scholarly journals Development of an algorithm for selecting the required frequency of injected current for multi-frequency electrical impedance tomography for tasksrelated to preoperative monitoring of human lung function

2021 ◽  
Vol 3 (5 (111)) ◽  
pp. 25-38
Author(s):  
Aleksanyan Grayr
Keyword(s):  
Lung Function ◽  
Fat Mass ◽  
Lung Ventilation ◽  
Rate Of Change ◽  
Postoperative Monitoring ◽  
Impedance Tomography ◽  
Injection Frequency ◽  
Artificial Lung Ventilation ◽  
Complete Process

This paper proposes an algorithm for selecting the required frequency of injected current for problems of personalized multi-frequency electricalimpedance tomography. The essence of the algorithm is to calculate the rate of change in the recorded difference of potentials for the assigned range of frequencies of injected current, followed by determining the frequency after which the rate of a change in potentials is minimal. Subsequently, the injection parameters are readjusted to the chosen frequency and the complete process of electricalimpedance tomography is started. The proposed solutions were studied on four subjects with different fat mass, defined by bioimpedance analysis. Thus, it seems possible to track the dynamics of a change in the lungs of a certain patient by visualizing the reconstructed conductivity field, taking into consideration its internal features. It was established that in the course of studying lungsby using the method of electricalimpedance tomography, it is necessary to take into account the frequency of injected current at an increase in percentage of fat mass. The results of the studies showing a change in the quality of imaging the breathing process at different frequencies of injected current (from 50 kHz to 400 kHz, with a pitch of 50 kHz) are presented. For the test participants with a fat weight of 7.6 kg, 23.3 kg, 15.2 kg and 37.3 kg, the injection frequency was determined as 150 kHz, 200 kHz, 200 kHz, and 350 kHz, respectively. The proposed algorithm enables visual monitoring of lung function and can be used in the problems of pre- and postoperative monitoring of respiratory function of patients. Its use is particularly relevant for patients connected to an apparatus of artificial lung ventilation.

scholarly journals FREQUENCY AND OUTCOME OF RETINOPATHY IN PROFOUNDLY PRETERM NEWBORNS RECEIVING SPECIALIZED MEDICAL CARE

2018 ◽  
Vol 63 (5) ◽  
pp. 51-54 ◽  
Author(s):  
N. A. Shilova ◽  
N. V. Kharlamova ◽  
Yu. A. Fisyuk ◽  
T. V. Chasha ◽  
E. V. Churakova ◽  
...  
Keyword(s):  
Medical Care ◽  
Gestational Age ◽  
Lung Ventilation ◽  
Scientific Research Institute ◽  
High Quality ◽  
Artificial Lung Ventilation ◽  
Quality Of Medical Care ◽  
Preterm Newborns ◽  
Significant Factors

Objective. To determine frequency of retinopathy cases in profoundly preterm newborns treated at Gorodkov Ivanovo Scientific Research Institute of Maternity and Childhood in 2016-2017, as well as to evaluate impact of the risk factors on disease severity in the conditions of specialized medical care. We examined 344 profoundly preterm newborns with gestational age of less than 32 weeks. 83 children (24.1%) were diagnosed with retinopathy of preterm newborns. A high quality of medical care was proved by a low percentage of children with severe forms of retinopathy in preterm newborns and absence of blindness in the children. A low gestational age, low Apgar score at the end of the first minute of life and traditional artificial lung ventilation are the most significant factors of severe retinopathy of preterm newborns.

Progressive Early Rehabilitation Program Applied to Patients with Acute Cerebrovascular Accident

2020 ◽  
Vol 25 (3) ◽  
pp. 17-25 ◽  
Author(s):  
G. R. Ramazanov ◽  
L. B. Zavaliy ◽  
L. L. Semenov ◽  
S. A. Abudeev ◽  
A. O. Ptitsyn ◽  
...  
Keyword(s):  
Cerebrovascular Accident ◽  
Lung Ventilation ◽  
Rehabilitation Program ◽  
Artificial Lung ◽  
Early Rehabilitation ◽  
Gravity Gradient ◽  
Acute Cerebrovascular Accident ◽  
Artificial Lung Ventilation ◽  
Bed Days ◽  
Severity Of The Disease

Abstract. Early rehabilitation (ER) of patients with acute cerebrovascular accident (ACA) is one of the priority tasks of the vascular centers; the issue of increasing the volume of rehabilitation measures in the resuscitation and intensive care units (ICU) is relevant. Objective. To evaluate the safety and effectiveness of the progressive ER program in patients with ACA. Material and research methods. The study included 129 patients with ACA in ICU. Each patient of the main group (MGr, n = 61) underwent progressive ER: at least 4–5 vertical adjustments per day, passive mode Kinesiotherapy 49 ± 9.3 minutes, a double load of physiotherapy exercises, preventive physiotherapy; the total time of classes reached 240 minutes per day. In the comparison group (СGr, n = 68), standard ER was performed no more than 120 minutes per day. The groups are comparable by sex, age, severity of the disease and comorbidity. The severity of ACA, the gravity gradient, patient mobility, functional status, degree of dependence, and the presence of complications were evaluated. Results. During a month of work with the MGr, 102 ICU bed-days, 94 days of the artificial lung ventilation use, p < 0.05 were saved. Mortality in MGr decreased -— 8 patients (13.1%) versus 14 (20.6%) in CGr (p < 0.05). In patients within CGr, pulmonary thromboembolism developed in 8.8%, in MGr – in 3.3%. The severity of the apoplectic attack decreased ( by 28% in MGr, and by 20% in CGr ), mobility increased. Comparing the modalities of post resuscitationsyndrome in MGr, it was noted that the score decreased by 2 times from 6 [5; 6] to 3 [2.3; 3.3], but it has not changed in the CGr. Patients in the MGr were 2-–3 days earlier adapted to the vertical adjustment. Conclusions. The progressive ER program in ICU is safe, effective, realisable, and allows reducing the number of bed-days in ICU, the number of days of the artificial lung ventilation use, complications, and mortality in comparison with standard medical care.

TECHNICAL AND ECONOMIC EVALUATION OF THE DEVELOPMENT OF A DEVICE FOR THE PREVENTION OF APNEA DURING PHYSIOLOGICAL SLEEP IN HUMANS

2020 ◽  
pp. 198-210
Author(s):  
Сергей Борисович Казаков ◽  
Дмитрий Михайлович Шишов ◽  
Антон Игоревич Ларин ◽  
Александр Петрович Николаев ◽  
Аза Валерьевна Писарева
Keyword(s):  
Sleep Apnea ◽  
Humidity Sensor ◽  
Lung Ventilation ◽  
High Price ◽  
Device Structure ◽  
Artificial Lung Ventilation ◽  
Exact Moment ◽  
The Cost ◽  
Technical Solutions ◽  
Physiological Sleep

В статье представлен обзор существующих технических решений в сфере мониторинга и предотвращения апноэ во сне. Произведён анализ существующих аппаратов для предотвращения апноэ, который показал, что на рынке присутствует большое количество импортных моделей, однако они имеют довольно высокую цену. Разработанный нами Российский аналог проектируемого аппарата, при схожих характеристиках, будет иметь более привлекательную цену, чем у импортных приборов. Интегрирование датчика влажности в персональную маску пациента даёт возможность отслеживать остановки дыхания пациента во время сна, и тем самым включать процесс принудительной подачи дыхательной смеси именно в тот момент, когда она необходима для устранения патологии. Целью научной работы является разработка конструкции прибора и создание алгоритма программы для управления аппарата искусственной вентиляции лёгких для предотвращения апноэ во сне. Показана разработка структуры устройства аппарата. Подобран компрессор и датчик влажности с обоснованными характеристиками для создания аппарата, а также основные элементы. Разработана конструкция корпуса аппарата и разработана компоновка. Выполнено технико-экономическое обоснование разработки аппаратно-программного комплекса для предотвращения апноэ во сне. Показано, что себестоимость готового изделия достаточно конкурентна The article presents an overview of existing technical solutions in the field of monitoring and prevention of sleep apnea. An analysis of existing devices for preventing apnea was made, which showed that there are a large number of imported models on the market, but they have a fairly high price. The Russian analog of the designed device developed by us, with similar characteristics, will have a more attractive price than that of imported devices. The integration of the humidity sensor into the patient's personal mask makes it possible to monitor the patient's breathing stops during sleep, and thus enable the process of forced delivery of the respiratory mixture at the exact moment when it is necessary to eliminate the pathology. The purpose of the research is to develop the device design and create a program algorithm for controlling the artificial lung ventilation device to prevent sleep apnea. The development of the device structure is shown. The compressor and humidity sensor with reasonable characteristics for creating the device, as well as the main elements are selected. The design of the device body and its layout were developed. A feasibility study for the development of a hardware and software system for preventing sleep apnea has been completed. It is shown that the cost of the finished product is quite competitive

Lung Function and Quality of Life in Workers with Chemical and Dust Exposure

2018 ◽  
Vol 69 (2) ◽  
pp. 346-349 ◽  
Author(s):  
Marina Ruxandra Otelea ◽  
Oana Cristina Arghir ◽  
Corina Zugravu ◽  
Eugenia Naghi ◽  
Sabina Antoniu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Occupational Exposure ◽  
Lung Function ◽  
Lung Diseases ◽  
Dust Exposure ◽  
Chronic Lung Diseases ◽  
Respiratory Exposure ◽  
Increased Risk ◽  
Occupational Settings

Regarding the widely distribution of respiratory exposure hazards in occupational settings, workers have an increased risk for chronic lung diseases. For assessing the quality of life and lung function in workers exposed to chemicals and dust, St George�s Respiratory Questionnaire (SGRQ) and spirometry were performed among 40 patients, admitted in Occupational Clinic Department of Colentina Hospital, Bucharest, Romania, during February, 2017. SGRQ showed different predictors for patients according to their occupational exposure and total symptoms score correlated better with decreased spirometric parameters in defining lung function deterioration. Quality of life is earlier affected than lung function deterioration and emphasises the need of more sensitive methods for an earlier identification and better evaluation of respiratory hazards in different workplaces.

Temperature control in a chemical reactor through variable area of the heat transfer surface. Simulation analysis

1982 ◽  
Vol 47 (2) ◽  
pp. 430-445
Author(s):  
Josef Horák ◽  
Zina Valášková
Keyword(s):  
Heat Exchange ◽  
Simulation Analysis ◽  
Batch Reactor ◽  
Chemical Reactor ◽  
Rate Of Change ◽  
Action Variable ◽  
Heat Exchange Surface ◽  
Relay With Hysteresis ◽  
Exchange Surface

An algorithm has been developed and on a mathematical model analyzed to stabilize the reaction temperature of a batch reactor. The reaction has been a zero-order one and the reactor has been operated in a instable operating point. The action variable is the heat exchange surface whose area is increased if the temperature is above, or decreased if the temperature is below the set point. The following two-point regulators have been studied: An ideal relay, a relay with hysteresis and an asymmetric PD relay. The effect has been discussed of the parameters of the regulators on the quality of regulation. Stability analysis has been made of the stationary switching cycles and the domains of applicability have been determined for individual regulators with respect to the rate of change of the area of heat exchange surface.

Early changes of lung function and structure in an elastase model of emphysema—a hyperpolarized 3He MRI study

2008 ◽  
Vol 104 (3) ◽  
pp. 773-786 ◽  
Author(s):  
Kiarash Emami ◽  
Robert V. Cadman ◽  
John M. Woodburn ◽  
Martin C. Fischer ◽  
Stephen J. Kadlecek ◽  
...  
Keyword(s):  
Lung Function ◽  
Lung Ventilation ◽  
Unit Group ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Entire Lung ◽  
Residual Capacity ◽  
Regional Basis ◽  
Mean Linear Intercept ◽  
Mri Study

Early changes of lung function and structure were studied in the presence of an elastase-induced model of emphysema in 35 Sprague-Dawley rats at mild (5 U/100 g) and moderate (10 U/100 g) severities. Lung ventilation was measured on a regional basis (at a planar resolution of 3.2 mm) by hyperpolarized 3He MRI at 5 and 10 wk after model induction. Subsequent to imaging, average alveolar diameter was measured from histological slices taken from the centers of each lobe. Changes of mean fractional ventilation, mean linear intercept, and intrasubject heterogeneity of ventilation were studied during disease progression. Mean fractional ventilation was significantly different between healthy controls (0.23 ± 0.04) and emphysematous animals at both time points in the 10-unit group (0.06 ± 0.02 and 0.12 ± 0.05, respectively). Changes in average alveolar diameter were not statistically observable until the 10th wk between healthy (37 ± 10 μm) and emphysematous rats (73 ± 25 and 95 ± 31 μm, for 5 and 10 units, respectively). Assessment of function-structure correlation suggested that the majority of the decline in fractional ventilation occurred in the first 5 wk, while enlargement of alveolar diameters appeared primarily between the 5th and 10th wk. A thresholding metric, based on the 20th percentile of fractional ventilation over the entire lung, was utilized to detect the onset of the disease with confidence, independent of whether the regional ventilation measurements were normalized with respect to the delivered tidal volume and estimated functional residual capacity of each individual rat.

scholarly journals Post-discharge critical COVID-19 lung function related to severity of radiologic lung involvement at admission

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Laurent Truffaut ◽  
Lucas Demey ◽  
Anne Violette Bruyneel ◽  
Alain Roman ◽  
Stephane Alard ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Function ◽  
Exercise Capacity ◽  
Lung Involvement ◽  
Post Discharge ◽  
Life Data ◽  
Icu Discharge ◽  
Function Impairment ◽  
Lung Function Impairment

AbstractLung function impairment persists in 55% of critical COVID-19 patients three months after ICU discharge. Patient lung function, exercise capacity, radiologic, and quality of life data suggest impairment is related to radiologic lung involvement at admission.

scholarly journals Adjunctive Garcinia mangostana Linn. (Mangosteen) Pericarp for Schizophrenia: A 24-Week Double-blind, Randomized, Placebo Controlled Efficacy Trial: Péricarpe d’appoint Garcinia mangostana Linn (mangoustan) pour la schizophrénie : un essai d’efficacité de 24 semaines, à double insu, randomisé et contrôlé par placebo

2020 ◽  
pp. 070674372098243
Author(s):  
Alyna Turner ◽  
Andrea Baker ◽  
Olivia M. Dean ◽  
Adam J. Walker ◽  
Seetal Dodd ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Schizoaffective Disorder ◽  
Negative Symptoms ◽  
Controlled Trial ◽  
Safety Data ◽  
Rate Of Change ◽  
Adjunctive Treatment ◽  
Garcinia Mangostana ◽  
Double Blind

Objectives: Garcinia mangostana Linn. (“mangosteen”) pericarp contains bioactive compounds that may target biological pathways implicated in schizophrenia. We conducted a double-blind randomized placebo-controlled trial evaluating the efficacy of adjunctive mangosteen pericarp, compared to placebo, in the treatment of schizophrenia. Methods: People diagnosed with schizophrenia or schizoaffective disorder ( Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition), recruited across 2 sites (Brisbane and Victoria, Australia), were randomized to receive 24 weeks of adjunctive mangosteen pericarp (1,000 mg/day) or matched placebo. The primary outcome measure was the Positive and Negative Symptom Scale total score. Secondary outcomes included positive and negative symptoms, general psychopathology, clinical global severity and improvement, participant reported overall improvement, depressive symptoms, functioning, quality of life, and safety data at 24 and 28 weeks (4 weeks postdiscontinuation). Data were collected from July 2016 to February 2019. Results: Baseline assessments were conducted on 148 people (mangosteen = 74, placebo = 74); data analyses were conducted on 136 (92%) participants with postbaseline data. The treatment group had significantly higher symptom severity compared to placebo, and both groups significantly improved on all symptom, functioning, and quality of life measures over time. No between-group differences were found for the rate of change between baseline and 24 or 28 weeks. Conclusion: Despite promising preclinical and clinical work, our results do not support mangosteen pericarp extract as an adjunctive treatment for schizophrenia or schizoaffective disorder.

scholarly journals Customized Human Milk Fortification Based on Measured Human Milk Composition to Improve the Quality of Growth in Very Preterm Infants: A Mixed-Cohort Study Protocol

2021 ◽  
Vol 18 (2) ◽  
pp. 823
Author(s):  
Manuela Cardoso ◽  
Daniel Virella ◽  
Israel Macedo ◽  
Diana Silva ◽  
Luís Pereira-da-Silva
Keyword(s):  
Human Milk ◽  
Preterm Infants ◽  
Fat Mass ◽  
Study Protocol ◽  
Milk Composition ◽  
Fixed Dose ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Pea Pod

Adequate nutrition of very preterm infants comprises fortification of human milk (HM), which helps to improve their nutrition and health. Standard HM fortification involves a fixed dose of a multi-nutrient HM fortifier, regardless of the composition of HM. This fortification method requires regular measurements of HM composition and has been suggested to be a more accurate fortification method. This observational study protocol is designed to assess whether the target HM fortification method (contemporary cohort) improves the energy and macronutrient intakes and the quality of growth of very preterm infants, compared with the previously used standard HM fortification (historical cohorts). In the contemporary cohort, a HM multi-nutrient fortifier and modular supplements of protein and fat are used for HM fortification, and the enteral nutrition recommendations of the European Society for Paediatric Gastroenterology Hepatology and Nutrition for preterm infants will be considered. For both cohorts, the composition of HM is assessed using the Miris Human Milk analyzer (Uppsala, Sweden). The quality of growth will be assessed by in-hospital weight, length, and head circumference growth velocities and a single measurement of adiposity (fat mass percentage and fat mass index) performed just after discharge, using the air displacement plethysmography method (Pea Pod, Cosmed, Italy). ClinicalTrials.gov registration number: NCT04400396.

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