Physico-Chemical Challenges in 3D Printing of Polymeric Nanocomposites and Hydrogels for Biomedical Applications

2021 ◽  
Vol 21 (5) ◽  
pp. 2778-2792
Author(s):  
Massimo Bonini
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Biomedical Applications ◽  
Nanocomposite Materials ◽  
Manufacturing Processes ◽  
Polymeric Nanocomposites ◽  
Physico Chemical ◽  
Polymeric Hydrogels ◽  
Manufacturing Techniques

Additive manufacturing techniques (i.e., 3D printing) are rapidly becoming one of the most popular methods for the preparation of materials to be employed in many different fields, including biomedical applications. The main reason is the unique flexibility resulting from both the method itself and the variety of starting materials, requiring the combination of multidisciplinary competencies for the optimization of the process. In particular, this is the case of additive manufacturing processes based on the extrusion or jetting of nanocomposite materials, where the unique properties of nanomaterials are combined with those of a flowing matrix. This contribution focuses on the physico-chemical challenges typically faced in the 3D printing of polymeric nanocomposites and polymeric hydrogels intended for biomedical applications. The strategies to overcome those challenges are outlined, together with the characterization approaches that could help the advance of the field.

scholarly journals 3D printing of graphene-based polymeric nanocomposites for biomedical applications

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Magda Silva ◽  
Isabel S. Pinho ◽  
José A. Covas ◽  
Natália M. Alves ◽  
Maria C. Paiva
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Biomedical Applications ◽  
Patient Specific ◽  
Polymeric Nanocomposites ◽  
New Paradigm ◽  
Graphene Derivatives ◽  
3D Printed ◽  
Biomedical Field ◽  
Manufacturing Techniques

AbstractAdditive manufacturing techniques established a new paradigm in the manufacture of composite materials providing a simple solution to build complex, custom designed shapes. In the biomedical field, 3D printing enabled the production of scaffolds with patient-specific requirements, controlling product architecture and microstructure, and have been proposed to regenerate a variety of tissues such as bone, cartilage, or the nervous system. Polymers reinforced with graphene or graphene derivatives have demonstrated potential interest for applications that require electrical and mechanical properties as well as enhanced cell response, presenting increasing interest for applications in the biomedical field. The present review focuses on graphene-based polymer nanocomposites developed for additive manufacturing fabrication, provides an overview of the manufacturing techniques available to reach the different biomedical applications, and summarizes relevant results obtained with 3D printed graphene/polymer scaffolds and biosensors.

scholarly journals Design of Additively Manufactured Structures for Biomedical Applications: A Review of the Additive Manufacturing Processes Applied to the Biomedical Sector

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Flaviana Calignano ◽  
Manuela Galati ◽  
Luca Iuliano ◽  
Paolo Minetola
Keyword(s):  
Additive Manufacturing ◽  
Biomedical Applications ◽  
Point Of View ◽  
Disruptive Technology ◽  
Manufacturing Processes ◽  
Medical Field ◽  
Successful Case ◽  
Design Perspective ◽  
Manufacturing Techniques ◽  
Am Processes

Additive manufacturing (AM) is a disruptive technology as it pushes the frontier of manufacturing towards a new design perspective, such as the ability to shape geometries that cannot be formed with any other traditional technique. AM has today shown successful applications in several fields such as the biomedical sector in which it provides a relatively fast and effective way to solve even complex medical cases. From this point of view, the purpose of this paper is to illustrate AM technologies currently used in the medical field and their benefits along with contemporary. The review highlights differences in processes, materials, and design of additive manufacturing techniques used in biomedical applications. Successful case studies are presented to emphasise the potentiality of AM processes. The presented review supports improvements in materials and design for future researches in biomedical surgeries using instruments and implants made by AM.

scholarly journals Advances in 3D Printing for Tissue Engineering

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3149
Author(s):  
Angelika Zaszczyńska ◽  
Maryla Moczulska-Heljak ◽  
Arkadiusz Gradys ◽  
Paweł Sajkiewicz
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Complex Structure ◽  
Three Dimensional ◽  
Computer Assisted ◽  
Scaffold Fabrication ◽  
Manufacturing Techniques ◽  
Printing Techniques ◽  
State Of Art

Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.

Manufacture of Lenses and Diffraction Gratings Using DLP As an Additive Manufacturing Technology

2018 ◽  
Author(s):  
Laura Daniela Vallejo Melgarejo ◽  
Jose García ◽  
Ronald G. Reifenberger ◽  
Brittany Newell
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Diffraction Grating ◽  
Diffraction Gratings ◽  
Optical Microscope ◽  
Manufacturing Technology ◽  
Manufacturing Processes ◽  
Digital Light Processing ◽  
Additive Manufacturing Technology ◽  
Potential Use

This document condenses the results obtained when 3D printing lenses and their potential use as diffraction gratings using Digital Light Processing (DLP), as an additive manufacturing technique. This project investigated the feasibility of using DLP additive manufacturing for producing custom designed lenses and gratings. DLP was identified as the preferred manufacturing technology for gratings fabrication. Diffraction gratings take advantage of the anisotropy, inherent in additive manufacturing processes, to produce a collated pattern of multiple fringes on a substrate with completely smooth surfaces. The gratings are transmissive and were manufactured with slit separations of 10, 25 and 50 μm. More than 50 samples were printed at various build angles and mechanically treated for maximum optical transparency. The variables of the irradiance equation were obtained from photographs taken with an optical microscope. These values were used to estimate theoretical irradiance patterns of a diffraction grating and compared against the experimental 3-D printed grating. The resulting patterns were found to be remarkably similar in amplitude and distance between peaks when compared to theoretical values.

Computational Study of Reinforcement Mechanisms of Cuttlefish Bone Inspired Structure for 3D Printing

2021 ◽  
Author(s):  
Brandon Bethers ◽  
Yang Yang
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Computational Study ◽  
High Energy ◽  
Simulation Software ◽  
Support Structures ◽  
Common Support ◽  
Potential Applications ◽  
Manufacturing Techniques ◽  
Traditional Manufacturing

Abstract Cuttlebone, the internal shell structure of a cuttlefish, presents a unique labyrinthian wall-septa design that promotes high energy absorption, porosity, and damage tolerance. This structure offers us an inspiration for the design of lightweight and strong structures for potential applications in mechanical, aerospace and biomedical engineering. However, the complexity of the cuttlebones structural design makes its fabrication by traditional manufacturing techniques not feasible. The advances in additive manufacturing (3D printing) make highly complex structures like cuttlebone possible to manufacture. In this work, the authors sought to establish comparative data between cuttlebone structures and some common support structures used in additive manufacturing. The structures compared to cuttlebone in this work include the cubic, honeycomb and triangular support structures. This was accomplished by using CAD modeling and simulation software. This study found that the cuttlefish structures had higher average stress values than the others but similar average strain values. This leads to a higher modulus of elasticity for the cuttlebone structures. The data suggests that further research into cuttlebone structures could produce future designs that improve upon the current well-established additive manufacturing support structures. Further study will be performed for the 3D printing of cuttlebone inspired structures by using various types of materials, such as soft and rigid polymers, functional ceramics, composites, and metals.

Variance Quantification of Different Additive Manufacturing Processes for Acoustic Meta Materials

2021 ◽  
Vol 263 (4) ◽  
pp. 2708-2723
Author(s):  
Manuel Bopp ◽  
Arn Joerger ◽  
Matthias Behrendt ◽  
Albert Albers
Keyword(s):  
Mechanical Properties ◽  
Additive Manufacturing ◽  
Production Process ◽  
Laser Scanning ◽  
Mode Shapes ◽  
Manufacturing Processes ◽  
3D Laser Scanning ◽  
Fused Filament Fabrication ◽  
Manufacturing Techniques ◽  
Different Levels

Many concepts for acoustic meta materials rely on additive manufacturing techniques. Depending on the production process and material of choice, different levels of precision and repeatability can be achieved. In addition, different materials have different mechanical properties, many of which are frequency dependent and cannot easily be measured directly. In this contribution the authors have designed different resonator elements, which have been manufactured utilizing Fused Filament Fabrication with ABSplus and PLA, as well as PolyJet Fabrication with VeroWhitePlus. All structures are computed in FEA to obtain the calculated Eigenfrequencies and mode shapes, with the respective literature values for each material. Furthermore, the dynamic behavior of multiple instances of each structure is measured utilizing a 3D-Laser-Scanning Vibrometer under shaker excitation, to obtain the actual Eigenfrequencies and mode shapes. The results are then analyzed in regards to variance between different print instances, and in regards to accordance between measured and calculated results. Based on previous work and this analysis the parameters of the FEA models are updated to improve the result quality.

scholarly journals Special Issue of the Manufacturing Engineering Society 2019 (SIMES-2019)

Materials ◽  
2020 ◽  
Vol 13 (9) ◽  
pp. 2133
Author(s):  
Eva María Rubio ◽  
Ana María Camacho
Keyword(s):  
Applied Sciences ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Manufacturing Industry ◽  
Green Manufacturing ◽  
Manufacturing Processes ◽  
New Materials ◽  
Special Issue ◽  
Engineering Society ◽  
Manufacturing Engineering

The Special Issue of the Manufacturing Engineering Society 2019 (SIMES-2019) has been launched as a joint issue of the journals “Materials” and “Applied Sciences”. The 29 contributions published in this Special Issue of Materials present cutting-edge advances in the field of manufacturing engineering focusing on additive manufacturing and 3D printing, advances and innovations in manufacturing processes, sustainable and green manufacturing, manufacturing of new materials, metrology and quality in manufacturing, industry 4.0, design, modeling, and simulation in manufacturing engineering and manufacturing engineering and society. Among them, these contributions highlight that the topic “additive manufacturing and 3D printing” has collected a large number of contributions in this journal because its huge potential has attracted the attention of numerous researchers over the last years.

scholarly journals DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1655 ◽  
Author(s):  
Giuseppe Melilli ◽  
Irene Carmagnola ◽  
Chiara Tonda-Turo ◽  
Fabrizio Pirri ◽  
Gianluca Ciardelli ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Carboxymethyl Cellulose ◽  
Biomedical Applications ◽  
Digital Light Processing ◽  
Chemically Modified ◽  
Significant Step ◽  
3D Printed ◽  
Biomedical Field

The development of new bio-based inks is a stringent request for the expansion of additive manufacturing towards the development of 3D-printed biocompatible hydrogels. Herein, methacrylated carboxymethyl cellulose (M-CMC) is investigated as a bio-based photocurable ink for digital light processing (DLP) 3D printing. CMC is chemically modified using methacrylic anhydride. Successful methacrylation is confirmed by 1H NMR and FTIR spectroscopy. Aqueous formulations based on M-CMC/lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator and M-CMC/Dulbecco’s Modified Eagle Medium (DMEM)/LAP show high photoreactivity upon UV irradiation as confirmed by photorheology and FTIR. The same formulations can be easily 3D-printed through a DLP apparatus to produce 3D shaped hydrogels with excellent swelling ability and mechanical properties. Envisaging the application of the hydrogels in the biomedical field, cytotoxicity is also evaluated. The light-induced printing of cellulose-based hydrogels represents a significant step forward in the production of new DLP inks suitable for biomedical applications.

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