Ectopic Immature Renal Tissue Over the Dorsum of Lumbar and Sacral Area in Two Infants

PEDIATRICS ◽  
1982 ◽  
Vol 69 (3) ◽  
pp. 336-339
Author(s):  
Zoltan Posalaky ◽  
Robert M. Drake ◽  
John R. Mawk ◽  
Ralph A. Franciosi ◽  
Bernard H. Spencer ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Renal Tissue ◽  
Female Infant ◽  
Soft Tissue Swelling ◽  
Lumbar Area ◽  
Disease Free ◽  
Renal Abnormalities

During reparative surgery for meningomyelocele of the lumbar area, a 7-week-old female infant was found to have a small, well-delineated, subcutaneous, renal blastema. A 3-month-old female infant was found to have immature renal tissue, consisting of glomeruli and tubules, in a soft tissue swelling dorsal to the sacrum. Neither of these patients showed neuroloic or renal abnormalities. The second patient has had a disease-free follow-up period of six years. The possible etiology and significance of these benign findings and their relation to the origin of Wilms tumors are discussed.

TUBERCULAR OSTEOMYELITIS OF METACARPALS AND PHALANGES IN CHILDREN

Hand Surgery ◽  
2011 ◽  
Vol 16 (01) ◽  
pp. 19-27 ◽  
Author(s):  
Anil Agarwal ◽  
Nadeem Akhtar Qureshi ◽  
Pawan Kumar ◽  
Shariq Khan
Keyword(s):  
Soft Tissue ◽  
Clinical Outcome ◽  
Disease Spectrum ◽  
Radiological Staging ◽  
Bony Destruction ◽  
Soft Tissue Swelling ◽  
Three Stages ◽  
Stage 1 ◽  
The Relationship

The purpose of the series is to describe the management of tubercular osteomyelitis of metacarpals and phalanges in 11 children (range, 3–12 years) and to retrospectively analyse the relationship between radiological staging and clinical outcome following treatment. The available literature on the clinical and radiological manifestations of tubercular osteomyelitis of the hand (excluding wrist) was also reviewed. Follow-up averaged 17.7 months following completion of treatment. The different radiological descriptions of the condition could be grouped into three stages: Stage 1 (stage of soft tissue swelling and no bony changes), Stage 2 (stage of bony expansion) and Stage 3 (stage of destruction). The previously described different radiological entities of tubercular osteomyelitis of metacarpals and phalanges appear to be a sequential manifestation of the disease spectrum. Healing with non-operative treatment is excellent provided the diagnosis is made when tuberculosis presents with soft tissue swelling alone and before bony destruction occurs.

scholarly journals Ossifying fibromyxoid tumor: a rare case

2019 ◽  
Vol 12 (8) ◽  
pp. e229371 ◽  
Author(s):  
Masood Umer ◽  
Javeria Saeed ◽  
Nasir Ud Din ◽  
Kiran Hilal
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Neoplasm ◽  
Wide Margin ◽  
X Ray ◽  
Diagnostic Biopsy ◽  
Long Term Follow Up ◽  
Disease Free ◽  
Ossifying Fibromyxoid Tumor

Ossifying fibromyxoid tumour (OFMT) is a rarely occurring soft tissue neoplasm of mesenchymal origin. It is a rarely found tumour with intermediate behaviour and differentiation. Although it is mostly benign, malignant variants also exist. We are presenting a case of 32-year-old man presented in clinic with complaints of painless swelling in left distal thigh. After reviewing his X-ray, a diagnostic biopsy was planned which came out to be suspicious of solitary fibrous tumour. Other radiological workup was done and the patient was planned to undergo wide margin excision. The final histopathology showed a diagnosis of OFMT of soft tissue, atypical variant. The patient is under follow-up and is disease free. This type of tumour possesses potential of local recurrence and metastases; therefore, it is important to keep a long-term follow-up of patient.

Eastern Cooperative Oncology Group: a comparison of adjuvant doxorubicin and observation for patients with localized soft tissue sarcoma.

1987 ◽  
Vol 5 (4) ◽  
pp. 613-617 ◽  
Author(s):  
H J Lerner ◽  
D A Amato ◽  
E D Savlov ◽  
W D DeWys ◽  
A Mittleman ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Eastern Cooperative Oncology Group ◽  
Primary Treatment ◽  
Oncology Group ◽  
Disease Free Interval ◽  
Group A ◽  
Age Range ◽  
Disease Free

Forty-seven patients with stage I, II, or III soft tissue sarcoma were entered into a prospective randomized Eastern Cooperative Oncology Group (ECOG) adjuvant protocol. Eligibility included conservative or radical primary treatment for local cure. Patients were then randomized to control or Adriamycin (Adria Laboratories, Columbus, OH). Adriamycin was administered at 70 mg/m2 (slow push, every 3 weeks for seven courses for a maximum of 550 mg/m2). To date, 32 patients, 17 males and 15 females, with an age range of 17 to 75 years (median, 44 years) have been followed sufficiently long to be included in this analysis. Nine patients have died. The median follow-up of the remaining 23 patients is 30 months (range, 2 to 50 months). Survival was not significantly different between Adriamycin or control. However, the disease-free interval was slightly different in favor of observation. This preliminary report does not support the hypothesis that Adriamycin is an effective adjuvant therapy for soft tissue sarcoma. Due to the small numbers, these results must be interpreted in relation to our ability to detect a difference, if in fact one existed. These preliminary data suggest that adjuvant Adriamycin not be used outside the confines of a clinical trial such as the current intergroup adjuvant sarcoma study.

Plate Fixation in Closed Ipsilateral Multiple Metacarpal Fractures

2008 ◽  
Vol 33 (6) ◽  
pp. 740-744 ◽  
Author(s):  
J. S. SOUER ◽  
C. S. MUDGAL
Keyword(s):  
Soft Tissue ◽  
Plate Fixation ◽  
Full Range ◽  
Treatment Method ◽  
Stable Fixation ◽  
Functional Rehabilitation ◽  
Metacarpal Fractures ◽  
Soft Tissue Swelling ◽  
Lost To Follow Up

Closed multiple metacarpal fractures are uncommon. They are usually associated with significant soft tissue swelling. Early stable fixation and functional rehabilitation optimises outcome. We present a review of 19 patients with 43 metacarpal fractures treated by early open reduction and internal fixation with 2 mm plates. Eighteen patients recovered a full range of motion, while one patient was lost to follow-up. Implant removal on account of extensor irritation was required in only two metacarpals in two patients. Plating of multiple closed metacarpal fractures is a safe, reliable and consistently reproducible treatment method.

Adjuvant Treatment of High-risk Adult Soft Tissue Sarcomas: A Survey by the Italian Sarcoma Group

2006 ◽  
Vol 92 (2) ◽  
pp. 92-97 ◽  
Author(s):  
Sergio Frustaci ◽  
Massimiliano Berretta ◽  
Alessandro Comandone ◽  
Ettore Bidoli ◽  
Antonino De Paoli ◽  
...  
Keyword(s):  
Overall Survival ◽  
High Risk ◽  
Soft Tissue ◽  
Survival Rates ◽  
Soft Tissue Sarcomas ◽  
Disease Free Survival ◽  
Free Survival ◽  
Disease Free ◽  
Overall Survival Rates

Aims and Background After the first adjuvant study on adult soft tissue sarcomas was concluded, the participating institutions continued to select and treat patients according to that protocol. The aim of this study was to test the protocol reproducibility when applied as a standard practice. Methods A call for retrospective data was launched in June 1999 (self-referral of consecutive unregistered patients); thereafter, a prospective follow-up was performed. The treatment regimen consisted of epirubicin (60 mg/m2 days 1 and 2), ifosfamide (3 g/m2/die for 3 days) and equimolar doses of 6-mercapto-ethansulfonate (MESNA), with 300 μg G-CSF administered subcutaneously from day +8 until recovery, every 3 weeks for a total of 5 cycles. Results From November 1996 to June 1999, 55 high-risk, adult patients were treated. The average median dose intensity was 89% of the planned program. Grade 3-4 toxicities were leukopenia (49%), thrombocytopenia (14%), transfusion requiring anemia in 7 patients (16%), and alopecia in all patients (100%). After a median follow-up of 70 months, 23 patients (41.8%) relapsed and 19 died. Median disease-free, local disease-free and overall survival rates have not yet been reached. The disease-free survival rates at 2 and 4 years were 73% and 57%, respectively; the corresponding overall survival rates were 91% and 70%, respectively. Conclusions The feasibility and reproducibility of the original protocol were confirmed, since disease-specific overall survival and disease-free survival rates at the same period of observation and with the same prolonged follow-up did not differ.

scholarly journals What Factors Influence the Outcome of Surgically Treated Soft Tissue Sarcomas of the Hand and Wrist?

Hand ◽  
2016 ◽  
Vol 12 (5) ◽  
pp. 493-500 ◽  
Author(s):  
Matthew T. Houdek ◽  
Brian E. Walczak ◽  
Benjamin K. Wilke ◽  
Sanjeev Kakar ◽  
Peter S. Rose ◽  
...  
Keyword(s):  
Overall Survival ◽  
Soft Tissue ◽  
Local Recurrence ◽  
Soft Tissue Sarcomas ◽  
Disease Free Survival ◽  
Disease Status ◽  
Distant Metastases ◽  
Factors Affecting ◽  
Disease Free

Background: Soft tissue sarcomas (STS) of the hand are exceedingly rare. The aim of this study was to review our institution’s experience with STS of the hand to identify factors affecting outcomes and survivorship. Methods: We retrospectively reviewed the records of 46 hand STS treated with definitive surgery at our institution between 1992 and 2013. Pertinent demographics as well as information regarding the surgical procedure, and disease status at latest follow-up were reviewed. Mean age at diagnosis was 38 years with a mean follow-up of 5 years. Results: The most common tumor subtypes were epithelioid (n = 10) and synovial sarcoma (n = 8). Sixty-one percent were superficial in location. Thirty-three patients had had a nononcologic resection prior to definitive surgical treatment at our institution. Ultimately, negative margins were obtained in all cases. Local recurrence was observed in 5 patients and distant metastases in 14 patients. Tumor sizes ≥2 cm, American Joint Committee on Cancer (AJCC) grade, and depth of the tumor were found to adversely affect the outcome in terms of disease-free and overall survival. Reexcision of an inadvertently excised tumor at an outside institution did not adversely affect the outcome. The 10-year overall and disease-free survival was 72% and 63%. Conclusions: Local recurrence after a wide excision was observed infrequently; however, distant disease was relatively common. Tumors with a size ≥2 cm were associated with a worse disease-free and overall survival, highlighting the aggressive nature of these tumors.

Patterns of recurrence in patients with high-grade soft-tissue sarcomas.

1985 ◽  
Vol 3 (3) ◽  
pp. 353-366 ◽  
Author(s):  
D A Potter ◽  
J Glenn ◽  
T Kinsella ◽  
E Glatstein ◽  
E E Lack ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Recurrent Disease ◽  
Soft Tissue Sarcomas ◽  
Disease Free Interval ◽  
Primary Sarcoma ◽  
Initial Recurrence ◽  
First Recurrence ◽  
Disease Free ◽  
Patterns Of Recurrence

From July 1975 to December 1982, 563 patients were referred to the Surgery Branch of the National Cancer Institute with the diagnosis of soft-tissue sarcoma. Three hundred and seven of these patients had fully resectable, localized high-grade soft-tissue sarcomas and were treated at the National Cancer Institute using standard protocols with surgery alone, or in combination with chemotherapy and/or radiotherapy. An aggressive surgical approach was undertaken in the management of patients who subsequently developed recurrent disease. These 307 cases have been reviewed, with a median duration of follow-up of 30 months, to determine the frequency of recurrent disease, the patterns of recurrence, and the impact of surgery on the survival of patients who developed recurrent disease. Disease recurred in one hundred seven patients (107/307, 35%), with a median disease-free interval of 18 months (range, 0.5 to 72.0 months). The frequency of recurrence by site of primary sarcoma was extremity, 31% (65/211); head and neck, 33% (4/12); trunk, 40% (17/42); retroperitoneum, 47% (17/36); and breast, 67% (4/6). Isolated pulmonary metastatic disease was the most common pattern of initial recurrence (56/107, 52%) followed by isolated local recurrence (21/107, 20%). Single other sites of recurrence and multiple concurrent sites of recurrence each accounted for 14% (15/107) of all initial recurrences. The relative frequency of each of these four patterns of recurrence varied with the site of the primary sarcoma. The outcome for patients with recurrent disease depended on the site of recurrence, rather than on the site of the primary sarcoma. Sixty-six patients (66/107, 62%) with recurrent disease were rendered surgically disease-free with the first recurrence, including 40 (40/56, 72%) patients with isolated pulmonary metastases, 20 patients (20/21, 96%) with isolated local recurrences, five patients (5/15, 33%), with isolated other sites of recurrence and one patient (1/15, 7%) with multiple sites of initial recurrence. Following surgical resection, the actuarial three-year survival for the 66 patients rendered disease-free was 51%. The median survival for the 41 patients not rendered surgically disease-free with the first recurrence was only 7.4 months. Thirty of the sixty-six patients (30/66, 45%) rendered disease-free with the first recurrence remained disease-free at follow-up, with a median follow-up of 28 months from the time of resection of the first recurrence. The remaining 36 patients (36/66, 55%) subsequently recurred, with a median disease-free interval of 7.3 months.(ABSTRACT TRUNCATED AT 400 WORDS)

Surgical treatment of pulmonary metastasis: report from a tertiary care center

2018 ◽  
Vol 26 (4) ◽  
pp. 296-301 ◽  
Author(s):  
Waleed Saleh ◽  
Abdullah AlShammari ◽  
Jumana Sarraj ◽  
Omniyah AlAshgar ◽  
Mohamed Hussein Ahmed ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Confidence Interval ◽  
Primary Tumor ◽  
Lung Metastases ◽  
Pulmonary Metastasectomy ◽  
Disease Free Interval ◽  
Free Interval ◽  
Disease Free

Objective This retrospective analysis aimed to determine the factors influencing prognosis in adult patients who presented to our thoracic surgery service with lung metastases and were eligible for pulmonary metastasectomy. Methods We retrospectively reviewed the data of 296 patients who underwent resection of 575 lung metastases from January 2000 to January 2016. Univariate and multivariate analyses were performed based on age, sex, histology of the primary tumor, disease-free interval, number and size of metastases. Results Sixty-eight (22.97%) patients developed lung metastases from bone sarcoma, 68 (22.97%) from soft-tissue sarcoma, 56 (18.9%) from head and neck cancers, 46 (15.5%) from colorectal cancer, and 58 (19.6%) from other epithelial tumors. The mean size of the lung nodules was 2.48 cm. Open surgical resection was performed in 217 (73.3%) patients. After a mean follow-up of 43 months, 120 (40.7%) patients had died or were lost to follow-up. Univariate analysis confirmed that patients with bone cancer, soft tissue sarcoma, or colorectal carcinoma had a worse prognosis ( p = 0.0003). Moreover, those with a disease-free interval >24 months had a better 5-year survival ( p = 0.0001). The number and size of metastases, age, and sex had no effect on prognosis. The actuarial survival after complete metastasectomy was 71.6% (95% confidence interval: 66–75) at 2 years and 59.3% (95% confidence interval: 56–64) at 5 years. Conclusions Pulmonary metastasectomy provides good long-term survival. The type of primary tumor and disease-free interval are independent prognostic factors for survival.

scholarly journals A rare location of primary extrahepatic hydatid cyst in the soft tissue

2020 ◽  
Vol 7 (6) ◽  
pp. 2012
Author(s):  
S. Uma Shanker ◽  
U. V. Sai Sreenivas ◽  
N. Swathanthra
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Hydatid Cyst ◽  
Cystic Lesion ◽  
Rare Condition ◽  
Lumbar Region ◽  
Soft Tissue Swelling ◽  
Rare Location ◽  
Multiple Cyst

Hydatid cyst or cystic echinococcosis in human is rare disease caused by tapeworm Echinococcus granulosa. Hydatid cyst of soft tissue is a rare condition and we had a case of large hydatid cyst in lumbar region. This is a case of 48 years old female presented to us during October 2018 with a large diffuse swelling over the left lumbar region which was gradually grown over the last 2 years without pain. The diagnosis of hydatid cyst was not sure even in CT scan but it was in our differential diagnosis. It is confirmed during surgery after seen the multiple cyst removed from the large cystic lesion. No recurrence even after 15 months of follow up. Presence of hydatid cyst in soft tissue is usually rare and its diagnosis is not expected clinically when it presents as a soft tissue swelling. We need to confirm it during surgery or by presence of typical germinal membrane under microscope.

Prognostic factors associated with long-term survival for retroperitoneal sarcoma: implications for management.

1997 ◽  
Vol 15 (8) ◽  
pp. 2832-2839 ◽  
Author(s):  
M J Heslin ◽  
J J Lewis ◽  
E Nadler ◽  
E Newman ◽  
J M Woodruff ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Term Survival ◽  
Long Term Survival ◽  
Increased Risk ◽  
Long Term Follow Up ◽  
Disease Free ◽  
Patterns Of Recurrence

PURPOSE Retroperitoneal soft tissue sarcomas are rare tumors. Studies characterizing long-term follow-up and patterns of recurrence are limited. The purpose of this analysis is to identify patterns of recurrence and prognostic factors associated with long-term survival after resection of retroperitoneal soft tissue sarcomas. METHODS Between July 1, 1982, and June 30, 1990, 198 adult patients were identified from our prospective soft tissue sarcoma database carrying the diagnosis of retroperitoneal soft tissue sarcoma who were eligible for > or = 5 years of follow-up. Of these, 48 patients (25%) were documented to be alive > or = 5 years from the time of operation. Statistical analysis was by log-rank or Wilcoxon test for univariate analysis. Multivariate analysis was by the Cox model. RESULTS The recurrence rate during the follow-up period was approximately 5% per year from the time of initial operation. Of the patients who were disease-free for > or = 5 years from initial surgery, 40% recurred by 10 years. Radiation therapy was the only factor significant (P = .02) for a reduction in the risk of local recurrence. Age < or = 50 years and high-grade tumors were significant factors (P = .003 and .009, respectively) for an increased risk of distant metastasis. Incomplete gross resection was the only factor significant for an increased risk of tumor mortality (P = .003). CONCLUSION Complete surgical resection at the time of primary presentation is likely to afford the best chance for long-term survival. With long-term follow-up, it is clear that recurrence will continue to occur, and a 5-year disease-free interval is not a cure. Patients with an incomplete initial resection, age less than 50 years, and high-grade tumors are candidates for investigational adjuvant therapy.

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