scholarly journals LOWER BIFIDOBACTERIA COUNTS IN ADULT PATIENTS WITH CELIAC DISEASE ON A GLUTEN-FREE DIET

2014 ◽  
Vol 51 (2) ◽  
pp. 139-143 ◽  
Author(s):  
Lisléia GOLFETTO ◽  
Fernanda Duarte de SENNA ◽  
Julia HERMES ◽  
Bruna Teles Soares BESERRA ◽  
Franciane da Silva FRANÇA ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Healthy Subjects ◽  
Microscopic Analysis ◽  
Mucosal Damage ◽  
Fecal Microbiota ◽  
Pathological Process ◽  
Selective Medium ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Fecal Ph

ContextThe ingestion of gluten is responsible for the symptoms of Celiac disease, but other environmental factors can also influence. Strains of theBifidobacterium genus have been shown to afford protection against the inflammatory response and mucosal damage caused by gliadin peptides in vitro.ObjectivesThis study was designed to compare the concentration of fecal bifidobacteria and pH of patients with celiac disease on gluten-free diet and control subjects in order to identify if the imbalance on fecal microbiota still remain during the treatment of celiac disease and identify the necessity of dietary supplementation with pre- or probiotics.MethodsIt was analyzed the feces of 42 healthy subjects and 14 celiac patients. The bifidobacteria count in feces was done in selective medium BIM-25. Microscopic analysis of the colonies was performed by Gram stain. The identification of the genus Bifidobacterium was performed by determination of fructose-6-phosphate phosphoketolase. Fecal pH was measured using a pH meter.ResultsThe concentration of bifidobacteria per gram of feces was significantly higher in healthy subjects (controls) (1.5 ± 0.63 x108 CFU/g) when compared to celiac patients (2.5 ± 1.5 x107 CFU/g). The fecal pH was not different between celiac patients (7.19 ± 0.521) and controls (7.18 ± 0.522).ConclusionsThese results suggest that with lower levels of bifidobacteria, celiac patients have an imbalance in the intestinal microbiota, regardless of pH, even while on a gluten-free diet. This fact could favor the pathological process of the disorder.

scholarly journals Baseline Fecal Microbiota in Pediatric Patients With Celiac Disease Is Similar to Controls But Dissimilar After 1 Year on the Gluten-Free Diet

JPGN Reports ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. e127
Author(s):  
Dory Sample ◽  
Janelle Fouhse ◽  
Seema King ◽  
Hien Q. Huynh ◽  
Levinus A. Dieleman ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Pediatric Patients ◽  
Fecal Microbiota ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review

2022 ◽  
Vol 40 ◽  
Author(s):  
Camila Fernanda Jedwab ◽  
Bruna Cardoso de Mattos Boccalini Roston ◽  
Ana Beatriz Ferreira de Souza Toge ◽  
Isadora Fagundes Echeverria ◽  
Guilherme Ojea Gomes Tavares ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Proinflammatory Cytokines ◽  
Randomized Clinical Trials ◽  
Pediatric Population ◽  
Immunological Response ◽  
Fecal Microbiota ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Qualitative Synthesis ◽  
Number Of Patients

ABSTRACT Objective: To evaluate changes in peripheral immunological response (decrease in blood proinflammatory cytokines) and fecal microbiota (especially Bacteroidetes and Firmicutes) after administration of probiotics in children with celiac disease on a gluten-free diet. Data source: The databases MEDLINE, LILACS, Springer and SciELO were used for this review, with the descriptors “celiac disease AND probiotics”. At the end of the search, 168 articles were retrieved, four of which were included in the final qualitative synthesis, having as inclusion criteria randomized clinical trials and pediatric population (1–19 years) and, as exclusion criteria, interventions other than probiotics, studies with patients with other diseases associated with celiac disease, or patients who did not meet the diagnostic criteria. All elected studies were published until September 2020, without language restriction, with patients receiving strains of Bifidobacterium breve or B. longum and on a gluten-free diet. Data synthesis: The studies show that the administration of probiotics along with a gluten-free diet, can approximate the fecal microbiota of celiac patients to typical conditions of healthy individuals, by restoring the abundance of some microbial communities that characterize the typical physiological condition. In addition, the administration of probiotics can reduce serum proinflammatory cytokines (mainly TNF-alpha). Conclusions: Despite the positive correlation between probiotics and fecal microbiota/serological markers in pediatric patients with celiac disease, we emphasize the need for future multicentric studies that should include a larger number of patients and a longer follow up period.%

scholarly journals Su1162 - Duodenal and Fecal Microbiota before and after a Gluten-Free Diet (GFD) in Patients with Celiac Disease, Non-Celiac Gluten Sensitivity and Controls

2018 ◽  
Vol 154 (6) ◽  
pp. S-490
Author(s):  
Xaira J. Rivera Gutierrez ◽  
Jose F. García-Mazcorro ◽  
Orestes Cobos-Quevedo ◽  
Francisco Javier Cabrera Jorge ◽  
Arturo Meixueiro ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Fecal Microbiota ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Before And After

scholarly journals Motility Disorders in Celiac Disease and Non-Celiac Gluten Sensitivity: The Impact of a Gluten-Free Diet

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1705 ◽  
Author(s):  
Paolo Usai-Satta ◽  
Francesco Oppia ◽  
Mariantonia Lai ◽  
Francesco Cabras
Keyword(s):  
Celiac Disease ◽  
Mucosal Damage ◽  
Gluten Free Diet ◽  
Mucosal Inflammation ◽  
Low Grade ◽  
Motor Disorders ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Motility Disorders ◽  
The Impact

Background: There is evidence that digestive motor disorders are frequently present in untreated celiac disease (CD) patients. Similarly, non-celiac gluten sensitivity (NCGS) can be associated with gut motor disorders. In both cases, gut dysmotility can improve or be completely reversed with a gluten-free diet (GFD). Methods: A literature search for motility disorders in CD and NCGS patients was carried out using the online databases PubMed, Medline and Cochrane. Results: Esophageal, gastric, small bowel and gallbladder motor disorders are common in both children and adults with CD. Although the clinical consequences of these disorders are not clearly defined, gastric dysfunction could affect drug absorption and metabolism in the thyroid and neurological conditions associated with CD. The impact of a GFD on motility disorders is, however, controversial. No systematic studies are available on NCGS. NCGS frequently overlaps with irritable bowel syndrome (IBS) and similar pathophysiological mechanisms may be hypothesized. Conclusions: Mucosal damage may affect gut motility in untreated CD through perturbation of hormonal and neuro-immunomodulatory regulation. A persistent low-grade mucosal inflammation could explain the cases of persistent motor disorders despite a GFD. Further studies are needed to definitely assess the role of gut motor disorders in NCGS.

HPLC determination of polyethylene glycol 400 in urine: oligomeric profile in healthy and celiac disease subjects

1994 ◽  
Vol 40 (8) ◽  
pp. 1571-1574 ◽  
Author(s):  
A Oliva ◽  
H Armas ◽  
J B Fariña
Keyword(s):  
Celiac Disease ◽  
Polyethylene Glycol ◽  
Intestinal Permeability ◽  
Healthy Subjects ◽  
Gluten Free Diet ◽  
Intestinal Biopsy ◽  
Gluten Free ◽  
Polyethylene Glycol 400 ◽  
Hplc Technique

Abstract The absorption of orally administered polyethylene glycol (PEG) has been used to assess intestinal permeability. We describe a simple HPLC technique to determine the oligomeric profile of PEG excreted in urine. We measured the total (%) PEG excreted in 6 h and the ratio of the four smallest oligomers to the three largest oligomers (expressed as mean percentages). The proposed method differentiates distinct groups of subjects with varying degrees of intestinal permeability detected by intestinal biopsy. The percent of PEG excreted and the oligomer ratio values for healthy subjects were, respectively, 30.1 +/- 3.87 and 0.35 +/- 0.03; for celiac patients on a gluten-free diet, 24.5 +/- 6.65 and 0.45 +/- 0.16; and for celiac patients, 15.0 +/- 5.93 and 1.12 +/- 0.55.

scholarly journals The role of nutrtion in children with celiac disease

2021 ◽  
Vol 5 (1) ◽  
pp. 80
Author(s):  
Muzal Kadim
Keyword(s):  
Celiac Disease ◽  
Growth And Development ◽  
Villous Atrophy ◽  
Mucosal Damage ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Nutrient Requirements ◽  
Gluten Sensitive Enteropathy ◽  
Nutritional Imbalance

Celiac disease, a permanent, irreversible but treatable disease  is an autoimmune disease triggered by gluten ingestion in genetically predisposed individuals, also known as celiac sprue and gluten sensitive enteropathy.  Recent findingsIntestinal inflammation and villous atrophy in small intestines by permanent intolerance to gluten in celiac disesea leads to seveare malabsorption. About 20%-38%  patients were basically nutritionally imbalance secondary malabsorption due to mucosal damage. Nutrition plays a very important role in the management of celiac disease. Gluten free diet must be balanced to cover nutrient requirements to prevent deficiencies and ensure children’s health, growth and development.Conclusion Gluten-free diet is the only accepted and available treatment in CD. It was a life-long treatment, if not carried out with attention, it may lead to nutritional imbalance which can affect children’s growth and development 

scholarly journals Diet, Perceived Intestinal Well-Being and Compositions of Fecal Microbiota and Short Chain Fatty Acids in Oat-Using Subjects with Celiac Disease or Gluten Sensitivity

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2570
Author(s):  
Lotta Nylund ◽  
Salla Hakkola ◽  
Leo Lahti ◽  
Seppo Salminen ◽  
Marko Kalliomäki ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Well Being ◽  
Short Chain Fatty Acids ◽  
Study Groups ◽  
Fecal Microbiota ◽  
Gluten Free Diet ◽  
Control Group ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Fiber Intake

A gluten-free diet may result in high fat and low fiber intake and thus lead to unbalanced microbiota. This study characterized fecal microbiota profiles by 16S MiSeq sequencing among oat-using healthy adult subjects (n = 14) or adult subjects with celiac disease (CeD) (n = 19) or non-celiac gluten sensitivity (NCGS) (n = 10). Selected microbial metabolites, self-reported 4d food diaries and perceived gut symptoms were compared. Subjects with NCGS experienced the highest amount of gut symptoms and received more energy from fat and less from carbohydrates than healthy and CeD subjects. Oat consumption resulted in reaching the lower limit of the recommended fiber intake. Frequent consumption of gluten-free pure oats did not result in microbiota dysbiosis in subjects with CeD or NCGS. Thus, the high number of gut symptoms in NCGS subjects was not linked to the microbiota. The proportion of fecal acetate was higher in healthy when compared to NCGS subjects, which may be linked to a higher abundance of Bifidobacterium in the control group compared to NCGS and CeD subjects. Propionate, butyrate and ammonia production and β-glucuronidase activity were comparable among the study groups. The results suggest that pure oats have great potential as the basis of a gluten-free diet and warrant further studies in minor microbiota disorders.

scholarly journals Comparative Study of Salivary, Duodenal, and Fecal Microbiota Composition Across Adult Celiac Disease

2020 ◽  
Vol 9 (4) ◽  
pp. 1109 ◽  
Author(s):  
Simona Panelli ◽  
Enrica Capelli ◽  
Giuseppe Francesco Damiano Lupo ◽  
Annalisa Schiepatti ◽  
Elena Betti ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Villous Atrophy ◽  
Duodenal Mucosa ◽  
Fecal Microbiota ◽  
Gluten Free Diet ◽  
Microbiota Composition ◽  
Gluten Free ◽  
Cross Sectional ◽  
Adult Celiac Disease ◽  
Tertiary Center

Background: Growing evidence suggests that an altered microbiota composition contributes to the pathogenesis and clinical features in celiac disease (CD). We performed a comparative analysis of the gut microbiota in adulthood CD to evaluate whether: (i) dysbiosis anticipates mucosal lesions, (ii) gluten-free diet restores eubiosis, (iii) refractory CD has a peculiar microbial signature, and (iv) salivary and fecal communities overlap the mucosal one. Methods: This is a cross-sectional study where a total of 52 CD patients, including 13 active CD, 29 treated CD, 4 refractory CD, and 6 potential CD, were enrolled in a tertiary center together with 31 controls. A 16S rRNA-based amplicon metagenomics approach was applied to determine the microbiota structure and composition of salivary, duodenal mucosa, and stool samples, followed by appropriate bioinformatic analyses. Results: A reduction of both α- and β-diversity in CD, already evident in the potential form and achieving nadir in refractory CD, was evident. Taxonomically, mucosa displayed a significant abundance of Proteobacteria and an expansion of Neisseria, especially in active patients, while treated celiacs showed an intermediate profile between active disease and controls. The saliva community mirrored the mucosal one better than stool. Conclusion: Expansion of pathobiontic species anticipates villous atrophy and achieves the maximal divergence from controls in refractory CD. Gluten-free diet results in incomplete recovery. The overlapping results between mucosal and salivary samples indicate the use of saliva as a diagnostic fluid.

A Clinical and Histochemical Study of Celiac Disease Before and During a Gluten-Free Diet

1965 ◽  
Vol 48 (2) ◽  
pp. 155-172 ◽  
Author(s):  
I. Michael Samloff ◽  
John S. Davis ◽  
Eric A. Schenk
Keyword(s):  
Celiac Disease ◽  
Histochemical Study ◽  
Gluten Free Diet ◽  
Gluten Free
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