scholarly journals Relationship Between METTL21C Gene Expression and Exercise in Human Skeletal Muscle: A Meta-Analysis

2021 ◽  
Vol 30 (1) ◽  
pp. 102-109
Author(s):  
Kyung-Wan Baek ◽  
Ji-Seok Kim ◽  
Jun-Il Yoo
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Human Skeletal Muscle ◽  
Meta Analysis ◽  
Exercise Group ◽  
Aerobic Exercise Training ◽  
Control Group

PURPOSE: Recently, METTL21C has been identified as a potential pleiotropic gene for osteoporosis and sarcopenia. The purpose of this study was to collect gene expression datasets of human skeletal muscle transcriptome and to determine their relationship to exercise through meta-analysis.METHODS: MetaMEx was used to determine whether METTL21C in human skeletal muscle was associated with age, sex, physical activity and obesity. In addition, the difference in gene expression of METTL21C according to exercise duration and exercise type was confirmed. Using MetaMEx, top 300 genes (positive and negative, respectively) with a high correlation with METTL21C were selected, and gene ontology analysis was performed to identify related pathways.RESULTS:The expression of METTL21C gene in human skeletal muscle was significantly lower in the elderly than in young subjects (p<.0001), and significantly lower in female than in male (p<.0001). Also, the obese subjects were significantly lower than lean subjects (p<.0001). However, subjects with high level of physical activity had significantly higher expression of METTL21C than subjects with low levels of physical activity (p<.0001). Acute resistance exercise (p<.0001) and acute high-intensity interval training (p<.05) were found to have significantly higher expression of METTL21C in the skeletal muscle of the exercise group compared to the control group. Aerobic exercise training (p<.0001) and resistance exercise training (p<.0001) showed significantly higher expression of METTL21C in the skeletal muscle of the exercise group compared to the control group.CONCLUSIONS: Physical activity and exercise is important to prevent and treat osteosarcopenia because it can increase the expression of METTL21C in human skeletal muscle and maintain bone and muscle homeostasis.

scholarly journals Effects of Resistance Exercise on Symptoms, Physical Function, and Quality of Life in Gastrointestinal Cancer Patients Undergoing Chemotherapy

2020 ◽  
Vol 19 ◽  
pp. 153473542095491
Author(s):  
Yijin Hong ◽  
Chunmei Wu ◽  
Biyu Wu
Keyword(s):  
Exercise Training ◽  
Resistance Exercise ◽  
Physical Function ◽  
Cancer Patients ◽  
Gastrointestinal Cancer ◽  
Acid Reflux ◽  
Exercise Group ◽  
Control Group ◽  
Resistance Exercise Training

This research aimed to investigate the effects of resistance exercise on symptoms, physical function, and quality of life (QoL) in gastrointestinal cancer patients undergoing chemotherapy. Patients were quasi-randomly divided into the resistance exercise group and the relaxation control group, and machine-based resistance exercise was performed twice a week for 12 weeks under the guidance of experienced therapists. The QoL of patients was analyzed by EORTC-QLQ-C30. Resistance exercise training significantly reduced the incidences of lack of energy (inter-group P = .011), nausea (inter-group P = .007), acid reflux (inter-group P = .042), and back pain (inter-group P = .0009). Twelve weeks of resistance exercise training significantly elevated the muscular strength of leg press (inter-group P = .021) and leg extension (inter-group P = .041), and the muscular endurance of leg press (inter-group P = .005). The participants’ performance in 6-m fast walk (inter-group P = .008), 6-m backwards walk (inter-group P = .016), and chair rise (inter-group P = .031) were dramatically improved. Fatigue (inter-group P = .024) and appetite loss (inter-group P = .012) in the resistance exercise group were significantly lower than the relaxation control group. In conclusion, the beneficial effects of resistance exercise on symptoms, physical function and QoL in gastrointestinal cancer patients undergoing chemotherapy were demonstrated. Resistance exercise training reduced the incidences of nausea and acid reflux, improved physical function, and alleviated fatigue and appetite loss in gastrointestinal cancer patients undergoing chemotherapy.

scholarly journals Aerobic and resistance exercise training reverses age‐dependent decline in NAD + salvage capacity in human skeletal muscle

2019 ◽  
Vol 7 (12) ◽  
Author(s):  
Roldan M. de Guia ◽  
Marianne Agerholm ◽  
Thomas S. Nielsen ◽  
Leslie A. Consitt ◽  
Ditte Søgaard ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Human Skeletal Muscle ◽  
Resistance Exercise Training ◽  
Age Dependent

scholarly journals Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle

2015 ◽  
Vol 47 (9) ◽  
pp. 1922-1931 ◽  
Author(s):  
CRAIG PORTER ◽  
PAUL T. REIDY ◽  
NISHA BHATTARAI ◽  
LABROS S. SIDOSSIS ◽  
BLAKE B. RASMUSSEN
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Mitochondrial Function ◽  
Human Skeletal Muscle ◽  
Resistance Exercise Training

scholarly journals Aerobic exercise training reduces blood pressure, angiotensin II and oxidative stress of patients with resistant hypertension: the EnRiCH trial

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
S Lopes ◽  
J Mesquita-Bastos ◽  
M Teixeira ◽  
D Figueiredo ◽  
J Oliveira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Resistant Hypertension ◽  
Exercise Group ◽  
Aerobic Exercise Training ◽  
Control Group ◽  
Exercise Training Program ◽  
And Oxidative Stress

Abstract Introduction Resistant hypertension is a major challenge of modern cardiovascular medicine, as it is a puzzling problem without a clear solution. Exercise training clearly reduces blood pressure (BP) and oxidative stress in patients with hypertension, however evidence is limited regarding resistant hypertension. Purpose To determine the effect of an aerobic exercise training program in BP, angiotensin II and oxidative stress in patients with resistant hypertension. Methods EnRicH is a prospective, two-center, single-blinded, randomized controlled trial with a parallel two-arm group. Sixty patients with resistant hypertension were randomly assigned in a 1:1 ratio to undergo a 12-week aerobic exercise training program (exercise) or usual care (control). The powered primary efficacy measure was 24-hour ambulatory systolic BP change from baseline. Secondary outcome measures included daytime and nighttime ambulatory BP, office BP, cardiorespiratory fitness, and oxidative stress and inflammatory biomarkers: Interferon-gamma (IFN-y), Angiotensin II, vascular endothelial growth factor (VEGF), and superoxide dismutase (SOD). Results Fifty-three patients (exercise n=26, control n=27) completed the study. Patients were mainly women (54.7%), with an office BP of 140.7±15.9/84.2±9.4 mm Hg and taking an average of 4.6 antihypertensive medications (median, 5; range, 3 to 7). At baseline, no differences were found between groups for the study outcomes and patient characteristics. Ambulatory systolic BP was reduced −7.1 mm Hg (95% CI, −12.8 to −1.4; P=0.015) in the exercise group (127.4±12.2 to 121.2±12.2, p=0.007) compared to control group (126.1±17.2 to 126.9±15.2, p=514) over 24-hour. In addition, 24-hour ambulatory diastolic BP (−5.1 mm Hg, −7.9 to −2.3, P=0.001), daytime ambulatory systolic (−8.4 mm Hg, −14.3 to −2.5, P=0.006), and diastolic BP (−5.7 mm Hg, −9.0 to −2.4, P=0.001) were also reduced in the exercise group compared to the control group. There were no differences in the change of nighttime ambulatory BP between groups. Cardiorespiratory fitness improved in the exercise group by 14% (4.7 ml.kg-1.min-1, P&lt;0.001), while it remained unchanged in the control group (−0.37 ml.kg-1.min-1, P=0.442). A significant between-group difference in favor of exercise group was found for IFN-y (−4.3 pg/mL, 95% CI: −7.1 to −1.5; P=0.003), Angiotensin II (−157.0 pg/mL, 95% CI: −288.1 to −25.9; P=0.020), VEGF (10.53 pg/mL, 95% CI: 0.60 to 22.54; P=0.035), and SOD (0.35 pg/mL, 95% CI: 0.10 to 0.58; P=0.009). Conclusions A 12-week moderate intensity aerobic exercise program reduced ambulatory BP, angiotensin II and oxidative stress in patients with resistant hypertension. The antihypertensive effects of exercise in patients with resistant hypertension may be mediated by positive changes in oxidative stress and inflammatory biomarkers. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): European Union through European Regional Development Fund – Operational Competitiveness Factors Program (COMPETE)Portuguese Government through FCT - Foundation for Science and Technology

scholarly journals Effects of Exercise Intervention on Peripheral Skeletal Muscle in Stable Patients With COPD: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Peijun Li ◽  
Jian Li ◽  
Yingqi Wang ◽  
Jun Xia ◽  
Xiaodan Liu
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Exercise Capacity ◽  
Meta Analysis ◽  
Exercise Interventions ◽  
Randomized Controlled ◽  
Copd Patients ◽  
Training Modalities

Objectives: Peripheral skeletal muscle dysfunction is an important extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD) that can be counteracted by exercise training. This study aimed to review the effect of three major exercise training modalities, which are used in pulmonary rehabilitation to improve on skeletal muscle mass, function, and exercise capacity in COPD.Methods: PubMed, Embase, EBSCO, Web of Science, and the PEDro database were searched on April 25, 2020. Only randomized controlled studies published in English evaluating the effects of exercise interventions on peripheral skeletal muscle mass, strength, and exercise capacity in stable COPD patients were included. The quality of included studies was evaluated using the PEDro scale. The mean difference (MD) or the standardized mean difference (SMD) with 95% CI was calculated to summarize the results. Subgroup meta-analysis was used to investigate the effects of different exercise training modalities and different outcome measures. The Grading of Recommendations Assessment, Development, and Evaluation guidelines were used to rate evidence quality.Results: A total of 30 randomized controlled trials involving 1,317 participants were included. Data from trials investigating endurance exercise (EE), resistance exercise (RE), and combined aerobic and resistance exercise (CE) were pooled into a meta-analysis, and the differences compared with the non-exercising COPD control were improvement in the muscle strength and exercise capacity in stable COPD patients. Subgroup meta-analysis for different exercise training modalities showed that RE significantly improved muscle strength (SMD = 0.6, 95% CI 0.35–0.84, I2 = 61%), EE and CE significantly increased VO2peak (EE: MD = 3.5, 95% CI 1.1–5.91, I2 = 92%; CE: MD = 1.66, 95% CI 0.22–3.1, I2 = 1%). Subgroup meta-analysis for different outcome measures showed that only isotonic strength was improved after exercise interventions (SMD = 0.89, 95% CI 0.51–1.26, I2 = 71%).Conclusion: Moderate evidence supports that exercise training in stable COPD patients has meaningful and beneficial effects on peripheral skeletal muscle strength and exercise capacity. Peripheral skeletal muscle shows a higher response to RE, and the isotonic test is relatively sensitive in reflecting muscle strength changes. The proportion of aerobic and resistance exercise components in a combined exercise program still needs exploration.Systematic Review Registration: The review was registered with the PROSPERO: (The website is https://www.crd.york.ac.uk/PROSPERO/, and the ID is CRD42020164868).

scholarly journals Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Julie Massart ◽  
Rasmus J. O. Sjögren ◽  
Brendan Egan ◽  
Christian Garde ◽  
Magnus Lindgren ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Metabolism ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Glucose Uptake ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Aerobic Exercise Training ◽  
Human Skeletal Muscle Cells

AbstractSkeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and after a 14-day aerobic exercise training regime. Among the exercise training-responsive miRNAs identified, miR-19b-3p was selected for further validation. Overexpression of miR-19b-3p in human skeletal muscle cells increases insulin signaling, glucose uptake, and maximal oxygen consumption, recapitulating the adaptive response to aerobic exercise training. Overexpression of miR-19b-3p in mouse flexor digitorum brevis muscle enhances contraction-induced glucose uptake, indicating that miR-19b-3p exerts control on exercise training-induced adaptations in skeletal muscle. Potential targets of miR-19b-3p that are reduced after aerobic exercise training include KIF13A, MAPK6, RNF11, and VPS37A. Amongst these, RNF11 silencing potentiates glucose uptake in human skeletal muscle cells. Collectively, we identify miR-19b-3p as an aerobic exercise training-induced miRNA that regulates skeletal muscle glucose metabolism.

Abstract 508: Resistance Exercise Training Performed Prior Diabetes Mellitus Suppresses Renal and Skeletal Muscle Abnormalities

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Kleiton A Silva ◽  
Ralmony A Santos ◽  
Marcelo R Arlotti ◽  
Luciana Jorge ◽  
Tatiana S Cunha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Signaling Pathway ◽  
Aerobic Exercise Training ◽  
Resistance Exercise Training ◽  
Muscle Weight ◽  
Renal System ◽  
Type Of Exercise

Prior study of our group shown that previous aerobic exercise training improved the damage caused by diabetes mellitus on renal and cardiovascular system. Resistance exercise training, also known as strength training, is traditionally performed to gain muscle mass; however, it is not clear whether this type of exercise modulates renal system. Additionally, it is also unknown whether previous resistance exercise training can potentially influence the kidney and skeletal muscle. Wistar rats were submitted to resistance exercise training in an apparatus developed especially to this type of exercise (8 - 12 climbs/day, 5 days/week, 12 weeks). Previous resistance exercise trained group (PTD) performed for 4 weeks before the establishment of the disease and after this period they were followed by 8 weeks of resistance exercise training. Additional trained groups such as trained diabetic (TD) and trained control (TC) groups were followed by 8 weeks of resistance exercise training. Control groups were also followed (control - C, diabetes - D). We have found that PTD suppressed abnormalities linked to renal system such as, water consumption and amount of urine PTD=71mL vs. DT=127mL vs. D=138mL (measured during metabolic cage period), as well as attenuated proteinuria and kidney weight. Regarding to skeletal muscle, PTD group had increased muscle weight (extensor digitorium longus - EDL; C=192mg, D=116mg, TD=106mg and PTD=126mg; Tibialis anterior, C=780mg, D=496mg, DT=450mg and PTD=535mg); we also found a great muscle force level in the PTD group (C=573g, CT=1037, D=414g, TD=737g and PTD=825g), suggesting a protective effect of previous exercise in this group. PTEN was suppressed in PTD group and Akt and 4EBP1 (upstream and downstream of mTOR) were activated in PTD group, measured by western blot. These data suggest that, resistance exercise performed prior the establishment of the diabetes mellitus can protect kidney from diabetic nephropathy and skeletal muscle from atrophy. The mechanisms by which kidney and skeletal muscle have been improved are linked to mTOR signaling pathway. Further studies will be performed to confirm the potential involvement of this signaling pathway. Support: FAPESP, CAPES, CNPq.

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