Effects of the Airway Obstruction on the Skin Microcirculation in Patients with Bronchial Asthma

Background: Pulmonary hemodynamic disorders depend on the inflammatory phases and severity of the obstructive syndrome. However, the effect of asthma bronchial obstruction on the state of peripheral hemodynamics remains insufficiently known. Aims: To study the effects of airway obstruction on skin blood flow parameters and its regulatory systems in patients with persistent atopic bronchial asthma in the remission state.Materials and methods: A comparative study of the skin peripheral blood flow in patients with bronchial asthma with severe airway obstruction (1st group) and without obstruction (2nd group) was conducted. 20 patients with confirmed diagnosis of atopic asthma of 50–74 years old participated in the study. All patients received basic therapy in a constant dosing of high doses of inhaled glucocorticosteroids/long-acting beta-2-agonists. The control group included 20 healthy volunteers without evidence of bronchial obstruction. The study lasted for 3 months. The forced expiratory volume in 1 s (FEV1) was used to evaluate the bronchial obstruction by spirometry technique. Skin blood perfusion changes were recorded by laser Doppler flowmetry at rest and in response to short-term local ischemia. Registered peripheral blood flow signals were examined using the amplitude temporal filtering in five frequency intervals to identify the functional features of the peripheral blood flow regulation systems. Results: Consistent two-fold decrease of the oscillation amplitudes was found in the neurogenic interval at rest (p=0.031), as well as in the myogenic (p=0.043; p=0.031) and endothelial intervals (p=0.037; p≤0.001) both at rest and during the postocclusive reactive hyperemia respectively in the 1st group of patients with bronchial obstruction (FEV1 80%) compared with the control group. No significant changes were revealed for skin blood flow parameters in the 2nd patient group (without obstruction, FEV1 80%) in comparison to control subjects.Conclusions: The presence of bronchial obstruction has a significant impact on the changes of the amplitudes of skin blood flow oscillations in patients with bronchial asthma in the myogenic, neurogenic and endothelial intervals.

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Cardiac Output Changes in Newborns With Hyperbilirubinemia Treated With Phototherapy

PEDIATRICS ◽

10.1542/peds.76.6.918 ◽

1985 ◽

Vol 76 (6) ◽

pp. 918-921

Author(s):

Frans J. Walther ◽

Paul Y. K. Wu ◽

Bijan Siassi

Keyword(s):

Blood Flow ◽

Cardiac Output ◽

Stroke Volume ◽

Skin Blood Flow ◽

Peripheral Blood ◽

Cardiovascular Effects ◽

Tissue Perfusion ◽

Peripheral Blood Flow ◽

Limb Blood Flow ◽

Term Infants

Phototherapy is known to increase peripheral blood flow in neonates, but information on the associated cardiovascular effects is not available. Using pulsed Doppler echocardiography we evaluated cardiac output and stroke volume in 12 preterm and 13 term neonates during and after phototherapy. We concomitantly measured arterial limb blood flow by strain gauge plethysmography and skin blood flow by photoplethysmography. Cardiac output decreased by 6% due to reduced stroke volume during phototherapy, whereas total limb blood flow and skin blood flow increased by 38% and 41%, respectively. Peripheral blood flow increments tended to be higher in the preterm than in the term infants. The reduced stroke volume during phototherapy may be an expression of reduced activity of the newborn during phototherapy. For healthy neonates the reduction in cardiac output is minimal, but for sick infants with reduced cardiac output, this reduction may further aggravate the decrease in tissue perfusion.

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Temperature Biofeedback Training to Improve Peripheral Blood Flow in the Upper Extremities of Diabetic Patients

Canadian Journal of Occupational Therapy ◽

10.1177/000841748405100501 ◽

1984 ◽

Vol 51 (5) ◽

pp. 219-224 ◽

Cited By ~ 1

Author(s):

Elizabeth Dean

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Diastolic Blood Pressure ◽

Peripheral Blood ◽

Diabetic Group ◽

Biofeedback Training ◽

Control Group ◽

Diabetic Patients ◽

Peripheral Blood Flow ◽

Temperature Biofeedback

Ten control and ten diabetic subjects were first given a baseline session of no temperature biofeedback, and then were exposed to four 40-minute temperature biofeedback sessions over consecutive days. As the result of feedback training, peripheral skin temperatures increased on the training (right) hands of both groups, and this occurred to a greater extent in the diabetic group. Concomitant temperature increases occurred also in the left hands of both groups. Neither group produced any significant changes in heart rate, respiration rate, or systolic blood pressure with the exception of a significant decrease in diastolic blood pressure for the diabetic group. No difference in diastolic blood pressure was observed, however, when the diabetics were compared with the control group. The results would suggest further evaluation of temperature biofeedback training is warranted in a diabetic population as a potential means of increasing peripheral blood flow in the extremities.

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Assessment of the Peripheral Blood Flow of Lower Limbs in Patients with Diabetes Mellitus with the Use of Digital Photoplethysmography

Acta Medica Martiniana ◽

10.1515/acm-2015-0008 ◽

2015 ◽

Vol 15 (2) ◽

pp. 21-29 ◽

Cited By ~ 1

Author(s):

G. Hubena ◽

O. Osina ◽

Busikova Prindesova ◽

T. Vasicko

Keyword(s):

Blood Flow ◽

Peripheral Blood ◽

Structural Changes ◽

Lower Limbs ◽

Control Group ◽

Diabetic Patients ◽

Peripheral Blood Flow ◽

Peak Time ◽

Pulse Peak ◽

The Mean

Abstract Introduction: The microcirculation of the lower limbs (LL) of diabetics is influenced by hyperglycemia and several factors (hypertension, obesity, dyslipidemia) leading to the functional and later the structural changes, manifesting as dysregulation of the peripheral blood flow. Materials and Methods: The study included 39 patients with type 2 diabetes, and the same number of the control group. The digital photoplethysmography (PPG) was used for assessment of the peripheral circulation with reflectance mode, sensing from the 1st and 2nd toe of the LL after acclimatisation of the patient in the supine position. The subjects were also asked to refrain from smoking, to avoid drinks containing caffeine and using of medicaments with vasodilatator function at least 2 hours before examination. Results: The pulse amplitudes and the peak times of the PPG curves were significantly higher in diabetic group than in the control group. The mean pulse amplitudes in diabetics were in the range of 0.69 % 0.86 %, the pulse peak time in the range of 140 - 154 ms. The mean pulse amplitudes in the control group were in the range of 0.37 0.54 %, the mean pulse peak time were in the range of 120 - 133 ms. The PPG findings of the LL were symmetrical (non-significant t-test). We have not found a correlation between the PPG records and duration, compensation of diabetes, age, glycemia, blood pressure, dyslipidemia, smoking and obesity. Conclusion: This simple-to-use technique shows the increased total skin microcirculation in diabetic patients. Microvascular shunting of blood presenting in peripheral nerves and in the skin of diabetic feet are responsible for reduced hyperemia response to any inflammatory process with the increased susceptibility for inquiring the diabetic foot infection.

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Influence of Peripheral Blood Flow Parameters on the Terms of Arteriovenous Fistula Maturation

Flebologiia ◽

10.17116/flebo20201401125 ◽

2020 ◽

Vol 14 (1) ◽

pp. 25

Author(s):

A. A. Repin ◽

P. F. Kravtsov ◽

S. E. Katorkin ◽

M. A. Melnikov ◽

Yu. B. Reshetnikova

Keyword(s):

Blood Flow ◽

Arteriovenous Fistula ◽

Peripheral Blood ◽

Peripheral Blood Flow ◽

Flow Parameters ◽

Fistula Maturation ◽

Arteriovenous Fistula Maturation

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Serum apelin-12 in bronchial asthma

Kazan medical journal ◽

10.17816/kmj2205 ◽

2014 ◽

Vol 95 (5) ◽

pp. 631-636

Author(s):

V N Mineev ◽

T M Lalaeva ◽

A A Kuzmina

Keyword(s):

Serum Level ◽

Bronchial Asthma ◽

Peripheral Blood ◽

Allergic Sensitization ◽

Serum Levels ◽

Atopic Asthma ◽

Bronchial Obstruction ◽

Blood Eosinophil ◽

Inverse Association ◽

Peripheral Blood Eosinophil

Aim. To evaluate the serum level of apelin-12 in patients with bronchial asthma. Methods. 11 healthy controls and 29 patients with bronchial asthma were examined (among them 19 with atopic asthma and 10 with non-atopic asthma). Serum apelin-12 levels were measured by enzyme immunoassay (ELISA, MyBioSource, USA). SPSS (Statistical Package for the Social Science, V. 13) for Windows was used for statistical analysis. Results. The phenomenon of low apelin-12 serum levels was revealed in patients with bronchial asthma. The most significant decrease of apelin-12 levels was noticed in atopic bronchial asthma. The apelin-12 levels were significantly correlated with a number of indices of bronchial obstruction. Apelin-12 levels correlated with a number of indicators characterizing the grade of bronchial obstruction. Moreover, low apelin-12 levels were suggesting bronchial obstruction. Besides, significant reverse correlation of apelin-12 levels and allergic sensitization was revealed. In addition, statistically significant relation between apelin-12 serum level and peripheral blood eosinophil and lymphocyte counts was revealed. There was an inverse association between apelin-12 serum level and peripheral blood neutrophil count. Conclusion. Literature analysis and our own results allow us to suppose the possible protective role of apelin-12 in bronchial asthma flare. Further studies of apelin-12 and of other isoforms of adipokines are needed for better understanding of the disease.

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Peripheral blood flow in patients with graves’ disease depending on level of thyroid status compensation

Kazan medical journal ◽

10.17816/kmj1794 ◽

2013 ◽

Vol 94 (6) ◽

pp. 804-807 ◽

Cited By ~ 1

Author(s):

I S Kulabukhova ◽

L N Eliseeva

Keyword(s):

Blood Flow ◽

Peripheral Blood ◽

Vascular Tone ◽

Control Group ◽

Graves Disease ◽

Peripheral Blood Flow ◽

Average Dose ◽

Thyroid Status ◽

Total Recovery ◽

Doppler Flowmetry

Aim. To study the features of peripheral blood flow using laser Doppler flowmetry in patients with Graves’ disease depending on level of thyroid status compensation. Methods. 45 patients with Graves’ disease were divided into three groups 15 patients each depending on level of thyroid status compensation. The first group included patients with compensated hyperthyroidism, the second - with subcompensated hyperthyroidism, the third - with decompensated hyperthyroidism. All patients received combined thyrotropic (thiamazole 15-30 mg, average dose 22.4±1.7 mg) and cardio- and vasotropic therapy (metoprolol 50-100 mg, average dose 72.1±3.3 mg, and fozinopril 10-20 mg, average dose 17.8±2.4 mg), doses were individually adjusted. Results were compared with the control group (15 healthy patients). The peripheral blood flow was evaluated using LAKK-01 («LAZMA», Russia) device. Results. The comparison of control group and patients with Graves’ disease depending on level of thyroid status compensation demonstrated substantial differences. Doppler flowmetry registered increased blood flow, square deviation, variation coefficient in patients with diffuse thyrotoxic goitre, reflecting increase of tissue blood perfusion and reduced vascular tone. The analysis of the frequency histogram showed that the increase of average blood flow amplitude in case of hyperthyroidism was initiated by increase in amplitudes of all flaxmotions characterizing metabolic processes in capillaries. The relevant correlation between registered variables of blood flow and level of thyroid status compensation was registered. The most marked changes were revealed in patients with subcompensated and decompensated hyperthyroidism. In patients with compensated hyperthyroidism, the blood flow was altered the least compared to control group. Increased impact of active blood flow modulation mechanisms due to neurogenic activity and vascular tone was revealed. At the same time, endothelial activity was decreased. Predominance of sympathetic stimuli and compensatory mechanisms intensifying were discovered. Conclusion. The changes of peripheral blood flow in patients with Graves’ disease were typical for congestive-hyperemic type of microcirculation. Intensity of blood flow alterations is defined by thyroid status compensation. However, even the complete clinical and laboratory compensation doesn’t result in total recovery of capillary blood flow compared to healthy people.

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Leukemia risk and rate of radiation dose accumulation. Part 2: Comparative analysis of leukocytic indices and dynamics of peripheral blood values in relation to external gamma-exposure dose

Radiatsionnaya Gygiena = Radiation Hygiene ◽

10.21514/1998-426x-2020-13-2-75-88 ◽

2020 ◽

Vol 13 (2) ◽

pp. 75-88

Author(s):

S. F. Sosnina ◽

A. M. Yurkin ◽

P. V. Okatenko ◽

S. A. Rogacheva ◽

E. A. Gruzdeva ◽

...

Keyword(s):

Bone Marrow ◽

Blood Flow ◽

Comparative Analysis ◽

Peripheral Blood ◽

Blood Cells ◽

Exposure Dose ◽

Control Group ◽

Peripheral Blood Flow ◽

Study Group ◽

Blast Cells

The results of a retrospective analysis of leukocytic indices and dynamics of peripheral blood values in relation to external gamma-exposure dose among the personnel of the first atomic production facility in Russia were presented. The study was performed on the basis of the database “Leukemia in the cohort of workers of the Mayak Production Association employed in 1948-1958”. The database contains hematological, clinical and dosimetry information on the two groups of workers: the study group includes individuals with leukemia as the cause of death (n=84); control group includes personnel without hematological cancer pathology (n=300). The control group was composed by selecting 3-4 internal control cases for each leukemia case taking into account gender, age of the start of the exposure and the same accumulated absorbed dose of gamma-exposure to red bone marrow. Based on 19592 analysis of peripheral blood we had described hematopoiesis shifts along cell lines, performed correlation analysis of interrelation between hemogram values and radiation dose, analyzed particular characteristics of blast cells’ appearance in peripheral blood flow in the period prior to leukemias. Comparative analysis of various leukocytic indices was performed among Mayak PA personnel for the first time. The diverse nature of the response of bone marrow hematopoiesis was noted; more pronounced hematological shifts were indicated regarding more intensive production exposure. A number of hematopoietic features were detected among people exposed to production radiation: 1) cytopenia in relation to minimum accumulated doses of radiation exposure in both studied groups; 2) more pronounced lability of hemograms in relation to increased accumulation dose of external gamma-exposure and period of radiation exposure among individuals who had developed leukemia in future in comparison to controls; 3) correlation between peripheral blood cells and accumulated doses of external gamma-exposure was characterized by the highest values of coefficients among individuals with future leukemias; 4) myeloblasts were most often registered among all the blast cells; proerythroblasts were characterized by the shortest average period from the start of the exposure and to the moment of their appearance in the peripheral blood flow (178 days in the study group); polychromatophile erythroblasts in peripheral blood were registered only among the workers with future leukemia; 5) when comparing leukocytic indices in proportion to the categories of accumulated doses of external gamma-exposure, a pronounced variability in the ratio of blood cells was observed among exposed individuals who were subsequently diagnosed with leukemia, especially in the range of 2.0-2.5 Gy. Thus, a comprehensive analysis of hematological parameters, including the assessment of leukocytic indices, is more informative than studying a standard hemogram. Particular features of the dynamics of the cellular composition of peripheral blood can be used as indicators of pathological hematopoiesis in exposed workers prior to clinical manifestation of leukemia.

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