scholarly journals National Medical Research Center for Children’s Health

2021 ◽  
Vol 1 (4) ◽  
pp. 5-10
Author(s):  
Karine O. Avetisyan
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Clinical Practice ◽  
Bronchial Asthma ◽  
Real World ◽  
Sports Participation ◽  
Complete Control ◽  
Basic Therapy ◽  
Detailed Medical History

Background. The clinical course of bronchial asthma (BA) in children is often mild. However, in real-world clinical practice it may not always be possible to attain complete control of BA symptoms. In the majority of cases cessation of basic therapy with inhaled corticosteroids (ICS) leads to a poorer BA control in spite of satisfactory general health status in patients. As a result of incomplete BA control, children demonstrate impaired activities of daily living, decreased daily physical activity and gradual reduction or withdrawal of sports participation and other activities. Under the conditions of restricted everyday activities children with mild BA and in the absence of continuous anti-inflammatory basic therapy may feel comfortable without any complaints. This may result in faulty evaluation of asthma as well controlled, which can cause disease progression.Case report. All the above mentioned situations are exemplified by the case report of a youngster suffering from mild bronchial asthma. Also, this article clearly demonstrates the significance of use of asthma control test (ACT) in real-world clinical practice in order to work out a strategy for asthma management. Besides, the role of taking a detailed medical history for correct assessment of mild BA symptom control is demonstrated. In a given clinical example we managed to evaluate, in a short space of time, everyday life changes of a youngster with mild BA (an increase in daily activities and improved quality of life) following administration of basic therapy with ICS.Conclusion. This case report demonstrates the significance of correct assessment of BA control regardless of severity of disease, in our case mild asthma, and shows its role in conducting proper basic therapy and achieving improvement of child’s quality of life.

Home versus outpatient pulmonary rehabilitation in COPD: a propensity-matched cohort study

Thorax ◽  
2019 ◽  
Vol 74 (10) ◽  
pp. 996-998 ◽  
Author(s):  
Claire Marie Nolan ◽  
Djeya Kaliaraju ◽  
Sarah Elizabeth Jones ◽  
Suhani Patel ◽  
Ruth Barker ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Clinical Practice ◽  
Real World ◽  
Treatment Strategy ◽  
Pulmonary Rehabilitation ◽  
Standard Of Care ◽  
Matched Cohort ◽  
Home Based

Home-based exercise has been proposed as an equivalent treatment strategy to supervised outpatient pulmonary rehabilitation (PR), but it is not known whether its implementation into clinical practice produces similar benefits to those observed in trials. We compared the real-world responses of 154 patients with COPD undergoing home-based exercise with a matched group attending supervised PR. We observed smaller improvements in exercise capacity with home-based exercise compared with PR, but similar improvements in quality of life. We propose that supervised PR remains the standard of care, with home-based exercise a less effective alternative for those unable to attend PR.

scholarly journals Health-related quality of life (QoL) in patients with advanced melanoma receiving immunotherapies in real-world clinical practice settings

2020 ◽  
Vol 29 (10) ◽  
pp. 2651-2660
Author(s):  
Richard W. Joseph ◽  
Frank Xiaoqing Liu ◽  
Alicia C. Shillington ◽  
Cynthia P. Macahilig ◽  
Scott J. Diede ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Real World ◽  
Repeated Measures ◽  
Advanced Melanoma ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Eq Vas

Abstract Background Pembrolizumab (PEMBRO) and ipilimumab + nivolumab (IPI + NIVO) are approved advanced melanoma (AM) immunotherapies. To address limited health-related quality of life (QoL) real-world evidence with immunotherapies in AM, we compared QoL in AM patients receiving either treatment in clinical practice. Methods A prospective US observational study enrolled adult AM patients initiating first-line PEMBRO or IPI + NIVO between June 2017 and March 2018. Endpoints included the QLQ-C30 global health score (GHS) and EuroQol visual analog scale (EQ-VAS) scores. Mean changes were compared using repeated measures mixed-effects models and are presented covariate adjusted. Results 225 PEMBRO and 187 IPI + NIVO patients were enrolled. From baseline through week 24, PEMBRO was associated with 3.2 mean GHS score increase (95% CI 0.5, 5.9; p = .02), while no change was observed with IPI + NIVO; 0.2 (95% CI − 2.6, 3.0; p = 0.87). Among objective treatment-responders, GHS scores associated with PEMBRO increased 6.0 (95% CI 3.1, 8.8; p < .0001); IPI + NIVO patients increased 3.8 (95% CI 0.8, 6.9; p = .01). In treatment non-responders, IPI + NIVO was associated with GHS/QoL deterioration of − 3.7 (95% CI − 6.8, − 0.6; p = .02), PEMBRO non-responders demonstrated no change; 0.7 (95% CI − 2.3, 3.7; p = 0.6). Between treatments, PEMBRO patients increased 2.6 greater in EQ-VAS (95% CI 0.6, 4.5; p = .01) vs IPI + NIVO at 24 weeks. Conclusions PEMBRO was associated with better 24-week QoL compared to IPI + NIVO in actual clinical practice settings. Real-world data has known limitations, but with further confirmation these results may have implications for treatment selection.

121-LB: Early Independent View of Quality of Life in Patients with Type 1 Diabetes Using Hybrid Closed-Loop Insulin Delivery System in Real-World Clinical Practice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 121-LB
Author(s):  
AHMED H. ELDIB ◽  
ELENA TOSCHI ◽  
NOOR MAHMOUD ◽  
MHD WAEL TASABEHJI ◽  
SAHAR ASHRAFZADEH ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 1 Diabetes ◽  
Clinical Practice ◽  
Delivery System ◽  
Real World ◽  
Closed Loop ◽  
Insulin Delivery ◽  
Insulin Delivery System

MP83-19 REAL-WORLD USE OF EPIC FOR CLINICAL PRACTICE (EPIC-CP) TO ASSESS PATIENT-REPORTED PROSTATE CANCER QUALITY-OF-LIFE IN THE CLINICAL SETTING

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Peter Chang ◽  
Arie Carneiro ◽  
Ostap Dovirak ◽  
Kimberly Taylor ◽  
Catrina Crociani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Clinical Practice ◽  
Real World ◽  
Clinical Setting ◽  
Patient Reported

scholarly journals Clinical efficacy of anti-ige-therapy in adult patients with severe uncontrolled bronchial asthma in real clinical practice

2018 ◽  
pp. 54-58
Author(s):  
G. L. Ignatova ◽  
E. V. Blinova ◽  
O. L. Minakina
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
Adult Patients ◽  
Asthma Exacerbations ◽  
Ige Mediated ◽  
Real Clinical Practice

The article presents the results of comprehensive assessment of the efficacy of anti-IgE therapy in adult patients with severe IgE-mediated uncontrolled bronchial asthma in real clinical practice. Omalizumab added to the background anti-inflammatory therapy allowed to reduce the incidence of asthma exacerbations, achieve stable positive dynamics during severe asthma and associated allergic diseases, increase control of the disease, and improve the patients’ quality of life. The drug has a wellcharacterized long-term use safety profile.

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