Effectiveness of radiofrequency renal denervation in diseases with increased sympathetic nervous system activity

The article discusses the role of sympathetic nervous system hyperactivity in the pathogenesis of various pathologies (hypertension, heart failure, atrial fibrillation, metabolic syndrome, diabetes and systemic inflammatory response syndrome). On the example of large randomized clinical trials using catheter-based radiofrequency ablation, the antihypertensive effect in patients with uncontrolled hypertension has been proven. The first experimental and clinical studies on the effectiveness of renal denervation in reducing the activity of inflammatory markers, the incidence of atrial fibrillation and ventricular arrhythmia episodes, and improving the left ventricular contractility. The first clinical results of the favorable effect of renal denervation on carbohydrate metabolism (insulin resistance and glycemic level) in patients with metabolic syndrome and diabetes have been studied in detail.

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The Relation of Glucose Metabolism to Left Ventricular Mass and Function and Sympathetic Nervous System Activity in Obese Subjects With Metabolic Syndrome

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2012-3277 ◽

2013 ◽

Vol 98 (2) ◽

pp. E227-E237 ◽

Cited By ~ 14

Author(s):

Nora E. Straznicky ◽

Mariee T. Grima ◽

Carolina I. Sari ◽

Sofie Karapanagiotidis ◽

Chiew Wong ◽

...

Keyword(s):

Metabolic Syndrome ◽

Nervous System ◽

Glucose Metabolism ◽

Sympathetic Nervous System ◽

Left Ventricular ◽

Sympathetic Nervous System Activity ◽

Nervous System Activity ◽

Obese Subjects ◽

Sympathetic Nervous ◽

And Function

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Faculty Opinions recommendation of The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.7633956.7939054 ◽

2011 ◽

Author(s):

Marleen van Baak

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Nervous System ◽

Sympathetic Nervous System ◽

Weight Loss Maintenance ◽

Sympathetic Nervous System Activity ◽

System Activity ◽

Nervous System Activity ◽

Sympathetic Nervous ◽

Metabolic Syndrome Components

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P6603Impact of paroxysmal atrial fibrillation ablation on cardiac sympathetic nervous system: a prospective randomized comparative study with cryoballoon catheter or radiofrequency ablation catheter

European Heart Journal ◽

10.1093/eurheartj/ehy566.p6603 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Author(s):

M Kawasaki ◽

T Yamada ◽

T Morita ◽

Y Furukawa ◽

S Tamaki ◽

...

Keyword(s):

Atrial Fibrillation ◽

Nervous System ◽

Radiofrequency Ablation ◽

Sympathetic Nervous System ◽

Comparative Study ◽

Paroxysmal Atrial Fibrillation ◽

Atrial Fibrillation Ablation ◽

Ablation Catheter ◽

System A ◽

Sympathetic Nervous

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MicroRNAs Regulating Renin–Angiotensin–Aldosterone System, Sympathetic Nervous System and Left Ventricular Hypertrophy in Systemic Arterial Hypertension

Biomolecules ◽

10.3390/biom11121771 ◽

2021 ◽

Vol 11 (12) ◽

pp. 1771

Author(s):

Alex Cleber Improta-Caria ◽

Marcela Gordilho Aras ◽

Luca Nascimento ◽

Ricardo Augusto Leoni De Sousa ◽

Roque Aras-Júnior ◽

...

Keyword(s):

Nervous System ◽

Sympathetic Nervous System ◽

Left Ventricular Hypertrophy ◽

Signaling Pathways ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

Renin Angiotensin Aldosterone System ◽

Renin Angiotensin ◽

Gene And Protein Expression ◽

Sympathetic Nervous

MicroRNAs are small non-coding RNAs that regulate gene and protein expression. MicroRNAs also regulate several cellular processes such as proliferation, differentiation, cell cycle, apoptosis, among others. In this context, they play important roles in the human body and in the pathogenesis of diseases such as cancer, diabetes, obesity and hypertension. In hypertension, microRNAs act on the renin–angiotensin–aldosterone system, sympathetic nervous system and left ventricular hypertrophy, however the signaling pathways that interact in these processes and are regulated by microRNAs inducing hypertension and the worsening of the disease still need to be elucidated. Thus, the aim of this review is to analyze the pattern of expression of microRNAs in these processes and the possible associated signaling pathways.

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Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System

Cardiology Research and Practice ◽

10.1155/2012/319432 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 21

Author(s):

Jeanie Park

Keyword(s):

Cardiovascular Disease ◽

Chronic Kidney Disease ◽

Renal Failure ◽

Nervous System ◽

Cardiovascular Risk ◽

Kidney Disease ◽

Sympathetic Nervous System ◽

Renal Disease ◽

Left Ventricular ◽

Sympathetic Nervous

Patients with chronic kidney disease are at significantly increased risk for cardiovascular disease and sudden cardiac death. One mechanism underlying increased cardiovascular risk in patients with renal failure includes overactivation of the sympathetic nervous system (SNS). Multiple human and animal studies have shown that central sympathetic outflow is chronically elevated in patients with both end-stage renal disease (ESRD) and chronic kidney disease (CKD). SNS overactivation, in turn, increases the risk of cardiovascular disease and sudden death by increasing arterial blood pressure, arrythmogenicity, left ventricular hypertrophy, and coronary vasoconstriction and contributes to the progression renal disease. This paper will examine the evidence for SNS overactivation in renal failure from both human and experimental studies and discuss mechanisms of SNS overactivity in CKD and therapeutic implications.

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