Reliability of Implant-Isolation Regions in Highly-Doped GaAs-Based Structures

1993 ◽  
Vol 300 ◽  
Author(s):  
F. Ren ◽  
S. J. Pearton ◽  
J. R. Lothian ◽  
T. R. Fullowan ◽  
C. R. Abernathy ◽  
...  
Keyword(s):  
High Resistance ◽  
Complete Loss ◽  
Gaas Surface ◽  
Near Surface ◽  
Nuclear Stopping ◽  
Heavily Doped ◽  
Reported Data ◽  
P Type ◽  
Heterostructure Devices

ABSTRACTHighly-doped n-type (2 × 1019 cm−3) and p-type (7 × 1019 cm−3) GaAs layers were implanted with multiple energy F+ or H+ ions and subsequently annealed at ∼550°C to produce high resistance regions. The resistance of these layers at 200°C was monitored as a function of time and showed no changes for periods of several months. This is in contrast to some previously reported data, which showed complete loss of isolation after a period of several days in proton-implanted n+ GaAs. Here, we show that isolation of heavily-doped near-surface regions by protons requires implantation through cap layers which place the peak of the nuclear stopping profile at the GaAs surface. The application of these results to isolation of thick, multilayer heterostructure devices is discussed and SIMS and TEM data are used to illustrate the redistribution of the implanted ions and the defects they create, respectively.

Investigating the functional link between TMEM165 and SPCA1

2019 ◽  
Vol 476 (21) ◽  
pp. 3281-3293 ◽  
Author(s):  
Elodie Lebredonchel ◽  
Marine Houdou ◽  
Hans-Heinrich Hoffmann ◽  
Kateryna Kondratska ◽  
Marie-Ange Krzewinski ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Complete Loss ◽  
Protein Family ◽  
Uncharacterized Protein ◽  
Functional Link ◽  
P Type

TMEM165 was highlighted in 2012 as the first member of the Uncharacterized Protein Family 0016 (UPF0016) related to human glycosylation diseases. Defects in TMEM165 are associated with strong Golgi glycosylation abnormalities. Our previous work has shown that TMEM165 rapidly degrades with supraphysiological manganese supplementation. In this paper, we establish a functional link between TMEM165 and SPCA1, the Golgi Ca2+/Mn2+ P-type ATPase pump. A nearly complete loss of TMEM165 was observed in SPCA1-deficient Hap1 cells. We demonstrate that TMEM165 was constitutively degraded in lysosomes in the absence of SPCA1. Complementation studies showed that TMEM165 abundance was directly dependent on SPCA1's function and more specifically its capacity to pump Mn2+ from the cytosol into the Golgi lumen. Among SPCA1 mutants that differentially impair Mn2+ and Ca2+ transport, only the Q747A mutant that favors Mn2+ pumping rescues the abundance and Golgi subcellular localization of TMEM165. Interestingly, the overexpression of SERCA2b also rescues the expression of TMEM165. Finally, this paper highlights that TMEM165 expression is linked to the function of SPCA1.

1158-P: Type 2 Diabetes Patients Subtype Analysis: Unbiased Machine Learning for Future Personalized T2D Care

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1158-P
Author(s):  
LI CHEN ◽  
LINGGE FENG ◽  
CUI TANG ◽  
YI ZHANG
Keyword(s):  
Machine Learning ◽  
Type 2 Diabetes ◽  
P Type ◽  
Diabetes Patients

1758-P: Type 2 Diabetes–Associated Mood Disorders: Role of Insulin Resistance in Serotonergic Neurons

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1758-P
Author(s):  
HUGO MARTIN ◽  
SÉBASTIEN BULLICH ◽  
FABIEN DUCROCQ ◽  
MARION GRALAND ◽  
CLARA OLIVRY ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mood Disorders ◽  
Serotonergic Neurons ◽  
P Type

1249-P: Type 2 Diabetes in Prepubertal Children under 10 Years Old

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1249-P
Author(s):  
MARCELA ASTUDILLO ◽  
AHMAD K. REFAEY ◽  
MUSTAFA TOSUR ◽  
ALEJANDRO F. SILLER ◽  
SIRIPOOM MCKAY ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Prepubertal Children ◽  
P Type

1460-P: Type 2 Diabetes Polygenic Score in Addition to Clinical Factors for Prediction of Diabetes Incidence in an Indigenous American Population

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1460-P
Author(s):  
LAUREN E. WEDEKIND ◽  
SAYUKO KOBES ◽  
WEN-CHI HSUEH ◽  
LESLIE BAIER ◽  
WILLIAM C. KNOWLER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Incidence ◽  
American Population ◽  
Clinical Factors ◽  
Polygenic Score ◽  
Prediction Of Diabetes ◽  
P Type

1135-P: Type 2 Diabetes Modulates DNA Methylation in Human Sperm

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 1135-P
Author(s):  
LEI SU ◽  
DANIELLE WOLFS ◽  
MARIE-FRANCE HIVERT ◽  
JAY PATEL ◽  
LAUREN RICHARDSON ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Human Sperm ◽  
P Type

381-P: Type 2 Diabetes Significantly Modulates the Power of Lipoprotein(a) to Predict Cardiovascular Events and Mortality in Young Coronary Artery Disease Patients

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 381-P
Author(s):  
ARTHUR MADER ◽  
MAXIMILIAN MAECHLER ◽  
BARBARA LARCHER ◽  
LUKAS SPRENGER ◽  
BEATRIX MUTSCHLECHNER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Events ◽  
Lipoprotein A ◽  
Artery Disease ◽  
P Type

Analysis of Defects in Heavily-Doped MBE-GaAs

1982 ◽  
Vol 14 ◽  
Author(s):  
C.B. Carter ◽  
D.M. Desimone ◽  
H.T. Griem ◽  
C.E.C. Wood
Keyword(s):  
Liquid Phase ◽  
Molecular Beam ◽  
Type Material ◽  
Grown Layer ◽  
Defect Clusters ◽  
Complex Defect ◽  
Heavily Doped ◽  
Rich Material ◽  
P Type ◽  
Very High

ABSTRACTGaAs Has Been Grown By Molecular-Beam Epitaxy (MBE) With Large Concentrations (∼1018CM−2) Of Sn, Si, Ge, And Mn As Dopants. The Heavily-Doped N-Type Material Has Been Found To Contain Regions Of A Very High Dislocation Density. An Analysis Of The Less Complex Defect Areas Shows That The Dislocations Originate In The MBE-Grown Layer. These Observations And Others On More Complex Defect Clusters Are Compared With Recent Studies Of Defects In Material Grown By Liquid Phase Epitaxy (LPE). The More Heavily Doped P-Type Material Contains Discs Of Mn-Rich Material At The Surface Of The MBEgrown Epilayer. Both The Structure And Composition Of These Regions Have Been Examined.

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