scholarly journals Outbreak of human toxoplasmosis in a rural area. A three year serologic follow-up study

1982 ◽  
Vol 77 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Sergio Gomes Coutinho ◽  
Anastácio Morgado ◽  
Marina Wagner ◽  
Renato Lobo ◽  
Frits Sutmoller
Keyword(s):  
Clinical Picture ◽  
Clinical Evidence ◽  
Toxoplasma Infection ◽  
Igg Antibody ◽  
Modes Of Transmission ◽  
Follow Up Study ◽  
Farm Population ◽  
Antibody Titres ◽  
Serologic Evidence

Thirty-six persons living on a farm located in the state of Minas Gerais (Brazil) were studied. Nine of them had the glandular form of toxoplasmosis, between May and August, 1976. These nine cases of toxoplasmosis were confirmed serologically by immunefluorescence-IF-, presenting IgG antibody titres between 1:4096 and 1:32000 and IgM antibody titres between 1:16 and 1:8000. Twelve out of thirty-six persons studied were considered to be "dubious cases". They were defined either by presenting a clinical picture compatible with acquired toxoplasmosis, yet having low serologic titres, or inversely they did not have a clear clinical picture but had serologic evidence of recent Toxoplasma infection. Fifteen out of thirty-six persons studied showed neither serologic nor clinical evidence of recent Toxoplasma infection. The epidemiologic information suggests two possible modes of transmission: a) poorly cooked pork at a barbecue party; b) farm vegetables and soil contaminated with Toxoplasma gondii oocysts (rat-cat cycle). Serologic follow-up nine months later in the human farm population demonstrated still high IgG titres, yet they tended to decline and IgM titres became negative. Three years later most of the IgG titres continued to decline and were almost compatible with the titres obtained in Brazilian population surveys.

Abstract 2425: Absence of Auto-Antibodies against Cardiac Troponin I Predicts Improvement of Left Ventricular Function after Acute Myocardial Infarction

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Florian Leuschner ◽  
Jin Li ◽  
Stefan Göser ◽  
Lars Reinhardt ◽  
Renate Öttl ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stroke Volume ◽  
Antibody Titer ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Igg Antibody ◽  
Follow Up Study

Application of antibodies against cardiac troponin I (cTnI-Ab) can induce dilation and dysfunction of the heart in mice. Recently, we demonstrated that immunization with cTnI induces inflammation and fibrosis in myocardium of mice. Others have shown that autoanti-bodies to cTnI are present in patients with acute coronary syndrome. But little is known about the clinical relevance of detected cTnI-Ab. First, anti-cTnI and anti-cTnT antibody titers were measured in sera from 272 patients with dilated- (DCM) and 185 with ischemic- (ICM) cardiomyopathy. Secondly, 108 patients with acute myocardial infarction (AMI) were included for a follow-up study. Heart characteristics were determined by magnetic resonance imaging 4 days and 6 –9 months after AMI. Altogether, in 7,0% of patients with DCM and in 9,2% with ICM an anti-cTnI IgG antibody titer ≥1:160 was measured. In contrast, only in 1,7% of patients with DCM and in 0,5% with ICM an anti-cTnT IgG antibody titer ≥1:160 was detected. Ten out of 108 patients included in the follow-up study were tested positive for cTnI-Ab with IgG Ab titers ≥1:160. TnI-Ab negative patients showed a significant increase in LVEF and stroke volume 6 –9 months after AMI. In contrast, there was no significant increase in LVEF and stroke volume in TnI-Ab positive patients. We demonstrate for the first time that the prevalence of cTnI-Abs in patients with AMI has an impact on the improvement of the LVEF over a study period of 6 –9 months.

THU-255-Long term outcomes of alcoholic patients without clinical evidence of liver disease: A 15 years follow-up study

2019 ◽  
Vol 70 (1) ◽  
pp. e274-e275
Author(s):  
sonia bernardo ◽  
Ricardo Crespo ◽  
Helena Cortez-Pinto ◽  
Mariana Machado
Keyword(s):  
Liver Disease ◽  
Clinical Evidence ◽  
Long Term Outcomes ◽  
Follow Up Study

scholarly journals Antibody-mediated Immunogenicity against SARS-CoV-2 following priming, boosting and hybrid immunity: insights from 11 months of follow-up of a healthcare worker cohort in Israel, December 2020-October 2021

2021 ◽  
Author(s):  
Michael Edelstein ◽  
Karine Beiruti ◽  
Hila Ben Amram ◽  
Naor Bar Zeev ◽  
Christian Sussan ◽  
...  
Keyword(s):  
Geometric Mean ◽  
Age Groups ◽  
Primary Vaccination ◽  
Optimal Timing ◽  
Infection Status ◽  
Igg Antibody ◽  
Antibody Titres ◽  
Previous Infection ◽  
Mean Concentration

Abstract Background: We determined circulating anti-S SARS-CoV-2 IgG antibody titres in a vaccinated healthcare workers (HCWs) cohort from Northern Israel in the 11 months following primary vaccination according to age, ethnicity, boosting timing and previous infection status. Methods: All consenting HCWs were invited to have their circulating IgG levels measured before vaccination and at 6 subsequent timepoints. All HCWs with suspected COVID-19 were PCR tested. We described trends in circulating IgG geometric mean concentration by age, ethnicity, timing of boosting and previous infection status and compared strata using Kruskall-Wallis tests. Results: Among 985 vaccinated HCWs. IgG titres gradually decreased in all groups over the study duration. Younger or previously infected individuals had higher initial IgG levels (p<0.001 in both cases); differences substantially decreased or disappeared at 7-9 months, before boosting. Pre-infection IgG levels in infected participants were similar to levels measured at the same timepoint in HCWs who remained uninfected (p>0.3). IgG GMC in those boosted 6-7 months after dose 2 was lower compared with those boosted 8-9 months after (1999-vs 2736, p=0.02). Conclusions: Immunity waned 6 months post-priming in all age groups and in previously infected individuals, reversed by boosting. IgG titres decrease among previously infected individuals and the proportion of reinfected individuals in this group, comparable to the proportion of breakthrough infection in previously uninfected individuals suggests individuals with hybrid immunity (infection+vaccination) may also require further doses. Our study also highlights the difficulty in determining protective IgG levels and the need to clarify the optimal timing in 3 dose regimens

scholarly journals A Comprehensive Follow-Up Study Identifying Diagnostic Evidences for Secondary Finding

2020 ◽  
Author(s):  
shu li ◽  
li haoyu ◽  
xiao neng ◽  
lin yixiang ◽  
yu wenxian ◽  
...  
Keyword(s):  
Clinical Evidence ◽  
Secondary Findings ◽  
Follow Up Study ◽  
Whole Exome ◽  
Clinical Presentations ◽  
Follow Up Studies ◽  
Genetics And Genomics ◽  
Secondary Variants ◽  
Secondary Finding

Abstract Background：There was a lacking of clinical diagnostic evidence in follow-up studies for reporting of secondary variants in 59 genes in American College of Medical Genetics and Genomics recommendations for reporting secondary findings and various strategies were applied to interpret the secondary variants. Results: Out of 1330 participants performed whole-exome sequencing, we identified 15 families with convincing clinical evidence. After Sanger validation and a comprehensive clinical follow-up, 10 families with both convincing clinical evidence and convincing genetic evidence of hereditary variants were found. Detailed clinical presentations and related clinical evidence were collected. Conclusions: Our research is a comprehensive follow-up study to identify secondary variants with convincing genetic and clinical evidence and it could help improve the strategy of screening actionable secondary variants and contribute to translation of genetic findings into medical practice.

Gender Identity Issues in Children and Adolescents

2017 ◽  
Vol 41 (S1) ◽  
pp. S57-S57
Author(s):  
T.D. Steensma
Keyword(s):  
Clinical Practice ◽  
Gender Identity ◽  
Medical Treatment ◽  
Children And Adolescents ◽  
Clinical Picture ◽  
Present Knowledge ◽  
Psychosexual Development ◽  
Follow Up Study ◽  
Competing Interest

Gender identity issues in children and adolescents.Gender dysphoria (GD) refers to the significant distress due to the incongruence between assigned gender at birth and experienced gender. Over the last decade, the care for prepubescent children and adolescents with GD is rapidly changing and there is a growing number of specialized gender clinics for youth. However, the offered care between countries is very different and the best clinical practice in this population is still controversial and under debate among dedicated professionals.The current presentation will focus on providing a clinical picture of children and adolescents referred to gender identity clinics. For prepubescent children the focus will be on the present knowledge about the psychosexual development of these children and treatment & counseling approaches are presented and discussed. With regard to the adolescents, medical treatment approaches are presented and discussed, followed by the results from the only follow-up study on medical treatment in adolescents with GD.Disclosure of interestThe author has not supplied his declaration of competing interest.

A Follow-Up Study of Hyperkinetic Children

1940 ◽  
Vol 86 (363) ◽  
pp. 624-631
Author(s):  
E. Guttmann ◽  
Mildred Creak
Keyword(s):  
Clinical Picture ◽  
Motor System ◽  
Early Stage ◽  
Neurological Diseases ◽  
Clear Cut ◽  
Follow Up Study

In a study on chorea, tics and compulsive utterances, Creak and Guttmann (1) discussed some problems of the inter-relation of organic neurological and neurotic symptoms. They showed that residuals, latent or manifest, of neurological diseases of the motor system may be instrumental in shaping the clinical picture of neuroses. There is generally no difficulty in demonstrating such interrelations, if the neurological anomalies are of a well-known type and clear cut in onset. Pareses, peripheral or central, or aphasic disorders, are generally not difficult to recognize where they are the nucleus of a neurotic picture, and not much objection is encountered if one tries to assess their importance, pathogenetic or pathoplastic, in a given clinical picture. This, however, is difficult where less well known syndromes are concerned, such as apraxic or agnosic pictures, or where beginning or end are gradual and the whole picture less clearly defined, as in disturbances of the extra-pyramidal motor system. To recognize an early stage of Parkinsonianism within a depression or other “neurotic” illness is not easy. The same is true of mild extra-pyramidal hyperkinetic states, partly because they may be so similar to normal movements (pseudo-purposeful), and partly because the milder anomalies as seen in early or later stages (and in abortive cases) are little known.

scholarly journals The Problems of Tracing

1986 ◽  
Vol 10 (3) ◽  
pp. 51-52
Author(s):  
Art O'Connor ◽  
Joan Daly
Keyword(s):  
Clinical Picture ◽  
Treatment Methods ◽  
Follow Up Study ◽  
Follow Up Studies ◽  
Long Term Follow Up

The importance of tracing technique and persistence was stressed by Sims. Long-term follow-up studies help to complete the clinical picture, a phrase used by Morris. They also help to clarify such issues as the effectiveness of treatment methods and changes in the socio-demographic status of patients. Unless a high percentage of the follow-up group is effectively traced, then the results of a long-term follow-up study must be suspect.

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