Subependymal Germinal Matrix Hemorrhage in Full-Term Neonates

A population of healthy, full-term newborn infants was studied in order to obtain documentation of the prevalence of intracranial hemorrhage. Cerebral ultrasonography was performed within 72 hours of birth on 505 healthy newborn infants, 37 weeks of gestation or greater. Sonographic abnormalities were detected in 23 (4.6%) neonates. Bilateral subependymal germinal matrix hemorrhage occurred in 14 and unilateral hemorrhage in five infants. Other abnormalities detected included agenesis of the corpus callosum in two infants, a cyst involving the subependymal germinal matrix in one (presumably the result of a previous subependymal hemorrhage), and mild ventricular dilation of unknown etiology in one. Newborns with subependymal hemorrhage were compared with newborns without hemorrhage in order to determine whether any significant differences existed between the two populations. No significant differences existed between infants with and without subependymal hemorrhage with regard to gender, obstetrical presentation, use of forceps, birth trauma, Apgar scores, need for resuscitation, maternal age and parity, and neonatal clinical problems. Infants with subependymal hemorrhage were of significantly lower gestational age and birth weight; the overall difference in weight was attributable to lower weight in female infants with subependymal hemorrhage. Significantly more infants with subependymal hemorrhage were small for gestational age, vaginally delivered, and black.

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Neurotoxicity of Hexachlorophene in the Human: I. A Clinicopathologic Study of 248 Children

PEDIATRICS ◽

10.1542/peds.54.6.689 ◽

1974 ◽

Vol 54 (6) ◽

pp. 689-695

Author(s):

Robert M. Shuman ◽

Richard W. Leech ◽

Ellsworth C. Alvord

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Newborn Infants ◽

Whole Body ◽

Human Beings ◽

Term Neonates ◽

Experimental Animals ◽

Clinicopathologic Study ◽

Neurotoxic Effects ◽

Sick Children

To assess the susceptibility of human beings to the neurotoxic effects of hexachlorophene demonstrated in experimental animals, a blind clinicopathologic analysis was made of 248 children coming to autopsy over a 7.5-year period in the two Seattle institutions to which practically all premature or sick children are referred. Repeated whole-body bathing of premature newborn infants in 3% hexachlorophene-bearing soap (undiluted pHisoHex) is associated with a vacuolar encephalopathy of the brainstem reticular formation. The prevalence of the vacuolar encephalopathy appears to be related to the number of exposures to hexachlorophene, to the concentration of hexachiorophene, to the birth weight (gestational age), to the length of survival and to the thoroughness of rinsing. From these observations we conclude that hexachlorophene should not be used on neonates under 1,400 gm birth weight and should be used only sparingly in full-term neonates with thorough rinsing.

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Hypoglycaemia and seizures in large-for-gestational-age (LGA) full-term neonates

Acta Paediatrica ◽

10.1111/j.1651-2227.2006.tb02359.x ◽

2007 ◽

Vol 95 (7) ◽

pp. 874-876

Author(s):

Floris Groenendaal ◽

Patty M. Elferink-Stinkens ◽

Keyword(s):

Gestational Age ◽

Full Term ◽

Large For Gestational Age ◽

Term Neonates

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SUBEPENDYMAL GERMINAL MATRIX HEMORRHAGE (SEH) IN TERM NEONATES

Pediatric Research ◽

10.1203/00006450-198404001-01496 ◽

1984 ◽

Vol 18 ◽

pp. 342A-342A

Author(s):

Karen E Shattuck ◽

C Joan Richardson ◽

C Keith Hayden

Keyword(s):

Germinal Matrix ◽

Term Neonates ◽

Germinal Matrix Hemorrhage

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Clot formation of neonates tested by thromboelastography correlates with gestational age

Thrombosis and Haemostasis ◽

10.1160/th09-05-0282 ◽

2010 ◽

Vol 103 (02) ◽

pp. 344-350 ◽

Cited By ~ 46

Author(s):

Tzipi Strauss ◽

Yael Levy-Shraga ◽

Bruria Ravid ◽

Irit Schushan-Eisen ◽

Ayala Maayan-Metzger ◽

...

Keyword(s):

Cord Blood ◽

Gestational Age ◽

Blood Clot ◽

Full Term ◽

Clot Formation ◽

Clotting Time ◽

Term Infants ◽

Term Neonates ◽

Pregnancy And Delivery ◽

Clot Formation Time

SummaryEvaluation of clot formation in neonates is troublesome. Our aim was to investigate cord blood clot formation of pre-term versus full-term infants and adults, using rotating thromboelastogram (ROTEM®, Pentafarm, Munich, Germany). ROTEM was investigated in cord blood of 184 full-term and 47 pre-term infants. Measurements of the clotting time (CT), clot formation time (CFT) and maximal clot firmness (MCF) were obtained in order to asses reference values for this age group, and compare between full-term and pre-term neonates and compared to adult controls. For each infant demographic information and data regarding pregnancy and delivery were gathered. Infants were prospectively followed until discharge. CT and CFT were significantly shorter among pre-term and term infants as compared to adults [median CT: 185, 194, 293 seconds respectively, p≤0.001, CFT: 80, 76, 103 seconds respectively, p≤0.001). MCF was lower in pre-term and term as compared to adults (p≤0.001) with significantly lower values in pre-term as compared to full-term neonates (p=0.004). Clotting time and MCF correlated with gestational age (R=0.132, p=0.045, R= 0.259, p<0.001, respectively). No association was found between any ROTEM values and the occurrence of post-natal complications in infants of our study group. This is the first study assessing clot formation by ROTEM in pre-term infants. Clot formation parameters of term and premature infants correlated with gestational age. The predictive value of clot formation tests in neonates deserves further attention.

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Effect of early and delayed cord clamping on hemoglobin and hematocrit among full term neonates.

The Professional Medical Journal ◽

10.29309/tpmj/2021.28.08.5574 ◽

2021 ◽

Vol 28 (08) ◽

pp. 1114-1119

Author(s):

Saqib Aslam ◽

◽

Sadaf Minhas ◽

Muhammad Azhar Farooq ◽

Beenish Bashir Mughal ◽

...

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Full Term ◽

P Value ◽

Delayed Cord Clamping ◽

Term Neonates ◽

Cord Clamping ◽

Significant Difference ◽

Early Cord Clamping ◽

The Mean

Objective: To compare the mean hemoglobin levels and frequency of polycythemia in full term neonates after early and delayed cord clamping. Study Design: Randomized Controlled Trial. Setting: KRL General Hospital Islamabad (Labor Room/ Neonatology). Periods: December 2017 to June 2018. Material & Methods: 190 full term neonates were selected and divided into 2 equal groups randomly: Early cord clamping group after delivery and late cord clamping group. Two hours after clamping the venous blood samples were taken for the hemoglobin and hematocrit levels. Mean and standard deviation were calculated for gestational age, birth weight, hemoglobin and hematocrit. Frequency and proportions were calculated for gender and polycythemia. Results: Mean gestational age of the mothers was 39.27 ± 1.50 weeks. Of 190 neonates, 91 (47.9%) were males, 99 (52.1%) were females. Mean birth weight was 3.64 ± 0.72 kg while mean Hb and HCT levels were 16.07 ± 2.30 g/dl and 63.26 ± 5.32% respectively. Keeping cut off value of 13.5 g/dl of Hb to label anemia or no, 35 (18.4%) neonates were anemic in this study. The polycythemia (HCT >65%) was present in 72 (37.9%) of neonates. There was no difference between groups in terms of gender, anemia, gestational age and birth weight (p values 0.663, 0.852, 0.700 and 0.491 respectively). The distribution of polycythemia was different among groups (p value 0.007). The mean hemoglobin level in group A was 15.52 ± 1.90 g/dl while in group B it was 16.62 ± 2.53 g/dl (p value 0.001). Mean Hb levels were statistically not different among some of the groups (gestational age <40 weeks, birth weight <4 kg) while HCT levels are significantly different among male group and category of birth weight >4 kg. Rest of the stratification groups showed significant difference. Conclusion: The delayed cord clamping in neonates results in increased mean hemoglobin and hematocrit levels with increased frequency of polycythemia as compared to early cord clamping.

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Associations of gestational age and birth anthropometric indicators with brain white matter maturation in full‐term neonates

Human Brain Mapping ◽

10.1002/hbm.24620 ◽

2019 ◽

Author(s):

Chao Jin ◽

Yanyan Li ◽

Xianjun Li ◽

Congcong Liu ◽

Miaomiao Wang ◽

...

Keyword(s):

White Matter ◽

Gestational Age ◽

Full Term ◽

Term Neonates ◽

Anthropometric Indicators ◽

Brain White Matter ◽

White Matter Maturation

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Diminished HLA-DR expression on monocyte and dendritic cell subsets indicating impairment of cellular immunity in pre-term neonates: a prospective observational analysis

Journal of Perinatal Medicine ◽

10.1515/jpm-2014-0226 ◽

2015 ◽

Vol 43 (5) ◽

Cited By ~ 8

Author(s):

Joerg C. Schefold ◽

Linn Porz ◽

Barbara Uebe ◽

Holger Poehlmann ◽

Stephan von Haehling ◽

...

Keyword(s):

Gestational Age ◽

Human Leukocyte ◽

Severe Infection ◽

Full Term ◽

Term Neonates ◽

Observational Analysis ◽

Leukocyte Antigen ◽

Hla Dr ◽

Leukocyte Counts ◽

Antigen Presenting

AbstractThe risk of neonates for severe infection/sepsis is reciprocally proportional to gestational age and birth weight. As monocytes and dendritic cells (DC) are recognised key antigen-presenting immune cells, we aimed to elucidate whether neonatal age is associated with reduced expression of human-leukocyte antigen-DR (HLA-DR) antigens on subsets of monocytes and DCs.Forty-three consecutive neonates (20 male, mean gestational age 236.0±26.8 days; mean 1-min Apgar score 7.5±2.0) were included in a monocentric prospective observational analysis. Patients were grouped according to gestational age (n=15 full-term, n=28 pre-term defined as <33 weeks). Ten healthy adult volunteers were assessed also. Flow-cytometric assessment of HLA-DR expression was performed in subsets of peripheral blood myeloid and plasmacytoid DCs (MDC and PDC) and monocytes (CD14At birth, leukocyte counts were increased in full-term neonates. Monocyte counts were significantly increased in neonates when compared with adults (all P<0.05). A significant numerical increase of CD14We observed a markedly diminished HLA-DR expression on monocyte and DC subsets in pre-term and full-term neonates, which may contribute to impaired antimicrobial defence mechanisms in the early days of life.

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Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China

10.21203/rs.3.rs-32762/v1 ◽

2020 ◽

Author(s):

Dongyan Cui ◽

Yan Hou ◽

Ling Feng ◽

Guo Li ◽

Chi Zhang ◽

...

Keyword(s):

Platelet Count ◽

Gestational Age ◽

Reference Interval ◽

Reference Intervals ◽

Capillary Blood ◽

Full Term ◽

Term Neonates ◽

First Time ◽

Early Phases

Abstract Background No consensus has been reached on reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of gender, gestational age and postnatal age on platelet parameters. Methods This study was implemented in 594 healthy full-term neonates from 12 to 84 hours of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th − 97.5th percentiles. Results Capillary reference interval for platelet count was (152–464) × 109/L. No significance was found between gender-divided reference intervals for platelet parameters. The values of platelet count changed significantly across gestational age and postnatal age. Reference intervals for other platelet parameters were affected by these factors to a different extent. Conclusions We established capillary blood reference intervals for platelet parameters in the early phases after birth of full-term neonates in China for the first time.

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Evaluation of Lipid Profile in Premature, Near-term and Term Newborn Infants

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol02-i09/16 ◽

2017 ◽

Vol 2 (09) ◽

Author(s):

Dr. Ram Manohar Kurrey ◽

Dr. Kavita J. Lall ◽

Dr. Karan Singh Chandrakar

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Gestational Age ◽

Newborn Infants ◽

Precipitation Method ◽

Assay Method ◽

P Value ◽

Term Neonates ◽

Significant Difference ◽

Near Term

In this study we evaluate the activity of lipid profile in premature, near term and term neonates. A total number of 68 newborn infants were selected for this study. They were delivered normally, or by caesarean section, and their gestational age was included. The infants with congenital anomalies or those, whose mothers had medical problems, were excluded from the study. The gestational age was determined according to the date of the last menstrual period, or the early ultrasound in 20 weeks of gestation. All the information related to the newborns and their mothers were recorded in the prepared forms. Following the delivery, blood samples were taken from the umbilical cord immediately, and were separated after clotting, for at least 30 min at room temperature. Serum was stored at 4°C to -80C for a maximum of 2 days, prior to the analysis. Total cholesterol, triglycerides and HDL were analyzed by enzymatic method using auto-analyzer. Serum Total Cholesterol estimated by enzymatic kit method, Triglyceride estimated by bioluminescent assay method and HDL-cholesterol estimated by phasphotungstate precipitation method manufactured by ERBS Transasia. LDL-C and VLDL-C calculated by Friedewald formula. The three groups were significantly different, regarding the means of age, weight and cholesterol and LDL-C level, whereas no significant difference was observed concerning the level of triglyceride and HDL-C,. Gender has no effect on the level of cholesterol, triglyceride, HDL-C and LDL-C in the total population and in all subgroups (P value more than 0.05). On the basis of present study we assume that the cholesterol level was higher in those with prematurity and pre-term delivery, and is also inversely correlated with the infant’s birth weight. Therefore, we believe that monitoring, observation and early-lifestyle modifications may decrease the severity of atherosclerosis in the vessels in adulthood. This study says, it is evident that the total cholesterol and LDL cholesterol in premature and near term neonates was higher than a term neonates ; triglyceride and VLDL were higher in term neonates as compared to near term neonates. Fall in HDL was significantly observed in premature neonates than term neonates and near term neonates but no significance found in term and near term neonates.

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