scholarly journals Testicular morphometry of rats with Walker 256 tumor supplemented with L-glutamine

2021 ◽  
Vol 18 (2) ◽  
Author(s):  
Nayara Rodrigues Rocha ◽  
Janine Karla França da Silva Braz ◽  
Sara Raquel Garcia de Souza ◽  
Luciane Fracaro ◽  
Fabiana Cristina Silveira Alves de Melo ◽  
...  
Keyword(s):  
Walker 256 ◽  
Walker 256 Tumor

DNA polymerase activities in fractionated walker-256 tumor cell nuclei

1970 ◽  
Vol 40 (5) ◽  
pp. 1201-1208 ◽  
Author(s):  
N. Raghuveer Ballal ◽  
Michael S. Collins ◽  
Richard M. Halpern ◽  
Roberts A. Smith
Keyword(s):  
Tumor Cell ◽  
Dna Polymerase ◽  
Cell Nuclei ◽  
Walker 256 ◽  
Walker 256 Tumor

Insulin secretion in Walker 256 tumor cachexia

1990 ◽  
Vol 258 (6) ◽  
pp. E1033-E1036 ◽  
Author(s):  
L. C. Fernandes ◽  
U. F. Machado ◽  
C. R. Nogueira ◽  
A. R. Carpinelli ◽  
R. Curi
Keyword(s):  
Insulin Secretion ◽  
Islets Of Langerhans ◽  
Adult Male ◽  
Male Rats ◽  
Control Group ◽  
Tumor Bearing ◽  
Isolated Islets Of Langerhans ◽  
Outflow Rate ◽  
Walker 256 ◽  
Walker 256 Tumor

The effect of cachexia on insulin secretion was examined in adult male rats. Isolated islets of Langerhans from Walker 256 tumor-bearing rats secreted less insulin by glucose stimuli as compared with the control group; this was accompanied by significant change in 45Ca2+ outflow rate. Reduced insulin secretion to glucose stimuli in tumor-bearing rats probably led to low insulinemia (one-third). These findings indicate that reduced insulin secretion is probably an important factor for the development of cachexia in Walker 256 tumor-bearing rats.

Nucleotide metabolizing ecto-enzymes in Walker 256 tumor cells: Molecular identification, kinetic characterization and biochemical properties

Life Sciences ◽  
2007 ◽  
Vol 80 (10) ◽  
pp. 950-958 ◽  
Author(s):  
Andréia Buffon ◽  
Vanessa B. Ribeiro ◽  
Márcia R. Wink ◽  
Emerson A. Casali ◽  
João J.F. Sarkis
Keyword(s):  
Tumor Cells ◽  
Molecular Identification ◽  
Biochemical Properties ◽  
Kinetic Characterization ◽  
Walker 256 ◽  
Walker 256 Tumor

scholarly journals The oophorectomy effect on Walker 256 tumor inoculated into the vagina and uterine cervix of female rats

2009 ◽  
Vol 24 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Nara Macedo Botelho Brito ◽  
Rita de Kássia Vidigal Carvalho ◽  
Lia Tavares de Moura Brasil Matos ◽  
Rodolfo Costa Lobato ◽  
Rosângela Baía Brito
Keyword(s):  
Acetic Acid ◽  
Tumor Growth ◽  
Uterine Cervix ◽  
Statistical Difference ◽  
Female Rats ◽  
Tumor Mass ◽  
Tumor Group ◽  
Walker 256 ◽  
Similar Development ◽  
Walker 256 Tumor

PURPOSE: Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats. METHODS: Ten Wistar, female rats were used, distributed into two groups with 05 animals each: Tumor group (TG): Rats inoculated with Walker 256 tumor; Oophorectomy group (OG): oophorectomized rats inoculated with Walker 256 tumor. The day before the tumor vaginal inoculation, acetic acid was inoculated into the vaginas of both groups of rats; the following day, the vaginal walls were scarified with an endocervix brush, and then Walker 256 tumor was inoculated. After 12 days, the tumor was removed together with the vagina and uterine horns for macro and microscopic analyses. The data were submitted to statistical analyses. RESULTS: There was no statistical difference between the two groups; however it was observed that the behavior of tumor growth on the OG group presented greater invasion, compromising the uterine horns. CONCLUSION: The results of the study on the GO group presented a macroscopic behavior different from the TG group, however, both of them presented similar development in terms of tumor mass.

NTPDase and 5′ ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor

2007 ◽  
Vol 1770 (8) ◽  
pp. 1259-1265 ◽  
Author(s):  
A. Buffon ◽  
M.R. Wink ◽  
B.V. Ribeiro ◽  
E.A. Casali ◽  
T.A. Libermann ◽  
...  
Keyword(s):  
Expression Profiles ◽  
Extracellular Atp ◽  
Atp Metabolism ◽  
Walker 256 ◽  
Walker 256 Tumor

Variability and Discontinuity of the Pathognomonic Systemic Effects Caused by Walker 256 Tumor Progression in Rats

1995 ◽  
Vol 81 (5) ◽  
pp. 370-377 ◽  
Author(s):  
Ovidio Rettori ◽  
Ana Neuza Vieira-Matos ◽  
Quivo S. Tahin
Keyword(s):  
Tumor Growth ◽  
Primary Tumor ◽  
Marked Reduction ◽  
Prognostic Indicator ◽  
Individual Variability ◽  
Systemic Effects ◽  
Primary Tumor Growth ◽  
Multifocal Tumor ◽  
Walker 256 ◽  
Walker 256 Tumor

Cancer pathognomonic systemic effects (PSE) have high individual variability. For this reason present data were collected daily and synchronized considering four main points: inoculation day, onset of PSE, aggravation and death. The subclinical period free of PSE ranged between 15.7±2.2 days, the clinical period was less variable, 8.9±0.5 days, divided in a moderate and a grave phase of nearly the same length. PSE involved disturbances of fundamental homeostatic regulations: appetite, sodium, water, immune, etc. PSE triggering correlated highly with survival (r2=0.95, P<0.01), but poorly with primary tumor growth, and it was anticipated by metastases from 20.5±2.6 to 10.6±1.1 days (P<0.01). After multifocal simultaneous inoculations, PSE triggering was anticipated to 4.2±0.2 days (marked reduction of individual variability), in the presence of small total-tumor masses, absence of macroscopic metastases, and without changes in the following clinical period features. PSE triggering seems to be a major prognostic indicator probably related to multifocal tumor growth.

Nocturnal depletion of hypothalamic dynorphin in anorexic walker-256 tumor-bearing rats

1988 ◽  
Vol 29 (3) ◽  
pp. 541-545 ◽  
Author(s):  
T.D. Steele ◽  
H.U. Bryant ◽  
P.V. Malven ◽  
G.K.W. Yim
Keyword(s):  
Tumor Bearing ◽  
Walker 256 ◽  
Walker 256 Tumor

scholarly journals Walker-256 Tumor: Experimental Model, Implantation Sites and Number of Cells for Ascitic and Solid Tumor Development

2019 ◽  
Vol 62 ◽  
Author(s):  
Luane Aparecida do Amaral ◽  
Gabriel Henrique Oliveira de Souza ◽  
Mirelly Romeiro Santos ◽  
Yasmin Lany Ventura Said ◽  
Bruna Brandão de Souza ◽  
...  
Keyword(s):  
Experimental Model ◽  
Solid Tumor ◽  
Tumor Development ◽  
Implantation Sites ◽  
Walker 256 ◽  
Number Of Cells ◽  
Walker 256 Tumor

scholarly journals l-Glutamine supplementation promotes an improved energetic balance in Walker-256 tumor–bearing rats

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769596 ◽  
Author(s):  
Heber Amilcar Martins ◽  
Roberto Barbosa Bazotte ◽  
Geraldo Emilio Vicentini ◽  
Mariana Machado Lima ◽  
Flavia Alessandra Guarnier ◽  
...  
Keyword(s):  
Phosphoenolpyruvate Carboxykinase ◽  
Experimental Period ◽  
Plasma Corticosterone ◽  
Glutamine Supplementation ◽  
Tumor Bearing ◽  
Male Wistar Rats ◽  
Energetic Balance ◽  
Walker 256 ◽  
Immunohistochemical Techniques ◽  
Walker 256 Tumor

We evaluated the effects of supplementation with oral l-glutamine in Walker-256 tumor–bearing rats. A total of 32 male Wistar rats aged 54 days were randomly divided into four groups: rats without Walker-256 tumor, that is, control rats (C group); control rats supplemented with l-glutamine (CG group); Walker-256 tumor rats without l-glutamine supplementation (WT group); and WT rats supplemented with l-glutamine (WTG group). l-Glutamine was incorporated into standard food at a proportion of 2 g/100 g (2%). After 10 days of the experimental period, the jejunum and duodenum were removed and processed. Protein expression levels of key enzymes of gluconeogenesis, that is, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, were analyzed by western blot and immunohistochemical techniques. In addition, plasma corticosterone, glucose, insulin, and urea levels were evaluated. The WTG group showed significantly increased plasma glucose and insulin levels ( p < 0.05); however, plasma corticosterone and urea remained unchanged. Moreover, the WTG group showed increased immunoreactive staining for jejunal phosphoenolpyruvate carboxykinase and increased expression of duodenal glucose-6-phosphatase. Furthermore, the WTG group presented with less intense cancer cachexia and slower tumor growth. These results could be attributed, at least partly, to increased intestinal gluconeogenesis and insulinemia, and better glycemia maintenance during fasting in Walker-256 tumor rats on a diet supplemented with l-glutamine.

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