scholarly journals Seroprevalence and associated factors of viral agents of the bovine respiratory disease complex in buffaloes of Colombia

2022 ◽  
Vol 52 (8) ◽  
Author(s):  
Misael Enrique Oviedo Pastrana ◽  
Erly Carrascal-Triana ◽  
Matiluz Doria Ramos ◽  
Diego Ortiz Ortega
Keyword(s):  
Respiratory Disease ◽  
Bovine Respiratory Disease ◽  
Diarrhea Virus ◽  
Disease Complex ◽  
High Prevalence ◽  
Bovine Respiratory Disease Complex ◽  
Syncytial Virus ◽  
Viral Diarrhea Virus ◽  
Bovine Parainfluenza Virus ◽  
Transversal Study

ABSTRACT: The bovine respiratory disease complex causes sizable losses for livestock producers. Its presentation involves the interaction among multiple viral and bacterial pathogens. Viral agents include: bovine viral diarrhea virus (BVDV), bovine alphaherpesvírus 1 (BoHV-1), bovine parainfluenza virus (bPI3v) and bovine respiratory syncytial virus (BRSV); so far, these viruses have been little studied in the buffalo population. This study is aimed to assess the presence of these viruses in buffalo populations of the department of Córdoba, Colombia. A transversal study was conducted upon assessment of 37 farms and 861 buffaloes. Seroprevalence in animals were as follows: 21.7% (BVDV), 51.5% (BoHV-1), 73.6% (bPI3v) and 58.9% (BSRV), while seroprevalence in farms stood at: 94.6% (BVDV), 100% (BoHV-1), 100% (bPI3v) and 100% (BSRV). Conversely, the multiple seropositivity in buffaloes or past coinfection of viral agents amounted to 23.3% for a single virus, 31.8% for two viruses, 29.4% for three viruses and 7.1% for four viruses; only 8.4% of buffaloes were seronegative for four viruses. This is the first regional epidemiological study in the buffalo populations of Colombia and the results showed viral circulation and multiple seropositivity in animals; in addition, the high prevalence found pose a concerning epidemiological threat.

scholarly journals Coinfection of Swiss cattle with bovine parainfluenza virus 3 andMycoplasma bovisat acute and chronic stages of bovine respiratory disease complex

2019 ◽  
Vol 31 (5) ◽  
pp. 674-680 ◽  
Author(s):  
Kemal Mehinagic ◽  
Paola Pilo ◽  
Beatriz Vidondo ◽  
Nadine Stokar-Regenscheit
Keyword(s):  
Respiratory Disease ◽  
Defense Mechanisms ◽  
Bovine Respiratory Disease ◽  
Parainfluenza Virus ◽  
Detection Methods ◽  
Single Infection ◽  
Disease Complex ◽  
Bovine Respiratory Disease Complex ◽  
Syncytial Virus ◽  
Bovine Parainfluenza Virus

Viral agents such as bovine respiratory syncytial virus (BRSV) and bovine parainfluenza virus 3 (BPIV-3) are considered primary infectious agents in bovine respiratory disease complex (BRDC). Information regarding the pathogenesis of BRDC is scarce, especially at an advanced chronicity stage, in addition to ongoing coinfection with other primary agents such as Mycoplasma bovis. Based on a retrospective review of histology slides from 104 autopsy cases, we classified cases according to type of pneumonia and chronicity. We performed immunohistochemistry (IHC) for BRSV, BPIV-3, and M. bovis as well as real-time PCR (rtPCR) for M. bovis on lung tissue of all 104 cases and correlated results with the morphologic type of pneumonia. Histomorphologically, 79 cases were classified as bronchopneumonia, 16 as bronchointerstitial pneumonia, and 9 as interstitial pneumonia. In 89 cases, at least 1 of the investigated agents was detected by IHC; 44 of these cases had a coinfection. BPIV-3 was the predominant agent present, as a single infection in 39 cases, and in coinfection with M. bovis in 39 cases. Comparing the detection methods for M. bovis, rtPCR was more specific and sensitive than IHC. The combination of both methods provided a good visual tool for assessing severity and distribution of M. bovis antigen within the tissue. Unlike BRSV, BPIV-3 and M. bovis persisted in chronic BRDC, suggesting ongoing impairment of defense mechanisms in the lung.

scholarly journals Serological Evidence of Influenza D Virus Circulation Among Cattle and Small Ruminants in France

Viruses ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 516 ◽  
Author(s):  
Justine Oliva ◽  
Amit Eichenbaum ◽  
Jade Belin ◽  
Maria Gaudino ◽  
Jean Guillotin ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Bovine Respiratory Disease ◽  
Small Ruminants ◽  
Serological Evidence ◽  
Disease Complex ◽  
High Prevalence ◽  
Bovine Respiratory Disease Complex ◽  
The Usa

Influenza D virus (IDV) has first been identified in 2011 in the USA and was shown to mainly circulate in cattle. While IDV is associated with mild respiratory signs, its prevalence is still unknown. In the present study we show that IDV has been circulating throughout France in cattle and small ruminants, with 47.2% and 1.5% seropositivity, respectively. The high prevalence and moderate pathogenicity of IDV in cattle suggest that it may play an initiating role in the bovine respiratory disease complex.

scholarly journals Bovine respiratory disease in Brasil: a short review

2021 ◽  
pp. 2081-2110
Author(s):  
Mariana Motta Castro ◽  
◽  
Thalita Evani Silva de Oliveira ◽  
Selwyn Arligton Headley ◽  
◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Bovine Respiratory Disease ◽  
Epidemiological Data ◽  
Short Review ◽  
Adult Cattle ◽  
Diarrhea Virus ◽  
Etiologic Agents ◽  
Syncytial Virus ◽  
Viral Diarrhea Virus

The bovine respiratory disease (BRD) complex is a multifactorial and multietiological disease entity described in all geographic regions of Brazil. This brief review discusses aspects related to epidemiology, etiologic agents, clinical and pathological manifestations, and challenges in the diagnosis of BRD in Brazil. The main infectious disease agents associated with respiratory outbreaks in cattle from Brazil are bovine alphaherpesvirus type 1, bovine viral diarrhea virus, bovine respiratory syncytial virus, and Mycoplasma bovis. Ovine gammaherpesvirus-2 and HoBi-like pestivirus have been associated with the development of pneumonia in adult cattle and calves, respectively in Brazil, and should be considered as possible causes of BRD. Additionally, studies using epidemiological data, histopathological and molecular associations with morbidity and mortality should be carried out in Brazil, to demonstrate the real impacts of BRD on livestock.

scholarly journals Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD): Emerging role of orthomyxoviruses in the pathogenesis of BRD

2020 ◽  
Author(s):  
Ruth H. Nissly ◽  
Noriza Zaman ◽  
Puteri Ainaa S. Ibrahim ◽  
Kaitlin McDaniel ◽  
Levina Lim ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Geometric Mean ◽  
Bovine Respiratory Disease ◽  
The United States ◽  
Influenza Viruses ◽  
Cattle Industry ◽  
Diarrhea Virus ◽  
Viral Loads ◽  
Influenza C Virus ◽  
Syncytial Virus

AbstractBovine respiratory disease (BRD) is the costliest disease affecting the cattle industry globally. Despite decades of research, the pathophysiology of BRD is not yet fully understood. It is widely believed that viruses predispose cattle to bacterial infection by causing direct damage to the respiratory tract and interfering with the immune system, leading to bacterial pneumonia. BRD remains a major challenge despite extensive vaccination against all major viral pathogens associated with the disease. Orthomyxoviruses (Influenza C & D viruses), have recently been found to infect cattle throughout the United States and are implicated to play a role in BRD. Here, we use the largest cohort study to date to investigate the association of influenza viruses in cattle with BRD. Cattle (n=599) from 3 locations were individually observed and scored for respiratory symptoms using the McGuirk scoring system. Deep pharyngeal and mid-nasal swabs were collected from each animal and were tested quantitatively for bovine viral diarrhea virus, bovine herpesvirus 1, bovine respiratory syncytial virus, bovine coronavirus, influenza C virus (ICV) and influenza D virus (IDV) by real-time PCR. Cattle that have higher viral loads of IDV and ICV also have greater numbers of co-infecting viruses than controls. More strikingly, in BRD-symptomatic cattle, the geometric mean of detectable IDV viral RNA was nearly 2 logs higher in co-infected animals (1.30×104) than those singly infected with IDV (2.19×102). This is strong evidence that viral coinfections can lead to higher replication of IDV. Our results strongly suggest that orthomyxoviruses may be significant contributors to BRD.

scholarly journals Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Susanta K. Behura ◽  
Polyana C. Tizioto ◽  
JaeWoo Kim ◽  
Natalia V. Grupioni ◽  
Christopher M. Seabury ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Bovine Respiratory Disease ◽  
Transcriptional Response ◽  
Tissue Tropism ◽  
Disease Complex ◽  
Bovine Respiratory Disease Complex

Bovine respiratory disease research (1983–2009)

2009 ◽  
Vol 10 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Robert W. Fulton
Keyword(s):  
Respiratory Disease ◽  
Viral Vectors ◽  
Pasteurella Multocida ◽  
Bovine Respiratory Disease ◽  
Economic Incentives ◽  
T Cell Subsets ◽  
Specific Information ◽  
Diarrhea Virus ◽  
New Antibiotics ◽  
Syncytial Virus

AbstractBovine respiratory disease (BRD) research has provided significant understanding of the disease over the past 26 years. Modern research tools that have been used include monoclonal antibodies, genomics, polymerase chain reaction, immunohistochemistry (IHC), DNA vaccines and viral vectors coding for immunogens. Emerging/reemerging viruses and new antigenic strains of viruses and bacteria have been identified. Methods of detection and the role for cattle persistently infected bovine viral diarrhea virus (BVDV) were identified; viral subunits, cellular components and bacterial products have been characterized. Product advances have included vaccines for bovine respiratory syncytial virus, Mannheimia haemolytica and Pasteurella multocida; the addition of BVDV2 to the existing vaccines and new antibiotics. The role of Mycoplasma spp., particularly Mycoplasma bovis in BRD, has been more extensively studied. Bovine immunology research has provided more specific information on immune responses, T cell subsets and cytokines. The molecular and genetic basis for viral–bacterial synergy in BRD has been described. Attempts have been made to document how prevention of BRD by proper vaccination and management prior to exposure to infectious agents can minimize disease and serve as economic incentives for certified health programs.

0288 Calculation of genomic predicted transmitting abilities for bovine respiratory disease complex in Holsteins

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 136-137
Author(s):  
C. P. VanTassell ◽  
G. Spangler ◽  
D. M. Bickhart ◽  
G. R. Wiggans ◽  
J. B. Cole ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Bovine Respiratory Disease ◽  
Disease Complex ◽  
Bovine Respiratory Disease Complex
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