scholarly journals New Ablation Technologies and Techniques

2014 ◽  
Vol 3 (2) ◽  
pp. 107 ◽  
Author(s):  
Saagar Mahida ◽  
Benjamin Berte ◽  
Seigo Yamashita ◽  
Nicolas Derval ◽  
Arnaud Denis ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Cardiac Arrhythmias ◽  
Imaging Techniques ◽  
Novel Technologies ◽  
The Past ◽  
Resolution Imaging ◽  
Vt Ablation ◽  
Procedural Success ◽  
Established Treatment

Catheter ablation is an established treatment strategy for a range of different cardiac arrhythmias. Over the past decade two major areas of expansion have been ablation of atrial fibrillation (AF) and ventricular tachycardia (VT) in the context of structurally abnormal hearts. In parallel with the expanding role of catheter ablation for AF and VT, multiple novel technologies have been developed which aim to increase safety and procedural success. Areas of development include novel catheter designs, novel navigation technologies and higher resolution imaging techniques. The aim of the present review is to provide an overview of novel developments in AF ablation and VT ablation in patients with of structural cardiac diseases.

scholarly journals Role of Contact Force Sensing in Catheter Ablation of Cardiac Arrhythmias

2018 ◽  
Vol 4 (6) ◽  
pp. 707-723 ◽  
Author(s):  
Nilshan Ariyarathna ◽  
Saurabh Kumar ◽  
Stuart P. Thomas ◽  
William G. Stevenson ◽  
Gregory F. Michaud
Keyword(s):  
Catheter Ablation ◽  
Contact Force ◽  
Cardiac Arrhythmias ◽  
Force Sensing

scholarly journals The biophysical role of hemodynamics in the pathogenesis of cerebral aneurysm formation and rupture

2019 ◽  
Vol 47 (1) ◽  
pp. E11 ◽  
Author(s):  
Sauson Soldozy ◽  
Pedro Norat ◽  
Mazin Elsarrag ◽  
Ajay Chatrath ◽  
John S. Costello ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Aneurysm Rupture ◽  
Biological Interactions ◽  
Hemodynamic Forces ◽  
The Past ◽  
Aneurysm Formation ◽  
Hemodynamic Variables ◽  
Vessel Remodeling ◽  
Vessel Morphology

The pathogenesis of intracranial aneurysms remains complex and multifactorial. While vascular, genetic, and epidemiological factors play a role, nascent aneurysm formation is believed to be induced by hemodynamic forces. Hemodynamic stresses and vascular insults lead to additional aneurysm and vessel remodeling. Advanced imaging techniques allow us to better define the roles of aneurysm and vessel morphology and hemodynamic parameters, such as wall shear stress, oscillatory shear index, and patterns of flow on aneurysm formation, growth, and rupture. While a complete understanding of the interplay between these hemodynamic variables remains elusive, the authors review the efforts that have been made over the past several decades in an attempt to elucidate the physical and biological interactions that govern aneurysm pathophysiology. Furthermore, the current clinical utility of hemodynamics in predicting aneurysm rupture is discussed.

scholarly journals Pediatric catheter ablation at the beginning of the 21st century: results from the European Multicenter Pediatric Catheter Ablation Registry ‘EUROPA’

EP Europace ◽  
2020 ◽  
Author(s):  
Ulrich Krause ◽  
Thomas Paul ◽  
Paolo Della Bella ◽  
Simone Gulletta ◽  
Roman A Gebauer ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Pediatric Patients ◽  
Efficacy And Safety ◽  
Junctional Ectopic Tachycardia ◽  
Permanent Pacing ◽  
Focal Atrial Tachycardia ◽  
Vt Ablation ◽  
Procedural Success

Abstract Aims Contemporary data from prospective multicentre registries on catheter ablation in pediatric patients are sparse. Aim of the European Pediatric Catheter Ablation Registry EUROPA was to contribute data to fill this gap of knowledge. Methods and results From July 2012 to June 2017, data on catheter ablation in pediatric patients (≤18 years of age) including a 1-year follow-up from five European pediatric EP centres were collected prospectively. A total of 683 patients (mean age 12.4 ± 3.9 years, mean body weight 50.2 ± 19 kg) were enrolled. Target tachycardia was WPW/atrioventricular-nodal re-entrant tachycardia (AVRT) in 380 (55.7%) patients, AVNRT in 230 (33.8%) patients, ventricular tachycardia (VT) in 24 (3.5) patients, focal atrial tachycardia (FAT) in 20 (2.9%) patients, IART in 14 (2%) patients, and junctional ectopic tachycardia in 3 (0.45) patients. Overall procedural success was 95.6%. Compared with all other substrates, success was significantly lower in FAT patients (80%, n = 16, P = 0.001). Mean procedure duration was 136 ± 67 min and mean fluoroscopy time was 4.9 ± 6.8 min. Major complications occurred in 0.7% of the patients. No persisting AV block requiring permanent pacing was reported. At 1-year follow-up (605/683 patients, 95%), tachycardia recurrence was reported in 7.8% of patients. Recurrence after VT ablation (33%) was significantly higher (P = 0.001) than after ablation of all other substrates. Conclusion The present study proves overall high efficacy and safety of catheter ablation of various tachycardia substrates in pediatric patients. Of note, complication rate was exceptionally low. Long-term success was high except for patients after VT ablation.

scholarly journals Radiofrequency Ablation Strategies for Intramural Ventricular Arrhythmias

2021 ◽  
pp. 08-12
Keyword(s):  
Radiofrequency Ablation ◽  
Catheter Ablation ◽  
Ventricular Arrhythmias ◽  
Radiofrequency Energy ◽  
Success Rates ◽  
The Past ◽  
Energy Delivery ◽  
Radiofrequency Energy Delivery ◽  
Mapping Techniques ◽  
Established Treatment

Catheter ablation is an established treatment strategy for ventricular arrhythmias. However, the presence of intramural substrate poses challenges with mapping and delivery of radiofrequency energy, limiting overall success of catheter ablation. Advances over the past decade have improved our understanding of intramural substrate and paved the way for innovative treatment approaches. Modifications in catheter ablation techniques and development of novel ablation technologies have led to improved clinical outcomes for patients with ventricular arrhythmias. In this review, we explore mapping techniques to identify intramural substrate and describe available radiofrequency energy delivery techniques that can improve overall success rates of catheter ablation.

Imaging Techniques for the Evaluation of Glenohumeral Instability

2000 ◽  
Vol 28 (3) ◽  
pp. 414-434 ◽  
Author(s):  
Timothy G. Sanders ◽  
William B. Morrison ◽  
Mark D. Miller
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Conventional Radiography ◽  
Magnetic Resonance Arthrography ◽  
Resonance Imaging ◽  
Glenohumeral Instability ◽  
The Past

The ability to image lesions associated with glenohumeral instability has evolved significantly over the past 2 decades. In the past, several imaging techniques ranging from conventional radiography to computerized axial arthrography and, most recently, to magnetic resonance imaging have been used to depict various labral abnormalities. In most instances, conventional radiography remains the initial imaging study for evaluating the patient with persistent shoulder pain and instability. Recently, however, magnetic resonance arthrography has been firmly established as the imaging modality of choice for demonstrating specific soft tissue abnormalities associated with glenohumeral instability. This article will review the role of various imaging modalities including conventional radiography, conventional arthrography, computerized axial arthrography, magnetic resonance imaging, and magnetic resonance arthrography. Emphasis will be placed on the role of magnetic resonance arthrography as it pertains to the lesions associated with glenohumeral instability. A thorough discussion of the appearance of normal anatomic structures, anatomic variations that mimic abnormality, and the various lesions associated with glenohumeral instability will be provided.

scholarly journals The Role of the Electrophysiologist in Convergent Ablation

2020 ◽  
Vol 9 (1) ◽  
pp. 8-14
Author(s):  
Nadeev Wijesuriya ◽  
Nikos Papageorgiou ◽  
Edd Maclean ◽  
Bunny Saberwal ◽  
Syed Ahsan
Keyword(s):  
Catheter Ablation ◽  
Sinus Rhythm ◽  
Radiofrequency Catheter Ablation ◽  
Hybrid Technique ◽  
Surgical Ablation ◽  
Safety And Efficacy ◽  
Hybrid Ablation ◽  
Established Treatment ◽  
The Coordinator

Catheter ablation is a well-established treatment for patients with AF in whom sinus rhythm is desired. Both radiofrequency catheter ablation and cryoablation are widely performed, rapidly developing techniques. Convergent ablation is a novel hybrid technique combining an endocardial radiofrequency ablation with a minimally invasive epicardial surgical ablation. Some suggest that hybrid ablation may be more effective than lone endocardial ablation in achieving the elusive goal of maintaining sinus rhythm in patients with non-paroxysmal AF. In this article, the authors examine the safety and efficacy of catheter ablation and convergent ablation for long-standing, persistent AF. We also outline the crucial role that electrophysiologists play, not only as a procedure operator, but also as the coordinator and developer of this multidisciplinary service.

scholarly journals Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis

2021 ◽  
Author(s):  
Roberta Costa ◽  
Maria Teresa Rodia ◽  
Nicoletta Zini ◽  
Valentina Pegoraro ◽  
Roberta Marozzo ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Alternative Splicing ◽  
Imaging Techniques ◽  
Splicing Factors ◽  
Structured Illumination ◽  
Muscle Disorders ◽  
Electron Microscopy Analysis ◽  
Microscopy Analysis ◽  
Resolution Imaging

AbstractTransportin3 (TNPO3) shuttles the SR proteins from the cytoplasm to the nucleus. The SR family includes essential splicing factors, such as SRSF1, that influence alternative splicing, controlling protein diversity in muscle and satellite cell differentiation. Given the importance of alternative splicing in the myogenic process and in the maintenance of healthy muscle, alterations in the splicing mechanism might contribute to the development of muscle disorders. Combining confocal, structured illumination and electron microscopy, we investigated the expression of TNPO3 and SRSF1 during myogenesis, looking at nuclear and cytoplasmic compartments. We investigated TNPO3 and its interaction with SRSF1 and we observed that SRSF1 remained mainly localized in the nucleus, while TNPO3 decreased in the cytoplasm and was strongly clustered in the nuclei of differentiated myotubes. In conclusion, combining different imaging techniques led us to describe the behavior of TNPO3 and SRSF1 during myogenesis, showing that their dynamics follow the myogenic process and could influence the proteomic network necessary during myogenesis. The combination of different high-, super- and ultra-resolution imaging techniques led us to describe the behavior of TNPO3 and its interaction with SRSF1, looking at nuclear and cytoplasmic compartments. These observations represent a first step in understanding the role of TNPO3 and SRFSF1 in complex mechanisms, such as myogenesis.

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