Eleven Plasma Proteins as Indicators of Protein Nutritional Status in Very Low Birth Weight Infants

PEDIATRICS ◽  
1990 ◽  
Vol 86 (6) ◽  
pp. 916-921 ◽  
Author(s):  
Staffan K. T. Polberger ◽  
Göran A. Fex ◽  
Irene E. Axelsson ◽  
Niels C. R. Räihä
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Nutritional Status ◽  
Protein Intake ◽  
Plasma Proteins ◽  
Very Low Birth Weight ◽  
Binding Protein ◽  
Plasma Concentrations ◽  
Retinol Binding Protein ◽  
Low Birth Weight Infants

Concentrations of 11 plasma proteins were measured in 28 healthy, growing, very low birth weight, appropriate-for-gestational-age infants fed varying levels of human milk protein intake (range 1.7 to 3.9 g/kg per day). Significant positive correlations were found between ween mean protein intake and concentrations of 7 of the plasma proteins studied (transthyretin, retinol-binding protein, and transferrin: P < .001; vitamin D-binding protein and apolipoprotein B: P < .01; albumin and apolipoprotein A I: P < .05). A weak negative correlation with mean protein intake was seen for the plasma level of orosomucoid, whereas no significant correlations were found for the plasma concentrations of fibronectin and α1-antichymotrypsin. Protein intake, not energy intake, constituted the main contribution to the changes in the concentrations of transthyretin, retinol-binding protein, and transferrin. The levels of plasma transthyretin and transferrin were also strongly correlated with weight and length growth of the infants during the study as well as with other indicators of protein nutritional status such as preprandial concentrations of plasma amino acids and serum and urine urea. These data indicate that of the 11 plasma proteins studied, transthyretin, transferrin, and retinol-binding protein are the most suitable to evaluate protein nutritional status in very low birth weight infants.

scholarly journals The early changes in retinol-binding protein and prealbumin concentrations in plasma of protein–energy malnourished children after treatment with retinol and an improved diet

1980 ◽  
Vol 43 (3) ◽  
pp. 393-402 ◽  
Author(s):  
Suzanne Large ◽  
G. Neal ◽  
J. Glover ◽  
O. Thanangkul ◽  
R. E. Olson
Keyword(s):  
Body Weight ◽  
Vitamin A ◽  
Nutritional Status ◽  
Plasma Proteins ◽  
Binding Protein ◽  
Vitamin A Deficiency ◽  
Plasma Concentrations ◽  
Retinol Binding Protein ◽  
Mean Values ◽  
The Mean

1. Changes in total retinol-binding protein (RBP), the holoprotein (holoRBP) and prealbumin (PA) concentrations have been monitored in plasma of thirty protein- and vitamin A-deficient preschool children from within a few hours up to 7 weeks after treatment with retinol and a good-quality protein diet.2. The children were classified into groups according to nutritional status as having either kwashiorkor, marasmus-kwashiorkor or marasmus, and given formula diets whose protein and energy contents increased stepwise from 1 g and 105 kJ/kg body-weight respectively up to 4 g and 733 kJ/kg body-weight after 4 weeks. Retinol was administered in the forms of retinyl palmitate either orally or intramuscularly.3. PA and total RBP were determined by electroimmunoassay procedures and the holoRBP by its fluorescence after separation from other plasma proteins.4. RBP in plasma of the vitamin A-deficient child is largely denatured and incapable of binding administered retinol, which must first be taken up by the liver before native holoRBP is released. An increased pool of native apoprotein accumulates in the liver during vitamin A deficiency which is released into plasma quickly after retinol uptake to form peak concentrations of total and holoRBP approximately 3 h after dosing intramuscularly and 6 h orally.5. The accumulated pool of RBP was highest in livers from the marasmus group and lowest in those from the kwashiorkor group, reflecting their relative capacities to synthesize plasma proteins.6. The mean plasma concentrations of total and holoRBP for the various groups were minimal 24–48 h after dosing with retinol and then improved almost linearly over the following week.7. Mean plasma PA concentrations of the various groups on admission were also in order of the severity of their malnutrition. There was little or no change in this protein concentration over the first 24 h after dosing with retinol, but thereafter the mean values rose almost linearly over 2 weeks. Albumin on the other hand changed little during the first week. The results show that PA is the more sensitive measurement of protein nutritional status.

scholarly journals Plasma Levels of Retinol, Retinol-binding Protein, all-trans Beta-Carotene and Cryptoxanthin in Low Birth Weight Infants.

1995 ◽  
Vol 41 (6) ◽  
pp. 595-606 ◽  
Author(s):  
Hideki MOJI ◽  
Takushi MURATA ◽  
Takao MORINOBU ◽  
Mitsuhiro MANAGO ◽  
Hiroshi TAMAI ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Plasma Levels ◽  
Binding Protein ◽  
Beta Carotene ◽  
Retinol Binding Protein ◽  
Low Birth Weight Infants

scholarly journals IGF-I, IGF Binding Protein (IGFBP)-3, Phosphoisoforms of IGFBP-1, and Postnatal Growth in Very Low Birth Weight Infants

2002 ◽  
Vol 87 (5) ◽  
pp. 2171-2179 ◽  
Author(s):  
Eero Kajantie ◽  
Leo Dunkel ◽  
Eeva-Marja Rutanen ◽  
Markku Seppälä ◽  
Riitta Koistinen ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Binding Protein ◽  
Postnatal Growth ◽  
Low Birth Weight Infants ◽  
Igf I ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Igfbp 3

scholarly journals Does enteral protein intake affect renal glomerular and tubular functions in very low birth weight infants?

2013 ◽  
Vol 80 (11) ◽  
pp. 355-360 ◽  
Author(s):  
Hayriye Gozde Kanmaz ◽  
Banu Mutlu ◽  
Omer Erdeve ◽  
Fuat Emre Canpolat ◽  
Serife Suna Oguz ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Protein Intake ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Tubular Functions

Amino Acid Concentrations in Plasma and Urine in Very Low Birth Weight Infants Fed Protein-Unenriched or Human Milk Protein-Enriched Human Milk

PEDIATRICS ◽  
1990 ◽  
Vol 86 (6) ◽  
pp. 909-915
Author(s):  
Staffan K. T. Polberger ◽  
Irene E. Axelsson ◽  
Niels C. R. Räihä
Keyword(s):  
Birth Weight ◽  
Amino Acid ◽  
Low Birth Weight ◽  
Human Milk ◽  
Protein Intake ◽  
Milk Protein ◽  
Very Low Birth Weight ◽  
Plasma Concentrations ◽  
Amino Acid Concentrations ◽  
Human Milk Protein

Preprandial plasma and urine amino acid concentrations were measured in 28 growing, very low birth weight, appropriate-for-gestational-age infants randomly assigned to either protein-unenriced (n = 14) or human milk protein-enriched (n = 14) human milk. The two groups of infants had similar birth weights (900 to 1500 g) and gestational ages (26 to 32 weeks). The study was initiated at a mean age of 19 days when the infants tolerated full feeding volumes and lasted for a mean time of 28 days. Mean protein intake values were 2.1 ± 0.3 and 3.6 ± 0.3 g/kg per day (mean ± SD) and weight gain values were 26.6 ± 7.4 and 35.1 ± 3.6 g/day in the protein-unenriched and the protein-enriched groups of infants, respectively. Human milk protein enrichment resulted in significantly increased concentrations of all plasma amino acids except serine, taurine, and histidine. Most urine amino acid concentrations correlated with protein intake and with the plasma concentrations, suggesting that the effects of protein quality and quantity can be evaluated by measuring urinary amino acid concentrations alone, thereby making such studies less invasive. Infants fed protein-unenriched human milk had growth rates below the estimated intrauterine rate as well as low plasma and urine amino acid concentrations, indicating suboptimal protein intake levels. When the plasma concentrations of the essential amino acids in tenrichedhe protein-enriched infants from the present study were compared with concentrations found in the literature in fetal and umbilical cord plasma, both were found to be much higher. The plasma essential amino acid concentrations in the well-growing, protein-supplemented infants from the present study corresponded best to plasma concentrations found in breast-fed, growing, term infants at 1 to 3 months of age. It is suggested that preprandial plasma amino acid concentrations found in healthy, growing, breast-fed, term infants can be used as reference standard values when evaluating preprandial plasma amino acid concentrations in appropriate-for-gestational age, very low birth weight infants.

scholarly journals The role of serum and urinary urea in the evaluation of enteral protein intake in adequate and small-for-gestational-age very low birth weight infants

2005 ◽  
Vol 123 (6) ◽  
pp. 261-265
Author(s):  
Silvana Darcie ◽  
Cléa Rodrigues Leone
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Protein Intake ◽  
Very Low Birth Weight ◽  
Pearson Correlation ◽  
Serum Urea ◽  
Low Birth Weight Infants ◽  
Vlbw Infants

CONTEXT AND OBJECTIVE: Very low birth weight (VLBW) infants have special nutritional needs. There is a current tendency to individualize their protein needs. The objective of this study was to determine the suitability of serum and urinary urea as indicators for protein intake in adequate-for-gestational-age (AGA) and small-for-gestational-age (SGA) VLBW infants. DESIGN AND SETTING: Prospective study in the nursery attached to the Maternity Ward of the "Prof. Pedro de Alcântara" Children's Institute, Hospital das Clínicas, Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, Brazil. METHODS: Seventy-two VLBW infants (mean protein intake = 3.7 mg/kg/day) were enrolled in a prospective cohort study in two groups: AGA (n = 34) and SGA (n = 38). Blood samples, six-hour urine (6hUr) collections and urine sample tests (STUr) were obtained for urea and creatinine assays at three and five weeks of life. Statistical analysis: Student's t test, Pearson correlation and linear regression (p < 0.05). RESULTS: There were no differences between groups for serum urea, 6hUr and STUr, or between two assessments within each group. Serum urea correlated with 6hUr in both AGA and SGA, and to STUr in SGA; 6hUr correlated with STUr in both AGA and SGA. There was no correlation between protein intake and serum or urine urea. CONCLUSIONS: Serum and urinary urea did not reflect protein intake when mean intakes of 3.7 g/kg/day were used. Sample tests of urinary urea can be as reliable as urea from urine collected over longer periods.

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