scholarly journals CORRELATION BETWEEN PRE AND POSTOPERATIVE LEVELS OF GLP-1/GLP-2 AND WEIGHT LOSS AFTER ROUX-EN-Y GASTRIC BYPASS: A PROSPECTIVE STUDY

2016 ◽  
Vol 29 (4) ◽  
pp. 257-259 ◽  
Author(s):  
Everton CAZZO ◽  
◽  
Martinho Antonio GESTIC ◽  
Murillo Pimentel UTRINI ◽  
José Carlos PAREJA ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Prospective Study ◽  
Gut Hormones ◽  
Tolerance Test ◽  
Beneficial Effects ◽  
Excess Loss ◽  
Before And After ◽  
One Year ◽  
A Prospective Study

ABSTRACT Background: The role of gut hormones in glucose homeostasis and weight loss achievement and maintenance after bariatric surgery appears to be a key point in the understanding of the beneficial effects observed following these procedures. Aim: To determine whether there is a correlation between the pre and postoperative levels of both GLP-1 and GLP-2 and the excess weight loss after Roux-en-Y gastric bypass (RYGB). Methods: An exploratory prospective study which enrolled 11 individuals who underwent RYGB and were followed-up for 12 months. GLP-1 and GLP-2 after standard meal tolerance test (MTT) were determined before and after surgery and then correlated with the percentage of excess loss (%EWL). Results: GLP-2 AUC presented a significant postoperative increase (945.3±449.1 vs.1787.9±602.7; p=0.0037); GLP-1 AUC presented a non-significant trend towards increase after RYGB (709.6±320.4 vs. 1026.5±714.3; p=0.3808). Mean %EWL was 66.7±12.2%. There was not any significant correlation between both the pre and postoperative GLP-1 AUCs and GLP-2 AUCs and the %EWL achieved after one year. Conclusion: There was no significant correlation between the pre and postoperative levels of the areas under the GLP-1 and GLP-2 curves with the percentage of weight loss reached after one year.

scholarly journals Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Christian Hellmuth ◽  
Franca Fabiana Kirchberg ◽  
Nina Lass ◽  
Ulrike Harder ◽  
Wolfgang Peissner ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Clinical Markers ◽  
Obese Children ◽  
Intervention Programme ◽  
Before And After ◽  
Branched Chain ◽  
One Year

In obese children, hyperinsulinaemia induces adverse metabolic consequences related to the risk of cardiovascular and other disorders. Branched-chain amino acids (BCAA) and acylcarnitines (Carn), involved in amino acid (AA) degradation, were linked to obesity-associated insulin resistance, but these associations yet have not been studied longitudinally in obese children. We studied 80 obese children before and after a one-year lifestyle intervention programme inducing substantial weight loss >0.5 BMI standard deviation scores in 40 children and no weight loss in another 40 children. At baseline and after the 1-year intervention, we assessed insulin resistance (HOMA index), fasting glucose, HbA1c, 2 h glucose in an oral glucose tolerance test, AA, and Carn. BMI adjusted metabolite levels were associated with clinical markers at baseline and after intervention, and changes with the intervention period were evaluated. Only tyrosine was significantly associated with HOMA (p<0.05) at baseline and end and with change during the intervention (p<0.05). In contrast, ratios depicting BCAA metabolism were negatively associated with HOMA at baseline (p<0.05), but not in the longitudinal profiling. Stratified analysis revealed that the children with substantial weight loss drove this association. We conclude that tyrosine alterations in association with insulin resistance precede alteration in BCAA metabolism. This trial is registered with ClinicalTrials.gov IdentifierNCT00435734.

Serum Ghrelin, Leptin and Adiponectin Levels before and after Weight Loss: Comparison of Three Methods of Treatment – A Prospective Study

2006 ◽  
Vol 16 (11) ◽  
pp. 1425-1432 ◽  
Author(s):  
Efstathios Kotidis ◽  
George Koliakos ◽  
Vasilios Baltzopoulos ◽  
Konstantinos Ioannidis ◽  
John Yovos ◽  
...  
Keyword(s):  
Weight Loss ◽  
Prospective Study ◽  
Before And After ◽  
A Prospective Study ◽  
Serum Ghrelin ◽  
Methods Of Treatment

scholarly journals Toward a Medical Gastric Bypass: Chronic Feeding Studies With Liraglutide + PYY3-36 Combination Therapy in Diet-Induced Obese Rats

2021 ◽  
Vol 11 ◽  
Author(s):  
Ulrich Dischinger ◽  
Julia Hasinger ◽  
Malina Königsrainer ◽  
Carolin Corteville ◽  
Christoph Otto ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Food Intake ◽  
Combination Therapy ◽  
Gut Hormones ◽  
Abnormal Behavior ◽  
Sham Operation ◽  
High Fat ◽  
Beneficial Effects ◽  
Male Wistar Rats

BackgroundCombination therapies of anorectic gut hormones partially mimic the beneficial effects of bariatric surgery. Thus far, the effects of a combined chronic systemic administration of Glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine 3-36 (PYY3-36) have not been directly compared to Roux-en-Y gastric bypass (RYGB) in a standardized experimental setting.MethodsHigh-fat diet (HFD)-induced obese male Wistar rats were randomized into six treatment groups: (1) RYGB, (2) sham-operation (shams), (3) liraglutide, (4) PYY3-36, (5) PYY3-36+liraglutide (6), saline. Animals were kept on a free choice high- and low-fat diet. Food intake, preference, and body weight were measured daily for 4 weeks. Open field (OP) and elevated plus maze (EPM) tests were performed.ResultsRYGB reduced food intake and achieved sustained weight loss. Combined PYY3-36+liraglutide treatment led to similar and plateaued weight loss compared to RYGB. Combined PYY3-36+liraglutide treatment was superior to PYY3-36 (p ≤ 0.0001) and liraglutide (p ≤ 0.05 or p ≤ 0.01) mono-therapy. PYY3-36+liraglutide treatment and RYGB also reduced overall food intake and (less pronounced) high-fat preference compared to controls. The animals showed no signs of abnormal behavior in OF or EPM.ConclusionsLiraglutide and PYY3-36 combination therapy vastly mimics reduced food intake, food choice and weight reducing benefits of RYGB.

scholarly journals Weight Changes (in kg) in Mandible Fracture Patients After IMF: A Prospective Study

2019 ◽  
Vol 1 (1) ◽  
pp. 35-37
Author(s):  
Parveen Akhter Lone ◽  
Mohammed Israr ul Khaliq ◽  
Mandeep Sharma ◽  
Owais Ahmed Malik ◽  
Bashir Ahmed Lone
Keyword(s):  
Weight Loss ◽  
Prospective Study ◽  
Fixation Method ◽  
Weight Changes ◽  
Loss Of Weight ◽  
Maxillofacial Fractures ◽  
Before And After ◽  
Nutrition Intake ◽  
Moderate Malnutrition ◽  
A Prospective Study

Background: This prospective study is done to assess weight loss due to maxillomandibular fixation (MMF) in patients who have undergone treatment for maxillofacial fractures. This fixation method is a closed reduction technique that can interfere with normal nutrition intake of solid and semisolid foods and thus can result in weight loss and malnutrition. Therefore, in this study we explain the degree and pattern of weight loss in patients treated with MMF. Materials and Methods: We treated 300 patients for 4 to 6 weeks of MMF. We measured and compared the weight before and after MMF. Results: The loss of weight was statistically significant ( P < .001) with MMF treatment. Conclusion: MMF caused mild to moderate malnutrition in some cases so protein diet was recommended to such patients post treatment.

Quality of Life Before and After Endovascular and Open Repair of Asymptomatic AAAs: A Prospective Study

2000 ◽  
Vol 7 (5) ◽  
pp. 372-379 ◽  
Author(s):  
Martin Malina ◽  
Marie Nilsson ◽  
Jan Brunkwall ◽  
Krasnodar Ivancev ◽  
Timothy Resch ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prospective Study ◽  
Open Repair ◽  
Before And After ◽  
A Prospective Study

Influence of Gastric Bypass on Obese Women Sexual Function—a Prospective Study

2021 ◽  
Author(s):  
Mariano de Almeida Menezes ◽  
Fernando Augusto Mardiros Herbella ◽  
Guilherme de Godoy dos Santos ◽  
Antônio Carlos Valezi
Keyword(s):  
Gastric Bypass ◽  
Prospective Study ◽  
Sexual Function ◽  
Obese Women ◽  
A Prospective Study
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