scholarly journals Research on the Distribution of Coronary Arteries in Pig (Sus Scrofa Domesticus)

2021 ◽  
Vol 78 (2) ◽  
pp. 43
Author(s):  
Gavrilă ZAGRAI ◽  
Cristian Romeo BELU ◽  
Iulian DUMITRESCU ◽  
Ștefania Mariana RAITA ◽  
Mădălina DOBRILĂ ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Arteries ◽  
Sus Scrofa ◽  
Left Coronary Artery ◽  
Plastic Material ◽  
Experimental Models ◽  
Morphological Features ◽  
Major Objective ◽  
Sus Scrofa Domesticus ◽  
Pig Carcasses

Pigs are some of the most widely used experimental models, an advantage being the characteristics of homeostasis and many morphological features comparable to those in humans. For this reason, we addressed this topic in this paper, with the major objective of completing the data and even identifying some features not described in the literature. The present study was performed on 20 pig carcasses, with different weights and ages (2-4 months). The aim was to highlight some peculiarities regarding the coronary artery system in this species, using as a method the injection of vessels with contrasting plastic material. The collaterals and terminals of the coronary arteries, their distribution territories as well as the identified individual variants were described. As a general conclusion, regardless of the polymorphism in all dissected cases, the left coronary artery was the dominant artery, there being no exception from the data known in the literature.

scholarly journals Myorelaxant Effect of the Dysphania ambrosioides Essential Oil on Sus scrofa domesticus Coronary Artery and Its Toxicity in the Drosophila melanogaster Model

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2041
Author(s):  
Luiz Jardelino de Lacerda Neto ◽  
Andreza Guedes Barbosa Ramos ◽  
Renata Evaristo Rodrigues da Silva ◽  
Luís Pereira-de-Morais ◽  
Fernanda Maria Silva ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Smooth Muscle ◽  
Coronary Artery ◽  
Essential Oil ◽  
Coronary Arteries ◽  
Sus Scrofa ◽  
Ex Vivo ◽  
Alternative Methods ◽  
Major Constituent ◽  
Sus Scrofa Domesticus

Purpose: Alternative methods for the use of animals in research have gained increasing importance, due to assessments evaluating the real need for their use and the development of legislation that regulates the subject. The principle of the 3R’s (replacement, reduction and refinement) has been an important reference, such that in vitro, ex vivo and cord replacement methods have achieved a prominent place in research. Methods: Therefore, due to successful results from studies developed with these methods, the present study aimed to evaluate the myorelaxant effect of the Dysphania ambrosioides essential oil (EODa) using a Sus scrofa domesticus coronary artery model, and the toxicity of both the Dysphania ambrosioides essential oil and its major constituent, α-terpinene, against Drosophila melanogaster in toxicity and negative geotaxis assays. Results: The EODa relaxed the smooth muscle of swine coronary arteries precontracted with K+ and 5-HT in assays using Sus scrofa domesticus coronary arteries. The toxicity results presented LC50 values of 1.546 mg/mL and 2.282 mg/mL for the EODa and α-terpinene, respectively, thus showing the EODa and α-terpinene presented toxicity to these dipterans, with the EODa being more toxic. Conclusions: Moreover, the results reveal the possibility of using the EODa in vascular disease studies since it promoted the relaxation of the Sus scrofa domesticus coronary smooth muscle.

scholarly journals Myocardial bridges and coronary distribution in dairy cattle from Brazil Northeast

2021 ◽  
Vol 4 (4) ◽  
pp. 31-42
Author(s):  
Vinícius Lima Brito ◽  
◽  
Kethelyn Freitas de Lima ◽  
Anielly Mirelly de Assunção Ramalho ◽  
Jadson Vieira de Melo ◽  
...  
Keyword(s):  
Veterinary Medicine ◽  
Coronary Artery ◽  
Dairy Cattle ◽  
Coronary Arteries ◽  
Left Coronary Artery ◽  
Experimental Models ◽  
Northeastern Brazil ◽  
Age Group ◽  
Myocardial Bridges ◽  
Path Lengths

This study evaluated the distribution and possible variations of the coronary arteries and the presence of myocardial bridges in dairy cattle from Northeastern Brazil. Thus, healthy hearts were analyzed according to many variables. Left coronary artery originate the rami paraconalis, circumflexus et subsinuosus. Ramus subsinuosus and right coronary artery showed a short subepicardial path. Lengths of the main branches showed statistical differences only in relation to age group and weight of the animal. Myocardial bridges had a prevalence of 55% and were more frequent over the ramus paraconalis. Veterinary medicine is able to provide experimental models to expand the necessary study to understand pathophysiology and clinical relevance of the bridges.

scholarly journals Prognostic value of non-invasive coronary artery flow velocity assessment in elderly patients

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
E Kalinina ◽  
A Zagatina ◽  
N Zhuravskaya ◽  
D Shmatov
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Elderly Patients ◽  
Flow Velocity ◽  
Coronary Arteries ◽  
Coronary Flow ◽  
Prognostic Value ◽  
Area Under Curve ◽  
Left Coronary Artery ◽  
Maximal Velocity

Abstract Funding Acknowledgements Type of funding sources: None. Background There is a high prevalence of coronary artery disease (CAD) in the elderly population. However, symptoms of CAD are often non-specific. Dyspnoe, non-anginal pains are among the main symptoms in older patients. Exercise tests are of limited feasibility in these patients, due to neuro-muscular weakness, physical deconditioning, and orthopaedic limitations. Pharmacological tests often are contraindicated in a substantial percentage of elderly patients. Some recent studies indicate using local flow acceleration during routine echocardiography has prognostic potential for coronary artery assessments without stress testing. The aim of the study was to define the prognostic value of coronary artery ultrasound assessment in patients ≥75 years old. Methods This is a prospective cohort study. Patients ≥ 75 years old who underwent routine echocardiography with additional scans for coronary arteries over a period of 24 months were included in the study. The study group consisted of 80 patients aged 75-90 years (56 women; mean age 79 ± 4). Initial exams were performed for other reasons, primarily for arterial hypertension. Fifteen patients had known CAD. Death, non-fatal myocardial infarction (MI), and revascularization were defined as major adverse cardiac events (MACE). All patients were followed up with at a median of 32 months. Results There were 34 patients with high local velocities in the left coronary artery. Eight deaths, two non-fatal myocardial infarctions occurred, and 13 revascularizations were performed. With a ROC analysis, a coronary flow velocity >110 cm/s was the best predictor for risk of death (area under curve 0.84 [95% CI 0.74–0.92]; sensitivity 75%; specificity 88%). Only the maximal velocity in proximal left-sided coronary arteries was independently associated with death (HR 1.03, 95% CI 1.01; 1.05; p < 0.002), or death/MI (HR 1.03, 95% CI 1.01; 1.04; p < 0.0001). The cut-off value of 66 cm/s was a predictor of all MACE (area under curve 0.87 [95% CI 0.77–0.94]; sensitivity 80%; specificity 86%). Any causes of death or MI occurred more frequently in patients with velocities of >66 cm/s (27% vs. 2%; p < 0.002). The rates of MACE were 58.0% vs. 2%; p < 0.0000001, respectively. Conclusion The analysis of coronary flow in the left coronary artery during echocardiography can be used as a predictor of outcomes in elderly patients. Maximal velocities in proximal left-sided coronary arteries is independently associated with further death or myocardial infarction.

scholarly journals Normal values of coronary arteries branching height in women

2021 ◽  
Vol 27 (4) ◽  
pp. 41-46
Author(s):  
U.Ye. Pidvalna ◽  
D.M. Beshley ◽  
M.Z. Mirchuk ◽  
L.R. Mateshuk-Vatseba
Keyword(s):  
Body Mass Index ◽  
Coronary Artery ◽  
Body Mass ◽  
Coronary Arteries ◽  
Body Surface ◽  
Left Coronary Artery ◽  
Statistical Significance ◽  
Lower Edge ◽  
The Mean ◽  
The Right

Morphometric analysis of the structures of the aortic bulb and coronary arteries is necessary for the planning of cardiac surgery and endovascular interventions. The aim of the study was to determine the height of the coronary arteries branching in healthy women of Lviv city and Lviv region and to determine the relationship between the height of the location of the orifice of the coronary artery with anthropometric indicators. Fifteen computed tomography images with contrast of female thorax without heart and ascending aortic lesions (normal) were selected for the study. The height of the upper and lower edges of the coronary arteries was measured; height of Valsalva sinuses. The comparison of the mean values was performed according to the Student’s t-test. The correlation between the observed variables (age, height, body weight, body mass index, body surface area, height of the sinuses of Valsalva) was calculated using the Pearson linear correlation method (r). According to the study, the population group consisted of persons of the second period of adulthood (46.67 %) and the elderly (53.33 %). According to the body mass index, 80 % were overweight or obese I-II degree. The mean height of the coronary artery orifice in women without structural changes of the heart and ascending aorta was: 11.19±1.96 mm for the left and 11.68±1.80 mm for the right. The height of the orifice of the right and left coronary arteries were almost the same, without statistical significance (p=0.26). Analysis of the correlation between the values of the height of the orifice of the coronary artery did not show a probable dependence on height, weight, age, body mass index and body surface area. There is a direct relationship between the parameters of the height of the lower edge of the right coronary artery and the height of the upper edge of the right coronary artery (r=+0.75, p=0.001) and between the value of the lower edge of the left coronary artery and the upper edge of the left coronary artery (r=+0.63, p=0.01). Thus, the analysis of the correlation between the values of the height of the orifice of the coronary artery in women in norm and anthropometric indicators did not show a significant relationship. There was no statistical significance between the indicators of the height of the orifice of the right and left coronary arteries in women.

A CADAVERIC STUDY ON CORONARY ARTERY VARIATIONS AND ITS CLINICAL `SIGNIFICANCE

2021 ◽  
pp. 20-22
Author(s):  
Sony Jhansi Priya ◽  
Sangeetha A ◽  
M. Sai Krishna
Keyword(s):  
Coronary Artery ◽  
Coronary Arteries ◽  
Left Coronary Artery ◽  
Coronary Vessels ◽  
Average Diameter ◽  
Cadaveric Study ◽  
Aortic Sinus ◽  
Clinical Procedures ◽  
Human Cadavers ◽  
The Right

Coronary artery variations are one of the commonest variations observed during clinical procedures. Normally, there are two main coronary arteries, the right coronary artery (RCA), left coronary artery (LCA).Left coronary artery gives two important branches left circumex artery (LCX) and left anterior descending (LAD) arteries. Knowledge about the coronary vessels and its variations are essential to clinicians to prevent untoward injury of vessels during any procedures. To study the morphology and variations of coronar Aim: y arteries by dissection. Materials and Methods: The present study was a cadaveric study which was conducted on 50 hearts obtained from adult human cadavers. Coronary arteries were dissected to see the origin, course and variations. The data was entered in Microsoft excel sheet and expressed in percentage. The Right Results: coronary artery branched out from the right aortic sinus and had an average diameter of 3.5mm. The left coronary artery arouse from left aortic sinus and had an average diameter of 4mm. LMCA divided into two branches in 60 percent, three branches in 30 percent and four branches in 06 percent of the hearts and direct branches from left aortic sinuus in 4 percent hearts.Based on the origin of Posterior descending or interventricular artery, Right dominance was observed in 68 percent, left dominance in 26 percent, and equal dominance in 06 percent of the hearts. Conclusion: Knowledge about the variations of coronary vessels is a prerequisite for clinicians to perform interventions of coronary vessels.

Echocardiographic diagnosis of congenital coronary artery abnormalities in a continuous series of adolescent football players

2019 ◽  
Vol 26 (9) ◽  
pp. 988-994 ◽  
Author(s):  
Stephan Gerling ◽  
Oliver Loose ◽  
Robert Zant ◽  
Holger Michel ◽  
Michael Melter ◽  
...  
Keyword(s):  
Coronary Artery ◽  
High Risk ◽  
Coronary Arteries ◽  
Left Coronary Artery ◽  
Screening Tests ◽  
Continuous Series ◽  
Football Players ◽  
Coronary Artery Abnormalities ◽  
2D Echocardiography ◽  
The Usa

Background Sudden cardiac death (SCD) in children and adolescents is rare. Several studies have reported a higher risk of SCD during athletic competition. High risk congenital coronary artery abnormalities are the second leading cause of SCD in young athletes in the USA. Echocardiographic assessment of coronary arteries has not been routinely used in screening programmes for junior athletes so far. Design Prospective cohort study in 1045 consecutive adolescent elite football players. Methods All athletes underwent a standardized cardiovascular screening protocol with a medical history, a physical examination, 12-lead resting electrocardiogram and a complete transthoracic 2D-echocardiography. Results Two athletes (0.19%) showed a high-risk coronary artery abnormality (CAA) with a right coronary artery originating abnormal from the aorta and coursing inter-arterial. Low-risk CAAs were found in 16 athletes (1.53%). There was an ectasia of the left coronary artery (+3.9z and +4.3z) and a fistula from the left coronary artery in two cases (0.19%), respectively. In 1.05% ( n = 11) we found a high take-off (2.3–6.8 mm) and in one case (0.096%) there was a tangential take-off of the right main coronary artery. Variants of coronary arterial anatomy were identified in 335 of 1045 athletes (32.06%). Conclusion Basic pre-participation screening tests including 12-lead or exercise electrocardiogram do not safely identify high-risk CAAs. In adolescent athletes an expert cardiologist is able to describe the origin and the proximal course of the coronary arteries and identify major abnormalities in most of the cases by transthoracic 2D-echocardiography.

Location of Early Atheroma in the Human Coronary Arteries

1981 ◽  
Vol 103 (3) ◽  
pp. 208-212 ◽  
Author(s):  
B. Fox ◽  
W. A. Seed
Keyword(s):  
Coronary Artery ◽  
Coronary Arteries ◽  
Right Coronary Artery ◽  
Left Coronary Artery ◽  
Coronary Artery Lesions ◽  
Circumferential Distribution ◽  
Mechanical Factors ◽  
The Right

We have correlated the location of early atheroma with vessel geometry in the major coronary arteries of subjects dying of noncardiovascular causes under 40 yr of age. We analyzed only those vessels affected minimally by very early (fatty) disease. In each of the three major branches, disease was concentrated close to the entrance and diminished with distance downstream. Circumferential distribution of disease was also not random. In the right coronary artery, lesions were concentrated on the inner wall of the major curvature. Immediately downstream of the entrances of both branches of the left coronary artery, the flow-dividing walls were spared. Further downstream in the left anterior, descending branch plaques followed a spiral distribution. We believe these patterns may be determined by local mechanical factors.

The coronary arteries and cardiac veins

2019 ◽  
pp. 175-186
Keyword(s):  
Coronary Artery ◽  
Coronary Arteries ◽  
Right Coronary Artery ◽  
Coronary Sinus ◽  
Left Coronary Artery ◽  
Venous System ◽  
Cardiac Veins ◽  
Coronary Ostia ◽  
The Right

This chapter describes the anatomy of the coronary arteries and cardiac veins. It covers the coronary ostia and left coronary artery, the right coronary artery, the cardiac venous system, and the coronary sinus and its tributaries.

scholarly journals Morphometric analysis of the coronary arteries: a study of the external diameters

2016 ◽  
Vol 33 (03) ◽  
pp. 138-141 ◽  
Author(s):  
J. Silva ◽  
A. Nagato ◽  
R. Reis ◽  
C. Nardeli ◽  
F. Abreu ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Arteries ◽  
Right Coronary Artery ◽  
Left Coronary Artery ◽  
The Body ◽  
External Diameter ◽  
Artery Disease ◽  
Student’S T ◽  
The Right ◽  
The Masses

Abstract Introduction: Approximately a third of worldwide deaths are caused by ischemic or coronary heart disease, suggesting that greater attention is needed to study the coronary diameter and myocardial vasculature. Material and Methods: In this study, 39 human adult hearts were dissected. The masses of the hearts were measured according to the principle of Scherle and the external diameters of the right coronary artery, the left coronary artery, and the ascending part of the Aorta were measured in millimeters (mm), using a Mitutoyo digital caliper. In the statistical analysis, normal distribution of the variables was assessed using the Kolmogorov-Smirnov test, external diameters were compared using the unpaired Student's t-test, and Pearson's correlation was applied to investigate the correlation of the diameters of the left coronary artery and right coronary artery with the Aorta. Significance was set at P <0.05, and the data were analyzed using GraphPad Prism v.5.00 (GraphPad Software, San Diego, CA). Results: The external diameters were as follows: left coronary artery, 5.55±0.16 mm; right coronary artery, 4.38±0.15 mm (P <0.0001); and Aorta, 22.85±0.80 mm. Thus, it was demonstrated that the external diameter of the left coronary artery is 22% larger than that of the right coronary artery, resulting in a greater blood supply via the left coronary artery and a greater passage of atherosclerotic factors. Conclusions: Despite the importance of the coronary arteries for the heart and the body as a whole, few studies correlated morphometric data and possible clinical implications related to coronary artery disease.

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