Additive manufacturing of Co–Cr alloys for biomedical applications: A concise review

Additive manufacturing techniques (i.e., 3D printing) are rapidly becoming one of the most popular methods for the preparation of materials to be employed in many different fields, including biomedical applications. The main reason is the unique flexibility resulting from both the method itself and the variety of starting materials, requiring the combination of multidisciplinary competencies for the optimization of the process. In particular, this is the case of additive manufacturing processes based on the extrusion or jetting of nanocomposite materials, where the unique properties of nanomaterials are combined with those of a flowing matrix. This contribution focuses on the physico-chemical challenges typically faced in the 3D printing of polymeric nanocomposites and polymeric hydrogels intended for biomedical applications. The strategies to overcome those challenges are outlined, together with the characterization approaches that could help the advance of the field.

Download Full-text

DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels

Polymers ◽

10.3390/polym12081655 ◽

2020 ◽

Vol 12 (8) ◽

pp. 1655 ◽

Cited By ~ 4

Author(s):

Giuseppe Melilli ◽

Irene Carmagnola ◽

Chiara Tonda-Turo ◽

Fabrizio Pirri ◽

Gianluca Ciardelli ◽

...

Keyword(s):

Mechanical Properties ◽

Additive Manufacturing ◽

3D Printing ◽

Carboxymethyl Cellulose ◽

Biomedical Applications ◽

Digital Light Processing ◽

Chemically Modified ◽

Significant Step ◽

3D Printed ◽

Biomedical Field

The development of new bio-based inks is a stringent request for the expansion of additive manufacturing towards the development of 3D-printed biocompatible hydrogels. Herein, methacrylated carboxymethyl cellulose (M-CMC) is investigated as a bio-based photocurable ink for digital light processing (DLP) 3D printing. CMC is chemically modified using methacrylic anhydride. Successful methacrylation is confirmed by 1H NMR and FTIR spectroscopy. Aqueous formulations based on M-CMC/lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator and M-CMC/Dulbecco’s Modified Eagle Medium (DMEM)/LAP show high photoreactivity upon UV irradiation as confirmed by photorheology and FTIR. The same formulations can be easily 3D-printed through a DLP apparatus to produce 3D shaped hydrogels with excellent swelling ability and mechanical properties. Envisaging the application of the hydrogels in the biomedical field, cytotoxicity is also evaluated. The light-induced printing of cellulose-based hydrogels represents a significant step forward in the production of new DLP inks suitable for biomedical applications.

Download Full-text

Additive Manufacturing of Titanium Alloys for Biomedical Applications

Additive Manufacturing of Emerging Materials ◽

10.1007/978-3-319-91713-9_5 ◽

2018 ◽

pp. 179-196

Author(s):

Lai-Chang Zhang ◽

Yujing Liu

Keyword(s):

Additive Manufacturing ◽

Titanium Alloys ◽

Biomedical Applications

Download Full-text

Ceramic Additive Manufacturing Using VAT Photopolymerization

Volume 1: Additive Manufacturing; Bio and Sustainable Manufacturing ◽

10.1115/msec2018-6389 ◽

2018 ◽

Cited By ~ 1

Author(s):

Diptanshu ◽

Erik Young ◽

Chao Ma ◽

Suleiman Obeidat ◽

Bo Pang ◽

...

Keyword(s):

Surface Roughness ◽

Additive Manufacturing ◽

Thermal Processing ◽

Biomedical Applications ◽

Ceramic Materials ◽

Ceramic Suspension ◽

Alumina Particles ◽

Compressive Testing ◽

The Difference ◽

Porosity Percentage

The popularity of additive manufacturing for producing porous bio-ceramics using vat photopolymerization in the recent years has gained a lot of impetus due to its high resolution and low surface roughness. In this study, a commercial vat polymerization printer (Nobel Superfine, XYZprinting) was used to create green bodies using a ceramic suspension consisting of 10 vol.% of alumina particles in a photopolymerizable resin. Four different sizes of cubical green bodies were printed out. They were subjected to thermal processing which included de-binding to get rid of the polymer and thereafter sintering for joining of the ceramic particles. The porosity percentage of the four different sizes were measured and compared. The lowest porosity was observed in the smallest cubes (5 mm). It was found to be 43.3%. There was an increase in the porosity of the sintered parts for the larger cubes (10, 15 and 20 mm). However, the difference in the porosity among these sizes was not significant and ranged from 61.5% to 65.2%. The compressive testing of the samples showed that the strength of the 5-mm cube was the maximum among all samples and the compressive strength decreased as the size of the samples increased. These ceramic materials of various densities are of great interest for biomedical applications.

Download Full-text

Design of Additively Manufactured Structures for Biomedical Applications: A Review of the Additive Manufacturing Processes Applied to the Biomedical Sector

Journal of Healthcare Engineering ◽

10.1155/2019/9748212 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 15

Author(s):

Flaviana Calignano ◽

Manuela Galati ◽

Luca Iuliano ◽

Paolo Minetola

Keyword(s):

Additive Manufacturing ◽

Biomedical Applications ◽

Point Of View ◽

Disruptive Technology ◽

Manufacturing Processes ◽

Medical Field ◽

Successful Case ◽

Design Perspective ◽

Manufacturing Techniques ◽

Am Processes

Additive manufacturing (AM) is a disruptive technology as it pushes the frontier of manufacturing towards a new design perspective, such as the ability to shape geometries that cannot be formed with any other traditional technique. AM has today shown successful applications in several fields such as the biomedical sector in which it provides a relatively fast and effective way to solve even complex medical cases. From this point of view, the purpose of this paper is to illustrate AM technologies currently used in the medical field and their benefits along with contemporary. The review highlights differences in processes, materials, and design of additive manufacturing techniques used in biomedical applications. Successful case studies are presented to emphasise the potentiality of AM processes. The presented review supports improvements in materials and design for future researches in biomedical surgeries using instruments and implants made by AM.

Download Full-text

Self-Assembling Peptides and Carbon Nanomaterials Join Forces for Innovative Biomedical Applications

Molecules ◽

10.3390/molecules26134084 ◽

2021 ◽

Vol 26 (13) ◽

pp. 4084

Author(s):

Petr Rozhin ◽

Costas Charitidis ◽

Silvia Marchesan

Keyword(s):

Carbon Nanostructures ◽

Biomedical Applications ◽

Carbon Nanomaterials ◽

Chemical Properties ◽

Building Blocks ◽

Research Areas ◽

Self Assembling ◽

Concise Review ◽

Physico Chemical ◽

Great Progress

Self-assembling peptides and carbon nanomaterials have attracted great interest for their respective potential to bring innovation in the biomedical field. Combination of these two types of building blocks is not trivial in light of their very different physico-chemical properties, yet great progress has been made over the years at the interface between these two research areas. This concise review will analyze the latest developments at the forefront of research that combines self-assembling peptides with carbon nanostructures for biological use. Applications span from tissue regeneration, to biosensing and imaging, and bioelectronics.

Download Full-text