Glomus Tumor of the Oral Cavity: Report of a Rare Case and Literature Review

Abstract Glomus tumor is a benign neoplasm composed of a perivascular proliferation of glomic cells that resembles the normal glomus body. Usually, it appears as a solitary, symptomatic small blue-red nodule, located in the deep dermis or subcutis of upper or lower extremities of young to middle-aged adults. Cases affecting the oral cavity are very rare, with only 23 well-documented cases reported in the English-language literature. Herein, we present a rare case of glomus tumor of the upper lip, and review the literature of cases involving the mouth.

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Intralingual Dermoid Cysts: A Report of Two New Cases

Ear Nose & Throat Journal ◽

10.1177/014556130007900511 ◽

2000 ◽

Vol 79 (5) ◽

pp. 380-383 ◽

Cited By ~ 22

Author(s):

David Myssiorek ◽

James Lee ◽

Patricia Wasserman ◽

Elizabeth Lustrin

Keyword(s):

Magnetic Resonance Imaging ◽

Differential Diagnosis ◽

Magnetic Resonance ◽

Oral Cavity ◽

English Language ◽

Surgical Excision ◽

Resonance Imaging ◽

Common Site ◽

Floor Of The Mouth ◽

Language Literature

Dermoid cysts of the oral cavity are rare. When they do occur, the most common site is the floor of the mouth. Intralingual dermoid cysts are even more rare, and until now, there were only 15 such reports in the English-language literature. In this article, we describe two additional cases. Magnetic resonance imaging is extremely helpful in establishing a differential diagnosis. Surgical excision is recommended to correct deglutition and speech problems. Its rarity notwithstanding, dermoid cyst should be considered in the differential diagnosis of tongue masses in the younger population.

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Synchronous subungual glomus tumors in the same finger

Anais Brasileiros de Dermatologia ◽

10.1590/s0365-05962012000300021 ◽

2012 ◽

Vol 87 (3) ◽

pp. 475-476 ◽

Cited By ~ 5

Author(s):

Nilton Di Chiacchio ◽

Walter Refkalefsky Loureiro ◽

Nilton Gioia Di Chiacchio ◽

Diego Leonardo Bet

Keyword(s):

Rare Case ◽

Glomus Tumor ◽

Benign Neoplasm ◽

Glomus Tumors ◽

Nail Bed ◽

Glomus Cells

The glomus tumor is an uncommon benign neoplasm of glomus cells. In the majority of the cases it is presented as a solitary painful papule in the subungual region. We report a rare case of a patient with two individual synchronous glomus tumors under the nail bed of the same finger.

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Verrucous carcinoma of the maxillary antrum

The Journal of Laryngology & Otology ◽

10.1017/s0022215100109107 ◽

1989 ◽

Vol 103 (4) ◽

pp. 415-416 ◽

Cited By ~ 12

Author(s):

M. P. Bacon ◽

E. B. Chevretton ◽

R. W. T. Slack ◽

T. I. F. MacLeod

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

English Language ◽

Maxillary Antrum ◽

Verrucous Carcinoma ◽

Rare Type ◽

A Site ◽

Language Literature

AbstractVerrucous carcinoma is a rare type of squamous cell carcinoma which is most often seen in the oral cavity and larynx. This paper describes a case of verrucous carcinoma of the maxillary antrum, a site in which this tumour has been described on only two previous occasions in the English language literature.

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A Solitary Volar Extradigital Glomus Tumor Mimicking a Painful Ganglion

Case Reports in Orthopedic Research ◽

10.1159/000511427 ◽

2021 ◽

pp. 6-10

Author(s):

Dae-Geun Kim ◽

Seung-Rim Kang

Keyword(s):

Literature Review ◽

Skin Temperature ◽

Glomus Tumor ◽

Distal Phalanx ◽

Benign Tumors ◽

Glomus Tumors ◽

Extradigital Glomus ◽

Glomus Body

Glomus tumors are neoplasms arising from the glomus body, which regulate skin temperature. They are mostly benign tumors and present in the subungual area of a distal phalanx. However, they can occur in extradigital location, and they may not be typical of intradigital glomus tumors. This makes it difficult to diagnose extradigital glomus tumors. We report a volar extradigital tumor mimicking a painful ganglion with a literature review.

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Unusual glomus tumor of the bladder: a rare case report and literature review

BMC Urology ◽

10.1186/s12894-021-00837-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Li Chen ◽

Bin Lai ◽

Xiaoyan Su ◽

Jiwei Wang

Keyword(s):

Literature Review ◽

Rare Case ◽

Glomus Tumor ◽

Polypoid Lesion ◽

Lateral Wall ◽

Endoscopic Examination ◽

Maximum Diameter ◽

Gold Standard Method ◽

Rare Case Report ◽

The Right

Abstract Background Glomus tumor (GT), which are neoplasms of the glomus body, usually occur in the extremities, particularly under the nail bed. GT occurring in the bladder is very rare and has been reported as sporadic. In the present study, a rare case of bladder GT is reported and its clinical and histopathological characteristics are summarized by literature review. Case presentation A 57-year-old woman presented with intermittent gross hematuria for 2 years. Urinalysis displayed hematuria. The bladder ultrasound showed an avascular and homogeneous isoechoic polypoid mass with a maximum diameter of 6 mm at the right lateral wall of bladder. The bladder endoscopic examination showed a polypoid lesion, with a smooth surface, located in the right lateral wall. Then, a transurethral resection was performed, its histopathological features indicated a benign GT. Conclusions GT arising in the bladder is extremely rare, and only four cases have been identified in studies reported in English. It is difficult to diagnose bladder GTs according to their clinical features. The gold standard method used for their diagnosis is histopathology. However, it should also be considered in the differential diagnosis for bladder mass.

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Otophyma: a case report

The Journal of Laryngology & Otology ◽

10.1017/s0022215107008419 ◽

2007 ◽

Vol 122 (5) ◽

pp. 524-526 ◽

Cited By ~ 3

Author(s):

K Daniels ◽

K Haddow

Keyword(s):

Case Report ◽

Rare Case ◽

English Language ◽

Rare Condition ◽

Successful Management ◽

English Language Literature ◽

First Case ◽

End Stage ◽

Slow Growing ◽

Language Literature

AbstractObjective:We report a rare case of otophyma.Method:A case report of otophyma and a review of the current literature concerning otophyma and the more common rhinophyma, are presented.Results:A 46-year-old male presented with slow growing fleshy growths on both auricles which were excised. A diagnosis of otophyma was made. Although rosacea is more common, otophyma and other ‘phymas’ are thought to be the end stage of the rosacea spectrum of skin disease. However, unlike rhinophyma, otophyma is rarely seen and as a result there is little in the English language literature regarding it. Consequently, the management of otophyma is largely based on previous experiences with rhinophyma.Conclusion:To our knowledge this is the first case report of otophyma in the otolaryngology literature and only the second described in the English language literature. This case demonstrates the difficulties faced in diagnosing this rare condition and our successful management of this case.

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Glomus Tumour of the Lip Mimicking Squamous Cell Carcinoma - A Rare Case Report

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/138 ◽

2021 ◽

Vol 10 (9) ◽

pp. 649-651

Author(s):

Hatice Boyacioglu ◽

Nagihan Koc ◽

Nihal Avcu ◽

Ozay Gokoz

Keyword(s):

Oral Cavity ◽

Rare Case ◽

World Health ◽

Glomus Tumour ◽

Histopathological Analysis ◽

Anatomical Site ◽

Arteriovenous Anastomosis ◽

Lower Lip ◽

Hands And Feet ◽

Glomus Body

Glomus tumour is a rare soft tissue neoplasm arising from glomus body, which is in an arteriovenous anastomosis located particularly in the dermis. This tumour occurs most commonly in hands and feet, and is seldom found in other sites. The purpose of this report is to describe an unusual case of glomus tumour in the lip. A 17-year-old woman with a firm, painless and ulcerated lump in her lower lip was admitted to our clinic. Excisional biopsy was performed, and histopathological analysis revealed the lesion to be a subtype of glomus tumour called as a glomangioma. Most glomus tumours are benign and may be treated by simple surgical excision. A typical glomus tumour of the hand is readily diagnosed, but it may occur anywhere such as oral cavity or internal organs, and its small size and atypical anatomical site presents a diagnostic dilemma. Therefore, a glomus tumour should be considered in the differential diagnosis of mass in the lips. Glomus tumour was first mentioned by Wood as a painful subcutaneous tubercle.1,2 It is classified as a pericystic (perivascular) tumour by the World Health Organization. Perivascular tumours are most frequently noticed in the superficial soft tissues at any age and are not seen commonly in the oral cavity. Synonyms for glomus tumour include glomangioma, glomangiomyoma, glomangiomatosis, glomangiopericytoma, and Popoff tumour. 3 Glomus tumour is presumed to arise from glomus body, which may be defined as a special arteriovenous anastomosis located in the stratum reticular of the dermis. It is lined by smooth muscle and glomus cells.4 The glomus body has been implicated in playing a role in thermal regulation.5 It is ubiquitous but digits are the most common sites. Clinically, the lesion is usually seen as a painful nodule located in the nail bed of the distal phalanges. Occurrence in the oral cavity is particularly rare. In this article, we present a rare case of glomus tumour located in the lower lip mimicking a malignant tumour.

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Case Report: A Rare Case of Autoinflammatory Phospholipase Cγ2 (PLCγ2)-Associated Antibody Deficiency and Immune Dysregulation Complicated With Gangrenous Pyoderma and Literature Review

Frontiers in Immunology ◽

10.3389/fimmu.2021.667430 ◽

2021 ◽

Vol 12 ◽

Author(s):

Na Wu ◽

Bingqing Zhang ◽

Tao Wang ◽

Min Shen ◽

Xuejun Zeng

Keyword(s):

Literature Review ◽

Rare Case ◽

English Language ◽

Missense Variant ◽

Immune Dysregulation ◽

High Serum ◽

Antibody Deficiency ◽

Recurrent Fever ◽

Chinese Han ◽

First Case

BackgroundAutoinflammatory phospholipase Cγ2 (PLCγ2)-associated antibody deficiency and immune dysregulation (APLAID) is a rare autoinflammatory disease caused by gain-of-function mutations in the PLCG2 gene. Here we report a rare case of APLAID patient carrying a novel heterozygous missense PLCG2 I169V mutation with gangrenous pyoderma and concomitant high serum immunoglobulin (Ig) E level.MethodsThe patient was diagnosed as APLAID and has been treated in our department. His phenotype and genotype were carefully documented and studied. We also conducted a comprehensive literature review on APLAID.ResultsA 23-year-old Chinese Han man presented with recurrent fever for 18 years and vesiculopustular rashes for 9 years, along with chronic bronchitis, leukocytosis, increased C-reactive protein, immunodeficiency and high serum IgE. Skin biopsy showed chronic inflammatory cells infiltration. A paternal heterozygous missense variant in exon 6 of the PLCG2 gene p. I169V was identified. His vesiculopustular and IgE level responded to medium dose corticosteroids. After withdrawal of steroids, he developed severe arthritis and a large deteriorating ulceration resembling pyoderma gangrenosum on the left knee. Large dose corticosteroids were suboptimal. Then he received adalimumab with satisfactory response for arthritis and skin lesion. But he got an immunodeficiency-associated lymphoproliferative disorder 2 months later. Through literature review, there were a total of 10 APLAID patients reported by six English-language publications. Vesiculopustular rashes, sinopulmonary infection and immunodeficiency were the most frequent symptoms of APLAID patients. Glucocorticoids, intravenous immunoglobulin and biologics were clinically used to treat APLAID but none of these patients had a complete recovery.ConclusionsThe rarity and diversity of APLAID make it difficult to be diagnosed. Our study reported the first case of APLAID with gangrenous pyoderma and concomitant high IgE carrying a novel PLCG2 mutation, which may expand the clinical phenotype and genotype of APLAID.

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Pial fistula in infancy: Report of two cases and literature review with special emphasis on the ruptured group

Interventional Neuroradiology ◽

10.1177/1591019918763146 ◽

2018 ◽

Vol 24 (4) ◽

pp. 444-449 ◽

Cited By ~ 1

Author(s):

Mostafa Mahmoud ◽

Ramez Nader Abdalla ◽

Ayman Hemdan Mohamed ◽

Mostafa Farid

Keyword(s):

Heart Failure ◽

Literature Review ◽

English Language ◽

Case Reports ◽

Cerebral Haemorrhage ◽

Venous Hypertension ◽

High Flow ◽

Vascular Pathology ◽

Age Group ◽

Language Literature

Cerebral pial fistula is a rare vascular pathology with no more than 150 cases reported. Most cases reported in infancy have been published as case reports. Owing to its high flow, its occurrence in this age group carries the potential risk of heart failure, chronic venous hypertension, seizures and, less frequently, cerebral haemorrhage. We present two cases of pial fistulae in infancy treated by endovascular embolisation using N-butyl cyanoacrylate. A review of the English-language literature was performed for this age group with special emphasis on ruptured cases.

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Leiomyomatous Hamartomas of the Oral Cavity: Clinicopathological and Immunohistochemical Features of 4 Cases and Literature Review

International Journal of Surgical Pathology ◽

10.1177/1066896919843337 ◽

2019 ◽

Vol 27 (6) ◽

pp. 624-630

Author(s):

Celeste Sánchez-Romero ◽

Paulo Rogério Ferreti Bonan ◽

Fábio Ramôa Pires ◽

Geraldo Oliveira Silva-Junior ◽

Wilson Delgado Azañero ◽

...

Keyword(s):

Smooth Muscle ◽

Literature Review ◽

English Language ◽

Oral Pathology ◽

Anterior Maxilla ◽

English Language Literature ◽

Rare Lesion ◽

Pathology Reports ◽

Myogenic Markers ◽

Language Literature

Objective. To present 4 new cases of oral leiomyomatous hamartomas (OLH), describing its clinical, microscopical, and immunohistochemical features, and a literature review. Methods. The OLH cases were retrieved from the files of 2 Brazilian and 1 Peruvian oral pathology services. Clinical data were obtained from the pathology reports. Microscopical features were reviewed, and immunohistochemical reactions were performed. A review of the English-language literature about OLH was done. Results. The sample was composed of 3 females (4-, 10-, and 15-year-old) and 1 male (3-year-old). Three cases affected the dorsum of the tongue and one the incisive papilla, and all presented sessile or pedunculated smooth nodules. Microscopically, the lesions were composed of varying-size fascicles of smooth muscle fibers in a fibrous connective tissue background. Immunohistochemistry revealed positivity of the smooth muscle bundles for myogenic markers. The English-language literature review revealed 38 OLH cases reported, most were congenital or diagnosed up to 5 years old. The main locations were tongue and anterior maxilla. Conclusions. Although OLH is a rare lesion, it must be considered in the differential diagnosis of midline tongue or maxillary masses in newborns, infants, and youngsters.

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