Effect of Prenatal Alcohol Exposure on Growth and Morphology of Offspring at 8 Months of Age

PEDIATRICS ◽  
1990 ◽  
Vol 85 (5) ◽  
pp. 748-752
Author(s):  
Nancy L. Day ◽  
Gale Richardson ◽  
Nadine Robles ◽  
Usha Sambamoorthi ◽  
Paul Taylor ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Fetal Alcohol ◽  
Alcohol Effects ◽  
Prenatal Alcohol ◽  
Minor Physical Anomalies ◽  
Continuous Use ◽  
Fetal Alcohol Effects

In this prospective study of alcohol and other substance use during pregnancy, a cohort of women was interviewed at each trimester of pregnancy and when the offspring were 8 months of age. Data are presented concerning the outcome for 461 infants. A significant relationship was found between alcohol use during pregnancy and the growth and morphology of the offspring at the 8-month follow-up observation. Alcohol use during the second and third trimesters of pregnancy and continuous use of alcohol throughout pregnancy were significantly related to lower weight, length, and head circumference in the exposed infants at the follow-up observation. A significant increase in the risk of minor physical anomalies and fetal alcohol effects was also predicted by prenatal alcohol exposure.

scholarly journals Exploring the experiences of social workers in working with children suspected to have fetal alcohol spectrum disorders

2021 ◽  
Vol 45 (2) ◽  
pp. 155-172
Author(s):  
David J Gilbert ◽  
Raja AS Mukherjee ◽  
Nisha Kassam ◽  
Penny A Cook
Keyword(s):  
Social Workers ◽  
Social Services ◽  
Child Protection ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Fetal Alcohol ◽  
The Social ◽  
Prenatal Alcohol ◽  
Fetal Alcohol Spectrum ◽  
Lack Of Knowledge

Fetal alcohol spectrum disorder (FASD) is one outcome from prenatal alcohol exposure. Social workers are likely to encounter children with the condition, due to the greater likelihood of prenatal alcohol exposure among children in social services settings. This study explores the experiences of social workers in working with children suspected of having FASD and the support offered to social workers, the children and their families. Semi-structured interviews followed by qualitative framework analysis were conducted with seven child and family social workers along with one child protection solicitor who had experience of handling FASD cases. The two main themes that emerged from the data were a lack of knowledge about FASD and the paucity of diagnosis. Lack of knowledge among the social workers was linked to difficulty in managing children suspected to have the condition, feelings of frustration and normalisation of challenging behaviours. The paucity of diagnosis led to an under-emphasis of FASD in assessments, a dearth of specialist services and confusion about its specific effects in contexts of multiple substance misuse and harmful socio-environmental factors. The need for increased FASD awareness within social services and the development of FASD-targeted support for children and families is highlighted. Social workers would benefit from the inclusion of FASD-focused training in their curricula and professional development plans. Improving the diagnostic capacities of health institutions would address the paucity of diagnosis and raise the profile of FASD, especially in the social services setting.

Synthesizing Animal and Human Studies of Prenatal Alcohol Exposure

2001 ◽  
Vol 7 (5) ◽  
pp. 648-649 ◽  
Author(s):  
Paul D. Connor
Keyword(s):  
Fetal Alcohol Syndrome ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Fetal Alcohol ◽  
Behavioral Disturbances ◽  
Quarter Century ◽  
Prenatal Alcohol ◽  
Primary Focus ◽  
Maternal Alcohol Abuse ◽  
The Impact

The primary focus of this volume is on the impact of alcohol on brain development. It is a perfect example of how research on both animals and humans can interact to produce very important findings. In the case of prenatal alcohol exposure, dialogue between animal and human researchers has proved to be very profitable for both lines of research. Initial observations by human researchers identified a syndrome of facial stigmata, physical malformations, and early behavioral disturbances that was related to maternal alcohol abuse during pregnancy. They gave this syndrome the name Fetal Alcohol Syndrome. However, human researchers were unable to state unequivocally that prenatal alcohol exposure was teratogenic to the fetus. Thus, they turned to animal researchers who were able to model Fetal Alcohol Syndrome in a variety of animals and to confirm the teratogenicity of alcohol on the developing fetus. The quarter century of studies of the damage caused by prenatal alcohol exposure is replete with such interactions between these two groups of researchers. Without the input and pioneering studies of animal researchers on the effects of prenatal alcohol exposure, human researchers would have much less understanding of the damage caused by alcohol exposure in utero or insights into possible treatment or remediation strategies for those damaged by alcohol exposure.

Neuroimaging effects of prenatal alcohol exposure on the developing human brain: a magnetic resonance imaging review

2015 ◽  
Vol 27 (5) ◽  
pp. 251-269 ◽  
Author(s):  
Kirsten Ann Donald ◽  
Emma Eastman ◽  
Fleur Margaret Howells ◽  
Colleen Adnams ◽  
Edward Patrick Riley ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Corpus Callosum ◽  
Human Brain ◽  
Grey Matter ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Resonance Imaging ◽  
Fetal Alcohol ◽  
Prenatal Alcohol

ObjectiveThis paper reviews the magnetic resonance imaging (MRI) literature on the effects of prenatal alcohol exposure on the developing human brain.MethodA literature search was conducted through the following databases: PubMed, PsycINFO and Google Scholar. Combinations of the following search terms and keywords were used to identify relevant studies: ‘alcohol’, ‘fetal alcohol spectrum disorders’, ‘fetal alcohol syndrome’, ‘FAS’, ‘FASD’, ‘MRI’, ‘DTI’, ‘MRS’, ‘neuroimaging’, ‘children’ and ‘infants’.ResultsA total of 64 relevant articles were identified across all modalities. Overall, studies reported smaller total brain volume as well as smaller volume of both the white and grey matter in specific cortical regions. The most consistently reported structural MRI findings were alterations in the shape and volume of the corpus callosum, as well as smaller volume in the basal ganglia and hippocampi. The most consistent finding from diffusion tensor imaging studies was lower fractional anisotropy in the corpus callosum. Proton magnetic resonance spectroscopy studies are few to date, but showed altered neurometabolic profiles in the frontal and parietal cortex, thalamus and dentate nuclei. Resting-state functional MRI studies reported reduced functional connectivity between cortical and deep grey matter structures.DiscussionThere is a critical gap in the literature of MRI studies in alcohol-exposed children under 5 years of age across all MRI modalities. The dynamic nature of brain maturation and appreciation of the effects of alcohol exposure on the developing trajectory of the structural and functional network argue for the prioritisation of studies that include a longitudinal approach to understanding this spectrum of effects and potential therapeutic time points.

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