scholarly journals Model of induction of thyroid dysfunctions in adult female mice

2007 ◽  
Vol 59 (5) ◽  
pp. 1245-1249 ◽  
Author(s):  
E. Ferreira ◽  
A.E. Silva ◽  
R. Serakides ◽  
A.E.S. Gomes ◽  
G.D. Cassali
Keyword(s):  
Drinking Water ◽  
Adult Female ◽  
Thyroid Dysfunction ◽  
The State ◽  
Female Mice ◽  
Thyroid Dysfunctions ◽  
Swiss Strain

It is described the elaboration of a protocol to induce hyperthyroidism and hypothyroidism in mice by administrating thyroxin and propylthiouracil, respectively, in the drinking water. The drugs were administered to adult female mice of the Swiss strain for 30 days in order to obtain a systemic status of thyroid dysfunction. The induction of hyperthyroidism and hypothyroidism in the animals was confirmed by the histomorphological analysis of the thyroid in the end of the experiment, when the state of gland dysfunction in the animals submitted to the treatment was observed.

scholarly journals Fluoxetine exposure in adolescent and adult female mice decreases cocaine and sucrose preference later in life

2018 ◽  
Vol 33 (1) ◽  
pp. 145-153 ◽  
Author(s):  
Francisco J Flores-Ramirez ◽  
Israel Garcia-Carachure ◽  
David O Sanchez ◽  
Celene Gonzalez ◽  
Samuel A Castillo ◽  
...  
Keyword(s):  
Drinking Water ◽  
Conditioned Place Preference ◽  
Early Development ◽  
Adult Female ◽  
Model System ◽  
Psychotropic Medications ◽  
Sucrose Preference ◽  
Female Mice ◽  
Male Subjects ◽  
Conditioned Place Preference Paradigm

Background: Preclinical evidence from male subjects indicates that exposure to psychotropic medications, during early development, results in long-lasting altered responses to reward-related stimuli. However, it is not known if exposure to the antidepressant fluoxetine, in female subjects specifically, changes sensitivity to natural and drug rewards, later in life. Aims: The aim of this work was to investigate if exposure to fluoxetine mediates enduring changes in sensitivity to the rewarding properties of cocaine and sucrose, using female mice as a model system. Methods: We exposed C57BL/6 female mice to fluoxetine (250 mg/L in their drinking water) for 15 consecutive days, either during adolescence (postnatal day 35–49) or adulthood (postnatal day 70–84). Twenty-one days later, mice were examined on their behavioral reactivity to cocaine (0, 2.5, 5, 7.5 mg/kg) using the conditioned place preference paradigm, or assessed on the two-bottle sucrose (1%) test. Results: We found that regardless of age of antidepressant exposure, female mice pre-exposed to fluoxetine displayed reliable conditioning to the cocaine-paired compartment. However, when compared to respective age-matched controls, antidepressant pre-exposure decreased the magnitude of conditioning at the 5 and 7.5 mg/kg cocaine doses. Furthermore, fluoxetine pre-exposure reduced sucrose preference without altering total liquid intake. Conclusions: The data suggest that pre-exposure to fluoxetine, during adolescence or adulthood, results in a prolonged decrease in sensitivity to the rewarding properties of both natural and drug rewards in female C57BL/6 mice.

STRESS PADA LANSIA MENJADI FAKTOR PENYEBAB DAN AKIBAT TERJADINYA PENYAKIT

2015 ◽  
Vol 6 (2) ◽  
Author(s):  
Nur Hidaayah
Keyword(s):  
Drinking Water ◽  
Free Radicals ◽  
The Elderly ◽  
The State ◽  
Young Age ◽  
Fresh Fruit ◽  
Stress Conditions ◽  
Harmful Substances ◽  
Available Resources

Stress conditions in the elderly means an imbalance condition of biological, psychological, and social are closely related to the response to the threats and dangers faced by the elderly. Pressure or interference that is not fun is usually created when the elderly see a mismatch between the state and the 3 systems available resources. Maintenance actions that need to be done there are 2 types, namely : prevention of exposure to a stressor (precipitation factor) and serious treatment of the imbalance condition/ illness (precipitation factor). Prevention includes: sports, hobbies, friendship, avoid eating foods high in free radicals and harmful substances, sex and setting arrangements adequate rest. Habits of the above if done at a young age to avoid exposure to stress in the elderly. Treatment of the imbalance condition / illness, include : drinking water, meditation, eating fresh fruit, and adequate rest.

scholarly journals Preconceptional Resveratrol Supplementation Partially Counteracts Age-Related Reproductive Complications in C57BL/6J Female Mice

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1934
Author(s):  
Marta Ziętek ◽  
Katarzyna Barłowska ◽  
Barbara Wijas ◽  
Ewa Szablisty ◽  
Atanas G. Atanasov ◽  
...  
Keyword(s):  
Drinking Water ◽  
Animal Models ◽  
Mating Success ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Polyphenolic Compound ◽  
Female Mice ◽  
Age Related ◽  
Increased Risk ◽  
Anti Oxidant

Aging is associated with a drastic decline in fertility/fecundity and with an increased risk of pregnancy complications. Resveratrol (RES), a natural polyphenolic compound, has shown anti-oxidant and anti-inflammatory activities in both human and animal models, thus representing a potential therapeutic and prophylactic anti-aging supplement. Here, we investigated whether preconceptional resveratrol supplementation improved reproductive outcomes in mid-aged (8-month-old) and old (12-month-old) C57BL/6J female mice. Female siblings were cohoused and assigned to either RES or vehicle supplementation to drinking water for 10 consecutive weeks. Subsequently, females were mated with non-supplemented males and their pregnancy outcomes were monitored. RES improved mating success in old, but not in mid-aged females, and prevented the occurrence of delivery complications in the latter. These results indicate that preconceptional RES supplementation could partially improve age-related reproductive complications, but it was not sufficient to restore fecundity in female mice at a very advanced age.

The State of Fluoride in Drinking Water

1957 ◽  
Vol 36 (2) ◽  
pp. 192-202 ◽  
Author(s):  
Isaac Feldman ◽  
Donald Morken ◽  
Harold C. Hodge
Keyword(s):  
Drinking Water ◽  
The State

Institutional variations in practice of demand responsive approach: evidence from rural water supply in India

Water Policy ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. 650-668 ◽  
Author(s):  
Satyapriya Rout
Keyword(s):  
Drinking Water ◽  
Water Supply ◽  
Rural Areas ◽  
The State ◽  
Indian Society ◽  
Institution Building ◽  
Rural Water Supply ◽  
Long Run ◽  
Rural Water ◽  
Village Communities

The paper reports the main findings of a study, designed to develop a better understanding of institutional variations in working with the demand responsive approach (DRA) in rural water supply in the state of Odisha in India. Data for the paper were collected from twelve village communities, where water is being supplied either through their community based institution or through the local government institution of the Gram Panchayat. The findings suggest that the two types of institutions performed differently in implementing the DRA. It depicted that the DRA under the broader rubric of institutional reforms in the water sector has failed to address the question of social inequality, and rather had reinforced and extended the already existing inequity of Indian society to access to safe and secure drinking water in rural areas. The study highlights that participation, cost recovery, full operation and management transfer may be an efficient proposition, but not sustainable in the long run without proper investment in institution building and support from the state, especially in provisioning of basic services like drinking water to rural poor.

scholarly journals Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice

2013 ◽  
Vol 304 (12) ◽  
pp. E1321-E1330 ◽  
Author(s):  
Kazunari Nohara ◽  
Rizwana S. Waraich ◽  
Suhuan Liu ◽  
Mathieu Ferron ◽  
Aurélie Waget ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Glucose Intolerance ◽  
Adult Female ◽  
Sympathetic Tone ◽  
Visceral Adiposity ◽  
Androgen Excess ◽  
Altered Expression ◽  
Female Mice ◽  
The Impact

Among women, the polycystic ovarian syndrome (PCOS) is considered a form of metabolic syndrome with reproductive abnormalities. Women with PCOS show increased sympathetic tone, visceral adiposity with enlarged adipocytes, hypoadiponectinemia, insulin resistance, glucose intolerance, increased inactive osteocalcin, and hypertension. Excess fetal exposure to androgens has been hypothesized to play a role in the pathogenesis of PCOS. Previously, we showed that neonatal exposure to the androgen testosterone (NT) programs leptin resistance in adult female mice. Here, we studied the impact of NT on lean and adipose tissues, sympathetic tone in cardiometabolic tissues, and the development of metabolic dysfunction in mice. Neonatally androgenized adult female mice (NTF) displayed masculinization of lean tissues with increased cardiac and skeletal muscle as well as kidney masses. NTF mice showed increased and dysfunctional white adipose tissue with increased sympathetic tone in both visceral and subcutaneous fat as well as increased number of enlarged and insulin-resistant adipocytes that displayed altered expression of developmental genes and hypoadiponectinemia. NTF exhibited dysfunctional brown adipose tissue with increased mass and decreased energy expenditure. They also displayed decreased undercarboxylated and active osteocalcin and were predisposed to obesity during chronic androgen excess. NTF showed increased renal sympathetic tone associated with increased blood pressure, and they developed glucose intolerance and insulin resistance. Thus, developmental exposure to testosterone in female mice programs features of cardiometabolic dysfunction, as can be observed in women with PCOS, including increased sympathetic tone, visceral adiposity, insulin resistance, prediabetes, and hypertension.

scholarly journals Assessment of Fertility and Reproductive Toxicity in Adult Female Mice after Long-Term Exposure to Pueraria mirifica Herb

2007 ◽  
Vol 53 (5) ◽  
pp. 995-1005 ◽  
Author(s):  
Sukanya JAROENPORN ◽  
Suchinda MALAIVIJITNOND ◽  
Kingkaew WATTANASIRMKIT ◽  
Gen WATANABE ◽  
Kazuyoshi TAYA ◽  
...  
Keyword(s):  
Adult Female ◽  
Reproductive Toxicity ◽  
Pueraria Mirifica ◽  
Female Mice

scholarly journals Analysis of Physiochemical Parameters to Evaluate the Drinking Water Quality in the State of Perak, Malaysia

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
N. Rahmanian ◽  
Siti Hajar Bt Ali ◽  
M. Homayoonfard ◽  
N. J. Ali ◽  
M. Rehan ◽  
...  
Keyword(s):  
Water Quality ◽  
Drinking Water ◽  
Quality Standard ◽  
The State ◽  
Drinking Water Quality ◽  
World Health ◽  
Physiochemical Parameters ◽  
Health Organization ◽  
Public Health Protection ◽  
Physical And Chemical

The drinking water quality was investigated in suspected parts of Perak state, Malaysia, to ensure the continuous supply of clean and safe drinking water for the public health protection. In this regard, a detailed physical and chemical analysis of drinking water samples was carried out in different residential and commercial areas of the state. A number of parameters such as pH, turbidity, conductivity, total suspended solids (TSS), total dissolved solids (TDS), and heavy metals such as Cu, Zn, Mg, Fe, Cd, Pb, Cr, As, Hg, and Sn were analysed for each water sample collected during winter and summer periods. The obtained values of each parameter were compared with the standard values set by the World Health Organization (WHO) and local standards such as National Drinking Water Quality Standard (NDWQS). The values of each parameter were found to be within the safe limits set by the WHO and NDWQS. Overall, the water from all the locations was found to be safe as drinking water. However, it is also important to investigate other potential water contaminations such as chemicals and microbial and radiological materials for a longer period of time, including human body fluids, in order to assess the overall water quality of Perak state.

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