A rare and overlooked cause of massive gastrointestinal bleeding: Distal duodenal GIST

2021 ◽  
Vol 19 (2) ◽  
pp. 189-192
Author(s):  
Tolga Düzenli ◽  
◽  
Hüseyin Köseoğlu ◽  
Behice Hande Erenler ◽  
◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Histopathological Examination ◽  
Proximal Part ◽  
Soft Tissue Density ◽  
Bleeding Vessel ◽  
Duodenal Gist ◽  
Eosinophilic Cytoplasm ◽  
Massive Gastrointestinal Bleeding ◽  
Abundant Eosinophilic Cytoplasm ◽  
Pleomorphic Cells

Introduction. Gastrointestinal stromal tumors (GIST) are tumors of mesenchymal origin which originate from the walls of gastrointestinal system (GIS) organs. Aim. In this case report we aim to discuss the clinical, labaratory and radiological presentation of distal duodenal GIST as a rare and overlooked cause of life-threatining GIS bleeding. Description of the case. A 76-year-old male patient was presented to the emergency department with massive gastrointestinal bleeding. Computerized tomography revealed a mass soft tissue density of 4x4cm at the level of the 3-4th segment of the duodenum. At the endoscopy, there was a deep ulcer in the proximal part of the 3rd segment of the duodenum with a diameter of 2 cm with a bleeding vessel protruding into the lumen. After endoscopic treatments, biopsies were taken from the edges of the ulcer. Histopathological examination revealed a sheet-like infiltration composed of mildly pleomorphic cells with oval-spindle nuclei and abundant eosinophilic cytoplasm in the duodenal lamina propria, as the patient was diagnosed of GIST. Conclusion. GIST and its clinical, labaratory and radiological presentation should be kept in mind in the approach to massive duodenal GIS bleeding.

scholarly journals Histopathological study of canine hepatoid gland tumours

2021 ◽  
Vol 52 (3) ◽  
Author(s):  
Sudheesh S. Nair ◽  
Sudheesh S. Nair ◽  
Sudheesh S. Nair ◽  
Sudheesh S. Nair ◽  
Sudheesh S. Nair
Keyword(s):  
Histopathological Examination ◽  
Excisional Biopsy ◽  
Histopathological Study ◽  
Surgical Removal ◽  
Tumour Mass ◽  
Eosinophilic Cytoplasm ◽  
Abundant Eosinophilic Cytoplasm ◽  
Mitotic Figures ◽  
The Masses ◽  
Animal Sciences

Hepatoid gland neoplasms arise due to disorganized and uncontrolled proliferation of cells of hepatoid glands. These are the modified sebaceous glands located mainly in the perianal area. Gross and histological findings of canine hepatoid gland tumours were evaluated. Dogs of different breed, age and sex that were presented to Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Mannuthy formed the materials for the present study. Grossly, tumours were solitary or multiple irregular shaped intradermal masses. The excisional biopsy samples were collected in 10 per cent neutral buffered formalin after surgical removal of tumour mass. Histopathologically, the masses were encircled by fibrovascular capsule which extended to the parenchyma as tumour stroma, which separated it into lobules. Two cases of hepatoid gland adenoma one case of hepatoid gland epithelioma and two cases of carcinoma were recognised on histopathological examination. Hepatoid adenoma were characterised by proliferation of hepatocyte like hepatoid gland epithelial cells with extensive sebaceous differentiation and were arranged in cords and anastomosing trabeculae. In hepatoid gland epithelioma, many of the cells were basaloid reserve cells with fewer hepatocyte like cells. Histopathological examination of carcinoma revealed irregular arrangement of the hepatoid cells which showed varying degrees of maturation and marked nuclear pleomorphism. The malignant hepatoid cells had abundant eosinophilic cytoplasm and large nuclei with several prominent nucleoli and mitotic figures.

scholarly journals Malignant Phyllodes Tumour with Rhabdomyosarcomatous Differentiation: A Rare Phenomenon

2021 ◽  
Author(s):  
Kusum Yadav ◽  
Jitendra Singh Nigam ◽  
Anshul Singh ◽  
Vatsala Misra
Keyword(s):  
Rare Tumour ◽  
Complete Excision ◽  
Eosinophilic Cytoplasm ◽  
Phyllodes Tumour ◽  
Abundant Eosinophilic Cytoplasm ◽  
One Year ◽  
Phyllodes Tumours ◽  
The Right ◽  
Pleomorphic Cells ◽  
Malignant Phyllodes Tumour

Phyllodes tumour is a rare tumour of the breast constituting less than 1% of all breast tumours. Malignant Phyllodes Tumour (MPT) accounts for only 10-30% of all phyllodes tumours. Heterologous sarcomatous differentiation in a MPT is an infrequent phenomenon, with the cases reported showing differentiation mostly towards liposarcoma, fibrosarcoma, angiosarcoma, osteosarcoma, or chondrosarcoma. MPTs with rhabdomyosarcomatous differentiation are scarcely seen with only three confirmed cases documented till date to the best of the knowledge after a thorough search of literature. Here, authors present a case of 45-year-old female who presented with a well-defined rapidly growing lump in the right breast for last one year. A core needle biopsy performed showed a sarcomatous picture on histology. Complete excision was subsequently done. On microscopy, most of the areas showed fibrosarcomatous changes with frequent mitoses. Some of the foci showed large pleomorphic cells in diffuse sheets that were polygonal with densely abundant eosinophilic cytoplasm and vesicular nucleus with prominent nucleoli (rhabdomyoblasts). Myogenin was diffusely positive on Immunohistochemistry (IHC). A diagnosis of MPT with rhabdomyosarcomatous differentiation was made. This case is reported here for its unusual presentation and to make pathologists aware of this rare heterologous differentiation of MPT.

Uncommon cause of massive gastrointestinal bleeding

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
K Rábai ◽  
M Bartha ◽  
F Ender ◽  
I Szántó ◽  
B Nádas ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Massive Gastrointestinal Bleeding

scholarly journals A case of COVID-19 complicated by massive gastrointestinal bleeding

2020 ◽  
Author(s):  
Yan-Ling Wang ◽  
Jin-Song Mu ◽  
Xiao-Bao Qi ◽  
Wen-Hui Zhang
Keyword(s):  
Gastrointestinal Bleeding ◽  
Massive Gastrointestinal Bleeding

Malignant Melanoma Presenting as an Intrathymic Tumor

2000 ◽  
Vol 124 (1) ◽  
pp. 130-134
Author(s):  
P. M. Alli ◽  
B. J. Crain ◽  
R. Heitmiller ◽  
P. Argani
Keyword(s):  
Malignant Melanoma ◽  
Previous History ◽  
Clinical History ◽  
Computed Tomographic ◽  
Eosinophilic Cytoplasm ◽  
S 100 ◽  
History Of ◽  
Solitary Metastases ◽  
Physical Findings ◽  
Pleomorphic Cells

Abstract The identification of malignant melanoma in a visceral organ of nonepidermal origin is not an uncommon occurrence. Frequently, these cases are solitary metastases that present years after a thin epidermal melanoma has been diagnosed (and sometimes forgotten). However, primary visceral melanomas have been reported that have not been preceded by an epidermal lesion. We describe herein a unique case of melanoma presenting as a primary intrathymic tumor. The patient had no previous history of epidermal melanoma, and extensive workup did not reveal evidence for an alternative primary site. The tumor exhibited histologic features characteristic of melanoma, including an abundance of large pleomorphic cells with eosinophilic cytoplasm, prominent nucleoli, and occasional intranuclear inclusions. Tumor cells stained for HMB-45 and S-100 protein and ultrastructural analysis revealed stage II and stage III melanosomes. The patient remained free of disease until intrathoracic recurrence was detected on a computed tomographic scan 14 months later. The lack of clinical history and physical findings of melanoma at presentation, the intrathymic location of the tumor, and the pattern of recurrence suggest that this case likely represents a primary thymic melanoma, a previously unreported entity.

Retrospective analysis of the appendiceal neoplasms: sampling technique may influence neoplasm detection

2021 ◽  
pp. postgradmedj-2021-141244
Author(s):  
Gizem Issin ◽  
Fatih Demir ◽  
Hasan Aktug Simsek ◽  
Diren Vuslat Cagatay ◽  
Mahir Tayfur ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Distal Part ◽  
Histopathological Examination ◽  
Small Diameter ◽  
Sampling Technique ◽  
Proximal Part ◽  
Longitudinal Section ◽  
Appendiceal Neoplasms ◽  
Macroscopic Findings ◽  
Distal Section

Background and aimsAppendiceal neoplasms are uncommon entities that are usually determined incidentally during the histopathological examination. Different techniques used for the macroscopic sampling of appendectomy material may affect the determinating neoplasms.Materials and methodsH&E-stained slides of 1280 cases who underwent appendectomy between 2013 and 2018 were reviewed retrospectively for histopathological features.ResultsNeoplasms were determined in 28 cases (3.09%); 1 lesion was observed in the proximal part of the appendix, 1 covering the entire length from proximal to distal and 26 in the distal part. In the 26 cases that observed in the distal part, the lesion was seen on both sides of the longitudinal section of the distal appendix in 20 cases, while it was seen on only one distal longitudinal section in the remaining 6 cases.ConclusionThe vast majority of appendiceal neoplasms are seen in the distal part of the appendix, and, in some cases, neoplasms might be seen on only one side of the distal section. Sampling only one-half of the distal part of the appendix, where tumours are most often observed, could result in some neoplasms being missed. Therefore, sampling the whole distal part would be more beneficial to determine small diameter tumours that do not create macroscopic findings.

Cutaneous paraneoplastic syndrome in a cat with thymoma

2013 ◽  
Vol 41 (04) ◽  
pp. 255-259 ◽  
Author(s):  
J. Karaś-Tęcza ◽  
R. Lechowski ◽  
A. Rodo ◽  
I. Dolka ◽  
O. Gójska-Zygner
Keyword(s):  
Paraneoplastic Syndrome ◽  
Histopathological Examination ◽  
Skin Condition ◽  
Radiographic Examination ◽  
Post Mortem ◽  
Ventral Part ◽  
Soft Tissue Density ◽  
Skin Changes ◽  
Exfoliative Dermatitis ◽  
Costs Of Treatment

SummaryFeline cutaneous paraneoplastic syndrome is a rare disorder associated mainly with pancreatic carcinoma and thymoma. In this report the authors describe the case of a 12-year-old cat with paraneoplastic exfoliative dermatitis associated with thymoma. Lateral radiographic examination of the chest showed a small subtle soft tissue density in the ventral part of the first and second intercostal space, which together with skin changes suggested thymoma. Because of pain associated with the skin condition, costs of treatment and the risk associated with surgical treatment, the owner chose euthanasia of the cat. Post-mortem examination revealed a tumour which was diagnosed as thymoma by histopathological examination.

scholarly journals Renal collision tumour of papillary cell carcinoma and chromophobe cell carcinoma with sarcomatoid transformation: A case report and review of the literature

2014 ◽  
Vol 8 (7-8) ◽  
pp. 536 ◽  
Author(s):  
Zhang Zhiqiang ◽  
Min Jie ◽  
Yu Dexin ◽  
Shi Haoqiang ◽  
Xie Dongdong
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Histopathological Examination ◽  
Papillary Renal Cell Carcinoma ◽  
Local Area ◽  
Simultaneous Occurrence ◽  
Renal Masses ◽  
Collision Tumour ◽  
Eosinophilic Cytoplasm

The simultaneous occurrence of different histological types of adjacent neoplasms in the same organ is called a collision tumour, and rarely occurs in the kidney. A 63-year-old female presented to the urology department with a 1-month history of a painless hematuria. The computed tomography scans of the abdomen revealed 2 heterogeneous incidental right renal masses. The patient underwent radical nephrectomy including lymphadenectomy without adjuvant therapy. Histopathological examination showed a type 2 renal collision tumour of the papillary renal cell carcinoma with eosinophilic cytoplasm and pseudo stratified nuclei on papillary cores, and chromophobe renal cell carcinoma characterized by large polygonal cells with transparent reticulated cytoplasm and prominent cell membranes, which exhibited sarcomatoid transformation in the local area. Routine follow-up demonstrated no localor distant metastasis signs of recurrence at 20 months.

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