Clinical factors determining the efficacy of urinary bladder tumour treatments in dogs: Surgery, chemotherapy or both?

2012 ◽  
Vol 60 (1) ◽  
pp. 55-68 ◽  
Author(s):  
Tamás Molnár ◽  
Péter Vajdovich
Keyword(s):  
Urinary Bladder ◽  
Bladder Tumour ◽  
Transitional Cell ◽  
Clinical Factors ◽  
Survival Times ◽  
High Incidence ◽  
Close Relationship ◽  
Assessment And Treatment ◽  
Urinary Bladder Tumour ◽  
Disease Free

In a study of 44 canine patients suffering from histopathologically proven urinary bladder tumour with a high incidence of transitional cell carcinoma (TCC) (n = 35), a close relationship was found either between the disease-free period and the age (r = −0.40) of animals or between the survival times and the age (r = −0.62) of animals after treatment. In addition to the dog breeds known to be prone to have urinary bladder tumour, we found an additional potentially sensitive breed, the Hungarian Vizsla. The median survival times obtained by the applied treatment types were as follow: ‘surgery and chemotherapy’ (n = 8/44) 475 days, ‘surgery alone’ (n = 19/44) 240 days, ‘chemotherapy alone’ (n = 7/44) 31 days, and ‘no treatment’ (n = 10/44) 7 days (P < 0.001). According to the findings, chemotherapy combined with surgery completed in time is the most effective protocol in the treatment of urinary bladder tumour cases in dogs. A rational and more effective procedure for the assessment and treatment of urinary bladder tumour cases is presented.

scholarly journals Case report of leiomyosarcoma, a very rare type of urinary bladder tumour

2017 ◽  
Vol 73 (7) ◽  
pp. 439-444
Author(s):  
Aleksandra Sobczyńska-Rak ◽  
Izabela Polkowska ◽  
Beata Żylińska ◽  
Anna Śmiech ◽  
Anna Łojszczyk- Szczepanik
Keyword(s):  
Urinary Bladder ◽  
Bladder Tumour ◽  
Transitional Cell ◽  
Diagnostic Techniques ◽  
Urinary Flow ◽  
Rare Type ◽  
Regional Lymph Nodes ◽  
Abdominal Organs ◽  
Urinary Bladder Tumour ◽  
Bladder Tumours

Urinary bladder tumours account for approximately 1% of all tumours in dogs. The majority of them are epithelial in origin and malignant. Transitional cell carcinoma (TCC) is the most commonly diagnosed tumour of the urinary bladder. Malignant mesenchymal tumours in humans and animals are far less frequent than epithelial ones. Malignant mesenchymal urinary bladder tumours are represented by rabdomyosarcoma (RMS) and leiomyosarcoma (LMS). LMS occurs in older dogs, aged 7 - 12 years, and originates from the urinary bladder trigone and urethra, thus disturbing the urinary flow. LMSs are usually invasive, with a tendency to metastasize rapidly to the regional lymph nodes or abdominal organs, such as the liver, pancreas, kidneys, intestines and omentum. The aim of this report is to describe the clinical presentation, diagnostic approach and surgical treatment of the urinary bladder leiomyosarcoma that occurred in a Bernese Mountain Dog. The paper also highlights the latest diagnostic techniques for urinary bladder tumour detection, general rules of surgical resection and chemotherapy.

scholarly journals Degeneration of the symphysis pubis presenting as a submucosal urinary bladder tumour

2012 ◽  
Vol 1 ◽  
pp. 55-58
Author(s):  
Tomasz R. Szopiński ◽  
Iwona Sudoł-Szopińska ◽  
Mariusz I. Furmanek ◽  
Tomasz Dzik ◽  
Piotr L. Chłosta ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Bladder Tumour ◽  
Symphysis Pubis ◽  
Urinary Bladder Tumour

scholarly journals A rare urinary bladder tumour

2014 ◽  
Vol 2014 (may15 1) ◽  
pp. bcr2013202994-bcr2013202994 ◽  
Author(s):  
J. E. M. Haddad-Lacle ◽  
C. J. Haddad ◽  
B. Villas
Keyword(s):  
Urinary Bladder ◽  
Bladder Tumour ◽  
Urinary Bladder Tumour

Clinical multi-colour fluorescence imaging of malignant tumours - initial experience

1998 ◽  
Vol 39 (1) ◽  
pp. 2-9 ◽  
Author(s):  
K. Svanberg ◽  
I. Wang ◽  
S. Colleen ◽  
I. Idvall ◽  
C. Ingvar ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Fluorescence Imaging ◽  
Bladder Tumour ◽  
Neck Region ◽  
Malignant Tumours ◽  
Head And Neck Region ◽  
Tumour Detection ◽  
Non Invasive ◽  
Urinary Bladder Tumour

Purpose: the detection of malignant tumours relies on a variety of diagnostic procedures including X-ray images and, for hollow organs, endoscopy. the purpose of this study was to present a new technique for non-invasive tumour detection based on tissue fluorescence imaging Material and Methods: A clinically adapted multi-colour fluorescence system was employed in the real-time imaging of malignant tumours of the skin, breast, head and neck region, and urinary bladder. Tumour detection was based on the contrast displayed in fluorescence between normal and malignant tissue, related to the selective uptake of tumour-marking agents, such as haematoporphyrin derivative (HPD) and δ-amino levulinic acid (ALA), and natural chromophore differences between various tissues. in order to demarcate basal cell carcinomas of the skin, ALA was applied topically 4–6 h before the fluorescence investigation. for urinary bladder tumour visualisation (transitional cell carcinoma of different stages including carcinoma in situ), ALA was instilled into the bladder 1–2 h prior to the study. Malignant and premalignant lesions in the head and neck region were imaged after i.v. injection of HPD (Photofrin). Finally, the extent of in situ and invasive carcinomas of the breast was investigated in surgically excised specimens from patients that received a low-dose injection of HPD 24 h prior to the study. the tumour imaging system was coupled to an endoscope. Fluorescence light emission from the tissue surface was induced with 100-nslong optical pulses at 390 nm, generated from a frequency-doubled alexandrite laser. with the use of special image-splitting optics, the tumour fluorescence, intensified in a micro-channel plate, was imaged in 3 selected wavelength bands. These 3 images were processed together to form a new optimised-contrast image of the tumour. This image, updated at a rate of about 3 frames/s, was mixed with a normal colour video image of the tissue Results: A clear demarcation from normal surrounding tissue was found during in vivo measurements of superficial bladder carcinoma, basal cell carcinoma of the skin, and leukoplakia with dysplasia of the lip, and in in vitro investigations of resected breast cancer Conclusions: the initial clinical experience of using multi-colour fluorescence imaging has shown that the technique has the potential to reveal malignant tumour tissue, including non-invasive early carcinoma and also precancerous tissue. Further investigations are needed to fully develop the method

scholarly journals En-bloc resection of urinary bladder tumour – a prospective controlled multicentre observational study

2020 ◽  
Author(s):  
Sławomir Poletajew ◽  
Wojciech Krajewski ◽  
Paweł Stelmach ◽  
Jan Adamowicz ◽  
Łukasz Nowak ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Observational Study ◽  
Bladder Tumour ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
En Bloc ◽  
Urinary Bladder Tumour

Paediatric urinary bladder 'tumour' due to perforated appendicitis

2003 ◽  
Vol 33 (12) ◽  
pp. 900-901
Author(s):  
Bela Lombay ◽  
Istvan Csizy ◽  
Katalin Losonczi ◽  
Eva Borbas ◽  
Edit Nyari ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Bladder Tumour ◽  
Perforated Appendicitis ◽  
Urinary Bladder Tumour

scholarly journals Long Non-Coding RNA MALAT1 Gene Polymorphism is Associated with Disease-Free Survival in Bladder Cancer Patients

2020 ◽  
Vol 27 (2) ◽  
pp. E202025
Author(s):  
Andrii Volkogon ◽  
Olena Kolnoguz ◽  
Viktoriia Harbuzova ◽  
Alexander Ataman
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Real Time ◽  
Cox Regression ◽  
Transitional Cell ◽  
Disease Free Survival ◽  
Free Survival ◽  
Disease Free

The objective of the research was to study the possible association between MALAT1 gene rs3200401 polymorphism and the survival of patients with bladder cancer and clinicopathological characteristics in bladder cancer. Materials and Methods. The venous blood of 141 patients with transitional cell carcinoma of the urinary bladder was used for study. Genotyping of MALAT1 gene rs3200401 polymorphism was performed by real-time polymerase chain reaction using the 7500 Fast Real-Time PCR System (Applied Biosystems, Foster City, USA) and Taq-Man Assays (TaqMan® SNP Assay C_3246069_10). Statistical analysis was performed using the SPSS software package (version 17.0). The Kaplan-Meier estimator and Cox regression were used to check the possible association between MALAT1 rs3200401-genotypes and the age of transitional cell carcinoma of the urinary bladder onset. P values ​​< 0.05 were considered as statistically significant. Results. The obtained results revealed that hemoglobin concentration was lower in patients with transitional cell carcinoma of the urinary bladder and rs3200401TT-genotype than in patients with rs3200401CC-genotype (p=0.024). Herewith, fasting glucose, creatinine concentration, and tumor width were significantly higher in patients with transitional cell carcinoma of the urinary bladder and rs3200401TT-genotype as compared to rs3200401CC-genotype carriers (p = 0.036, p = 0.039, p = 0.028, respectively). The results of survival analysis demonstrated that transitional cell carcinoma of the urinary bladder occurred much later in persons with rs3200401TT-genotype as compared to rs3200401C-allele carriers (log rank p = 0.016), and the risk of transitional cell carcinoma of the urinary bladder onset was lower in individuals with rs3200401TT than in major rs3200401C C-allele carriers (hazard ratio = 0.413; p = 0.047). Conclusions. Rs3200401 polymorphism of MALAT1 gene is associated with disease-free survival in Ukrainian patients with transitional cell carcinoma of the urinary bladder. Transitional cell carcinoma of the urinary bladder occurs later in persons with rs3200401TT-genotype than in individuals with rs3200401CC- and rs3200401CT-genotypes.

scholarly journals Urothelial Tumours of the Urinary Bladder: A Histopathological Study of Cystoscopic Biopsies

2013 ◽  
Vol 52 (191) ◽  
Author(s):  
Sujan Vaidya ◽  
Mamata Lakhey ◽  
Sabira KC ◽  
Suspana Hirachand
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bladder Tumour ◽  
Transitional Cell ◽  
Histopathological Study ◽  
Low Grade ◽  
High Grade ◽  
Urothelial Tumours ◽  
Bladder Tumours

Introduction: Bladder tumours constitute one of the most common urological conditions. Urothelial(transitional cell) carcinoma accounts for 90% of all primary tumours of the bladder. These tumoursare an important cause of morbidity and mortality. The objective of this study was to present thehistopathological patterns of urothelial tumours and to determine the grade and stage of thesetumours.Methods: This is a 3 year descriptive study of urothelial tumours carried out in the Departmentof Pathology, Patan Academy of Health Sciences (PAHS), Lalitpur, Nepal. Data of all cystoscopicbiopsies collected during this period were analyzed.Results: Of the 83 urinary bladder tumours, 81 (97.59%) cases were urothelial (transitional cell)tumours. Transitional cell carcinoma (TCC) was the most common bladder tumour which was seenin 67 (80.72%) cases. Thirty two (47.76%) cases of TCC were low grade while 35 (52.24%) were highgrade. Forty three (64.18%) cases of TCC were superficial or in early stage (pTa and pT1) while 24(35.82%) showed muscle invasion.Conclusions: Transitional cell carcinoma was the most common bladder cancer. Most of thesetumours were high grade. A large percentage of high grade carcinomas presented with muscleinvasion. Pathological grade and muscle invasion are the most valuable prognostic predictorsof survival. The importance of including smooth muscle in the biopsy specimens needs to beemphasized._______________________________________________________________________________________Keywords: cancer; high grade; low grade; transitional tumour; urinary bladder._______________________________________________________________________________________

scholarly journals No Evidence of Human Polyomavirus 9, WU and KI DNA in Kidney and Urinary Bladder Tumour Tissue Samples

Pathobiology ◽  
2016 ◽  
Vol 83 (5) ◽  
pp. 252-257 ◽  
Author(s):  
Eszter Csoma ◽  
László Bidiga ◽  
Gábor Méhes ◽  
Lajos Gergely
Keyword(s):  
Urinary Bladder ◽  
Bladder Tumour ◽  
Tumour Tissue ◽  
Human Polyomavirus ◽  
Tissue Samples ◽  
Human Polyomavirus 9 ◽  
Urinary Bladder Tumour
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