scholarly journals Clinical and immunological characteristic of natural course at the early stages of HIV infection

2020 ◽  
Vol 22 (3) ◽  
pp. 519-526
Author(s):  
E. R. Manapova ◽  
V. Kh. Fazylov ◽  
A. T. Beshimov
Keyword(s):  
Hiv Infection ◽  
Clinical Course ◽  
Fungal Infections ◽  
Early Stage ◽  
Elisa Test ◽  
Natural Course ◽  
Early Stages ◽  
Duration Of Infection ◽  
Stage Infection ◽  
Pronounced Inhibition

An early-stage infection induces the most powerful reactions of immune system. 137 clinical histories of patients with HIV infection, and HCV/HIV-infected at the early stages of HIV infection were subjected to analysis. Patients and methods: a group of 45 patients at early terms of HIV infection included 25 cases of HCV/HIV-infected patients (first group), and 20 cases with HIV mono-infection (second group). Duration of infection was less than 1 year (with positive ELISA test), with mean terms of HIV immunoblot positivity of 5.5±0.6 months. For comparative analysis, the natural course group was examined, i.e., 43 patients with combined HCV/HIV infection (third group), and 49, with HIV monoinfection (fourth group) with a duration of HIV infection for 4.4±0.21 years. The group of healthy controls included 52 persons. We aimed to perform a comparative evaluation of clinical course and immunological features from the early stages of infection in the patients with combined HCV/HIV and HIV infection. Results: at early stages of infection, clinical pattern in HCV/HIV-infected patients was dominated by purulent-inflammatory, fungal infections and secondary diseases, along with more pronounced inhibition of cellular immunity and increased viral load of RNA HIV, as compared to data on HIV-infected patients.

scholarly journals HIV Infection Care and Viral Suppression Among People Who Inject Drugs, 28 U.S. Jurisdictions, 2012-2013

2016 ◽  
Vol 10 (1) ◽  
pp. 127-135 ◽  
Author(s):  
Debra L. Karch ◽  
Kristen Mahle Gray ◽  
Jing Shi ◽  
H. Irene Hall
Keyword(s):  
Young People ◽  
Hiv Infection ◽  
Viral Suppression ◽  
People Who Inject Drugs ◽  
Early Stage ◽  
Linkage To Care ◽  
Retention In Care ◽  
Infected People ◽  
Hiv Surveillance ◽  
Stage Infection

Objectives: Assess outcomes along the care continuum for HIV-infected people who inject drugs (PWID), by type of facility and stage of infection at diagnosis. Methods: Data reported by 28 jurisdictions to the National HIV Surveillance System by December 2014 were used to identify PWID aged ≥13 years, diagnosed with HIV infection before December 31, 2013. Analyses used the CDC definition of linkage to care (LTC), retention in care (RIC), and viral suppression (VS), and are stratified by age, sex, race/ethnicity, and type of facility and stage of HIV infection at diagnosis. Results: Of 1,409 PWID diagnosed with HIV in 2013, 1,116 (79.2%) were LTC with the lowest percentages among males (78.4%); blacks (77.5%) ages 13-24 years (69.0%); those diagnosed in early stage infection (71.6%); and at screening, diagnostic, or referral agencies (60.0%). Of 80,958 PWID living with HIV in 2012, 40,234 (49.7%) were RIC and 34,665 (42.8%) achieved VS. The lowest percentages for RIC and VS were among males (47.1% and 41.3% respectively); those diagnosed with late stage disease (47.1% and 42.4%); and young people. Whites had the lowest RIC (47.0%) while blacks had the lowest VS (41.1%). Conclusion: Enhanced LTC activities are needed for PWID diagnosed at screening, diagnostic or referral agencies versus those diagnosed at inpatient or outpatient settings, especially among young people and blacks diagnosed in early stage infection. Less than half of PWID are retained in care or reach viral suppression indicating the need for continued engagement and return to care activities over the long term.

scholarly journals MULTIFORMITY OF FUNGAL INJURIES IN HIV INFECTION

2020 ◽  
Vol 12 (1) ◽  
pp. 105-112
Author(s):  
I. M. Uliukin ◽  
M. A. Bulygin ◽  
Y. I. Bulankov ◽  
E. S. Orlova ◽  
A. A. Sechin
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Psychosocial Support ◽  
Clinical Course ◽  
Fungal Infections ◽  
Universal Method ◽  
Social Psychological ◽  
Severe Damage ◽  
Specific Therapy ◽  
Long Course

The epidemic of HIV infection in the last decade has acquired new qualities — first of all, it is an epidemic of severe and comorbid forms of the disease with various pathways of infection, where most of the identified patients need antiretroviral therapy, and most patients die from secondary and concomitant diseases. Therefore, early diagnosis and effective treatment of both the underlying and concomitant diseases are relevant.Materials and methods. Two clinical cases with fungal infections during a long course of HIV infection in the absence and against the ineffective antiretroviral therapy are presented.Results. In the cases considered, one of the main reasons for the development of severe damage was late-detected HIV infection at the clinically expressed stages of the disease, which was due to social, psychological and medical (the complexity, and in some cases the inability to perform laboratory tests) fac- tors.Conclusion. Fungal lesions during HIV infection are diverse in their etiology, forms of manifestation and severity of the clinical course. The development of optimal algorithms and approaches for medical and psychosocial support of such patients is necessary. The high mortality rate of patients with HIV infection in the first week of hospital stay is often evidence of non-adherence to dispensary observation and treatment, all the more so because amid low adherence to specific therapy and chemoprophylaxis, treatment of opportunistic diseases without antiretroviral therapy is ineffective (although the timely appointment of this therapy is considered a universal method for the prevention of secondary diseases). The treatment-diagnostic tactics in diagnostically unclear cases are discussed.

SPECIFICITY OF THE CLINICAL COURSE OF THE INITIAL STAGES OF HYPERTENSION IN ARID ZONES OF UZBEKISTAN AND NON-DRUG APPROACHES TO TREATMENT

2020 ◽  
Author(s):  
U.R. Narzulaeva ◽  
G.U. Samieva ◽  
M.Sh. Ismatova
Keyword(s):  
At Risk ◽  
Drug Treatment ◽  
Healthy Lifestyle ◽  
Clinical Course ◽  
Arid Zones ◽  
Etiological Factors ◽  
Renin Angiotensin ◽  
Early Stages ◽  
Hot Climate ◽  
Patients At Risk

The article describes the etiological factors, the course and risks of the development of hypertension in the early stages in a hot climate. The data on the pathogenesis of hypertension and the effects of pathogenetic variants of the sympatho-adrenal and renin-angiotensin systems are summarized. Non-drug treatment is proposed by observing a healthy lifestyle in patients at risk.

scholarly journals Platelets as messengers of early-stage cancer

2021 ◽  
Author(s):  
Siamack Sabrkhany ◽  
Marijke J. E. Kuijpers ◽  
Mirjam G. A. oude Egbrink ◽  
Arjan W. Griffioen
Keyword(s):  
Tumor Angiogenesis ◽  
Blood Test ◽  
Early Stage ◽  
Human Studies ◽  
Early Stage Cancer ◽  
Reciprocal Interaction ◽  
Early Stages ◽  
New Strategy ◽  
Mrna Content

AbstractPlatelets have an important role in tumor angiogenesis, growth, and metastasis. The reciprocal interaction between cancer and platelets results in changes of several platelet characteristics. It is becoming clear that analysis of these platelet features could offer a new strategy in the search for biomarkers of cancer. Here, we review the human studies in which platelet characteristics (e.g., count, volume, protein, and mRNA content) are investigated in early-stage cancer. The main focus of this paper is to evaluate which platelet features are suitable for the development of a blood test that could detect cancer in its early stages.

scholarly journals The expression of microRNA-331-3p and microRNA-23b3 in Egyptian patients with early-stage hepatocellular carcinoma in hepatitis C-related liver cirrhosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Reham A. Aboelwafa ◽  
Walid Ismail Ellakany ◽  
Marwa A. Gamaleldin ◽  
Marwa A. Saad
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Early Stage ◽  
Group Iii ◽  
Real Time Quantitative Pcr ◽  
Early Stages ◽  
Group I ◽  
Egyptian Patients ◽  
Cirrhotic Patients

Abstract Background Hepatocellular carcinoma and hepatitis C are strongly associated. The current work aimed to study the expression levels of microRNA-331-3p and microRNA-23b-3p as propable biomarkers for detecting liver cancer (HCC) at its early stages in patients with HCV-related liver cirrhosis. The current prospective study included two hundred participants, divided into three groups: group I, 100 patients with HCV-related liver cirrhosis; group II, 50 HCC patients at early stages; and group III, 50 apparentlyhealthy controls. All patients had routine laboratory workup and ultrasound hepatic assessment. Values of microRNA-331-3p and microRNA-23b-3p were measured by real-time quantitative PCR. Results Levels of miR-331-3p were significantly higher in HCC patients than in cirrhotic patients and controls (p < 0.001), while levels of miR-23b-3p were significantly lower in HCC patients compared to cirrhotics and controls (p < 0.001). ROC curve revealed that miR-23b-3p had 80% sensitivity and 74% specificity, miR-331-3p had 66% sensitivity and 61% specificity, and AFP had 64% sensitivity and 61% specificity of 61% in discrimination between HCC patients from controls. Conclusion Serum miR-23b-3p is a more effective predictor than miR-331-3p and AFP for the development of hepatocellular carcinoma in hepatitis C (HCV)-related cirrhotic patients.

Lack of Medical Support in HIV Infection and Unstable Mood States

1997 ◽  
Vol 81 (2) ◽  
pp. 635-639
Author(s):  
Motoko Hayashi ◽  
Isao Fukunishi
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Major Depression ◽  
Hiv Infection ◽  
Mood Disorders ◽  
Early Stage ◽  
Mood States ◽  
Hiv Positive ◽  
Medical Support ◽  
Hiv Patients

This study examined what kinds of social support are related to mood states in a sample of 50 HIV-positive patients without AIDS (46 men and 4 women; M age 36.5 yr., SD = 9.8). In the early stage of HIV infection, HIV patients without AIDS may be prone to depressive symptoms although none of these HIV-positive patients' symptoms fulfilled the DSM-III-R Mood Disorders including Major Depression. The depressive symptoms were not significantly related to lack of ordinary social support such as friends and family but were significantly associated with dissatisfaction with HIV/AIDS-related medical support

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