scholarly journals High-intensity interval training improved fasting blood glucose and lipid profiles in type 2 diabetic rats more than endurance training; possible involvement of irisin and betatrophin

2019 ◽  
Vol 106 (3) ◽  
pp. 213-224 ◽  
Author(s):  
J Amri ◽  
M Parastesh ◽  
M Sadegh ◽  
SA Latifi ◽  
M Alaee
Keyword(s):  
Blood Glucose ◽  
High Intensity ◽  
Fasting Blood Glucose ◽  
Interval Training ◽  
Diabetic Rats ◽  
Lipid Profiles ◽  
High Intensity Interval Training ◽  
Training Groups ◽  
High Intensity Interval

Background and aims In this study, we aimed to investigate the effects of 10 weeks of high-intensity interval training (HIIT) and endurance training (END) on irisin, betatrophin, insulin, fasting blood glucose (FBG) concentrations, and lipid profiles in diabetic rats. Methods Twenty-four Wistar rats (weight: 200–250 g) were randomly assigned into four groups as follows: (1) control (Cnt), (2) diabetic (Dibt), (3) diabetic HIIT (Dibt-HIIT), and (4) diabetic END (Dibt-END). For inducing diabetes, after 12 h of food starvation, nicotinamide (120 mg/kg) and streptozotocin (STZ; 65 mg/kg) were intraperitoneally injected. The diabetic training groups received 10 weeks of HIIT or END training following the induction of diabetes. Twenty-four hours following the last training session, blood serum samples were collected for evaluating the concentration of irisin, betatrophin, and insulin hormones through enzyme-linked immunosorbent assay. Results FBG and lipid profiles were measured by biochemical kits. A significant increase in the serum concentration of irisin (p < 0.05), betatrophin (p < 0.05), and insulin (p < 0.001) and significant decrease in the FBG (P < 0.01) and lipid profiles (p < 0.01) were observed in the Dibt-HIIT group compared to the Dibt-END group. In addition, irisin revealed a significant positive association with betatrophin and insulin values in diabetic training groups (p < 0.01). Conclusions It seems that HIIT leads to a more extensive improvement in diabetic conditions compared to the END training. Therefore, HIIT appears to be an important time-efficient approach for the treatment of type 2 diabetes.

scholarly journals Effects of High Intensity Interval Training on the Gene Expression of PGC1-Α, CS and P-53 in the Cardiomyocyte of Male Obese Rats in Type 2 Diabetes

2021 ◽  
Author(s):  
Nadia Khayampour ◽  
Maghsoud Peeri ◽  
Mohammad Ali Azarbayjani ◽  
Maryam Delfan
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Diabetic Rats ◽  
Diabetic Patients ◽  
High Intensity Interval Training ◽  
Healthy Control ◽  
High Intensity Interval ◽  
Obese Male ◽  
P 53

Introduction: Exercise training with different intensity regulates metabolism at the cellular level by regulating the expression of genes involved in mitochondrial biogenesis in diabetic patients. The aim of this study was to evaluate the effect of 4 weeks of high intensity interval training on the expression of PGC-1α, CS and p-53 genes in the cardiomyocytes of obese male rats with type 2 diabetes. Methods: The present study was an experimental one. Eighteen obese male diabetic rats were divided into three groups of six: high intensity interval training (HIIT), diabetic control (DC), healthy control (NC). Diabetes was induced in all groups except the healthy control group by streptozotocin (STZ) injection. After anesthesia, blood serum was obtained directly from their left ventricle and immediately extracted from their left ventricle. Plasma glucose was measured by glucose oxidase assay. To determine the expression of PGC-1α, CS and P-53 genes, PCR-Real time method and group comparison were used by one-way ANOVA test with application 8 version  graph pad prism at alpha level of 0.05. Results: The increase in PGC-1α gene expression in HIIT group compared to DC (P = 0.0001) and NC (P = 0.001) groups was significant. Increased expression of CS gene in HIIT group was significant compared to DC (P = 0.0001) and NC (P = 0.009) groups. Decreased expression of P-53 gene in HIIT group compared to DC (P = 0.0001) and NC (P = 0.001) groups were significantly different. Weight and glucose were significantly reduced in the HIIT group. Conclusion: The results showed that by increasing the PGC-1α, CS genes and decreasing the expression of P-53 gene in cardiomyocytes of obese diabetic rats, it improves the energy metabolism in diabetic patients due to mitochondrial deficiency and possibly it can improve diabetic cardiomyopathy.

553-P: Differential Effects of High-Intensity Interval Training on Somatosensory and Autonomic Nerve Function in Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 553-P
Author(s):  
GIDON J. BÖNHOF ◽  
ALEXANDER STROM ◽  
MARIA APOSTOLOPOULOU ◽  
DOMINIK PESTA ◽  
MICHAEL RODEN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Intensity ◽  
Interval Training ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
High Intensity Interval Training ◽  
Differential Effects ◽  
Autonomic Nerve Function ◽  
High Intensity Interval

scholarly journals Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Zhaowei Kong ◽  
Shengyan Sun ◽  
Min Liu ◽  
Qingde Shi
Keyword(s):  
Body Composition ◽  
Blood Glucose ◽  
Cardiorespiratory Fitness ◽  
Young Women ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Short Term ◽  
High Intensity Interval

This study was to determine the effects of five-week high-intensity interval training (HIIT) on cardiorespiratory fitness, body composition, blood glucose, and relevant systemic hormones when compared to moderate-intensity continuous training (MICT) in overweight and obese young women.Methods. Eighteen subjects completed 20 sessions of HIIT or MICT for five weeks. HIIT involved 60 × 8 s cycling at ~90% of peak oxygen consumption (V˙O2peak) interspersed with 12 s recovery, whereas MICT involved 40-minute continuous cycling at 65% ofV˙O2peak.V˙O2peak, body composition, blood glucose, and fasting serum hormones, including leptin, growth hormone, testosterone, cortisol, and fibroblast growth factor 21, were measured before and after training.Results. Both exercise groups achieved significant improvements inV˙O2peak(+7.9% in HIIT versus +11.7% in MICT) and peak power output (+13.8% in HIIT versus +21.9% in MICT) despite no training effects on body composition or the relevant systemic hormones. Blood glucose tended to be decreased after the intervention (p=0.062). The rating of perceived exertion in MICT was higher than that in HIIT (p=0.042).Conclusion. Compared with MICT, short-term HIIT is more time-efficient and is perceived as being easier for improving cardiorespiratory fitness and fasting blood glucose for overweight and obese young women.

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