Possibilities of combined mukolytic syrup Pektolvan C to increase the antibiotic therapy efficiency in children with acute respiratory infections

2018 ◽  
pp. 74-80
Author(s):  
E. Okhotnikova ◽  
◽  
E. Ponochevna ◽  
Keyword(s):  
Antibiotic Therapy ◽  
Respiratory Infections ◽  
Acute Respiratory Infections

Procalcitonin-guided antibiotic therapy algorithms for different types of acute respiratory infections based on previous trials

2018 ◽  
Vol 16 (7) ◽  
pp. 555-564 ◽  
Author(s):  
Philipp Schuetz ◽  
Rebekka Bolliger ◽  
Meret Merker ◽  
Mirjam Christ-Crain ◽  
Daiana Stolz ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Different Types

scholarly journals Prevention of dysbiosis and antibiotic-associated diarrhea in children with acute respiratory infections after antibiotic therapy

2021 ◽  
Vol 5 (11) ◽  
pp. 712-720
Author(s):  
L.N. Mazankova ◽  
◽  
S.G. Perlovskaya ◽  
M.D. Ardatskaya ◽  
A.A. Korsunskiy ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Antibiotic Therapy ◽  
Respiratory Infections ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Acute Respiratory Infections ◽  
Antibiotic Associated Diarrhea ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim: to develop a method of dysbiotic abnormality prevention after antibiotic therapy (ABT) in early childhood. Patients and Methods: the study enrolled 90 children aged 12–60 months who were admitted to the hospital with complicated acute respiratory infections (ARIs) and received ABT. The children were randomized into three groups (each comprised of 30 children). The children received either a probiotic with Lactobacillus rhamnosus GG and Bifidobacterium BB-12 (group 1) or a cytomucoprotector, gelatin tannate (group 2) to prevent antibiotic-associated diarrhea (AAD). Group 3 children received ABT only. To assess microbiocenosis, short-chain fatty acids (SCFAs) in stool were measured by gas-liquid chromatography. Results: AAD was reported in 23.3% of group 1 children, 17% of group 2 children, and 46.7% of group 3 children (p=0.03). In group 2, the duration of diarrhea was significantly lower. Baseline stool concentration of SCFAs was 2.5-times lower compared to normal ranges. Further reduction in the total absolute level of SCFAs was reported in group 3 after treatment. An increase in total SCFA level, a significant increase in the relative amounts of acetic acid, and a reduction in propionic acid and (to a lesser degree) butyric acid were reported in groups 1 and 2 compared to group 3. Conclusions: an improvement in stool SCFA levels was reported in group 1 and 2 children who received probiotics or cytomucoprotector. Incorporation of these medications and ABT in the complex treatment for ARIs in children stabilized metabolic activity of microbiota through preserving the pool of indigenous microorganisms producing butyrate. KEYWORDS: antibiotic, antibiotic-associated diarrhea, acute respiratory viral infections, microbiota, short-chain fatty acids, probiotic, gelatin tannate. FOR CITATION: Mazankova L.N., Perlovskaya S.G., Ardatskaya M.D. et al. Prevention of dysbiosis and antibiotic-associated diarrhea in children with acute respiratory infections after antibiotic therapy. Russian Medical Inquiry. 2021;5(11):712–720 (in Russ.). DOI: 10.32364/2587-6821-2021-5-11-712-720.

scholarly journals The bacteriological research in case of acute respiratory infections: actual, informative and effective

2018 ◽  
Vol 22 (2) ◽  
pp. 394-397
Author(s):  
S. I. Klymnyuk ◽  
L .B. Romanyuk ◽  
L .A. Volianska ◽  
E .I. Burbelа ◽  
N. Ya. Kravets ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Family Doctor ◽  
Clinical Manifestations ◽  
Risk Groups ◽  
Symptomatic Therapy ◽  
Acute Respiratory Infections ◽  
Family Doctors ◽  
Opportunistic Bacteria

The most common nosology in the routine work of family doctors is acute respiratory infections. The etiological composition of the acute respiratory viral infections is changing from year to year, which causes difficulties with the use of treatments. Purpose - improvement of tactics of a family doctor for antibiotic therapy of acute respiratory infections. Clinical manifestations of all etiological forms of ARI are similar, which complicates their differentiation. One of the leading - respiratory syndrome, is determined by the local defeat of certain parts of the respiratory tract. The pathogens of these diseases are mainly viruses, but the role of bacteria is also indisputable. According to the results of bacteriological studies with ARI, pathogens often include opportunistic bacteria of the staphylococcus group, streptococci, other aerobic and anaerobic cocci, representatives of the intestinal group and Candida, which can cause antibiotic-resistant forms. The family doctor should establish the diagnosis of respiratory infections, solve the problem of symptomatic therapy and agree on a strategy for the appointment of antibiotics. Most acute respiratory infections even in the absence of antibiotic therapy are recovering. Therefore, the tactics for the appointment of antibiotics should be determined depending on the severity of the disease, the belonging of the patient to certain risk groups. It would be advisable to include the collection of information on previous bacteriological studies and the preliminary history of the use of antibacterial agents, which would allow a family doctor to be better targeted when prescribing antibiotic therapy. The algorithm of the physician's action in the case of acute respiratory infections should be expanded at the point of coordination of the strategy of antibiotic therapy, adding to it the purpose of bacteriological examination in each case of diagnosis of ARI.

Rational Antibiotic Therapy of Acute Respiratory Infections in Outpatient Practice

2016 ◽  
pp. 64-69
Author(s):  
Uliana Chulovska ◽  
Olha Tolokh
Keyword(s):  
Respiratory Tract ◽  
Antibiotic Therapy ◽  
Respiratory Tract Infections ◽  
Respiratory Infections ◽  
Macrolide Antibiotics ◽  
Pharmacokinetic Parameters ◽  
Acute Respiratory Infections ◽  
Antimicrobial Spectrum ◽  
Outpatient Practice ◽  
Tract Infections

The choice of optimal antibiotic therapy in acute respiratory infections is an important and responsible job physician outpatient practices. Macrolide antibiotics are the drugs of choice in many cases of infectious diseases of the respiratory system. Antimicrobial spectrum, pharmacokinetic parameters and safety profile of spiramycin, classic representative of 16-membered macrolides, allow you to use it successfully for the treatment of community-acquired respiratory tract infections.

scholarly journals Optimization of pneumonia complex therapy in children with acute respiratory diseases

2021 ◽  
pp. 38-43
Author(s):  
I.I. Pylyuk ◽  
Keyword(s):  
Antibiotic Therapy ◽  
Inpatient Treatment ◽  
Glutathione Transferase ◽  
Clinical Laboratory ◽  
Respiratory Infections ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Acute Respiratory Infections ◽  
Instrumental Methods ◽  
Rapid Regression

Purpose — to improve the pathogenetic treatment of pneumonia in children with recurrent acute respiratory infections by combining of protocol therapy with a drug has antioxidant, antihypoxic and organoprotective effects. Materials and methods. The analysis of the results of clinical, laboratory and instrumental methods of examination of children with pneumonia at the age of 3–8 years which have recurrent acute respiratory infections has performed. Children have had received standard protocol treatment of pneumonia and combination with a drug has antioxidant, antihypoxic and organoprotective effects. Results. Optimization the protocol treatment of pneumonia in children with recurrent acute respiratory infections by supplementing pathogenetic therapy with this drug made possible to improve the efficiency of treatment, what confirmed by the rapid regression of clinical manifestations of pneumonia (intoxication — to 1.9±0.04 days, cough — to 2.1±0.08 days, respiratory failure — to 1.7±0.08 days, shortness of breath — to 1.3±0.04 days, disorders of microcirculation and hemodynamics — to 2.1±0.05 and 1.8, respectively ± 0.09 days). This approach calls the decrease of percentage of children with pneumonic infiltration according to the control X-ray examination of the lungs — to 30.0%, myocardial hypoxia according to the ECG results — 20.0%, which made possible to reduce the duration of the course of antibiotic therapy to 2.0±0.04 days, inpatient treatment — to 2.2±0.08 bed-days. The positive dynamics laboratories values, clinical signs and instrumental methods of examination of such children occurred due to an increasing levels of glutathione reductase and glutathione transferase in the blood serum to 4 and 3 times, respectively, and a decreasing the content of glutathione peroxidase and gamma$glutamyl transpeptidase to 2.6 and 1.6 times. Conclusions. Supplement the protocol therapy of pneumonia in children with recurrent acute respiratory infections with a drug has antioxidant, antihypoxic and organoprotective effects promoted a rapid regression of clinical manifestations due to the improvement of the functional activity of the oxidative system of glutathione, which made possible to reduce the duration of the course of antibiotic therapy and inpatient treatment. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: children with recurrent acute respiratory infections, pneumonia, treatment.

scholarly journals Local antibiotic therapy for acute upper respiratory tract infections

2019 ◽  
pp. 112-115
Author(s):  
A. I. Safina
Keyword(s):  
Antibiotic Therapy ◽  
Primary Care Physicians ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Upper Respiratory Tract ◽  
Drug Of Choice ◽  
Tract Infections ◽  
Local Antibiotic ◽  
Bacterial Superinfection ◽  
Local Antibiotic Therapy

The article discusses the possibilities of local antibiotic therapy for acute respiratory infections in children. Despite the fact that most acute respiratory infections are caused by viruses, unreasonably high (up to 70% and higher in different countries) prescription of antibacterial drugs by primary care physicians has been observed. At the same time, it is highly likely that bacterial superinfection may develop in young children, in children with a prolonged course of acute respiratory infection, as well as in children with chronic ENT pathology, which requires the prescription of antibacterial therapy both to treat and, possibly, to prevent bacterial superinfection. In this case, the drug of choice should be antibiotics for topical (inhalation) use, such as Fluimucil®-antibiotic IT, which act directly at the infection site with the achievement of a quick therapeutic effect, without side effects that are associated with systemic antibiotics.

PERAN IBU DALAM PENINGKATAN SISTEM IMUN ANAK DENGAN INFEKSI SALURAN PERNAFASAN AKUT

2019 ◽  
Vol 11 (2) ◽  
pp. 79-86
Author(s):  
Cindy Ayustin Noya ◽  
Angkit Kinasih ◽  
Venti Agustina ◽  
R.Rr Maria Dyah Kurniasari
Keyword(s):  
Immune System ◽  
Acute Respiratory Infection ◽  
Lower Respiratory Tract ◽  
Research Method ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Clean Environment ◽  
History Of ◽  
Qualitative Descriptive

Infeksi saluran pernafasan akut atau yang sering disebut ISPA merupakan infeksi pada saluran pernafasan baik saluran pernafasan atas atau bawah.ISPA juga kebanyakan terjadi pada anak balita karena daya tahan tubuh mereka tidak kuat dalam menghadapi penyakit ISPA. ISPA mengakibatkan kematiansekitar15%-20% per tahun pada usia balita di Negara berkembang. Tujuan penelitian ini adalah untuk mengetahui dan menganalisa peran ibu dalam meningkatkan sistem imun anak dengan ISPA.Metode penelitian yang digunakan dalam penelitian ini adalah kualitatif deskriptif dengan sampel purposive sampling.Populasi dan sampel penelitian ini adalah ibu yang mempunyai anak dengan riwayat dan saat ini menderita penyakit ISPA di Batu Gajah Kota Ambon.Partisipan dalam penelitian ini berjumlah 5 orang. Hasil dari penelitian mendapati 4 kategori yaitu pemberian nutrisi pada anak untuk memenuhi kebutuhan agar sistem imunnya terjaga, kebersihan lingkungan, peran ibu dalam melakukan pencegahan pada anaknya yang mengalami ISPA, dan  peran ibu dalam menjaga dan mempertahankan kesehatan anaknya.   Kata kunci: peran ibu, sistem imun, ispa THE ROLE OF MOTHERS IN INCREASING IMMUNE SYSTEM OF CHILDREN WITH ACUTE RESPIRATORY INFECTION    ABSTRACT Acute respiratory infections or often called ARI is an infection of the upper or lower respiratory tract. ARI occurs mostly in children under the age of five because their endurance is not strong in dealing with ARI. ARI results in deaths of around 15%-20% per year at the age of under-five in developing countries. The purpose of this study was to determine and analyze the role of mothers in improving the immune system of children against ARI. The research method used in this study was qualitative descriptive with a purposive sampling sample. Respondents and samples of this study were five mothers who had children with a history of ARI and currently suffering from the disease in Batu Gajah, Ambon City. The results of the study found 4 categories, namely providing nutrition to children to meet their needs so that their immune systems are maintained, clean environment, mother's role in preventing children with ARI, and mother's role to preserve and maintain the health of their children. The findings indicated that in terms of coping or improving the immune system of a child to avoid ARI, it is necessary to have role the of mothers in providing nutrition so that the immune system is boosted, besides that the mother can prevent and protect her child from various diseases, especially ARI. Keywords: role of mothers, immune system, acute respiratory infections

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