scholarly journals Low levels of maximal aerobic power impair the profile of mood state in individuals with temporal lobe epilepsy

2015 ◽  
Vol 73 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Rodrigo Luiz Vancini ◽  
Claudio Andre Barbosa de Lira ◽  
Marília dos Santos Andrade ◽  
Cristiano de Lima ◽  
Ricardo Mario Arida
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Mood Disorders ◽  
Cardiorespiratory Fitness ◽  
Temporal Lobe ◽  
Aerobic Power ◽  
Mood State ◽  
Significant Negative Correlation ◽  
Maximal Aerobic Power ◽  
Healthy Control ◽  
Low Levels

ObjectiveTo investigate the correlation between cardiorespiratory fitness and mood state in individuals with temporal lobe epilepsy (TLE).MethodIndividuals with TLE (n = 20) and healthy control subjects (C, n = 20) were evaluated. Self-rating questionnaires were used to assess mood (POMS) and habitual physical activity (BAECKE). Cardiorespiratory fitness was evaluated by a maximal incremental test.ResultsPeople with TLE presented lower cardiorespiratory fitness; higher levels of mood disorders; and lower levels of vigor when compared to control health subjects. A significant negative correlation was observed between the levels of tension-anxiety and maximal aerobic power.ConclusionLow levels of cardiorespiratory fitness may modify the health status of individuals with TLE and it may be considered a risk factor for the development of mood disorders.

scholarly journals Pathophysiology of Mood Disorders in Temporal Lobe Epilepsy

2012 ◽  
Vol 34 ◽  
pp. 233-259 ◽  
Author(s):  
Ludmyla Kandratavicius ◽  
Rafael Naime Ruggiero ◽  
Jaime Eduardo Hallak ◽  
Norberto Garcia-Cairasco ◽  
João Pereira Leite
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Mood Disorders ◽  
Temporal Lobe

scholarly journals Role of the Nucleus Basalis as a Key Network Node in Temporal Lobe Epilepsy

Neurology ◽  
2021 ◽  
Vol 96 (9) ◽  
pp. e1334-e1346 ◽  
Author(s):  
Hernán F.J. González ◽  
Saramati Narasimhan ◽  
Graham W. Johnson ◽  
Kristin E. Wills ◽  
Kevin F. Haas ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Resting State Fmri ◽  
Clustering Coefficient ◽  
Nucleus Basalis ◽  
Core Network ◽  
Neurocognitive Deficits ◽  
Network Nodes ◽  
Healthy Control

ObjectiveTo determine whether the nucleus basalis of Meynert (NBM) may be a key network structure of altered functional connectivity in temporal lobe epilepsy (TLE), we examined fMRI with network-based analyses.MethodsWe acquired resting-state fMRI in 40 adults with TLE and 40 matched healthy control participants. We calculated functional connectivity of NBM and used multiple complementary network-based analyses to explore the importance of NBM in TLE networks without biasing our results by our approach. We compared patients to controls and examined associations of network properties with disease metrics and neurocognitive testing.ResultsWe observed marked decreases in connectivity between NBM and the rest of the brain in patients with TLE (0.91 ± 0.88, mean ± SD) vs controls (1.96 ± 1.13, p < 0.001, t test). Larger decreases in connectivity between NBM and fronto-parietal-insular regions were associated with higher frequency of consciousness-impairing seizures (r = −0.41, p = 0.008, Pearson). A core network of altered nodes in TLE included NBM ipsilateral to the epileptogenic side and bilateral limbic structures. Furthermore, normal community affiliation of ipsilateral NBM was lost in patients, and this structure displayed the most altered clustering coefficient of any node examined (3.46 ± 1.17 in controls vs 2.23 ± 0.93 in patients). Abnormal connectivity between NBM and subcortical arousal community was associated with modest neurocognitive deficits. Finally, a logistic regression model incorporating connectivity properties of ipsilateral NBM successfully distinguished patients from control datasets with moderately high accuracy (78%).ConclusionsThese results suggest that while NBM is rarely studied in epilepsy, it may be one of the most perturbed network nodes in TLE, contributing to widespread neural effects in this disabling disorder.

scholarly journals Endocannabinoid System and Cannabinoid 1 Receptors in Patients With Pharmacoresistant Temporal Lobe Epilepsy and Comorbid Mood Disorders

2020 ◽  
Vol 14 ◽  
Author(s):  
Luisa Rocha ◽  
Resat Cinar ◽  
Rosalinda Guevara-Guzmán ◽  
Mario Alonso-Vanegas ◽  
Daniel San-Juan ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Mood Disorders ◽  
Temporal Lobe ◽  
Endocannabinoid System

Is interictal EEG activity a biomarker for mood disorders in temporal lobe epilepsy?

2014 ◽  
Vol 125 (10) ◽  
pp. 1952-1958 ◽  
Author(s):  
José Augusto Bragatti ◽  
Carolina Machado Torres ◽  
Pedro Abrahim Cherubini ◽  
Sandra Leistner-Segal ◽  
Marino Muxfeldt Bianchin
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Mood Disorders ◽  
Temporal Lobe ◽  
Eeg Activity ◽  
Interictal Eeg

scholarly journals Pre-surgical mood disorders associated to worse post-surgical seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis

2012 ◽  
Vol 18 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Gerardo Maria de Araújo Filho ◽  
Francinaldo Lobato Gomes ◽  
Lenon Mazetto ◽  
Murilo Martinez Marinho ◽  
Igor Melo Tavares ◽  
...  
Keyword(s):  
Risk Factor ◽  
Temporal Lobe Epilepsy ◽  
Mood Disorders ◽  
Temporal Lobe ◽  
Seizure Outcome ◽  
Mesial Temporal Sclerosis ◽  
Retrospective Data ◽  
Favorable Prognosis ◽  
Dsm Iv ◽  
The Impact

OBJECTIVES: This study aims at verifying the impact of pre-surgical PD on seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS). METHODS: After previous consent, retrospective data from 115 surgically treated (corticoamygdalohyppocampectomy) TLE-MTS patients (65 females; 56.5%) were analyzed. Psychiatric evaluations were performed through DSM-IV criteria. Engel IA was established as a favorable prognosis. RESULTS: Forty-five patients (41.6%) were classified as Engel IA, while 47 (40.8%) presented pre-surgical PD. Depression (OR=5.11; p=0.004) appeared as a risk factor associated to a non-favorable seizure outcome. CONCLUSION: In patients with refractory TLE-MTS, the presence of depression predicts an unfavorable outcome.

Influence of Diet and/or Exercise on Body Composition and Cardiorespiratory Fitness in Obese Women

1998 ◽  
Vol 8 (3) ◽  
pp. 213-222 ◽  
Author(s):  
Alan C. Utter ◽  
David C. Nieman ◽  
Elizabeth M. Shannonhouse ◽  
Diane E. Butterworth ◽  
Cathy N. Nieman
Keyword(s):  
Body Composition ◽  
Cardiorespiratory Fitness ◽  
Aerobic Power ◽  
Maximal Aerobic Power ◽  
Aerobic Exercise Training ◽  
Obese Women ◽  
Intervention Period ◽  
Maximum Heart Rate ◽  
Before And After ◽  
Obese Subjects

The purpose of this study was to measure the influence of diet, exercise, or both on body composition and cardiorespiratory fitness in obese women. Ninety-one obese subjects were randomized into one of four groups: diet (D) (4.19–5.44 MJ or 1,200–1,300 kcal/day), exercise (E) (five 45-min sessions at 78.5 ± 0.5% maximum heart rate), exercise and diet (ED), and controls (C). Maximal aerobic power and body composition were measured in all subjects before and after a 12-week diet intervention period. Subjects in D and ED lost 7.8 ± 0.7 and 8.1 ± 0.6 kg body mass, with no significant change for E relative to C. Losses of percent body fat and fat mass were significantly greater in D and ED but not in E relative to C. The change in VO2max was greater in ED and E but not D when compared to C. Results indicate that moderate aerobic exercise training during a 12-week period has no discernible effects on body composition but does improve cardiorespiratory fitness in dieting obese women.

scholarly journals Automatic Lateralization of Temporal Lobe Epilepsy Based on MEG Network Features Using Support Vector Machines

Complexity ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Ting Wu ◽  
Duo Chen ◽  
Qiqi Chen ◽  
Rui Zhang ◽  
Wenyu Zhang ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Betweenness Centrality ◽  
Binary Classification ◽  
Brain Network ◽  
Support Vector ◽  
Classification Problems ◽  
Healthy Control ◽  
Control Right ◽  
Network Metrics

Correct lateralization of temporal lobe epilepsy (TLE) is critical for improving surgical outcomes. As a relatively new noninvasive clinical recording system, magnetoencephalography (MEG) has rarely been applied for determining lateralization of unilateral TLE. Here we propose a framework for using resting-state brain-network features and support vector machine (SVM) for TLE lateralization based on MEG. We recruited 15 patients with left TLE, 15 patients with right TLE, and 15 age- and sex-matched healthy controls. The lateralization problem was then transferred into a series of binary classification problems, including left TLE versus healthy control, right TLE versus healthy control, and left TLE versus right TLE. Brain-network features were extracted for each participant using three network metrics (nodal degree, betweenness centrality, and nodal efficiency). A radial basis function kernel SVM (RBF-SVM) was employed as the classifier. The leave-one-subject-out cross-validation strategy was used to test the ability of this approach to overcome individual differences. The results revealed that the nodal degree performed best for left TLE versus healthy control and right TLE versus healthy control, with accuracy of 80.76% and 75.00%, respectively. Betweenness centrality performed best for left TLE versus right TLE with an accuracy of 88.10%. The proposed approach demonstrated that MEG is a good candidate for solving the lateralization problem in unilateral TLE using various brain-network features.

scholarly journals Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Karabekir Ercan ◽  
Hediye Pinar Gunbey ◽  
Erhan Bilir ◽  
Elcin Zan ◽  
Halil Arslan
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Diffusion Tensor ◽  
Febrile Convulsion ◽  
Significant Negative Correlation ◽  
Quantitative Mr ◽  
Single Voxel ◽  
Adc Values ◽  
History Of ◽  
Preoperative Examination

Purpose. The objective is to compare lateralizing ability of three quantitative MR (qMRI) modalities to depict changes of hippocampal architecture with clinical entities in temporal lobe epilepsy.Methods. We evaluated 14 patients with clinical and EEG proven diagnosis of unilateral TLE and 15 healthy volunteers. T1-weighted 3D dataset for volumetry, single-voxel1H MR spectroscopy (MRS), and diffusion tensor imaging (DTI) were performed for bilateral hippocampi of all subjects.Results. Individual volumetric measurements provided accurate lateralization in 85% of the patients, spectroscopy in 57%, and DTI in 57%. Higher lateralization ratios were acquired combining volumetry-spectroscopy (85%), spectroscopy-DTI (85%), and volumetry-DTI (100%). Significantly decreased NAA/(Cho+Cr) ratios (p=0.002) and increased FA (p=0.001) values were obtained in ipsilateral to epileptogenic hippocampus. Duration of epilepsy and FA values showed a significant negative correlation (p=0.016,r=-0.847). The history of febrile convulsion associated with ipsilateral increased ADC values (p=0.015,r=0.851) and reduced NAA/(Cho+Cr) ratios (p=0.047,r=-761).Conclusion. Volumetry, MRS, and DTI studies provide complementary information of hippocampal pathology. For lateralization of epileptogenic focus and preoperative examination, volumetry-DTI combination may be indicative of diagnostic accuracy.

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