scholarly journals microRNA‐206 modulates important regulators of gene expression in response to aerobic exercise training in human skeletal muscle (706.3)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Cleber Alves ◽  
José Junior ◽  
Tiago Fernandes ◽  
Guilherme Alves ◽  
Carlos Negrão ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Human Skeletal Muscle ◽  
Aerobic Exercise Training

scholarly journals Time Course Analysis Reveals Gene-Specific Transcript and Protein Kinetics of Adaptation to Short-Term Aerobic Exercise Training in Human Skeletal Muscle

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74098 ◽  
Author(s):  
Brendan Egan ◽  
Paul L. O’Connor ◽  
Juleen R. Zierath ◽  
Donal J. O’Gorman
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Time Course ◽  
Human Skeletal Muscle ◽  
Aerobic Exercise Training ◽  
Short Term ◽  
Protein Kinetics ◽  
Specific Transcript ◽  
Kinetics Of

scholarly journals Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Julie Massart ◽  
Rasmus J. O. Sjögren ◽  
Brendan Egan ◽  
Christian Garde ◽  
Magnus Lindgren ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Metabolism ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Glucose Uptake ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Aerobic Exercise Training ◽  
Human Skeletal Muscle Cells

AbstractSkeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and after a 14-day aerobic exercise training regime. Among the exercise training-responsive miRNAs identified, miR-19b-3p was selected for further validation. Overexpression of miR-19b-3p in human skeletal muscle cells increases insulin signaling, glucose uptake, and maximal oxygen consumption, recapitulating the adaptive response to aerobic exercise training. Overexpression of miR-19b-3p in mouse flexor digitorum brevis muscle enhances contraction-induced glucose uptake, indicating that miR-19b-3p exerts control on exercise training-induced adaptations in skeletal muscle. Potential targets of miR-19b-3p that are reduced after aerobic exercise training include KIF13A, MAPK6, RNF11, and VPS37A. Amongst these, RNF11 silencing potentiates glucose uptake in human skeletal muscle cells. Collectively, we identify miR-19b-3p as an aerobic exercise training-induced miRNA that regulates skeletal muscle glucose metabolism.

scholarly journals Markers of Human Skeletal Muscle Mitochondrial Biogenesis and Quality Control: Effects of Age and Aerobic Exercise Training

2013 ◽  
Vol 69 (4) ◽  
pp. 371-378 ◽  
Author(s):  
Adam R. Konopka ◽  
Miranda K. Suer ◽  
Christopher A. Wolff ◽  
Matthew P. Harber
Keyword(s):  
Skeletal Muscle ◽  
Quality Control ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Mitochondrial Biogenesis ◽  
Human Skeletal Muscle ◽  
Aerobic Exercise Training

scholarly journals Relationship Between METTL21C Gene Expression and Exercise in Human Skeletal Muscle: A Meta-Analysis

2021 ◽  
Vol 30 (1) ◽  
pp. 102-109
Author(s):  
Kyung-Wan Baek ◽  
Ji-Seok Kim ◽  
Jun-Il Yoo
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Human Skeletal Muscle ◽  
Meta Analysis ◽  
Exercise Group ◽  
Aerobic Exercise Training ◽  
Control Group

PURPOSE: Recently, METTL21C has been identified as a potential pleiotropic gene for osteoporosis and sarcopenia. The purpose of this study was to collect gene expression datasets of human skeletal muscle transcriptome and to determine their relationship to exercise through meta-analysis.METHODS: MetaMEx was used to determine whether METTL21C in human skeletal muscle was associated with age, sex, physical activity and obesity. In addition, the difference in gene expression of METTL21C according to exercise duration and exercise type was confirmed. Using MetaMEx, top 300 genes (positive and negative, respectively) with a high correlation with METTL21C were selected, and gene ontology analysis was performed to identify related pathways.RESULTS:The expression of METTL21C gene in human skeletal muscle was significantly lower in the elderly than in young subjects (p<.0001), and significantly lower in female than in male (p<.0001). Also, the obese subjects were significantly lower than lean subjects (p<.0001). However, subjects with high level of physical activity had significantly higher expression of METTL21C than subjects with low levels of physical activity (p<.0001). Acute resistance exercise (p<.0001) and acute high-intensity interval training (p<.05) were found to have significantly higher expression of METTL21C in the skeletal muscle of the exercise group compared to the control group. Aerobic exercise training (p<.0001) and resistance exercise training (p<.0001) showed significantly higher expression of METTL21C in the skeletal muscle of the exercise group compared to the control group.CONCLUSIONS: Physical activity and exercise is important to prevent and treat osteosarcopenia because it can increase the expression of METTL21C in human skeletal muscle and maintain bone and muscle homeostasis.

The roles of aerobic exercise training and suppression IL-6 gene expression by RNA interference in the development of insulin resistance

Cytokine ◽  
2013 ◽  
Vol 61 (2) ◽  
pp. 394-405 ◽  
Author(s):  
Hui Tang ◽  
Min-hao Xie ◽  
Yu Lei ◽  
Liang Zhou ◽  
Yu-ping Xu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Rna Interference ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training

Acute high-intensity aerobic exercise increases gene expression of calcium-related proteins and activates endoplasmic reticulum stress responses in diabetic hearts

2020 ◽  
pp. 1-14
Author(s):  
H.O. Ness ◽  
K. Ljones ◽  
M. Pinho ◽  
M.A. Høydal
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Er Stress ◽  
Aerobic Exercise ◽  
Stress Responses ◽  
Mitochondrial Respiration ◽  
High Intensity ◽  
Acute Exercise ◽  
Contractile Function ◽  
Aerobic Exercise Training

Regular aerobic exercise training has a wide range of beneficial cardiac effects, but recent data also show that acute very strenuous aerobic exercise may impose a transient cardiac exhaustion. The aim of this study was to assess the response to acute high-intensity aerobic exercise on properties of mitochondrial respiration, cardiomyocyte contractile function, Ca2+ handling and transcriptional changes for key proteins facilitating Ca2+ handling and endoplasmic reticulum (ER) stress responses in type 2 diabetic mice. Diabetic mice were assigned to either sedentary control or an acute bout of exercise, consisting of a 10×4 minutes high-intensity interval treadmill run. Mitochondrial respiration, contractile and Ca2+ handling properties of cardiomyocytes were analysed 1 hour after completion of exercise. Gene expression levels of key Ca2+ handling and ER stress response proteins were measured in cardiac tissue samples harvested 1 hour and 24 hours after exercise. We found no significant changes in mitochondrial respiration, cardiomyocyte contractile function or Ca2+ handling 1 hour after the acute exercise. However, gene expression of Atp2a2, Slc8a1 and Ryr2, encoding proteins involved in cardiomyocyte Ca2+ handling, were all significantly upregulated 24 hours after the acute exercise bout. Acute exercise also altered gene expression of several key proteins in ER stress response and unfolded protein response, including Grp94, total Xbp1, Gadd34, and Atf6. The present results show that despite no significant alterations in functional properties of cardiomyocyte function, Ca2+ handling or mitochondrial respiration following one bout of high intensity aerobic exercise training, the expression of genes involved in Ca2+ handling and key components in ER stress and the unfolded protein response were changed. These transcriptional changes may constitute important steps in initiating adaptive remodelling to exercise training in type 2 diabetes.

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