scholarly journals Histopathological and immunohistochemical characteristics of malignant adenomyoepithelioma in a cat: case report

2021 ◽  
Vol 73 (6) ◽  
pp. 1351-1356
Author(s):  
M.M. Nunes ◽  
A.P.V. Garcia ◽  
K.Y.R. Nakagaki ◽  
G.D. Cassali
Keyword(s):  
Mammary Gland ◽  
Case Report ◽  
Epithelial Cells ◽  
Mammary Tumor ◽  
Neoplastic Cells ◽  
Microscopic Evaluation ◽  
Her 2 ◽  
Cox 2

ABSTRACT The malignant adenomyoepithelioma is a rare mammary tumor in women and uncommon in cats with only one report in this species. In this case report, the histopathological and immunohistochemical characteristics of six cases of malignant adenomyopithelioma in the feline mammary gland are described. Microscopic evaluation of tumors showed dense cellular neoplastic proliferation, composed of malignant myoepithelial and epithelial cells, formed by varied arrangements and presenting papillary, tubular and solid nest proliferation. Immunohistochemistry was performed for markers Ki67, Cox-2, RE, RP, p63 and HER-2. All cases were positive for p63, confirming the myoepithelial nature of neoplastic cells. The diagnosis of malignant adenomyopithelioma was made possible through the association between histopathological characteristics and immunohistochemical results.

scholarly journals Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms

2016 ◽  
Vol 18 (12) ◽  
pp. 1003-1012 ◽  
Author(s):  
Cecilia B De Campos ◽  
Karine A Damasceno ◽  
Conrado O Gamba ◽  
Ana M Ribeiro ◽  
Carla J Machado ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Mammary Gland ◽  
Growth Factor ◽  
Therapeutic Option ◽  
Histologic Grade ◽  
Clinical Staging ◽  
Ki 67 ◽  
Primary Tumors ◽  
Her 2 ◽  
Cox 2

Objectives The aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS). Methods Fifty-six primary malignant mammary gland neoplasms and 16 metastatic lymph nodes from 37 female cats were analyzed. Clinical staging, histologic type and grade, and immunohistochemistry for Ki-67, progesterone and estrogen receptor, human epidermal growth factor receptor type 2 (HER-2), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) were evaluated. Follow-up was performed in order to correlate prognostic factors with OS. Results Lymph node metastasis was found in 35% of cases. Clinical stage III, tubulopapillary carcinomas and histologic grade II cases prevailed in the study. Most neoplasms were positive for hormonal receptors, negative for HER-2 overexpression and presented VEGF overexpression. Immunoreactivity for Ki-67 ( P = 0.046) and COX-2 ( P = 0.007) was higher in metastases than in primary tumors. COX-2 ( P = 0.089), HER-2 ( P = 0.012) and histologic grade ( P = 0.080) were correlated with OS. Conclusions and relevance The data suggest that inhibition of ovarian hormones and COX-2 may represent a therapeutic option for malignant feline mammary gland neoplasms. When evaluating disease progression, COX-2 scores and Ki-67 index should be analyzed in primary tumors and metastases. Histologic grade, HER-2 status and COX-2 scores were found to have a direct influence on OS. Prognostic factors allow for a better understanding of disease outcome in a condition that is characterized by a poor prognosis. The present work highlights the need for further studies on endocrine therapy and COX-2 inhibitors, which could influence OS.

scholarly journals Invasive micropapillary carcinoma of the dog mammary gland: a case report

2002 ◽  
Vol 54 (4) ◽  
pp. 366-369 ◽  
Author(s):  
G.D. Cassali ◽  
R. Serakides ◽  
F. Gärtner ◽  
F.C. Schmitt
Keyword(s):  
Mammary Gland ◽  
Case Report ◽  
Epithelial Cells ◽  
Breast Tumor ◽  
Morphological Features ◽  
Invasive Micropapillary Carcinoma ◽  
Micropapillary Carcinoma ◽  
Micropapillary Pattern

This report describes the morphological and immunohistochemical findings of two cases of breast invasive micropapillary carcinoma occurring in dogs. Histologically, the tumors are characterized by the presence of numerous irregular cystic formations filled out with nests of epithelial cells that exhibit a micropapillary pattern. These morphological features are characteristic of invasive micropapillary carcinoma in woman, a breast tumor not previously described in dogs.

scholarly journals First description of basaloid carcinoma of the canine mammary gland: case report

2019 ◽  
Vol 71 (3) ◽  
pp. 878-882
Author(s):  
K.Y.R. Nakagaki ◽  
A.B.B. Gonçalves ◽  
R.M. Rocha ◽  
G.D. Cassali
Keyword(s):  
Mammary Gland ◽  
Case Report ◽  
Lymph Nodes ◽  
Distant Metastasis ◽  
Regional Lymph Nodes ◽  
Basaloid Carcinoma ◽  
Microscopic Evaluation ◽  
Peripheral Cells ◽  
Canine Mammary Gland ◽  
Cytokeratin 14

ABSTRACT The objective of this case report was to describe histopathological and immunohistochemical characteristics of the first reported basaloid carcinomas in the canine mammary gland. Two bitches were treated for tumors in the mammary gland and underwent mastectomy. Microscopic evaluation of these tumors revealed epithelial cells arranged in a predominantly solid pattern with hyperchromatic peripheral cells arranged in a palisade pattern. Metastases in regional lymph nodes were found in both animals, and one bitch exhibited pulmonary metastasis. Immunohistochemistry revealed positive labeling for the basal cell markers cytokeratin 14 and p63. Histopathological and immunohistochemical findings led to diagnoses of basaloid carcinoma of the canine mammary gland with regional and distant metastasis.

Contribution of stromal and epithelial cells to cyclooxygenase-2 (COX-2) activity in Barrett's esophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A78-A79
Author(s):  
N BUTTAR ◽  
K WANG ◽  
M ANDERSON ◽  
L LUTZKE ◽  
K KRISHNADATH
Keyword(s):  
Epithelial Cells ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cyclooxygenase 2 ◽  
Cox 2

The interdisciplinary management of a patient with a rare mammary tumor - a case report

2017 ◽  
Vol 2 (16) ◽  
pp. 44
Author(s):  
Octavian Munteanu ◽  
Dragoş Davițoiu ◽  
Irina Stavarache ◽  
Costin Berceanu ◽  
Alina Păltineanu ◽  
...  
Keyword(s):  
Case Report ◽  
Mammary Tumor ◽  
Interdisciplinary Management

scholarly journals Mammary gland adipocytes in lactation cycle, obesity and breast cancer

2021 ◽  
Author(s):  
Georgia Colleluori ◽  
Jessica Perugini ◽  
Giorgio Barbatelli ◽  
Saverio Cinti
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Epithelial Cells ◽  
Close Association ◽  
Critical Role ◽  
Exocrine Gland ◽  
Plastic Properties ◽  
Lactation Cycle ◽  
Gland Development

AbstractThe mammary gland (MG) is an exocrine gland present in female mammals responsible for the production and secretion of milk during the process of lactation. It is mainly composed by epithelial cells and adipocytes. Among the features that make the MG unique there are 1) its highly plastic properties displayed during pregnancy, lactation and involution (all steps belonging to the lactation cycle) and 2) its requirement to grow in close association with adipocytes which are absolutely necessary to ensure MG’s proper development at puberty and remodeling during the lactation cycle. Although MG adipocytes play such a critical role for the gland development, most of the studies have focused on its epithelial component only, leaving the role of the neighboring adipocytes largely unexplored. In this review we aim to describe evidences regarding MG’s adipocytes role and properties in physiologic conditions (gland development and lactation cycle), obesity and breast cancer, emphasizing the existing gaps in the literature which deserve further investigation.

scholarly journals Crime Scene Analysis Through DNA Testing of Canine Feces—A Case Report

2020 ◽  
Vol 10 (1) ◽  
pp. 56-61
Author(s):  
Vishal Somnay ◽  
Thomas Duong ◽  
Ray-Young Tsao ◽  
Joseph A. Prahlow
Keyword(s):  
Case Report ◽  
Epithelial Cells ◽  
Critical Role ◽  
Crime Scene ◽  
Scene Analysis ◽  
Dna Testing ◽  
Forensic Dna ◽  
Forensic Dna Testing ◽  
Positive Results ◽  
Crime Scene Analysis

Forensic DNA testing can play a critical role in homicide investigations. Selecting the appropriate evidence on which to perform DNA testing requires foresight and reasoning based on experience and science. Although successful DNA testing can occur using many substrates, including blood, hair, and sweat/epithelial cells, positive results can also result from testing various unorthodox samples. The authors report on a triple-murder investigation where DNA testing of dog feces at the crime scene matched DNA testing of feces found on the shoe of a suspect resulting in successful prosecution of the case.

scholarly journals Canine pyometra associated with Bacillus species: a case report

2018 ◽  
Vol 63 (No. 3) ◽  
pp. 143-149 ◽  
Author(s):  
MK Kim ◽  
HY Yoon ◽  
MH Lee ◽  
JH Kim
Keyword(s):  
Mammary Gland ◽  
Case Report ◽  
Bacillus Megaterium ◽  
Fatal Outcome ◽  
Bacillus Species ◽  
Bacterial Isolation ◽  
Sonographic Examination ◽  
First Time ◽  
Gland Tumour ◽  
Unilateral Mastectomy

An 11-year-old, female Maltese was presented for evaluation of a mammary gland tumour. An abdominal sonographic examination showed an echogenic, fluid-filled, dilated uterus; pyometra was also diagnosed. Ovariohysterectomy and unilateral mastectomy was performed and the dog recovered uneventfully. However, 11 h later, the dog’s condition suddenly deteriorated and it died on the day after the surgery. Bacillus circulans and Bacillus megaterium were isolated from its uterine content; these species had not been reported previously in canine pyometra. The two species were resistant to various antibiotics, including cefazolin used during the treatment. We describe for the first time the presentation, diagnosis, bacterial isolation and fatal outcome of B. circulans and B. megaterium infection in a Maltese dog with pyometra.

scholarly journals Ekstrak Etanol Kulit Buah Naga Menurunkan Indikasi Neoplasia Mammae Tikus Putih Berdasarkan Histopatologi dan Inhibitor Siklooksigenase-2

2018 ◽  
Vol 19 (1) ◽  
pp. 23
Author(s):  
Muhammad Thohawi Elziyad Purnama ◽  
Ragil Angga Prastiya ◽  
Faisal Fikri ◽  
Amung Logam Saputro ◽  
Bodhi Agustono
Keyword(s):  
Mammary Gland ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Growth Function ◽  
Histopathological Features ◽  
White Rats ◽  
Fruit Skin ◽  
Dragon Fruit ◽  
Cox 2 ◽  
Dermal Injection

Cancer caused uncontrolled cell proliferation and triggered by changes on cell information that regulate growth function. Each cell has different potential so many cancer prevalence such as endometrial cancer, lymph node cancer, lung cancer, skin and mammary gland cancer. The aims of this study were to assess the potential of dragon fruit skin ethanolic extract on white rats (Rattus norvegicus) exposed 7,12- Dimethylbenz(á)antrasena (DMBA) on mammary gland based on histopathological features and cyclooxygenase-2 (Cox-2) intensity. This study were used 20 of rats randomly divided into five group and each groups consisted of four rats, i.e: K+ weren’t treated DMBA and extract; K- were treated with DMBA; P1 were treated with DMBA and extract 10 mg/kg BW; P2 were treated with DMBA and extract 15 mg/kg BW; P3 were treated with DMBA and extract 20 mg/kg BW. The DMBA was given by intra dermal injection during twice a week for five weeks and the extracts with gastric tube everyday till 14 days. The data was analyzed by Anova test and continued with Duncan test. The result showed that the histopathological features were decrease significantly on P3. The variables of Cox-2 intensity were decrease significantly on P1, P2 and P3. Conclusion of this study was ethanol extract of dragon fruit skin can decrease neoplastic indication of mammary gland on white rats (R. norvegicus) based on histopathological features and Cox-2 inhibitors.

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