scholarly journals A diabetes és a depresszió együttes előfordulása, lehetséges kétirányú kapcsolata és szűrésük jelentősége

2019 ◽  
Vol 160 (21) ◽  
pp. 807-814
Author(s):  
Csenge Hargittay ◽  
Bernadett Márkus ◽  
Krisztián Vörös ◽  
Gy. Ádám Tabák
Keyword(s):  
Quality Of Life ◽  
Environmental Factors ◽  
Effective Treatment ◽  
Genetic Variants ◽  
Disease Onset ◽  
Internal Factors ◽  
Adequate Treatment ◽  
Timely Diagnosis ◽  
Physiological Processes

Abstract: Diabetes and depression are considered global epidemics. Both have multifactorial aetiologies, including external, environmental factors and internal factors in connection with physiological processes as well as genetic variants triggering disease onset. Although the co-occurrence of diabetes and depression is well described, the mechanisms underlying these diseases and their interactions are still not entirely revealed. The authors aimed to present known and potential explanations of the co-occurrence of these diseases and to highlight the importance of their timely diagnosis and effective treatment, as their co-occurrence may increase morbidity and mortality. Screening for depression among diabetes patients and for diabetes among patients with depression may decrease the incidence of complications and consequences of this comorbidity and may foster more effective treatment. General practitioners play a key role in the care of both diseases by providing timely diagnosis and adequate treatment potentially leading to a better quality of life, slower disease progression and decreased risk of complications. Orv Hetil. 2019; 160(21): 807–814.

scholarly journals OVERACTIVE BLADDER

World Science ◽  
2020 ◽  
Vol 1 (4(56)) ◽  
pp. 15-19
Author(s):  
Yordanov Delyan ◽  
Yordanova Lilyna
Keyword(s):  
Quality Of Life ◽  
Overactive Bladder ◽  
Negative Impact ◽  
Steady Increase ◽  
Overactive Bladder Syndrome ◽  
Basic Principles ◽  
Adequate Treatment ◽  
Timely Diagnosis ◽  
Methods Of Treatment

In recent years, there has been a steady increase in patients visiting a specialist for what is known as overactive bladder syndrome. Due to the extremely negative impact of the disease on patients' quality of life, timely diagnosis and adequate treatment choices are of the utmost importance. The guidelines presented include a description of the etiology and pathogenesis, basic principles of diagnosis, and current methods of treatment for this category of patients.

scholarly journals Treadmill in Parkinson’s: influence on gait, balance, BDNF and Reduced Glutathione

2017 ◽  
Vol 30 (suppl 1) ◽  
pp. 93-100
Author(s):  
Luciana Dias Belchior ◽  
Betina Santos Tomaz ◽  
Ana Paula Vasconcellos Abdon ◽  
Norberto Anizio Ferreira Frota ◽  
Daniela Gardano Bucharles Mont’Alverne ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Reduced Glutathione ◽  
Demographic Data ◽  
Strong Association ◽  
Disease Onset ◽  
Depression Scale ◽  
Blood Parameters ◽  
Treadmill Training ◽  
Static And Dynamic Analysis

Abstract Introduction: Parkinson’s disease (PD) is characterized by nigrostriatal degeneration, with dopaminergic depletion, and inflammatory and oxidative changes in the brain, leading to movement and coordination disorders. Recent studies have shown that treadmill training can be beneficial for these patients, but there is little evidence assessing the related blood parameters, such as oxidative stress and neurotrophin levels. Objective: Assess the influence of treadmill training for patients with Parkinson’s on gait, balance, Brain-Derived Neurotrophic Factor (BDNF) and reduced glutathione. Methods: Twenty-two patients with PD (Hoehn and Yahr II and III), older than 40 years, were randomly allocated to two groups: CG (n = 12) - drug treatment and IG (n = 10) - treadmill. Assessments related to functional capacity (quality of life, static and dynamic analysis of gait) and blood parameters such as GSH and BDNF were conducted before and after the eight-week intervention. Results: The demographic data of the groups were homogeneous in terms of age, sex, height, weight, time since disease onset, mini mental examination and the geriatric depression scale. Significant intergroup differences were found for the mental component summary, surface variation, latero-lateral oscillation, antero-posterior oscillation and mean velocity in the post-intervention period. The IG exhibited a strong association between BDNF and GSH, with statistically significant values. Conclusion: It was concluded that controlled treadmill walking improves static balance, quality of life and plasma BDNF and GSH levels in patients with PD.

scholarly journals Personalized, Predictive, Participatory, Precision, and Preventive (P5) Medicine in Rotator Cuff Tears

2021 ◽  
Vol 11 (4) ◽  
pp. 255
Author(s):  
Umile Giuseppe Longo ◽  
Arianna Carnevale ◽  
Carlo Massaroni ◽  
Daniela Lo Presti ◽  
Alessandra Berton ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rotator Cuff ◽  
Environmental Factors ◽  
Multidisciplinary Approach ◽  
Musculoskeletal Disorder ◽  
Scientific Evidence ◽  
Rotator Cuff Tears ◽  
Diagnosis And Therapy

Rotator cuff (RC) disease is a common musculoskeletal disorder of the shoulder entailing pain, with reduced functionality and quality of life. The main objective of this study was to present a perspective of the current scientific evidence about personalized, predictive, participatory, precision, and preventive approaches in the management of RC diseases. The personalized, predictive, participatory, precision and preventive (P5) medicine model is an interdisciplinary and multidisciplinary approach that will provide researchers and clinicians with a comprehensive patrimony of knowledge in the management of RC diseases. The ability to define genetic predispositions in conjunction with the evaluation of lifestyle and environmental factors may boost the tailoring of diagnosis and therapy in patients suffering from RC diseases.

scholarly journals Quality of life in patients with no-option critical limb ischemia underlines the need for new effective treatment

2010 ◽  
Vol 52 (4) ◽  
pp. 843-849.e1 ◽  
Author(s):  
Ralf W. Sprengers ◽  
Martin Teraa ◽  
Frans L. Moll ◽  
G. Ardine de Wit ◽  
Yolanda van der Graaf ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Effective Treatment ◽  
Critical Limb Ischemia ◽  
Limb Ischemia

Prediction of quality of life in people with ALS

2021 ◽  
Vol 21 (2) ◽  
pp. 5-17
Author(s):  
Anna Markella Antoniadi ◽  
Miriam Galvin ◽  
Mark Heverin ◽  
Orla Hardiman ◽  
Catherine Mooney
Keyword(s):  
Quality Of Life ◽  
Disease Onset ◽  
Model Performance ◽  
Sampling Technique ◽  
Clinical Decision ◽  
Gradient Boosting ◽  
Rapid Decline ◽  
Extreme Gradient Boosting ◽  
Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disease that causes a rapid decline in motor functions and has a fatal trajectory. ALS is currently incurable, so the aim of the treatment is mostly to alleviate symptoms and improve quality of life (QoL) for the patients. The goal of this study is to develop a Clinical Decision Support System (CDSS) to alert clinicians when a patient is at risk of experiencing low QoL. The source of data was the Irish ALS Registry and interviews with the 90 patients and their primary informal caregiver at three time-points. In this dataset, there were two different scores to measure a person's overall QoL, based on the McGill QoL (MQoL) Questionnaire and we worked towards the prediction of both. We used Extreme Gradient Boosting (XGBoost) for the development of the predictive models, which was compared to a logistic regression baseline model. Additionally, we used Synthetic Minority Over-sampling Technique (SMOTE) to examine if that would increase model performance and SHAP (SHapley Additive explanations) as a technique to provide local and global explanations to the outputs as well as to select the most important features. The total calculated MQoL score was predicted accurately using three features - age at disease onset, ALSFRS-R score for orthopnoea and the caregiver's status pre-caregiving - with a F1-score on the test set equal to 0.81, recall of 0.78, and precision of 0.84. The addition of two extra features (caregiver's age and the ALSFRS-R score for speech) produced similar outcomes (F1-score 0.79, recall 0.70 and precision 0.90).

scholarly journals Primary and Secondary Cone Cell Death Mechanisms in Inherited Retinal Diseases and Potential Treatment Options

2022 ◽  
Vol 23 (2) ◽  
pp. 726
Author(s):  
Alicia A. Brunet ◽  
Alan R. Harvey ◽  
Livia S. Carvalho
Keyword(s):  
Quality Of Life ◽  
Cell Death ◽  
Effective Treatment ◽  
Treatment Options ◽  
Retinal Diseases ◽  
Potential Treatment ◽  
Cone Cell ◽  
Similarities And Differences ◽  
Cell Death Mechanisms

Inherited retinal diseases (IRDs) are a leading cause of blindness. To date, 260 disease-causing genes have been identified, but there is currently a lack of available and effective treatment options. Cone photoreceptors are responsible for daylight vision but are highly susceptible to disease progression, the loss of cone-mediated vision having the highest impact on the quality of life of IRD patients. Cone degeneration can occur either directly via mutations in cone-specific genes (primary cone death), or indirectly via the primary degeneration of rods followed by subsequent degeneration of cones (secondary cone death). How cones degenerate as a result of pathological mutations remains unclear, hindering the development of effective therapies for IRDs. This review aims to highlight similarities and differences between primary and secondary cone cell death in inherited retinal diseases in order to better define cone death mechanisms and further identify potential treatment options.

scholarly journals Impact of Periodontal Disease on the Quality of Life of Older People in Indonesia: A Qualitative Study

2021 ◽  
pp. 238008442110419
Author(s):  
M. Hijryana ◽  
M. MacDougall ◽  
N. Ariani ◽  
L.S. Kusdhany ◽  
A.W.G. Walls
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Environmental Factors ◽  
Periodontal Disease ◽  
Older People ◽  
Structured Interviews ◽  
Research Perspective ◽  
The Impact ◽  
People’S Perceptions

Introduction: The impact of periodontal disease on oral health–related quality of life (OHRQoL) has often been investigated from a quantitative research perspective, which is based on clinical findings and an OHRQoL questionnaire. Very few studies have examined the issue from the view of qualitative research. To our knowledge, there have been no previous qualitative studies focusing the effect of periodontal disease on OHRQoL in Indonesian older people. Objectives: To explore and understand the impact of periodontal disease on the OHRQoL of older people as a subjective reflection in relation to periodontal disease experiences. Methods: Semi-structured interviews were conducted in a sample of 31 older people with generalized chronic periodontitis. Thematic analysis was used to identify the key issues in participants’ accounts. The analysis was undertaken by 2 independent coders to ensure reliability. To achieve thematic saturation, successive interviews were undertaken until 5 sequential interviews did not bring new themes. Results: Participants reported the negative effects likely related to periodontal disease. The impacts of periodontal disease were described by these older people as affecting more than pain, physical discomfort, and physical function restrictions. Periodontal disease also affected their psychological and social aspects of daily living. In addition, this study identified themes related to individual and environmental factors that may modify and personalize periodontal disease experiences. Furthermore, this study identified a misleading belief that problems related to periodontal disease were a normal part of aging, which might influence individuals’ expectations toward oral health. Relatedly, participants frequently reported that the progression of tooth mobility to tooth loss was an inevitable part of the aging process. Conclusions: Periodontal disease negatively affected participants’ OHRQoL. It is fundamental to understand older people’s perceptions toward their periodontal disease as well as individual and environmental factors that may have an influence on their periodontal disease experiences. Knowledge Transfer Statement: This study is a reflection of Indonesian older people’s subjective periodontal disease experiences. Therefore, the present study can be used to understand older people’s perceptions, attitudes, behaviors, and experiences toward periodontal disease and how this disease may affect their quality of life. This study also highlights a widespread and misleading belief that oral problems related to periodontal disease are an inevitable part of aging in this study population.

Behavioural and psychological symptoms of dementia

2020 ◽  
pp. 247-258
Author(s):  
Rianne van der Linde ◽  
Tom Dening
Keyword(s):  
Quality Of Life ◽  
Environmental Factors ◽  
Psychological Symptoms ◽  
Symptom Clusters ◽  
Psychotic Symptoms ◽  
Mixed Group ◽  
People With Dementia ◽  
Affective Symptoms ◽  
Behavioural And Psychological Symptoms

The term: ‘behavioural and psychological symptoms of dementia’ (BPSD) refers to a mixed group of phenomena. BPSD are the non-cognitive features of dementia and include depression, anxiety, psychotic symptoms, apathy, irritability, aggression, and sleep and eating problems. They occur in around 80% of people with dementia at some stage, several of them becoming more frequent as dementia progresses. Some BPSD, notably apathy, are very persistent. BPSD often limit the person’s quality of life and can be stressful for carers. Causes of BPSD include biological, psychological, social, and environmental factors. This chapter explores how they are assessed and measured, and how they may usefully grouped together in symptom clusters. Usually four symptom groups are found: affective symptoms, psychosis, hyperactivity, and euphoria. However, these are not always consistent and in particular apathy does not consistently belong in one group. Approaches to management of BPSD are outlined.

Psychosocial Treatments for Schizophrenia

2007 ◽  
pp. 243-270
Author(s):  
Alex Kopelowicz ◽  
Robert Paul Liberman ◽  
Roberto Zaratem
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Environmental Factors ◽  
Protective Factors ◽  
Psychiatric Treatment ◽  
Psychosocial Treatments ◽  
Level Of Functioning ◽  
Stress Vulnerability ◽  
Persons With Schizophrenia

Data from hundreds of intervention research studies validate a biopsychosocial view of treatment for schizophrenia that combines pharmacotherapy with psychosocial treatments and social support. Based on the stress-vulnerability-protective factors model, these treatments work by strengthening biological, personal, and environmental factors that protect against relapse while mitigating the stressors that adversely affect the course of schizophrenia. Psychiatric treatment and rehabilitation must be integrated in a seamless approach aimed at restoring persons with schizophrenia to their best possible level of functioning and quality of life.

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