmental models via the next-generation matrix approach after each model was parameterized using regional daily confirmed case reports of COVID-19 from 21-January-2020 to 21-June-2020. Our R_0 estimates characterize infectiousness of ancestral strains, but they can be used to determine HITs for a distinct, currently dominant circulating strain, such as SARS-CoV-2 variant Delta (lineage B.1.617.2), if the relative infectiousness of the strain can be ascertained. On the basis of Delta-adjusted HITs, vaccination data, and seroprevalence survey data, we find that no state has achieved herd immunity as of 20-September-2021.

scholarly journals Change in Five-Factor Model Personality Traits During the Acute Phase of the Coronavirus Pandemic

2020 ◽  
Author(s):  
Angelina Sutin ◽  
Martina Luchetti ◽  
Damaris Aschwanden ◽  
Ji Hyun Lee ◽  
Amanda A Sesker ◽  
...  
Keyword(s):  
United States ◽  
Personality Traits ◽  
Acute Phase ◽  
Factor Model ◽  
Five Factor Model ◽  
The United States ◽  
Anxiety And Depression ◽  
Psychological Function ◽  
Rapid Spread

The rapid spread of the coronavirus and the strategies to slow it have disrupted just about every aspect of our lives. Such disruption may be reflected in changes in psychological function. The present study used a pre-posttest design to test whether Five Factor Model personality traits changed with the coronavirus outbreak in the United States. Participants (N=2,137) were tested in early February 2020 and again during the President’s 15 Days to Slow the Spread guidelines. In contrast to the preregistered hypotheses, Neuroticism decreased across these six weeks, particularly the facets of Anxiety and Depression, and Conscientiousness did not change. Exploratory analyses indicated that quarantine/isolation status moderated change such that Neuroticism only decreased for those not in quarantine, whereas Openness, Agreeableness, and Conscientiousness declined for participants in quarantine. The present research suggests modest changes in personality traits across the acute phase of the coronavirus outbreak.

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