scholarly journals Assessment of Fertility and Reproductive Toxicity in Adult Female Mice after Long-Term Exposure to Pueraria mirifica Herb

2007 ◽  
Vol 53 (5) ◽  
pp. 995-1005 ◽  
Author(s):  
Sukanya JAROENPORN ◽  
Suchinda MALAIVIJITNOND ◽  
Kingkaew WATTANASIRMKIT ◽  
Gen WATANABE ◽  
Kazuyoshi TAYA ◽  
...  
Keyword(s):  
Adult Female ◽  
Reproductive Toxicity ◽  
Pueraria Mirifica ◽  
Female Mice

Chronic unpredictable stress and long-term ovariectomy affect arginine-vasopressin expression in the paraventricular nucleus of adult female mice

2014 ◽  
Vol 1588 ◽  
pp. 55-62 ◽  
Author(s):  
D. Grassi ◽  
N. Lagunas ◽  
I. Calmarza-Font ◽  
Y. Diz-Chaves ◽  
L.M. Garcia-Segura ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Adult Female ◽  
Arginine Vasopressin ◽  
Chronic Unpredictable Stress ◽  
Female Mice

scholarly journals Long-term exposure to polypharmacy impairs cognitive functions in young adult female mice

Aging ◽  
2021 ◽  
Author(s):  
Eroli Francesca ◽  
Johnell Kristina ◽  
Latorre-Leal María ◽  
Hilmer Sarah ◽  
Wastesson Jonas ◽  
...  
Keyword(s):  
Young Adult ◽  
Adult Female ◽  
Cognitive Functions ◽  
Female Mice

scholarly journals Effects of Long‐Term Exposure of Intermediate Frequency Magnetic Fields (20 kHz, 360 µT) on the Development, Pathological Findings, and Behavior of Female Mice

2021 ◽  
Author(s):  
Alexander Lerchl ◽  
Karen Drees (née Grote) ◽  
Isabel Gronau ◽  
Dirk Fischer ◽  
Julia Bauch ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Intermediate Frequency ◽  
Pathological Findings ◽  
Female Mice ◽  
And Behavior

scholarly journals Activation of Glutamate Transporter-1 (GLT-1) Confers Sex-Dependent Neuroprotection in Brain Ischemia

2021 ◽  
Vol 11 (1) ◽  
pp. 76
Author(s):  
Flavia A. Tejeda-Bayron ◽  
David E. Rivera-Aponte ◽  
Christian J. Malpica-Nieves ◽  
Gerónimo Maldonado-Martínez ◽  
Héctor M. Maldonado ◽  
...  
Keyword(s):  
Infarct Size ◽  
Glutamate Transporter ◽  
Triphenyltetrazolium Chloride ◽  
Stroke Outcomes ◽  
Female Mice ◽  
Protein Levels ◽  
Translational Activator ◽  
Glutamate Transporter 1 ◽  
Sensorimotor Performance

Stroke is one of the leading causes of long-term disability. During ischemic stroke, glutamate is released, reuptake processes are impaired, and glutamate promotes excitotoxic neuronal death. Astrocytic glutamate transporter 1 (GLT-1) is the major transporter responsible for removing excess glutamate from the extracellular space. A translational activator of GLT-1, LDN/OSU 0212320 (LDN) has been previously developed with beneficial outcomes in epileptic animal models but has never been tested as a potential therapeutic for ischemic strokes. The present study evaluated the effects of LDN on stroke-associated brain injury. Male and female mice received LDN or vehicle 24 h before or 2 h after focal ischemia was induced in the sensorimotor cortex. Sensorimotor performance was determined using the Rung Ladder Walk and infarct area was assessed using triphenyltetrazolium chloride staining. Males treated with LDN exhibited upregulated GLT-1 protein levels, significantly smaller infarct size, and displayed better sensorimotor performance in comparison to those treated with vehicle only. In contrast, there was no upregulation of GLT-1 protein levels and no difference in infarct size or sensorimotor performance between vehicle- and LDN-treated females. Taken together, our results indicate that the GLT-1 translational activator LDN improved stroke outcomes in young adult male, but not female mice.

The long term outcome of feminizing genital surgery for congenital adrenal hyperplasia: anatomical, functional and cosmetic outcomes, psychosexual development, and satisfaction in adult female patients

2003 ◽  
Vol 16 (5) ◽  
pp. 289-296 ◽  
Author(s):  
Nike M.M.L Stikkelbroeck ◽  
Catharina C.M Beerendonk ◽  
Wim N.P Willemsen ◽  
Conny A Schreuders-Bais ◽  
Wouter F.J Feitz ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adult Female ◽  
Psychosexual Development ◽  
Adrenal Hyperplasia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Genital Surgery ◽  
Female Patients ◽  
Cosmetic Outcomes

scholarly journals Short- and Long-Term Effects of Interleukin-2 Treatment on the Sensitivity of Periadolescent Female Mice to Interleukin-2 and Dopamine Uptake Inhibitor

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64473 ◽  
Author(s):  
James S. Rankin ◽  
Steven S. Zalcman ◽  
Youhua Zhu ◽  
Allan Siegel
Keyword(s):  
Interleukin 2 ◽  
Dopamine Uptake ◽  
Long Term Effects ◽  
Uptake Inhibitor ◽  
Female Mice ◽  
Short And Long Term

scholarly journals Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice

2013 ◽  
Vol 304 (12) ◽  
pp. E1321-E1330 ◽  
Author(s):  
Kazunari Nohara ◽  
Rizwana S. Waraich ◽  
Suhuan Liu ◽  
Mathieu Ferron ◽  
Aurélie Waget ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Glucose Intolerance ◽  
Adult Female ◽  
Sympathetic Tone ◽  
Visceral Adiposity ◽  
Androgen Excess ◽  
Altered Expression ◽  
Female Mice ◽  
The Impact

Among women, the polycystic ovarian syndrome (PCOS) is considered a form of metabolic syndrome with reproductive abnormalities. Women with PCOS show increased sympathetic tone, visceral adiposity with enlarged adipocytes, hypoadiponectinemia, insulin resistance, glucose intolerance, increased inactive osteocalcin, and hypertension. Excess fetal exposure to androgens has been hypothesized to play a role in the pathogenesis of PCOS. Previously, we showed that neonatal exposure to the androgen testosterone (NT) programs leptin resistance in adult female mice. Here, we studied the impact of NT on lean and adipose tissues, sympathetic tone in cardiometabolic tissues, and the development of metabolic dysfunction in mice. Neonatally androgenized adult female mice (NTF) displayed masculinization of lean tissues with increased cardiac and skeletal muscle as well as kidney masses. NTF mice showed increased and dysfunctional white adipose tissue with increased sympathetic tone in both visceral and subcutaneous fat as well as increased number of enlarged and insulin-resistant adipocytes that displayed altered expression of developmental genes and hypoadiponectinemia. NTF exhibited dysfunctional brown adipose tissue with increased mass and decreased energy expenditure. They also displayed decreased undercarboxylated and active osteocalcin and were predisposed to obesity during chronic androgen excess. NTF showed increased renal sympathetic tone associated with increased blood pressure, and they developed glucose intolerance and insulin resistance. Thus, developmental exposure to testosterone in female mice programs features of cardiometabolic dysfunction, as can be observed in women with PCOS, including increased sympathetic tone, visceral adiposity, insulin resistance, prediabetes, and hypertension.

scholarly journals Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhen Lyu ◽  
Shreya Ghoshdastidar ◽  
Karamkolly R. Rekha ◽  
Dhananjay Suresh ◽  
Jiude Mao ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Body Fat ◽  
Repetitive Behaviors ◽  
Developmental Exposure ◽  
Male And Female ◽  
Female Mice ◽  
Gut Dysbiosis ◽  
Study Results ◽  
Wide Range

AbstractDue to their antimicrobial properties, silver nanoparticles (AgNPs) are used in a wide range of consumer products that includes topical wound dressings, coatings for biomedical devices, and food-packaging to extend the shelf-life. Despite their beneficial antimicrobial effects, developmental exposure to such AgNPs may lead to gut dysbiosis and long-term health consequences in exposed offspring. AgNPs can cross the placenta and blood–brain-barrier to translocate in the brain of offspring. The underlying hypothesis tested in the current study was that developmental exposure of male and female mice to AgNPs disrupts the microbiome–gut–brain axis. To examine for such effects, C57BL6 female mice were exposed orally to AgNPs at a dose of 3 mg/kg BW or vehicle control 2 weeks prior to breeding and throughout gestation. Male and female offspring were tested in various mazes that measure different behavioral domains, and the gut microbial profiles were surveyed from 30 through 120 days of age. Our study results suggest that developmental exposure results in increased likelihood of engaging in repetitive behaviors and reductions in resident microglial cells. Echo-MRI results indicate increased body fat in offspring exposed to AgNPs exhibit. Coprobacillus spp., Mucispirillum spp., and Bifidobacterium spp. were reduced, while Prevotella spp., Bacillus spp., Planococcaceae, Staphylococcus spp., Enterococcus spp., and Ruminococcus spp. were increased in those developmentally exposed to NPs. These bacterial changes were linked to behavioral and metabolic alterations. In conclusion, developmental exposure of AgNPs results in long term gut dysbiosis, body fat increase and neurobehavioral alterations in offspring.

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