Evaluation of local – delivery system containing 80% aloe vera gel used as an adjunct to scaling and root planning in chronic periodontitis: A clinical study

Background: Phytotherapy is the usage of herbal species with medicinal properties for the management of various diseases. Gingivitis and periodontitis are diseases that involve the role of both the bacteria and the host immune response. Over the years, various researches have shown the importance of herbal products in the management of periodontal diseases. Aims of the study: To evaluate the efficacy of locally applied Salvia officinalis gel as adjunctive in the treatment of chronic periodontitis. Subjects and methods: Fourteen patients (10 males and 4 females) with chronic periodontitis were enrolled in the present study with total number of twenty-eight periodontal pockets utilizing a split mouth design, the pockets were divided into two groups, the test group which was treated with scaling and root planning procedure and the application of the S. officinalis gel, and the control group that treated with scaling and root planning only. Plaque index (PI) and gingival index (GI) were recorded for each site. Gingival crevicular fluid (GCF) was collected from each site by using PerioCol paper strips. The concentration of the transforming growth factor beta-1 in the gingival crevicular fluid was quantified by a high sensitivity enzyme-linked immunosorbent assay. Results: The test group demonstrated a significant reduction in GI at 1-week and 1-month after the treatment comparing to baseline (1.14 vs. 1.64, p = 0.003, and 1.21 vs. 1.64, p = 0.028, respectively), while no significant reduction in the PI at recall visits comparing to baseline. The control group demonstrated no significant reduction in PI and GI at recall visits, comparing to baseline. Both the test and control groups demonstrated no significant reduction in the transforming growth factor-beta 1 concentration in the gingival crevicular fluid at one week after the treatment comparing to baseline, while at one month after the treatment only the test group demonstrated a significant reduction comparing to baseline (3.91 vs. 9.62, p = 0.044). Conclusion: The findings of the present study indicated that the S. officinalis gel has a potential anti-inflammatory role in the treatment of chronic periodontitis by monitoring both the clinical and immunological parameters.

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Efficacy of 10% whole Azadirachta indica (neem) chip as an adjunct to scaling and root planning in chronic periodontitis: A clinical and microbiological study

Indian Journal of Dental Research ◽

10.4103/0970-9290.179808 ◽

2016 ◽

Vol 27 (1) ◽

pp. 15 ◽

Cited By ~ 7

Author(s):

K Vennila ◽

S Elanchezhiyan ◽

Sugumari Ilavarasu

Keyword(s):

Azadirachta Indica ◽

Chronic Periodontitis ◽

Microbiological Study ◽

Root Planning ◽

Scaling And Root Planning

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The Effect of Scaling and Root Planning on Salivary TNF-α and IL-1α Concentrations in Patients with Chronic Periodontitis

The Open Dentistry Journal ◽

10.2174/1874210601711010573 ◽

2017 ◽

Vol 11 (1) ◽

pp. 573-580 ◽

Cited By ~ 7

Author(s):

Masoome Eivazi ◽

Negar Falahi ◽

Nastaran Eivazi ◽

Mohammad Ali Eivazi ◽

Asad Vaisi Raygani ◽

...

Keyword(s):

Chronic Periodontitis ◽

Interleukin 1 ◽

Negative Relationship ◽

Inflammatory Factors ◽

Control Group ◽

Pocket Depth ◽

Necrosis Factor Alpha ◽

Tnf Α ◽

Root Planning ◽

Scaling And Root Planning

Objective:Periodontitis is one of the main diseases in the oral cavity that causes tooth loss. The host immune response and inflammatory factors have important role in periodontal tissue. The current study was done with the objective to determine the effect of scaling and root planning on the salivary concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-alpha (IL-1α).Methods:In this quasi-experimental clinical trial, 29 patients with chronic periodontitis and 29 healthy subjects without periodontitis were studied. Clinical examination findings and salivary TNF-α and IL-1α (using ELISA method) were compared before and after scaling, root planning.Results:Before starting treatment, salivary TNF-α and IL-1α concentrations were higher in healthy control group than in periodontitis group (P< 0.05). Non-surgical treatment increased the concentration of these two biomarkers in the saliva. However, increase in IL-1α concentration was not statistically significant (P= 0.056). There was a negative relationship between TNF-α and IL-1α levels with pocket depth and attachment loss (P< 0.05).Conclusion:Scaling and root planning improved periodontal disease indices and salivary TNF-α and IL-1α levels.

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Effectiveness of the adjunctive use of ozone and chlorhexidine in patients with chronic periodontitis

BDJ Open ◽

10.1038/s41405-019-0025-9 ◽

2019 ◽

Vol 5 (1) ◽

Cited By ~ 2

Author(s):

Kaveri Kranti Gandhi ◽

Emil G. Cappetta ◽

Rajdeep Pavaskar

Keyword(s):

Chronic Periodontitis ◽

Gold Standard ◽

Gingival Index ◽

Periodontal Pathogens ◽

Ozone Therapy ◽

Clinical Attachment Loss ◽

Probing Depth ◽

Root Planning ◽

Scaling And Root Planning

Abstract Background Scaling and root planning (SRP) is the gold standard approach for treatment of chronic periodontitis but used alone it may not be effective in removing periodontal pathogens from sites where access is poor. Objective To evaluate and compare the clinical and microbiological efficacy of ozone and chlorhexidine (CHX) as an adjunct to SRP in patients with chronic periodontitis. Methods Twenty-five patients with generalized moderate to severe chronic periodontitis with presence of at least one site in each quadrant with a probing depth ≥5 mm were recruited. In a split mouth study design, two quadrants were randomly allocated to the SRP and ozone therapy and the remaining two quadrants to SRP and CHX therapy. Plaque index (PI), Gingival index (GI), probing depth (PD), clinical attachment loss (CAL) were assessed. Subgingival plaque samples were obtained for assessment of Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg). Results Both groups demonstrated significant intragroup reduction in PI, GI, PD, CAL, Pg count and Aa count from baseline to 3 months follow-up. There were no significant differences between two groups for any of the parameters. Conclusion Ozonated olive oil can be used as an adjunctive subgingival irrigant in patients with chronic periodontitis.

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